The Experts below are selected from a list of 279 Experts worldwide ranked by ideXlab platform
Katsuyuki Ogura - One of the best experts on this subject based on the ideXlab platform.
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diastereoselective formation of 2 fluoro 2 trifluoromethyl 3 4 alkadienamides from propargyl alcohols and hexafluoropropene Diethylamine adduct ppda
Journal of Fluorine Chemistry, 2004Co-Authors: Motohiro Akazome, Katsuyuki OguraAbstract:Abstract Treatment of propargyl alcohols ( 1 ) with hexafluoropropene–Diethylamine adduct (PPDA) affords N , N -diethyl-2-fluoro-2-trifluoromethyl-3,4-alkadienamides ( 2 ) that are produced by the Claisen rearrangement of intermediary 2-alkynyl 1-( N , N -diethylamino)-2,3,3,3-tetrafluoro-1-propenyl ethers. Starting from propargyl alcohols bearing a triple bond at the terminal position, the corresponding products ( 2 ) were formed with a high stereoselectivity.
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a novel reaction of allylic alcohols with hexafluoropropene Diethylamine adduct ppda to form 2 fluoro 2 trifluoromethyl 4 alkenamide
Journal of Fluorine Chemistry, 2003Co-Authors: Motohiro Akazome, Katsuyuki OguraAbstract:Abstract Treatment of allylic alcohols with hexafluoropropene-Diethylamine adduct (PPDA) afforded N , N -diethyl-2-fluoro-2-trifluoromethyl-4-alkenamides which were formed by the Claisen rearrangement of intermediary 2-alkenyl-1-diethylamino-2,3,3,3-tetrafluoro-1-propenyl ethers. Although ( E )-allylic alcohols gave two diastereomeric products in about 1:1 ratio, ( Z )-allylic alcohols gave the corresponding product as a single diastereomer.
Grigorios Fotopoulos - One of the best experts on this subject based on the ideXlab platform.
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Effect of rubbing on the in vitro skin permeation of diclofenac-Diethylamine 1.16% gel
BMC Research Notes, 2012Co-Authors: Nathalie Hasler-nguyen, Grigorios FotopoulosAbstract:BackgroundRubbing a topical NSAID (non steroidal anti-inflammatory drug) on the skin may increase local drug permeation, affecting its distribution to the site of pain and inflammation. The present study evaluates this hypothesis, by assessing in vitro the effect on skin permeation of applying diclofenac-dieythylamine 1.16% gel with or without rubbing.MethodsA single dose of 5 mg/cm^2 diclofenac-Diethylamine 1.16% gel was applied on excised human skin mounted in Franz-type diffusion cells without or with rubbing for 45 s. Drug penetration into the skin layers was determined after 1 h using the tape stripping technique. In vitro cutaneous permeation into the receptor fluid of the diffusion chamber was measured up to 24 h. Skin electrical resistance was also recorded.ResultsApplication of diclofenac-Diethylamine 1.16% gel with rubbing resulted to a 5-fold higher flux of diclofenac through the skin than when applied without rubbing at 8 h ( P = 0.04). Skin rubbing for 45 s decreased by 2-fold skin electrical resistance when compared to the standard application. Application of diclofenac-Diethylamine 1.16% gel with rubbing tended to result in higher accumulation in the stripped skin vs. the superficial skin layers when applied without rubbing ( P = 0.2).ConclusionThese results suggest that rubbing may alter the superficial skin layer resulting in a transient faster initial diffusion of topically applied diclofenac through the stratum corneum into the deeper skin layer of the dermis to the tissue target.
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effect of rubbing on the in vitro skin permeation of diclofenac Diethylamine 1 16 gel
BMC Research Notes, 2012Co-Authors: Nathalie Haslernguyen, Grigorios FotopoulosAbstract:Rubbing a topical NSAID (non steroidal anti-inflammatory drug) on the skin may increase local drug permeation, affecting its distribution to the site of pain and inflammation. The present study evaluates this hypothesis, by assessing in vitro the effect on skin permeation of applying diclofenac-dieythylamine 1.16% gel with or without rubbing. A single dose of 5 mg/cm2 diclofenac-Diethylamine 1.16% gel was applied on excised human skin mounted in Franz-type diffusion cells without or with rubbing for 45 s. Drug penetration into the skin layers was determined after 1 h using the tape stripping technique. In vitro cutaneous permeation into the receptor fluid of the diffusion chamber was measured up to 24 h. Skin electrical resistance was also recorded. Application of diclofenac-Diethylamine 1.16% gel with rubbing resulted to a 5-fold higher flux of diclofenac through the skin than when applied without rubbing at 8 h (P = 0.04). Skin rubbing for 45 s decreased by 2-fold skin electrical resistance when compared to the standard application. Application of diclofenac-Diethylamine 1.16% gel with rubbing tended to result in higher accumulation in the stripped skin vs. the superficial skin layers when applied without rubbing (P = 0.2). These results suggest that rubbing may alter the superficial skin layer resulting in a transient faster initial diffusion of topically applied diclofenac through the stratum corneum into the deeper skin layer of the dermis to the tissue target.
