The Experts below are selected from a list of 6825 Experts worldwide ranked by ideXlab platform
Toril Dammen - One of the best experts on this subject based on the ideXlab platform.
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illness perception among patients with chest pain and palpitations before and after negative cardiac evaluation
Biopsychosocial Medicine, 2012Co-Authors: Egil Jonsbu, Egil W Martinsen, Gunnar Morken, Torbjorn Moum, Toril DammenAbstract:Patients with chest pain or palpitations often have poor outcomes following a negative cardiac evaluation, with symptom persistence, limitations in everyday activities, and reduced health-related quality of life. The aims of this study were to evaluate illness perceptions before and after negative cardiac evaluations and measure the ability of a self-report questionnaire to predict outcomes. Patients (N = 138) referred for chest pain or palpitations to a cardiac outpatient clinic were assessed before and six months after a negative cardiac evaluation. In addition to Brief Illness Perception Questionnaire (BIPQ), all patients completed the Beck Depression Inventory and SF-36 Health Survey. The emotional reactions to and understanding of symptoms had not improved six months after a negative cardiac evaluation. A stronger correlation between illness perceptions and health at follow-up than before the cardiac evaluation might explain the tendency for poor outcomes among these patients. Most of the eight BIPQ item scores before the negative cardiac evaluation were predictive of the outcome six months later. A single question asking about the perceived consequences of the complaints (BIPQ Item 1) rated before the cardiac evaluation was collapsed into a Dichotomous Variable with a cut-off at ≥4 which yields a sensitivity of 51%, a specificity of 85%, a positive predictive value of 71%, a negative predictive value of 69%, and an odds ratio of 5.7 (r = .38, p < .001) in predicting poor outcomes. Assessing illness perceptions is important in patients with negative cardiac tests for understanding and predicting outcomes.
R O Mirimanoff - One of the best experts on this subject based on the ideXlab platform.
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biopsy diagnosis of intraductal carcinoma is prognostic in intermediate and high risk prostate cancer patients treated by radiotherapy
European Journal of Cancer, 2012Co-Authors: T Van Der Kwast, Al N Daoud, Laurence Collette, Jenna Sykes, John Thoms, Michael Milosevic, Robert G Bristow, G Van Tienhoven, Padraig Warde, R O MirimanoffAbstract:Abstract Aim We investigated the prognostic significance of intraductal carcinoma of the prostate (IDC-P) in biopsies and transurethral resections prior to external beam radiotherapy with or without androgen deprivation. Methods Cohort 1 consisted of 118 intermediate risk prostate cancer patients treated by radiotherapy, with biochemical relapse as primary end-point (median follow-up 6.5 years). Cohort 2 consisted of 132 high risk patients, enrolled in a phase III randomised trial (EORTC 22863) comparing radiotherapy alone to radiotherapy with long-term androgen deprivation (LTAD) with clinical progression free survival as primary end-point (median follow-up 9.1 years). Presence of IDC-P was identified after central review. MultiVariable regression modelling and Kaplan–Meier analysis were performed with IDC-P as Dichotomous Variable. Results IDC-P was a strong prognosticator for early ( Conclusions IDC-P in diagnostic samples of patients with intermediate or high risk prostate cancer is an independent prognosticator of early biochemical relapse and metastatic failure rate after radiotherapy. We suggest that the presence of IDC-P in prostate biopsies should routinely be reported.
Maria Vandenberg - One of the best experts on this subject based on the ideXlab platform.
