The Experts below are selected from a list of 906 Experts worldwide ranked by ideXlab platform

Xiaoming Xie - One of the best experts on this subject based on the ideXlab platform.

  • Diallyl Disulfide inhibits breast cancer stem cell progression and glucose metabolism by targeting cd44 pkm2 ampk signaling
    Current Cancer Drug Targets, 2018
    Co-Authors: Xinhua Xie, Hailin Tang, Lu Yang, Xiaojia Huang, Xiaofang Guo, Zhi Tian, Xiaofang Xie, Cheng Peng, Xiaoming Xie
    Abstract:

    Background It has been reported that Diallyl Disulfide (DADS) has anti-proliferative activity in many cancers. Objective The purpose of this study was to investigate the functions of DADS and the underlying mechanisms of its effect in breast cancer stem cells (BCSCs). Method Mammosphere formation assay, glucose consumption assay, lactate production assay and mouse xenograft experiments were performed to explore the functions of DADS in BCSCs. ATPase activity assay, western blotting and immunohistochemistry (IHC) assay were conduct to explore the mechanisms underlying the effects of DADS in BCSCs. Results The results showed that DADS suppressed cell stemness and glucose metabolism in BCSCs. In vivo mouse xenograft experiments showed that DADS inhibited the proliferation and metastasis of BCSCs. Then, we continued to explore the mechanisms underlying the effects of DADS in BCSCs and found that DADS acts by targeting CD44, Pyruvate kinase M2 (PKM2) and AMP-activated protein kinase (AMPK) signaling pathways. IHC analysis of 125 breast cancer patients' tissues demonstrated that CD44, PKM2 and AMPK expression levels were positively correlated. In addition, positive CD44, PKM2 and AMPK expression was associated with poor patient overall survival (OS) and disease-free survival (DFS). Conclusion In summary, DADS suppresses cell stemness, proliferation, metastasis and glucose metabolism in BCSCs partly through the inhibition of CD44/PKM2/AMPK. DADS may be used as a potential therapy for breast cancer treatment.

  • Diallyl Disulfide suppresses SRC/Ras/ERK signaling-mediated proliferation and metastasis in human breast cancer by up-regulating miR-34a.
    PLoS ONE, 2014
    Co-Authors: Xiangsheng Xiao, Bo Chen, Xiaoping Liu, Peng Liu, Guopei Zheng, Hailin Tang, Xiaoming Xie
    Abstract:

    Diallyl Disulfide (DADS) is one of the major volatile components of garlic oil. DADS has various biological properties, including anticancer, antiangiogenic, and antioxidant effects. However, the anticancer mechanisms of DADS in human breast cancer have not been elucidated, particularly in vivo. In this study, we demonstrated that the expression of miR-34a was up-regulated in DADS-treated MDA-MB-231 cells. miR-34a not only inhibited breast cancer growth but also enhanced the antitumor effect of DADS, both in vitro and in vivo. Furthermore, Src was identified as a target of miR-34a, with miR-34a inhibiting SRC expression and consequently triggering the suppression of the SRC/Ras/ERK pathway. These results suggest that DADS could be a promising anticancer agent for breast cancer. miR-34a may also demonstrate a potential gene therapy agent that could enhance the antitumor effects of DADS.

  • Diallyl Disulfide suppresses src ras erk signaling mediated proliferation and metastasis in human breast cancer by up regulating mir 34a
    PLOS ONE, 2014
    Co-Authors: Xiangsheng Xiao, Bo Chen, Xiaoping Liu, Peng Liu, Guopei Zheng, Hailin Tang, Xiaoming Xie
    Abstract:

    Diallyl Disulfide (DADS) is one of the major volatile components of garlic oil. DADS has various biological properties, including anticancer, antiangiogenic, and antioxidant effects. However, the anticancer mechanisms of DADS in human breast cancer have not been elucidated, particularly in vivo. In this study, we demonstrated that the expression of miR-34a was up-regulated in DADS-treated MDA-MB-231 cells. miR-34a not only inhibited breast cancer growth but also enhanced the antitumor effect of DADS, both in vitro and in vivo. Furthermore, Src was identified as a target of miR-34a, with miR-34a inhibiting SRC expression and consequently triggering the suppression of the SRC/Ras/ERK pathway. These results suggest that DADS could be a promising anticancer agent for breast cancer. miR-34a may also demonstrate a potential gene therapy agent that could enhance the antitumor effects of DADS.

