The Experts below are selected from a list of 180 Experts worldwide ranked by ideXlab platform
Daniel O Martire - One of the best experts on this subject based on the ideXlab platform.
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drug repurposing for the treatment of alveolar echinococcosis in vitro and in vivo effects of silica nanoparticles modified with Dichlorophen
Parasitology, 2019Co-Authors: Valeria B Arce, Daniel O Martire, Julia Fabbri, Patricia Eugenia Pensel, Clara Maria Albani, Maria Celina ElissondoAbstract:Alveolar echinococcosis is a neglected parasitic zoonosis caused by the metacestode Echinococcus multilocularis, which grows as a malignant tumour-like infection in the liver of humans. Albendazole (ABZ) is the antiparasitic drug of choice for the treatment of the disease. However, its effectiveness is low, due to its poor absorption from the gastro-intestinal tract. It is also parasitostatic and in some cases produces side-effects. Therefore, an alternative to the treatment of this severe human disease is necessary. In this context, the repositioning of drugs combined with nanotechnology to improve the bioavailability of drugs emerges as a useful, fast and inexpensive tool for the treatment of neglected diseases. The in vitro and in vivo efficacy of Dichlorophen (DCP), an antiparasitic agent for intestinal parasites, and silica nanoparticles modified with DCP (NP-DCP) was evaluated against E. multilocularis larval stage. Both formulations showed a time and dose-dependent in vitro effect against protoscoleces. The NP-DCP had a greater in vitro efficacy than the drug alone or ABZ. In vivo studies demonstrated that the NP-DCP (4 mg kg-1) had similar efficacy to ABZ (25 mg kg-1) and greater activity than the free DCP. Therefore, the repurposing of DCP combined with silica nanoparticles could be an alternative for the treatment of echinococcosis.
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the effect of Dichlorophen binding to silica nanoparticles on its photosensitized degradation in water
Water Research, 2014Co-Authors: Juan Pablo Escalada, Valeria B Arce, Gabriela V Porcal, Alicia M Biasutti, Susana Criado, Norman A Garcia, Daniel O MartireAbstract:Abstract The production of Dichlorophen (2,2′-methylenebis(4-chlorophenol), DCP) and its use as an anthelmintic and in pesticide products result in its direct release to the environment. To the purpose of modelling the possible photodegradation routes of DCP sorbed on sediments or suspended particles, the synthesis and characterization of silica nanoparticles modified with DCP (NP–DCP) is reported. The reactivity of NP–DCP with the excited states of riboflavin, a sensitizer usually present in natural waters, and with singlet oxygen were investigated. Comparison of the kinetic results obtained here to those previously reported for irradiated aqueous solutions of DCP allowed the discussion of the effect of adsorption of the pesticide on its photodegradation. We show with the aid of computer simulations that in natural waters the relevance of the different photodegradation routes Dichlorophen is very much affected by attachment to sediments.
Norman A Garcia - One of the best experts on this subject based on the ideXlab platform.
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the effect of Dichlorophen binding to silica nanoparticles on its photosensitized degradation in water
Water Research, 2014Co-Authors: Juan Pablo Escalada, Valeria B Arce, Gabriela V Porcal, Alicia M Biasutti, Susana Criado, Norman A Garcia, Daniel O MartireAbstract:Abstract The production of Dichlorophen (2,2′-methylenebis(4-chlorophenol), DCP) and its use as an anthelmintic and in pesticide products result in its direct release to the environment. To the purpose of modelling the possible photodegradation routes of DCP sorbed on sediments or suspended particles, the synthesis and characterization of silica nanoparticles modified with DCP (NP–DCP) is reported. The reactivity of NP–DCP with the excited states of riboflavin, a sensitizer usually present in natural waters, and with singlet oxygen were investigated. Comparison of the kinetic results obtained here to those previously reported for irradiated aqueous solutions of DCP allowed the discussion of the effect of adsorption of the pesticide on its photodegradation. We show with the aid of computer simulations that in natural waters the relevance of the different photodegradation routes Dichlorophen is very much affected by attachment to sediments.