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Validity of the chi-square test in Dichotomous Variable factor analysis when expected frequencies are small
British Journal of Mathematical and Statistical Psychology, 1994Co-Authors: Mark Reiser, Maria VandenbergAbstract:This paper presents a comparison of results from two methods for estimating and testing a model for the factor analysis of Dichotomous Variables. For k manifest Dichotomous Variables, the data can be crossclassified to form a vector of 2 k frequencies, and nonlinear methods that use the full information in these 2 k frequencies are available for factor analysis. In addition, another method that uses only the limited information in the first-, and second-order marginal frequencies is available for the same model. As k becomes larger, substantial differences between the full-information and limited-information methods become apparent in results from the test of fit. For large k, Type I and Type II error rates may be higher in the fullineormation approach, because as the vector of 2 k frequencies becomes sparse, the chi-square approximation for the distribution of the goodness-offit test statistic becomes poorer
Volkher Scharnhorst - One of the best experts on this subject based on the ideXlab platform.
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effect of duration of red blood cell storage on early and late mortality after coronary artery bypass grafting
The Journal of Thoracic and Cardiovascular Surgery, 2011Co-Authors: Albert H M Van Straten, Mohamed Soliman A Hamad, Andre Van Zundert, Elisabeth J Martens, Joost F Ter Woorst, Andre M De Wolf, Volkher ScharnhorstAbstract:Objectives Recently, concern has been expressed about the transfusion of older red blood cells after cardiac surgery. We tested the hypothesis that longer storage of transfused red blood cells increases the risk of early and late mortality in patients who undergo coronary artery bypass grafting. Methods We retrospectively analyzed data of patients who underwent isolated coronary artery bypass grafting between January 1998 and December 2007 in Catharina Hospital, Eindhoven, The Netherlands, and received up to 10 U of red blood cells intraoperatively or during the first 5 postoperative days. The patients were divided into 3 groups according to the storage time of the red blood cells, with a cutoff point of 14 days, as follows: "only younger blood" (n = 1422), "only older blood" (n = 1719), and at least 1 U of older RBCs ("any older blood"; n = 2175). Results The mean follow-up time was 1693 ± 1058 days (range, 0–3708 days). The median follow-up time was 1629 days. Univariate and multivariate logistic regression analyses revealed that the number of transfused units but not the storage time of blood entered either as a continuous Variable or as a Dichotomous Variable with a cutoff point of 14 days was a risk factor for early mortality. Neither the number of transfused units nor the storage time was an independent risk factor for late mortality. Log-rank testing revealed no statistical difference in survival among the groups. Conclusions The storage time of transfused red blood cells is not a risk factor for early or late mortality in patients who undergo coronary artery bypass grafting.
Egil W Martinsen - One of the best experts on this subject based on the ideXlab platform.
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illness perception among patients with chest pain and palpitations before and after negative cardiac evaluation
Biopsychosocial Medicine, 2012Co-Authors: Egil Jonsbu, Egil W Martinsen, Gunnar Morken, Torbjorn Moum, Toril DammenAbstract:Patients with chest pain or palpitations often have poor outcomes following a negative cardiac evaluation, with symptom persistence, limitations in everyday activities, and reduced health-related quality of life. The aims of this study were to evaluate illness perceptions before and after negative cardiac evaluations and measure the ability of a self-report questionnaire to predict outcomes. Patients (N = 138) referred for chest pain or palpitations to a cardiac outpatient clinic were assessed before and six months after a negative cardiac evaluation. In addition to Brief Illness Perception Questionnaire (BIPQ), all patients completed the Beck Depression Inventory and SF-36 Health Survey. The emotional reactions to and understanding of symptoms had not improved six months after a negative cardiac evaluation. A stronger correlation between illness perceptions and health at follow-up than before the cardiac evaluation might explain the tendency for poor outcomes among these patients. Most of the eight BIPQ item scores before the negative cardiac evaluation were predictive of the outcome six months later. A single question asking about the perceived consequences of the complaints (BIPQ Item 1) rated before the cardiac evaluation was collapsed into a Dichotomous Variable with a cut-off at ≥4 which yields a sensitivity of 51%, a specificity of 85%, a positive predictive value of 71%, a negative predictive value of 69%, and an odds ratio of 5.7 (r = .38, p < .001) in predicting poor outcomes. Assessing illness perceptions is important in patients with negative cardiac tests for understanding and predicting outcomes.