  • Diallyl Disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22.
    Cancer letters, 2013
    Co-Authors: Hailin Tang, Yanan Kong, Jiaoli Guo, Yi Tang, Xinhua Xie, Lu Yang, Xiaoming Xie
    Abstract:

    The purpose of this study was to identify a mechanism related to miRNA pathway which plays a role in the anti-tumor effects of Diallyl Disulfide. Alterations in miRNA expression were observed in Diallyl Disulfide-treated MGC-803 cells, including up-regulation of miR-200b and miR-22 expression. Furthermore, Wnt-1 was identified as a target of both miR-200b and miR-22. MiR-200b and miR-22 not only synergistically inhibited gastric cancer growth, but also enhanced the antitumor effect of Diallyl Disulfide both in vitro and in vivo. It indicated that miR-200b and miR-22 may serve as potential gene therapy and enhance Diallyl Disulfide antitumor effects.

Hailin Tang - One of the best experts on this subject based on the ideXlab platform.

  • Diallyl Disulfide inhibits breast cancer stem cell progression and glucose metabolism by targeting cd44 pkm2 ampk signaling
    Current Cancer Drug Targets, 2018
    Co-Authors: Xinhua Xie, Hailin Tang, Lu Yang, Xiaojia Huang, Xiaofang Guo, Zhi Tian, Xiaofang Xie, Cheng Peng, Xiaoming Xie
    Abstract:

    Background It has been reported that Diallyl Disulfide (DADS) has anti-proliferative activity in many cancers. Objective The purpose of this study was to investigate the functions of DADS and the underlying mechanisms of its effect in breast cancer stem cells (BCSCs). Method Mammosphere formation assay, glucose consumption assay, lactate production assay and mouse xenograft experiments were performed to explore the functions of DADS in BCSCs. ATPase activity assay, western blotting and immunohistochemistry (IHC) assay were conduct to explore the mechanisms underlying the effects of DADS in BCSCs. Results The results showed that DADS suppressed cell stemness and glucose metabolism in BCSCs. In vivo mouse xenograft experiments showed that DADS inhibited the proliferation and metastasis of BCSCs. Then, we continued to explore the mechanisms underlying the effects of DADS in BCSCs and found that DADS acts by targeting CD44, Pyruvate kinase M2 (PKM2) and AMP-activated protein kinase (AMPK) signaling pathways. IHC analysis of 125 breast cancer patients' tissues demonstrated that CD44, PKM2 and AMPK expression levels were positively correlated. In addition, positive CD44, PKM2 and AMPK expression was associated with poor patient overall survival (OS) and disease-free survival (DFS). Conclusion In summary, DADS suppresses cell stemness, proliferation, metastasis and glucose metabolism in BCSCs partly through the inhibition of CD44/PKM2/AMPK. DADS may be used as a potential therapy for breast cancer treatment.

  • Diallyl Disulfide suppresses SRC/Ras/ERK signaling-mediated proliferation and metastasis in human breast cancer by up-regulating miR-34a.
    PLoS ONE, 2014
    Co-Authors: Xiangsheng Xiao, Bo Chen, Xiaoping Liu, Peng Liu, Guopei Zheng, Hailin Tang, Xiaoming Xie
    Abstract:

    Diallyl Disulfide (DADS) is one of the major volatile components of garlic oil. DADS has various biological properties, including anticancer, antiangiogenic, and antioxidant effects. However, the anticancer mechanisms of DADS in human breast cancer have not been elucidated, particularly in vivo. In this study, we demonstrated that the expression of miR-34a was up-regulated in DADS-treated MDA-MB-231 cells. miR-34a not only inhibited breast cancer growth but also enhanced the antitumor effect of DADS, both in vitro and in vivo. Furthermore, Src was identified as a target of miR-34a, with miR-34a inhibiting SRC expression and consequently triggering the suppression of the SRC/Ras/ERK pathway. These results suggest that DADS could be a promising anticancer agent for breast cancer. miR-34a may also demonstrate a potential gene therapy agent that could enhance the antitumor effects of DADS.