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Effect of rubbing on the in vitro skin permeation of diclofenac-Diethylamine 1.16% gel
BMC Research Notes, 2012Co-Authors: Nathalie Hasler-nguyen, Grigorios FotopoulosAbstract:Rubbing a topical NSAID (non steroidal anti-inflammatory drug) on the skin may increase local drug permeation, affecting its distribution to the site of pain and inflammation. The present study evaluates this hypothesis, by assessing in vitro the effect on skin permeation of applying diclofenac-dieythylamine 1.16% gel with or without rubbing. A single dose of 5 mg/cm2 diclofenac-Diethylamine 1.16% gel was applied on excised human skin mounted in Franz-type diffusion cells without or with rubbing for 45 s. Drug penetration into the skin layers was determined after 1 h using the tape stripping technique. In vitro cutaneous permeation into the receptor fluid of the diffusion chamber was measured up to 24 h. Skin electrical resistance was also recorded. Application of diclofenac-Diethylamine 1.16% gel with rubbing resulted to a 5-fold higher flux of diclofenac through the skin than when applied without rubbing at 8 h (P = 0.04). Skin rubbing for 45 s decreased by 2-fold skin electrical resistance when compared to the standard application. Application of diclofenac-Diethylamine 1.16% gel with rubbing tended to result in higher accumulation in the stripped skin vs. the superficial skin layers when applied without rubbing (P = 0.2). These results suggest that rubbing may alter the superficial skin layer resulting in a transient faster initial diffusion of topically applied diclofenac through the stratum corneum into the deeper skin layer of the dermis to the tissue target.
Hao Zeng - One of the best experts on this subject based on the ideXlab platform.
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Isobaric Vapor–Liquid Equilibrium for the Binary Systems (Diethylamine + Ethanol), (Ethanol + N,N-Diethylethanolamine), and (Diethylamine + N,N-Diethylethanolamine) at p = (80.0 and 40.0) kPa
Journal of Chemical & Engineering Data, 2014Co-Authors: Changsheng Yang, Ping Zhang, Yang Feng, Hao ZengAbstract:In this work, isobaric vapor–liquid equilibrium (VLE) data for the three binary systems composed of Diethylamine (1) + ethanol (2), ethanol (1) + N,N-diethylethanolamine (2), and Diethylamine (1) + N,N-diethylethanolamine (2) at p = (80.0 and 40.0) kPa have been measured using a modified Rose–Williams still. All of the experimental data passed thermodynamic consistency tests, including the area test of Herington and the point test of Van Ness and co-workers. No azeotropic behavior was observed at the two reduced pressures. The Wilson, NRTL, and UNIQUAC activity coefficient models were used to correlate the experimental data. The obtained results indicated that the UNIQUAC model was more suitable than the Wilson and NRTL models for correlating the measured isobaric VLE data.
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isobaric vapor liquid equilibrium for the binary systems Diethylamine ethanol ethanol n n diethylethanolamine and Diethylamine n n diethylethanolamine at p 80 0 and 40 0 kpa
Journal of Chemical & Engineering Data, 2014Co-Authors: Changsheng Yang, Ping Zhang, Yang Feng, Hao ZengAbstract:In this work, isobaric vapor–liquid equilibrium (VLE) data for the three binary systems composed of Diethylamine (1) + ethanol (2), ethanol (1) + N,N-diethylethanolamine (2), and Diethylamine (1) + N,N-diethylethanolamine (2) at p = (80.0 and 40.0) kPa have been measured using a modified Rose–Williams still. All of the experimental data passed thermodynamic consistency tests, including the area test of Herington and the point test of Van Ness and co-workers. No azeotropic behavior was observed at the two reduced pressures. The Wilson, NRTL, and UNIQUAC activity coefficient models were used to correlate the experimental data. The obtained results indicated that the UNIQUAC model was more suitable than the Wilson and NRTL models for correlating the measured isobaric VLE data.
