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Ismaila Alhaji Umar - One of the best experts on this subject based on the ideXlab platform.
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Elevated serum sialic acids, a potent biomarker of alloxan-induced type 1 Diabetes in Dogs by ethanolic extract of Anogeissus leiocarpus
Journal of Diabetes & Metabolic Disorders, 2021Co-Authors: King Akpofure Nelson Esievo, Sabina Mbafan Num-adom, Sani Adamu, Ngozi Ejum Ogbuagu, Tagang Aluwong, Ismaila Alhaji UmarAbstract:Objectives This study investigated serum sialic acids for a predictive and diagnostic biomarker of Diabetes mellitus (DM) in Dogs and its prognostic value with ethanolic extract of Anogeissus leiocarpus . Design Four groups of 3 Dogs were used; non-diabetic controls (ND), diabetic-untreated (DU), diabetic insulin-treated (DI) and diabetic extract-treated (DE). Free serum sialic acids (FSSA) and erythrocyte surface sialic acids (ESSA) were assayed in all groups, pre-and post-induction of hyperglycaemia and results were presented as means ± standard error of means (SEM) and subjected to ANOVA using Tukey’s post-hoc tests with GraphPad Prism® statistical package. Results FSSA increased in DU and plateaued at third week (61.8 ± 0.41 μg/ml), ( P
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Elevated serum sialic acids, a potent biomarker of alloxan-induced type 1 Diabetes in Dogs by ethanolic extract of Anogeissus leiocarpus
Journal of Diabetes & Metabolic Disorders, 2021Co-Authors: King Akpofure Nelson Esievo, Sabina Mbafan Num-adom, Sani Adamu, Ngozi Ejum Ogbuagu, Tagang Aluwong, Ismaila Alhaji UmarAbstract:This study investigated serum sialic acids for a predictive and diagnostic biomarker of Diabetes mellitus (DM) in Dogs and its prognostic value with ethanolic extract of Anogeissus leiocarpus. Four groups of 3 Dogs were used; non-diabetic controls (ND), diabetic-untreated (DU), diabetic insulin-treated (DI) and diabetic extract-treated (DE). Free serum sialic acids (FSSA) and erythrocyte surface sialic acids (ESSA) were assayed in all groups, pre-and post-induction of hyperglycaemia and results were presented as means ± standard error of means (SEM) and subjected to ANOVA using Tukey’s post-hoc tests with GraphPad Prism® statistical package. FSSA increased in DU and plateaued at third week (61.8 ± 0.41 μg/ml), (P
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elevated serum sialic acids a potent biomarker of alloxan induced type 1 Diabetes in Dogs by ethanolic extract of anogeissus leiocarpus
Journal of diabetes and metabolic disorders, 2021Co-Authors: King Akpofure Nelson Esievo, Sani Adamu, Ngozi Ejum Ogbuagu, Tagang Aluwong, Sabina Mbafan Numadom, Ismaila Alhaji UmarAbstract:This study investigated serum sialic acids for a predictive and diagnostic biomarker of Diabetes mellitus (DM) in Dogs and its prognostic value with ethanolic extract of Anogeissus leiocarpus. Four groups of 3 Dogs were used; non-diabetic controls (ND), diabetic-untreated (DU), diabetic insulin-treated (DI) and diabetic extract-treated (DE). Free serum sialic acids (FSSA) and erythrocyte surface sialic acids (ESSA) were assayed in all groups, pre-and post-induction of hyperglycaemia and results were presented as means ± standard error of means (SEM) and subjected to ANOVA using Tukey’s post-hoc tests with GraphPad Prism® statistical package. FSSA increased in DU and plateaued at third week (61.8 ± 0.41 μg/ml), (P < 0.002) with additional 38.2 μg/ml (62%) generated, coinciding with hyperglycaemia. FSSA of DI increased but declined to 22.3 ± 1.55 μg/ml. Extract of Anogeissus leiocarpus effectively modulated FSSA in DE as increased value declined to 21.4 ± 0.78 μg/ml. Pre-induction DU ESSA (8.27 ± 0.11 μg/ml) significantly (P < 0.002) decreased by third week (2.33 ± 1.49 μg/ml), coinciding with hyperglycaemia. Strong negative correlation coefficient (r = −0.92) occurred between DU’s FSSA and ESSA and ND (P < 0.03). Sialic acid expression in dog’s insulin dependent Diabetes mellitus (IDDM) is 18% lower than normal. Extract of A. leiocarpus restored ESSA completely. ESSA cleaved in DU, 5.94 μg/ml (72%), could not account for the extra FSSA (32.26 μg/ml); liver and kidneys are contributors. FSSA predicts canine DM.
