The Experts below are selected from a list of 222 Experts worldwide ranked by ideXlab platform
J. F. Hecker - One of the best experts on this subject based on the ideXlab platform.
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Long term stability of heparin in Dextrose‐saline intravenous fluids
International Journal of Pharmacy Practice, 1995Co-Authors: Alex Wright, J. F. HeckerAbstract:In vitro studies showed that heparin added at liu per ml to 5 per cent Dextrose solution lost most of its activity during 12 months' storage at both 20 to 25C and 2 to 5C but retained its activity when added to normal saline and to a 3.75 per cent Dextrose-saline mixture at these temperatures. Activity of 10iu per ml of heparin in 5 per cent Dextrose solution was retained at 20 to 25C for 12 months. These findings suggest that low-dose heparin is stable for long periods in Dextrose-saline but not in Dextrose solutions
Robert S Ware - One of the best experts on this subject based on the ideXlab platform.
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a randomised controlled trial of hartmann s solution versus half normal saline in postoperative paediatric spinal instrumentation and craniotomy patients
Archives of Disease in Childhood, 2012Co-Authors: Mark G Coulthard, Debbie Long, Amanda J Ullman, Robert S WareAbstract:Objective To compare the difference in plasma sodium at 16–18 h following major surgery in children who were prescribed either Hartmann9s and 5% Dextrose or 0.45% saline and 5% Dextrose. Design A prospective, randomised, open label study. Setting The paediatric intensive care unit (650 admissions per annum) in a tertiary children9s hospital in Brisbane, Australia. Patients The study group comprised 82 children undergoing spinal instrumentation, craniotomy for brain tumour resection, or cranial vault remodelling. Interventions Patients received either Hartmann9s and 5% Dextrose at full maintenance rate or 0.45% saline and 5% Dextrose at two-thirds maintenance rate. Main outcomes measures Primary outcome measure: plasma sodium at 16–18 h postoperatively; secondary outcome measure: number of fluid boluses administered. Results Mean postoperative plasma sodium levels of children receiving 0.45% saline and 5% Dextrose were 1.4 mmol/l (95% CI 0.4 to 2.5) lower than those receiving Hartmann9s and 5% Dextrose (p=0.008). In the 0.45% saline group, seven patients (18%) became hyponatraemic (Na Conclusions The postoperative fall in plasma sodium was smaller in children who received Hartmann9s and 5% Dextrose compared to those who received 0.45% saline and 5% Dextrose. It is suggested that Hartmann9s and 5% Dextrose should be administered at full maintenance rate postoperatively to children who have undergone major surgery in preference to hypotonic fluids.
Alex Wright - One of the best experts on this subject based on the ideXlab platform.
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Long term stability of heparin in Dextrose‐saline intravenous fluids
International Journal of Pharmacy Practice, 1995Co-Authors: Alex Wright, J. F. HeckerAbstract:In vitro studies showed that heparin added at liu per ml to 5 per cent Dextrose solution lost most of its activity during 12 months' storage at both 20 to 25C and 2 to 5C but retained its activity when added to normal saline and to a 3.75 per cent Dextrose-saline mixture at these temperatures. Activity of 10iu per ml of heparin in 5 per cent Dextrose solution was retained at 20 to 25C for 12 months. These findings suggest that low-dose heparin is stable for long periods in Dextrose-saline but not in Dextrose solutions
Johannes Tramper - One of the best experts on this subject based on the ideXlab platform.
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The Use of Freezing‐Point Depression for the Theoretical Dextrose Equivalent Measurement
Starch-starke, 2006Co-Authors: Leon M Marchal, Jan Jonkers, Johannes TramperAbstract:The determination of the theoretical Dextrose equivalent was investigated, by measuring the osmolality (mol dissolved particles/kg H2O) by freezing-point depression. Relations for Dextrose equivalent and increase in dry weight during a hydrolysis were derived as a function of molality and amount of dry weight at the start of the hydrolysis. With freezing-point depression it was possible to determine the theoretical Dextrose equivalent of oligosaccharides (Dextrose to maltoheptaose), whereas a traditional titration method (Luff-Schoorl) overestimates 20-50%. The relation for the increase of dry weight during the hydrolysis of starch with an α-amylase was experimentally validated. The overestimation of Dextrose equivalent by Luff-Schoorl titration was also evident in the hydrolysis of amylopectin potato starch. With freezing-point depression it was possible to determine the theoretical Dextrose equivalent fast and accurate.
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the use of freezing point depression for the theoretical Dextrose equivalent measurement
Starch-starke, 1996Co-Authors: Leon M Marchal, Jan Jonkers, Johannes TramperAbstract:The determination of the theoretical Dextrose equivalent was investigated, by measuring the osmolality (mol dissolved particles/kg H2O) by freezing-point depression. Relations for Dextrose equivalent and increase in dry weight during a hydrolysis were derived as a function of molality and amount of dry weight at the start of the hydrolysis. With freezing-point depression it was possible to determine the theoretical Dextrose equivalent of oligosaccharides (Dextrose to maltoheptaose), whereas a traditional titration method (Luff-Schoorl) overestimates 20-50%. The relation for the increase of dry weight during the hydrolysis of starch with an α-amylase was experimentally validated. The overestimation of Dextrose equivalent by Luff-Schoorl titration was also evident in the hydrolysis of amylopectin potato starch. With freezing-point depression it was possible to determine the theoretical Dextrose equivalent fast and accurate.
