The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Omar M L Alharbi - One of the best experts on this subject based on the ideXlab platform.
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synthesis of chitosan composite iron nanoparticles for removal of Diclofenac Sodium drug residue in water
International Journal of Biological Macromolecules, 2020Co-Authors: Zeid A Alothman, Ahmad Yacine Badjah, Omar M L AlharbiAbstract:Abstract Iron composite nanoparticles were prepared (90% yield) using macromolecule chitosan and characterized by spectroscopic techniques (FT-IR, XRD, SEM, TEM & EDX). These were utilized to remove Diclofenac Sodium in water. The adjusted parameters were 400 μg/ L, 50.0 min., 5.0, 2.0 g/ L and 25.0 °C as concentration, contact time, pH, adsorbent amount and temperature for the elimination of Diclofenac Sodium in water with maximum 85% elimination. The sorption was spontaneous with exothermic. Data followed Langmuir, Temkin and Dubinin-Radushkevich models. Thermodynamic parameter ΔG° values were −12.19, −13.74 and −15.67 kJ/mol at 20, 25 and 30 °C temperatures. The values of ΔH° and ΔS° were 8.58 and 20.84 kJ/mol. Pseudo-first-order and liquid film diffusion mechanisms were proposed for the adsorption. This adsorption method is fast, effective eco-friendly and low-cost as it may be used in natural circumstances of water resources. The sorption method may be applied for the elimination of Diclofenac Sodium in any water body at a huge and financial scale.
Boni E Elewski - One of the best experts on this subject based on the ideXlab platform.
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Diclofenac Sodium 3 gel as a potential treatment for disseminated superficial actinic porokeratosis
Journal of The European Academy of Dermatology and Venereology, 2009Co-Authors: Shellie Marks, R Varma, Wendy Cantrell, S C Chen, M Gold, M Muellenhoff, Boni E ElewskiAbstract:Background Disseminated superficial actinic porokeratosis (DSAP) is a chronic cutaneous disorder of keratinization for which there is no known cure. Current therapies are often ineffective, painful, or unappealing. Objective To investigate the efficacy and safety of Diclofenac Sodium 3% gel for the treatment of DSAP. Methods Seventeen adult patients with a diagnosis of DSAP applied Diclofenac Sodium 3% gel to a target area (forearm) twice daily for 3 months up to a maximum of 6 months in an open-label, multicentre pilot study. Target area lesion counts were performed monthly, and global lesion counts were performed at baseline and at weeks 12 and 24. A treatment satisfaction questionnaire was completed at weeks 12 and 24. Results Thirteen patients completed 12 weeks of treatment and 10 completed 24 weeks. Among patients who completed 12 weeks, there was a mean decrease of 4% in target area lesions, while a mean increase of 12% was noted in global lesions. Among patients who completed 24 weeks, there was a mean increase of 19% in global lesions, but only a 10% increase noted in the target area. Seven of 13 patients had a decrease in target area lesions at week 12 and 3 of 10 patients at week 24. Questionnaire responses indicated 6 out of 10 patients would use the medication again. Conclusion Target area DSAP lesions in the majority of patients treated with Diclofenac Sodium 3% gel (both 12 and 24 weeks) progressed to a lesser extent as compared to the global lesion count.
F A Mohammed - One of the best experts on this subject based on the ideXlab platform.
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topical permeation characteristics of Diclofenac Sodium from nacmc gels in comparison with conventional gel formulations
Drug Development and Industrial Pharmacy, 2001Co-Authors: F A MohammedAbstract:Topical gel formulations of Diclofenac Sodium were prepared by using Sodium carboxymethylcellulose (NaCMC), a low-toxicity cellulose polymer as a gel-forming material that is biocompatible and biodegradable. The influence of various formulation variables, such as initial drug concentrations and NaCMC concentration, and certain skin permeation enhancers on release characteristics of the Diclofenac Sodium from the prepared gels through a standard cellophane membrane was studied in comparison with four commercially available gel formulations of Diclofenac Sodium,. The cumulative amounts released and the apparent release rates were higher for the prepared gels in comparison with the commercial formulations. Skin permeation studies using abdominal rat skin revealed good improvement of skin permeation characteristics of Diclofenac Sodium using NaCMC gels as compared to the commercial gels. The cumulative amount permeated at 6 h (microg/cm2), steady-state flux Jss (microg/cm2 h), lag time tL (h), permeability coefficient kp (cm/s), partition coefficient k, and diffusion coefficient D (cm2/s) were determined for the prepared gels in comparison with the commercial gels. Skin permeation enhancers such as isopropyl alcohol (IPA), Tween 80, and alpha-tocopherol polyethylene glycol succinate (TPGS) exhibited little or no effect on the permeation characteristics of Diclofenac Sodium. Infrared (IR) spectrum and differential scanning calorimetry (DSC) studies on the pure Diclofenac Sodium, NaCMC, and their physical mixture at a 1:1 ratio revealed that there was no positive evidence for the interactions between the drug and NaCMC, indicating the compatibility of the drug and the vehicle. Based on experimental results, preparation of Diclofenac Sodium gels using NaCMC vehicle is promising.