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photosensitized degradation in water of the phenolic pesticides bromoxynil and Dichlorophen in the presence of riboflavin as a model of their natural photodecomposition in the environment
Journal of Hazardous Materials, 2011Co-Authors: Juan P Escalada, Susana Criado, Adriana Pajares, Jose Gianotti, Alicia Biasutti, Patricia Molina, Walter A Massad, F Amatguerri, Norman A GarciaAbstract:Abstract Within the context of environmentally friendly methods for the elimination of surface-water pollutants, the photodegradation of the phenolic pesticides bromoxynil (BXN) and Dichlorophen (DCP) under simulated natural conditions has been studied. The work was done in the presence of the visible-light absorber photosensitizer riboflavin (Rf), usually present in trace quantities in natural waters. Under aerobic conditions, an efficient photooxidation of both pesticides was observed. The relatively intricate photochemical mechanism involves pesticide and oxygen consumption and, to a lesser extent, Rf degradation. The kinetic and mechanistic study supports that both H 2 O 2 and singlet molecular oxygen, O 2 ( 1 Δ g ), are involved in the process. Kinetic data for the O 2 ( 1 Δ g )-mediated oxidation indicate that BXN and DCP are photodegraded with this species faster than the parent compound phenol, very frequently employed as a model for aquatic contaminants, likely due to their lower p K a values. This observation allows the design of phenolic pesticides with different photodegradation rates under environmental conditions.
Xiao Wei - One of the best experts on this subject based on the ideXlab platform.
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thermally sensitive molecularly imprinted polymerson mesoporous silica nanospheres preparation characterization andproperties as novel adsorbents for Dichlorophen
Journal of Chemical & Engineering Data, 2019Co-Authors: Jifeng Guo, Hui Chen, Xiao WeiAbstract:Novel thermally responsive mesoporous silica nanosphere molecularly imprinted polymers (T-MMIPs) were prepared via a two-step precipitation polymerization process for selective adsorption and remov...
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a core shell spherical silica molecularly imprinted polymer for efficient selective recognition and adsorption of Dichlorophen
Fibers and Polymers, 2019Co-Authors: Xiao Wei, Jifeng GuoAbstract:A core-shell surface-imprinted polymer was successfully synthesized on the surface of silica spheres by precipitation polymerization. The polymers were used to selectively identify Dichlorophen in complex environmental system. The physical-chemical properties of the silica sphere molecularly imprinted polymers were analyzed by scanning electron microscopy and transmission electron microscopy scans characterization. The adsorption properties of core-shell polymers were examined by adsorption isotherms, kinetics and selectivity experiments. The Langmuir adsorption isotherm well fitted the adsorption experimental data, and an increase of temperature enhanced the adsorption capacity. The maximum binding capacity of imprinted polymers reached 72.46 mg g-1 at 318 K. Meanwhile, the adsorption data of binding experiments were well-fitting by the pseudo-second-order equation. Compared with nonimprinted polymer, the imprinted polymer not only has specific selectivity towards Dichlorophen but also has higher adsorption performance. Moreover, via the regeneration experiments, it has been demonstrated that the MIPs have certain stability to the adsorption for the target, which provides a good reference for the adsorption of Dichlorophen by the imprinted polymer in water.
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preparation of core shell magnetic molecularly imprinted polymer with uniform thin polymer layer for adsorption of Dichlorophen
Journal of Chemical & Engineering Data, 2018Co-Authors: Jifeng Guo, Xiao Wei, Lihui HuangAbstract:In this work, the magnetic Fe3O4 imprinted polymers were prepared with the precipitation polymerization method. The polymers were used to selectively identify Dichlorophen in complex environmental system. The scanning electron microscopy and transmission electron microscopy scans of magnetic Fe3O4 molecularly imprinted polymers (MMIPs) were carried out. The adsorption properties of MMIPs were examined by adsorption isotherms, kinetics, and selectivity experiments. The Langmuir adsorption isotherm well fitted the adsorption experimental data, and an increase of temperature enhanced the adsorption capacity. The equilibrium adsorption capacity of MMIPs at 318 K was 50.45 mg g–1. The data of kinetics experiments were well fitted by pseudo-second-order equation. Compared to nonimprinted polymer, the MMIPs had more specific selectivity and higher adsorption performance for chlorophene with similar structure. In addition, the regeneration experiments demonstrated that MMIPs have stable adsorption capacity for ta...
Jifeng Guo - One of the best experts on this subject based on the ideXlab platform.
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thermally sensitive molecularly imprinted polymerson mesoporous silica nanospheres preparation characterization andproperties as novel adsorbents for Dichlorophen
Journal of Chemical & Engineering Data, 2019Co-Authors: Jifeng Guo, Hui Chen, Xiao WeiAbstract:Novel thermally responsive mesoporous silica nanosphere molecularly imprinted polymers (T-MMIPs) were prepared via a two-step precipitation polymerization process for selective adsorption and remov...