King Akpofure Nelson Esievo - One of the best experts on this subject based on the ideXlab platform.
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Elevated serum sialic acids, a potent biomarker of alloxan-induced type 1 Diabetes in Dogs by ethanolic extract of Anogeissus leiocarpus
Journal of Diabetes & Metabolic Disorders, 2021Co-Authors: King Akpofure Nelson Esievo, Sabina Mbafan Num-adom, Sani Adamu, Ngozi Ejum Ogbuagu, Tagang Aluwong, Ismaila Alhaji UmarAbstract:Objectives This study investigated serum sialic acids for a predictive and diagnostic biomarker of Diabetes mellitus (DM) in Dogs and its prognostic value with ethanolic extract of Anogeissus leiocarpus . Design Four groups of 3 Dogs were used; non-diabetic controls (ND), diabetic-untreated (DU), diabetic insulin-treated (DI) and diabetic extract-treated (DE). Free serum sialic acids (FSSA) and erythrocyte surface sialic acids (ESSA) were assayed in all groups, pre-and post-induction of hyperglycaemia and results were presented as means ± standard error of means (SEM) and subjected to ANOVA using Tukey’s post-hoc tests with GraphPad Prism® statistical package. Results FSSA increased in DU and plateaued at third week (61.8 ± 0.41 μg/ml), ( P
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Elevated serum sialic acids, a potent biomarker of alloxan-induced type 1 Diabetes in Dogs by ethanolic extract of Anogeissus leiocarpus
Journal of Diabetes & Metabolic Disorders, 2021Co-Authors: King Akpofure Nelson Esievo, Sabina Mbafan Num-adom, Sani Adamu, Ngozi Ejum Ogbuagu, Tagang Aluwong, Ismaila Alhaji UmarAbstract:This study investigated serum sialic acids for a predictive and diagnostic biomarker of Diabetes mellitus (DM) in Dogs and its prognostic value with ethanolic extract of Anogeissus leiocarpus. Four groups of 3 Dogs were used; non-diabetic controls (ND), diabetic-untreated (DU), diabetic insulin-treated (DI) and diabetic extract-treated (DE). Free serum sialic acids (FSSA) and erythrocyte surface sialic acids (ESSA) were assayed in all groups, pre-and post-induction of hyperglycaemia and results were presented as means ± standard error of means (SEM) and subjected to ANOVA using Tukey’s post-hoc tests with GraphPad Prism® statistical package. FSSA increased in DU and plateaued at third week (61.8 ± 0.41 μg/ml), (P
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elevated serum sialic acids a potent biomarker of alloxan induced type 1 Diabetes in Dogs by ethanolic extract of anogeissus leiocarpus
Journal of diabetes and metabolic disorders, 2021Co-Authors: King Akpofure Nelson Esievo, Sani Adamu, Ngozi Ejum Ogbuagu, Tagang Aluwong, Sabina Mbafan Numadom, Ismaila Alhaji UmarAbstract:This study investigated serum sialic acids for a predictive and diagnostic biomarker of Diabetes mellitus (DM) in Dogs and its prognostic value with ethanolic extract of Anogeissus leiocarpus. Four groups of 3 Dogs were used; non-diabetic controls (ND), diabetic-untreated (DU), diabetic insulin-treated (DI) and diabetic extract-treated (DE). Free serum sialic acids (FSSA) and erythrocyte surface sialic acids (ESSA) were assayed in all groups, pre-and post-induction of hyperglycaemia and results were presented as means ± standard error of means (SEM) and subjected to ANOVA using Tukey’s post-hoc tests with GraphPad Prism® statistical package. FSSA increased in DU and plateaued at third week (61.8 ± 0.41 μg/ml), (P < 0.002) with additional 38.2 μg/ml (62%) generated, coinciding with hyperglycaemia. FSSA of DI increased but declined to 22.3 ± 1.55 μg/ml. Extract of Anogeissus leiocarpus effectively modulated FSSA in DE as increased value declined to 21.4 ± 0.78 μg/ml. Pre-induction DU ESSA (8.27 ± 0.11 μg/ml) significantly (P < 0.002) decreased by third week (2.33 ± 1.49 μg/ml), coinciding with hyperglycaemia. Strong negative correlation coefficient (r = −0.92) occurred between DU’s FSSA and ESSA and ND (P < 0.03). Sialic acid expression in dog’s insulin dependent Diabetes mellitus (IDDM) is 18% lower than normal. Extract of A. leiocarpus restored ESSA completely. ESSA cleaved in DU, 5.94 μg/ml (72%), could not account for the extra FSSA (32.26 μg/ml); liver and kidneys are contributors. FSSA predicts canine DM.