  • Diallyl Disulfide suppresses src ras erk signaling mediated proliferation and metastasis in human breast cancer by up regulating mir 34a
    PLOS ONE, 2014
    Co-Authors: Xiangsheng Xiao, Bo Chen, Xiaoping Liu, Peng Liu, Guopei Zheng, Hailin Tang, Xiaoming Xie
    Abstract:

    Diallyl Disulfide (DADS) is one of the major volatile components of garlic oil. DADS has various biological properties, including anticancer, antiangiogenic, and antioxidant effects. However, the anticancer mechanisms of DADS in human breast cancer have not been elucidated, particularly in vivo. In this study, we demonstrated that the expression of miR-34a was up-regulated in DADS-treated MDA-MB-231 cells. miR-34a not only inhibited breast cancer growth but also enhanced the antitumor effect of DADS, both in vitro and in vivo. Furthermore, Src was identified as a target of miR-34a, with miR-34a inhibiting SRC expression and consequently triggering the suppression of the SRC/Ras/ERK pathway. These results suggest that DADS could be a promising anticancer agent for breast cancer. miR-34a may also demonstrate a potential gene therapy agent that could enhance the antitumor effects of DADS.

  • Diallyl Disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22.
    Cancer letters, 2013
    Co-Authors: Hailin Tang, Yanan Kong, Jiaoli Guo, Yi Tang, Xinhua Xie, Lu Yang, Xiaoming Xie
    Abstract:

    The purpose of this study was to identify a mechanism related to miRNA pathway which plays a role in the anti-tumor effects of Diallyl Disulfide. Alterations in miRNA expression were observed in Diallyl Disulfide-treated MGC-803 cells, including up-regulation of miR-200b and miR-22 expression. Furthermore, Wnt-1 was identified as a target of both miR-200b and miR-22. MiR-200b and miR-22 not only synergistically inhibited gastric cancer growth, but also enhanced the antitumor effect of Diallyl Disulfide both in vitro and in vivo. It indicated that miR-200b and miR-22 may serve as potential gene therapy and enhance Diallyl Disulfide antitumor effects.

Xiangsheng Xiao - One of the best experts on this subject based on the ideXlab platform.

  • Diallyl Disulfide suppresses SRC/Ras/ERK signaling-mediated proliferation and metastasis in human breast cancer by up-regulating miR-34a.
    PLoS ONE, 2014
    Co-Authors: Xiangsheng Xiao, Bo Chen, Xiaoping Liu, Peng Liu, Guopei Zheng, Hailin Tang, Xiaoming Xie
    Abstract:

    Diallyl Disulfide (DADS) is one of the major volatile components of garlic oil. DADS has various biological properties, including anticancer, antiangiogenic, and antioxidant effects. However, the anticancer mechanisms of DADS in human breast cancer have not been elucidated, particularly in vivo. In this study, we demonstrated that the expression of miR-34a was up-regulated in DADS-treated MDA-MB-231 cells. miR-34a not only inhibited breast cancer growth but also enhanced the antitumor effect of DADS, both in vitro and in vivo. Furthermore, Src was identified as a target of miR-34a, with miR-34a inhibiting SRC expression and consequently triggering the suppression of the SRC/Ras/ERK pathway. These results suggest that DADS could be a promising anticancer agent for breast cancer. miR-34a may also demonstrate a potential gene therapy agent that could enhance the antitumor effects of DADS.

  • Diallyl Disulfide suppresses src ras erk signaling mediated proliferation and metastasis in human breast cancer by up regulating mir 34a
    PLOS ONE, 2014
    Co-Authors: Xiangsheng Xiao, Bo Chen, Xiaoping Liu, Peng Liu, Guopei Zheng, Hailin Tang, Xiaoming Xie
    Abstract:

    Diallyl Disulfide (DADS) is one of the major volatile components of garlic oil. DADS has various biological properties, including anticancer, antiangiogenic, and antioxidant effects. However, the anticancer mechanisms of DADS in human breast cancer have not been elucidated, particularly in vivo. In this study, we demonstrated that the expression of miR-34a was up-regulated in DADS-treated MDA-MB-231 cells. miR-34a not only inhibited breast cancer growth but also enhanced the antitumor effect of DADS, both in vitro and in vivo. Furthermore, Src was identified as a target of miR-34a, with miR-34a inhibiting SRC expression and consequently triggering the suppression of the SRC/Ras/ERK pathway. These results suggest that DADS could be a promising anticancer agent for breast cancer. miR-34a may also demonstrate a potential gene therapy agent that could enhance the antitumor effects of DADS.

Guopei Zheng - One of the best experts on this subject based on the ideXlab platform.