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a core shell spherical silica molecularly imprinted polymer for efficient selective recognition and adsorption of Dichlorophen
Fibers and Polymers, 2019Co-Authors: Xiao Wei, Jifeng GuoAbstract:A core-shell surface-imprinted polymer was successfully synthesized on the surface of silica spheres by precipitation polymerization. The polymers were used to selectively identify Dichlorophen in complex environmental system. The physical-chemical properties of the silica sphere molecularly imprinted polymers were analyzed by scanning electron microscopy and transmission electron microscopy scans characterization. The adsorption properties of core-shell polymers were examined by adsorption isotherms, kinetics and selectivity experiments. The Langmuir adsorption isotherm well fitted the adsorption experimental data, and an increase of temperature enhanced the adsorption capacity. The maximum binding capacity of imprinted polymers reached 72.46 mg g-1 at 318 K. Meanwhile, the adsorption data of binding experiments were well-fitting by the pseudo-second-order equation. Compared with nonimprinted polymer, the imprinted polymer not only has specific selectivity towards Dichlorophen but also has higher adsorption performance. Moreover, via the regeneration experiments, it has been demonstrated that the MIPs have certain stability to the adsorption for the target, which provides a good reference for the adsorption of Dichlorophen by the imprinted polymer in water.
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preparation of core shell magnetic molecularly imprinted polymer with uniform thin polymer layer for adsorption of Dichlorophen
Journal of Chemical & Engineering Data, 2018Co-Authors: Jifeng Guo, Xiao Wei, Lihui HuangAbstract:In this work, the magnetic Fe3O4 imprinted polymers were prepared with the precipitation polymerization method. The polymers were used to selectively identify Dichlorophen in complex environmental system. The scanning electron microscopy and transmission electron microscopy scans of magnetic Fe3O4 molecularly imprinted polymers (MMIPs) were carried out. The adsorption properties of MMIPs were examined by adsorption isotherms, kinetics, and selectivity experiments. The Langmuir adsorption isotherm well fitted the adsorption experimental data, and an increase of temperature enhanced the adsorption capacity. The equilibrium adsorption capacity of MMIPs at 318 K was 50.45 mg g–1. The data of kinetics experiments were well fitted by pseudo-second-order equation. Compared to nonimprinted polymer, the MMIPs had more specific selectivity and higher adsorption performance for chlorophene with similar structure. In addition, the regeneration experiments demonstrated that MMIPs have stable adsorption capacity for ta...
Sergio Aguila - One of the best experts on this subject based on the ideXlab platform.
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enhanced degradation of pesticide Dichlorophen by laccase immobilized on nanoporous materials a cytotoxic and molecular simulation investigation
Bioconjugate Chemistry, 2018Co-Authors: Abraham Vidallimon, Patricia Concepcion Garcia Suarez, Evarista Arellanogarcia, O Contreras, Sergio AguilaAbstract:Use of pesticides is usually related to overproduction of crops in order to overcome worldwide demand of food and alimentary safety. Nevertheless, pesticides are environmental persistent molecules, such as the organochlorine pesticides, which are often found in undesired places. In this work, we show that a hybrid nanomaterial (laccase–MSU-F) readily oxidizes the pesticide Dichlorophen, reducing its acute genotoxicity and apoptotic effects. In order to predict chronic alterations related to endocrine disruption, we compared the calculated affinity of Dichlorophen oxidized subproducts to steroid hormone nuclear receptors (NRs), using molecular simulation methods. We found a reduction in theoretical affinity of subproducts of oxidized Dichlorophen for the ligand-binding pocket of NRs (∼5 kcal/mol), likewise of changes in binding modes, that suggests a reduction in binding events (RMSD values < 10 A).
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Enhanced Degradation of Pesticide Dichlorophen by Laccase Immobilized on Nanoporous Materials: A Cytotoxic and Molecular Simulation Investigation
2018Co-Authors: Abraham Vidal-limon, Patricia Concepción García Suárez, Evarista Arellano-garcía, Oscar E. Contreras, Sergio AguilaAbstract:Use of pesticides is usually related to overproduction of crops in order to overcome worldwide demand of food and alimentary safety. Nevertheless, pesticides are environmental persistent molecules, such as the organochlorine pesticides, which are often found in undesired places. In this work, we show that a hybrid nanomaterial (laccase–MSU-F) readily oxidizes the pesticide Dichlorophen, reducing its acute genotoxicity and apoptotic effects. In order to predict chronic alterations related to endocrine disruption, we compared the calculated affinity of Dichlorophen oxidized subproducts to steroid hormone nuclear receptors (NRs), using molecular simulation methods. We found a reduction in theoretical affinity of subproducts of oxidized Dichlorophen for the ligand-binding pocket of NRs (∼5 kcal/mol), likewise of changes in binding modes, that suggests a reduction in binding events (RMSD values < 10 Å)