Jonathan P. Whitehead - One of the best experts on this subject based on the ideXlab platform.
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distinct adiponectin profiles might contribute to differences in susceptibility to type 2 Diabetes in Dogs and humans
Domestic Animal Endocrinology, 2011Co-Authors: K.r. Verkest, John M. Morton, Ayanthi A. Richards, F.j. Rose, J S Rand, L M Fleeman, Jonathan P. WhiteheadAbstract:Dogs develop obesity-associated insulin resistance but not type 2 Diabetes mellitus. Low adiponectin is associated with progression to type 2 Diabetes in obese humans. The aims of this study were to compare total and high molecular weight (HMW) adiponectin and the ratio of HMW to total adiponectin (SA) between Dogs and humans and to examine whether total or HMW adiponectin or both are associated with insulin resistance in naturally occurring obese Dogs. We compared adiponectin profiles between 10 lean Dogs and 10 lean humans and between 6 lean Dogs and 6 age- and sex-matched, client-owned obese Dogs. Total adiponectin was measured with assays validated in each species. We measured SA with velocity centrifugation on sucrose gradients. The effect of total and HMW adiponectin concentrations on MinMOD-estimated insulin sensitivity was assessed with linear regression. Lean Dogs had total and HMW adiponectin concentrations three to four times higher than lean humans (total: Dogs 32 ± 5.6 mg/L, humans 10 ± 1.3 mg/L, P<0.001; HMW: Dogs 25 ± 4.5 mg/L, humans 6 ± 1.3 mg/L, P<0.001) and a higher SA (Dogs: 0.78 ± 0.05; humans: 0.54 ± 0.08, P = 0.002). Adiponectin concentrations and SA were not lower in obese Dogs (0.76 ± 0.05 in both groups; P=1). Total adiponectin, HMW adiponectin, and SA were not associated with insulin sensitivity in Dogs. We propose that differences in adiponectin profiles between humans and Dogs might contribute to the propensity of humans but not Dogs to develop type 2 Diabetes. Dogs with chronic, naturally occurring obesity do not have selectively reduced HMW adiponectin, and adiponectin does not appear to be important in the development of canine obesity-associated insulin resistance.
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Distinct adiponectin profiles might contribute to differences in susceptibility to type 2 Diabetes in Dogs and humans.
Domestic animal endocrinology, 2011Co-Authors: K.r. Verkest, Linda M. Fleeman, Jacquie Rand, John M. Morton, Ayanthi A. Richards, F.j. Rose, Jonathan P. WhiteheadAbstract:Dogs develop obesity-associated insulin resistance but not type 2 Diabetes mellitus. Low adiponectin is associated with progression to type 2 Diabetes in obese humans. The aims of this study were to compare total and high molecular weight (HMW) adiponectin and the ratio of HMW to total adiponectin (SA) between Dogs and humans and to examine whether total or HMW adiponectin or both are associated with insulin resistance in naturally occurring obese Dogs. We compared adiponectin profiles between 10 lean Dogs and 10 lean humans and between 6 lean Dogs and 6 age- and sex-matched, client-owned obese Dogs. Total adiponectin was measured with assays validated in each species. We measured SA with velocity centrifugation on sucrose gradients. The effect of total and HMW adiponectin concentrations on MinMOD-estimated insulin sensitivity was assessed with linear regression. Lean Dogs had total and HMW adiponectin concentrations three to four times higher than lean humans (total: Dogs 32 ± 5.6 mg/L, humans 10 ± 1.3 mg/L, P
Sani Adamu - One of the best experts on this subject based on the ideXlab platform.