  • Diallyl Disulfide suppresses SRC/Ras/ERK signaling-mediated proliferation and metastasis in human breast cancer by up-regulating miR-34a.
    PLoS ONE, 2014
    Co-Authors: Xiangsheng Xiao, Bo Chen, Xiaoping Liu, Peng Liu, Guopei Zheng, Hailin Tang, Xiaoming Xie
    Abstract:

    Diallyl Disulfide (DADS) is one of the major volatile components of garlic oil. DADS has various biological properties, including anticancer, antiangiogenic, and antioxidant effects. However, the anticancer mechanisms of DADS in human breast cancer have not been elucidated, particularly in vivo. In this study, we demonstrated that the expression of miR-34a was up-regulated in DADS-treated MDA-MB-231 cells. miR-34a not only inhibited breast cancer growth but also enhanced the antitumor effect of DADS, both in vitro and in vivo. Furthermore, Src was identified as a target of miR-34a, with miR-34a inhibiting SRC expression and consequently triggering the suppression of the SRC/Ras/ERK pathway. These results suggest that DADS could be a promising anticancer agent for breast cancer. miR-34a may also demonstrate a potential gene therapy agent that could enhance the antitumor effects of DADS.

  • Diallyl Disulfide suppresses src ras erk signaling mediated proliferation and metastasis in human breast cancer by up regulating mir 34a
    PLOS ONE, 2014
    Co-Authors: Xiangsheng Xiao, Bo Chen, Xiaoping Liu, Peng Liu, Guopei Zheng, Hailin Tang, Xiaoming Xie
    Abstract:

    Diallyl Disulfide (DADS) is one of the major volatile components of garlic oil. DADS has various biological properties, including anticancer, antiangiogenic, and antioxidant effects. However, the anticancer mechanisms of DADS in human breast cancer have not been elucidated, particularly in vivo. In this study, we demonstrated that the expression of miR-34a was up-regulated in DADS-treated MDA-MB-231 cells. miR-34a not only inhibited breast cancer growth but also enhanced the antitumor effect of DADS, both in vitro and in vivo. Furthermore, Src was identified as a target of miR-34a, with miR-34a inhibiting SRC expression and consequently triggering the suppression of the SRC/Ras/ERK pathway. These results suggest that DADS could be a promising anticancer agent for breast cancer. miR-34a may also demonstrate a potential gene therapy agent that could enhance the antitumor effects of DADS.

Peng Liu - One of the best experts on this subject based on the ideXlab platform.

  • Diallyl Disulfide suppresses SRC/Ras/ERK signaling-mediated proliferation and metastasis in human breast cancer by up-regulating miR-34a.
    PLoS ONE, 2014
    Co-Authors: Xiangsheng Xiao, Bo Chen, Xiaoping Liu, Peng Liu, Guopei Zheng, Hailin Tang, Xiaoming Xie
    Abstract:

    Diallyl Disulfide (DADS) is one of the major volatile components of garlic oil. DADS has various biological properties, including anticancer, antiangiogenic, and antioxidant effects. However, the anticancer mechanisms of DADS in human breast cancer have not been elucidated, particularly in vivo. In this study, we demonstrated that the expression of miR-34a was up-regulated in DADS-treated MDA-MB-231 cells. miR-34a not only inhibited breast cancer growth but also enhanced the antitumor effect of DADS, both in vitro and in vivo. Furthermore, Src was identified as a target of miR-34a, with miR-34a inhibiting SRC expression and consequently triggering the suppression of the SRC/Ras/ERK pathway. These results suggest that DADS could be a promising anticancer agent for breast cancer. miR-34a may also demonstrate a potential gene therapy agent that could enhance the antitumor effects of DADS.

  • Diallyl Disulfide suppresses src ras erk signaling mediated proliferation and metastasis in human breast cancer by up regulating mir 34a
    PLOS ONE, 2014
    Co-Authors: Xiangsheng Xiao, Bo Chen, Xiaoping Liu, Peng Liu, Guopei Zheng, Hailin Tang, Xiaoming Xie
    Abstract:

    Diallyl Disulfide (DADS) is one of the major volatile components of garlic oil. DADS has various biological properties, including anticancer, antiangiogenic, and antioxidant effects. However, the anticancer mechanisms of DADS in human breast cancer have not been elucidated, particularly in vivo. In this study, we demonstrated that the expression of miR-34a was up-regulated in DADS-treated MDA-MB-231 cells. miR-34a not only inhibited breast cancer growth but also enhanced the antitumor effect of DADS, both in vitro and in vivo. Furthermore, Src was identified as a target of miR-34a, with miR-34a inhibiting SRC expression and consequently triggering the suppression of the SRC/Ras/ERK pathway. These results suggest that DADS could be a promising anticancer agent for breast cancer. miR-34a may also demonstrate a potential gene therapy agent that could enhance the antitumor effects of DADS.