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S Bonnafous - One of the best experts on this subject based on the ideXlab platform.

Annesophie Schneck - One of the best experts on this subject based on the ideXlab platform.

Deming Gong - One of the best experts on this subject based on the ideXlab platform.

  • cinnamomum camphora seed kernel oil improves lipid metabolism and enhances β3 adrenergic receptor expression in diet induced Obese rats
    Lipids, 2016
    Co-Authors: Jing Fu, Cheng Zeng, Zheling Zeng, Baogui Wang, Ping Yu, Deming Gong
    Abstract:

    The effects of dietary Cinnamomum camphora seed kernel oil (CCSKO) containing medium-chain triacylglycerols on lipid metabolism and mRNA and protein expression of β-3 adrenergic receptor in adipose tissue were studied in Diet-Induced Obese rats. High fat food-induced Obese rats were randomly divided into CCSKO group, Lard group, Soybean oil (SOY) group and naturally restoring group (n = 10). Rats fed with low fat food were used as a normal control group. Significant decreases in body mass and abdominal fat mass/body mass after 12 weeks were found in CCSKO group as compared with Lard and SOY groups (p < 0.05). Levels of blood total cholesterol (TC), triglyceride, free fatty acid, fasting insulin and insulin resistance in the CCSKO group were decreased significantly, and noradrenaline level and insulin sensitivity index in the CCSKO group were significantly higher than other groups. Meanwhile liver TC and triglyceride levels in the CCSKO group were also decreased markedly. Expression levels of β3-adrenergic receptor mRNA and protein were higher in CCSKO group than in Lard and SOY groups. These results suggest that CCSKO may contribute to reduction of the body fat mass, promote lipid metabolism and up-regulate β3-adrenergic receptor expression in high fat Diet-Induced Obese rats.

  • cinnamomum camphora seed kernel oil ameliorates oxidative stress and inflammation in diet induced Obese rats
    Journal of Food Science, 2016
    Co-Authors: Jing Fu, Cheng Zeng, Zheling Zeng, Baogui Wang, Deming Gong
    Abstract:

    Cinnamomum camphora seed kernel oil (CCSKO) was found to reduce body fat deposition and improve blood lipid in both healthy and Obese rats. The study was aimed to investigate the antioxidative stress and anti-inflammatory effects of CCSKO in high-fat-Diet-Induced Obese rats. The Obese rats were treated with CCSKO, lard, and soybean oil, respectively, for 12 wk. The level of total antioxidant capacity (T-AOC), activities of superoxide dismutase (SOD), glutathione peroxidase, and catalase, and levels of malondialdehyde (MDA), tumor necrosis factor (TNF)-α, peroxisome proliferator-activated receptor (PPAR)-γ, interleukin (IL)-6, and P65 were compared among CCSKO, lard, and soybean oil groups. Our results showed that the level of T-AOC and activities of SOD and catalase were significantly increased and the level of MDA was significantly decreased in CCSKO group. In addition, CCSKO treatment reduced the activities of serum glutamic oxaloacetic transaminase and glutamate-pyruvate transaminase, and levels of serum TNF-α, IL-6, and P65 through raising the level of PPAR-γ. In conclusion, CCSKO has, for the first time, been found to ameliorate oxidative stress and inflammation in high-fat-Diet-Induced Obese rats.

Deborah Rousseau - One of the best experts on this subject based on the ideXlab platform.

Stephanie Patouraux - One of the best experts on this subject based on the ideXlab platform.