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Elevated serum sialic acids, a potent biomarker of alloxan-induced type 1 Diabetes in Dogs by ethanolic extract of Anogeissus leiocarpus
Journal of Diabetes & Metabolic Disorders, 2021Co-Authors: King Akpofure Nelson Esievo, Sabina Mbafan Num-adom, Sani Adamu, Ngozi Ejum Ogbuagu, Tagang Aluwong, Ismaila Alhaji UmarAbstract:Objectives This study investigated serum sialic acids for a predictive and diagnostic biomarker of Diabetes mellitus (DM) in Dogs and its prognostic value with ethanolic extract of Anogeissus leiocarpus . Design Four groups of 3 Dogs were used; non-diabetic controls (ND), diabetic-untreated (DU), diabetic insulin-treated (DI) and diabetic extract-treated (DE). Free serum sialic acids (FSSA) and erythrocyte surface sialic acids (ESSA) were assayed in all groups, pre-and post-induction of hyperglycaemia and results were presented as means ± standard error of means (SEM) and subjected to ANOVA using Tukey’s post-hoc tests with GraphPad Prism® statistical package. Results FSSA increased in DU and plateaued at third week (61.8 ± 0.41 μg/ml), ( P
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Elevated serum sialic acids, a potent biomarker of alloxan-induced type 1 Diabetes in Dogs by ethanolic extract of Anogeissus leiocarpus
Journal of Diabetes & Metabolic Disorders, 2021Co-Authors: King Akpofure Nelson Esievo, Sabina Mbafan Num-adom, Sani Adamu, Ngozi Ejum Ogbuagu, Tagang Aluwong, Ismaila Alhaji UmarAbstract:This study investigated serum sialic acids for a predictive and diagnostic biomarker of Diabetes mellitus (DM) in Dogs and its prognostic value with ethanolic extract of Anogeissus leiocarpus. Four groups of 3 Dogs were used; non-diabetic controls (ND), diabetic-untreated (DU), diabetic insulin-treated (DI) and diabetic extract-treated (DE). Free serum sialic acids (FSSA) and erythrocyte surface sialic acids (ESSA) were assayed in all groups, pre-and post-induction of hyperglycaemia and results were presented as means ± standard error of means (SEM) and subjected to ANOVA using Tukey’s post-hoc tests with GraphPad Prism® statistical package. FSSA increased in DU and plateaued at third week (61.8 ± 0.41 μg/ml), (P
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elevated serum sialic acids a potent biomarker of alloxan induced type 1 Diabetes in Dogs by ethanolic extract of anogeissus leiocarpus
Journal of diabetes and metabolic disorders, 2021Co-Authors: King Akpofure Nelson Esievo, Sani Adamu, Ngozi Ejum Ogbuagu, Tagang Aluwong, Sabina Mbafan Numadom, Ismaila Alhaji UmarAbstract:This study investigated serum sialic acids for a predictive and diagnostic biomarker of Diabetes mellitus (DM) in Dogs and its prognostic value with ethanolic extract of Anogeissus leiocarpus. Four groups of 3 Dogs were used; non-diabetic controls (ND), diabetic-untreated (DU), diabetic insulin-treated (DI) and diabetic extract-treated (DE). Free serum sialic acids (FSSA) and erythrocyte surface sialic acids (ESSA) were assayed in all groups, pre-and post-induction of hyperglycaemia and results were presented as means ± standard error of means (SEM) and subjected to ANOVA using Tukey’s post-hoc tests with GraphPad Prism® statistical package. FSSA increased in DU and plateaued at third week (61.8 ± 0.41 μg/ml), (P < 0.002) with additional 38.2 μg/ml (62%) generated, coinciding with hyperglycaemia. FSSA of DI increased but declined to 22.3 ± 1.55 μg/ml. Extract of Anogeissus leiocarpus effectively modulated FSSA in DE as increased value declined to 21.4 ± 0.78 μg/ml. Pre-induction DU ESSA (8.27 ± 0.11 μg/ml) significantly (P < 0.002) decreased by third week (2.33 ± 1.49 μg/ml), coinciding with hyperglycaemia. Strong negative correlation coefficient (r = −0.92) occurred between DU’s FSSA and ESSA and ND (P < 0.03). Sialic acid expression in dog’s insulin dependent Diabetes mellitus (IDDM) is 18% lower than normal. Extract of A. leiocarpus restored ESSA completely. ESSA cleaved in DU, 5.94 μg/ml (72%), could not account for the extra FSSA (32.26 μg/ml); liver and kidneys are contributors. FSSA predicts canine DM.
Ngozi Ejum Ogbuagu - One of the best experts on this subject based on the ideXlab platform.