Kenneth Dean Reeves - One of the best experts on this subject based on the ideXlab platform.
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short term analgesic effects of 5 Dextrose epidural injections for chronic low back pain a randomized controlled trial
Anesthesiology and Pain Medicine, 2016Co-Authors: Liza Maniquissmigel, Kenneth Dean Reeves, Howard J Rosen, John Lyftogt, Cassie Grahamcoleman, Anlin Cheng, David RabagoAbstract:Background: Hypertonic Dextrose injection (prolotherapy) is reported to reduce pain including non-surgical chronic low back pain (CLBP), and subcutaneous injection of 5% Dextrose is reported to reduce neurogenic pain, hyperalgesia and allodynia. The mechanism in both cases is unclear, though a direct effect of Dextrose on neurogenic pain has been proposed. This study assessed the short-term analgesic effects of epidural 5% Dextrose injection compared with saline for non-surgical CLBP. Methods: Randomized double-blind (injector, participant) controlled trial. Adults with moderate-to-severe non-surgical low back pain with radiation to gluteal or leg areas for at least 6 months received a single epidurogram-confirmed epidural injection of 10 mL of 5% Dextrose or 0.9% saline using a published vertical caudal injection technique. The primary outcome was change in a numerical rating scale (NRS, 0 - 10 points) pain score between baseline and 15 minutes; and 2, 4, and 48 hours and 2 weeks post-injection. The secondary outcome was percentage of participants achieving 50% or more pain improvement at 4 hours. Results and Conclusions: No baseline differences existed between groups; 35 participants (54 ± 10.7 years old; 11 female) with moderate-to-severe CLBP (6.7 ± 1.3 points) for 10.6 ± 10.5 years. Dextrose participants reported greater NRS pain score change at 15 minutes (4.4 ± 1.7 vs 2.4 ± 2.8 points; P = 0.015), 2 hours (4.6 ± 1.9 vs 1.8 ± 2.8 points; P = 0.001), 4 hours (4.6 ± 2.0 vs 1.4 ± 2.3 points; P < 0.001), and 48 hours (3.0 ± 2.3 vs 1.0 ± 2.1 points; P = 0.012), but not at 2 weeks (2.1 ± 2.9 vs 1.2 ± 2.4 points; P = 0.217). Eighty four percent (16/19) of Dextrose recipients and 19% (3/16) of saline recipients reported ≥ 50% pain reduction at 4 hours (P < 0.001). These findings suggest a neurogenic effect of 5% Dextrose on pain at the dorsal root level; waning pain control at 2 weeks suggests the need to assess the effect of serial Dextrose epidural injections in a long-term study with robust outcome assessment.
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Hyperosmolar Dextrose injection for recalcitrant Osgood-Schlatter disease.
Pediatrics, 2011Co-Authors: Gastón Andrés Topol, Leandro Ariel Podesta, Kenneth Dean Reeves, Marcelo Francisco Raya, Bradley D. Fullerton, Hung-wen YehAbstract:OBJECTIVE: To examine the potential of Dextrose injection versus lidocaine injection versus supervised usual care to reduce sport alteration and sport-related symptoms in adolescent athletes with Osgood-Schlatter disease. PATIENTS AND METHODS: Girls aged 9 to 15 and boys aged 10 to 17 were randomly assigned to either therapist-supervised usual care or double-blind injection of 1% lidocaine solution with or without 12.5% Dextrose. Injections were administered monthly for 3 months. All subjects were then offered Dextrose injections monthly as needed. Unaltered sport (Nirschl Pain Phase Scale RESULTS: Sixty-five knees in 54 athletes were treated. Compared with usual care at 3 months, unaltered sport was more common in both Dextrose-treated (21 of 21 vs 13 of 22; P = .001) and lidocaine-treated (20 of 22 vs 13 of 22; P = .034) knees, and asymptomatic sport was more frequent in Dextrose-treated knees than either lidocaine-treated (14 of 21 vs 5 of 22; P = .006) or usual-care–treated (14 of 21 vs 3 of 22; P P = .024) or only usual care (32 of 38 vs 2 of 14; P CONCLUSIONS: Our results suggest superior symptom-reduction efficacy of injection therapy over usual care in the treatment of Osgood-Schlatter disease in adolescents. A significant component of the effect seems to be associated with the Dextrose component of a Dextrose/lidocaine solution. Dextrose injection over the apophysis and patellar tendon origin was safe and well tolerated and resulted in more rapid and frequent achievement of unaltered sport and asymptomatic sport than usual care.