Roman Szostak - One of the best experts on this subject based on the ideXlab platform.
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quantitative determination of Diclofenac Sodium and aminophylline in injection solutions by ft raman spectroscopy
Journal of Pharmaceutical and Biomedical Analysis, 2006Co-Authors: Sylwester Mazurek, Roman SzostakAbstract:Abstract The FT-Raman quantification of Diclofenac Sodium and aminophylline commercial injection solutions was performed. The efficiency of various spectra treatment procedures including classical univariate intensity ratio and multivariate partial least squares (PLS) and principal component regression (PCR) methods was compared. First, the calibration models were built using unnormalised spectra. Next, spectra normalised by the intensity of a selected band of CH 3 CN added as an internal standard to the studied samples were utilised. To compare the predictive ability of the models constructed, the relative standard error of prediction (RSEP) was calculated. The errors found for multivariate calibrations were a few times smaller than those for the univariate ones. Usually, the most effective was the PLS method, for which RSEP values of the order of 1–2% for calibration and 2–3% for testing data sets were obtained. Four commercial preparations of Diclofenac Sodium and one of aminophylline containing by weight, 2.4% of the active pharmaceutical ingredient (API) were quantified applying the developed models. Concentrations found from the Raman data analysis correlate with the declared values and the results of reference analyses. For the studied Diclofenac Sodium solutions they amount to 99.2–101.2% of the former and 101.2–102.4% of the latter quantities for the PLS models optimised for each medicine based on unnormalised spectra. These values for the aminophylline preparation were found to be 101.0 and 99.1%, respectively. It shows that the proposed procedure based on the chemometric treatment of FT-Raman spectra can be a fast and convenient alternative to the standard pharmacopoeial procedures of API quantification even in relatively diluted injection solutions.
Chennam Srinivasulu Shyamala Devi - One of the best experts on this subject based on the ideXlab platform.
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gastroprotective effect of terminalia arjuna bark on Diclofenac Sodium induced gastric ulcer
Chemico-Biological Interactions, 2007Co-Authors: R S Devi, Shoba Narayan, G Vani, Chennam Srinivasulu Shyamala DeviAbstract:Abstract Aim The present study was aimed to evaluate the effect of methanolic extract of Terminalia arjuna (TA) on Diclofenac Sodium induced gastric ulcer in experimental rats. Methods Animals were induced for gastric ulcer with Diclofenac Sodium (DIC) (80 mg/kg bodyweight in water, orally) and treated orally with TA in various doses ranging from 100 mg/kg bodyweight to 500 mg/kg bodyweight. The effective dose was 400 mg/kg bodyweight, since this dose elicited a maximum reduction in lesion index. The gastroprotective effect of TA was assessed from volume of gastric juice, pH, free and total acidity, pepsin concentration, acid output in gastric juice, the levels of non-protein sulfhydryls (NP-SH), lipid peroxide (LPO), reduced glutathione (GSH), and activities of enzymic antioxidants—super oxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and myeloperoxidase (MPO) in gastric mucosa. The levels of DNA, protein bound carbohydrate complexes—hexose, hexoseamine, sialic acid, fucose in gastric mucosa and gastric juice and the levels of RNA in gastric mucosa were assessed. The stomach tissues were used for adherent mucus content and also for the histological examination. Results A significant reduction in lesion index was observed in ulcer induced animals treated with TA (DIC + TA) compared to ulcerated rats (DIC). A significant increase was observed in pH, NP-SH, GSH, enzymic antioxidants, protein bound carbohydrate complexes, adherent mucus content, nucleic acids with a significant decrease in volume of gastric juice, free and total acidity, pepsin concentration, acid output, LPO levels and MPO activities in DIC + TA rats compared to DIC rats. Histological studies confirmed the gastroprotective activity of TA. Conclusion From the data presented in this study it could be concluded that T. arjuna acts as an gastroprotective agent probably due to its free radical scavenging activity and cytoprotective nature.