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Elevated serum sialic acids, a potent biomarker of alloxan-induced type 1 Diabetes in Dogs by ethanolic extract of Anogeissus leiocarpus
Journal of Diabetes & Metabolic Disorders, 2021Co-Authors: King Akpofure Nelson Esievo, Sabina Mbafan Num-adom, Sani Adamu, Ngozi Ejum Ogbuagu, Tagang Aluwong, Ismaila Alhaji UmarAbstract:Objectives This study investigated serum sialic acids for a predictive and diagnostic biomarker of Diabetes mellitus (DM) in Dogs and its prognostic value with ethanolic extract of Anogeissus leiocarpus . Design Four groups of 3 Dogs were used; non-diabetic controls (ND), diabetic-untreated (DU), diabetic insulin-treated (DI) and diabetic extract-treated (DE). Free serum sialic acids (FSSA) and erythrocyte surface sialic acids (ESSA) were assayed in all groups, pre-and post-induction of hyperglycaemia and results were presented as means ± standard error of means (SEM) and subjected to ANOVA using Tukey’s post-hoc tests with GraphPad Prism® statistical package. Results FSSA increased in DU and plateaued at third week (61.8 ± 0.41 μg/ml), ( P
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Elevated serum sialic acids, a potent biomarker of alloxan-induced type 1 Diabetes in Dogs by ethanolic extract of Anogeissus leiocarpus
Journal of Diabetes & Metabolic Disorders, 2021Co-Authors: King Akpofure Nelson Esievo, Sabina Mbafan Num-adom, Sani Adamu, Ngozi Ejum Ogbuagu, Tagang Aluwong, Ismaila Alhaji UmarAbstract:This study investigated serum sialic acids for a predictive and diagnostic biomarker of Diabetes mellitus (DM) in Dogs and its prognostic value with ethanolic extract of Anogeissus leiocarpus. Four groups of 3 Dogs were used; non-diabetic controls (ND), diabetic-untreated (DU), diabetic insulin-treated (DI) and diabetic extract-treated (DE). Free serum sialic acids (FSSA) and erythrocyte surface sialic acids (ESSA) were assayed in all groups, pre-and post-induction of hyperglycaemia and results were presented as means ± standard error of means (SEM) and subjected to ANOVA using Tukey’s post-hoc tests with GraphPad Prism® statistical package. FSSA increased in DU and plateaued at third week (61.8 ± 0.41 μg/ml), (P
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elevated serum sialic acids a potent biomarker of alloxan induced type 1 Diabetes in Dogs by ethanolic extract of anogeissus leiocarpus
Journal of diabetes and metabolic disorders, 2021Co-Authors: King Akpofure Nelson Esievo, Sani Adamu, Ngozi Ejum Ogbuagu, Tagang Aluwong, Sabina Mbafan Numadom, Ismaila Alhaji UmarAbstract:This study investigated serum sialic acids for a predictive and diagnostic biomarker of Diabetes mellitus (DM) in Dogs and its prognostic value with ethanolic extract of Anogeissus leiocarpus. Four groups of 3 Dogs were used; non-diabetic controls (ND), diabetic-untreated (DU), diabetic insulin-treated (DI) and diabetic extract-treated (DE). Free serum sialic acids (FSSA) and erythrocyte surface sialic acids (ESSA) were assayed in all groups, pre-and post-induction of hyperglycaemia and results were presented as means ± standard error of means (SEM) and subjected to ANOVA using Tukey’s post-hoc tests with GraphPad Prism® statistical package. FSSA increased in DU and plateaued at third week (61.8 ± 0.41 μg/ml), (P < 0.002) with additional 38.2 μg/ml (62%) generated, coinciding with hyperglycaemia. FSSA of DI increased but declined to 22.3 ± 1.55 μg/ml. Extract of Anogeissus leiocarpus effectively modulated FSSA in DE as increased value declined to 21.4 ± 0.78 μg/ml. Pre-induction DU ESSA (8.27 ± 0.11 μg/ml) significantly (P < 0.002) decreased by third week (2.33 ± 1.49 μg/ml), coinciding with hyperglycaemia. Strong negative correlation coefficient (r = −0.92) occurred between DU’s FSSA and ESSA and ND (P < 0.03). Sialic acid expression in dog’s insulin dependent Diabetes mellitus (IDDM) is 18% lower than normal. Extract of A. leiocarpus restored ESSA completely. ESSA cleaved in DU, 5.94 μg/ml (72%), could not account for the extra FSSA (32.26 μg/ml); liver and kidneys are contributors. FSSA predicts canine DM.