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isobaric vapor liquid equilibrium for the binary systems of methanol Diethylamine and n n diethylethanolamine at p 60 0 and 101 3 kpa
Journal of Chemical & Engineering Data, 2013Co-Authors: Changsheng Yang, Yali Xu, Hao Zeng, Ping Zhang, Yang FengAbstract:Isobaric vapor–liquid equilibrium (VLE) data have been measured with a modified Rose–Williams still for the binary systems of methanol (1) + Diethylamine (2), methanol (1) + N,N-diethylethanolamine (2), and N,N-diethylethanolamine (1) + Diethylamine (2) at p = (60.0 and 101.3) kPa. All of the experimental data pass the thermodynamic consistency test by the method of Herington and the point test of Van Ness. The system of methanol + Diethylamine (DEA) at two pressures exhibits a maximum temperature azeotrope. The other two systems did not show that behavior. The experimental VLE data were well-correlated with the Wilson and universal quasichemical (UNIQUAC) activity coefficient models, and the average absolute deviations (AAD) of the vapor-phase mole fraction Δy between the experimental and the calculated values for all of the measured systems are less than 0.01.
Changsheng Yang - One of the best experts on this subject based on the ideXlab platform.
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Isobaric Vapor–Liquid Equilibrium for the Binary Systems (Diethylamine + Ethanol), (Ethanol + N,N-Diethylethanolamine), and (Diethylamine + N,N-Diethylethanolamine) at p = (80.0 and 40.0) kPa
Journal of Chemical & Engineering Data, 2014Co-Authors: Changsheng Yang, Ping Zhang, Yang Feng, Hao ZengAbstract:In this work, isobaric vapor–liquid equilibrium (VLE) data for the three binary systems composed of Diethylamine (1) + ethanol (2), ethanol (1) + N,N-diethylethanolamine (2), and Diethylamine (1) + N,N-diethylethanolamine (2) at p = (80.0 and 40.0) kPa have been measured using a modified Rose–Williams still. All of the experimental data passed thermodynamic consistency tests, including the area test of Herington and the point test of Van Ness and co-workers. No azeotropic behavior was observed at the two reduced pressures. The Wilson, NRTL, and UNIQUAC activity coefficient models were used to correlate the experimental data. The obtained results indicated that the UNIQUAC model was more suitable than the Wilson and NRTL models for correlating the measured isobaric VLE data.
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isobaric vapor liquid equilibrium for the binary systems Diethylamine ethanol ethanol n n diethylethanolamine and Diethylamine n n diethylethanolamine at p 80 0 and 40 0 kpa
Journal of Chemical & Engineering Data, 2014Co-Authors: Changsheng Yang, Ping Zhang, Yang Feng, Hao ZengAbstract:In this work, isobaric vapor–liquid equilibrium (VLE) data for the three binary systems composed of Diethylamine (1) + ethanol (2), ethanol (1) + N,N-diethylethanolamine (2), and Diethylamine (1) + N,N-diethylethanolamine (2) at p = (80.0 and 40.0) kPa have been measured using a modified Rose–Williams still. All of the experimental data passed thermodynamic consistency tests, including the area test of Herington and the point test of Van Ness and co-workers. No azeotropic behavior was observed at the two reduced pressures. The Wilson, NRTL, and UNIQUAC activity coefficient models were used to correlate the experimental data. The obtained results indicated that the UNIQUAC model was more suitable than the Wilson and NRTL models for correlating the measured isobaric VLE data.
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isobaric vapor liquid equilibrium for the binary systems of methanol Diethylamine and n n diethylethanolamine at p 60 0 and 101 3 kpa
Journal of Chemical & Engineering Data, 2013Co-Authors: Changsheng Yang, Yali Xu, Hao Zeng, Ping Zhang, Yang FengAbstract:Isobaric vapor–liquid equilibrium (VLE) data have been measured with a modified Rose–Williams still for the binary systems of methanol (1) + Diethylamine (2), methanol (1) + N,N-diethylethanolamine (2), and N,N-diethylethanolamine (1) + Diethylamine (2) at p = (60.0 and 101.3) kPa. All of the experimental data pass the thermodynamic consistency test by the method of Herington and the point test of Van Ness. The system of methanol + Diethylamine (DEA) at two pressures exhibits a maximum temperature azeotrope. The other two systems did not show that behavior. The experimental VLE data were well-correlated with the Wilson and universal quasichemical (UNIQUAC) activity coefficient models, and the average absolute deviations (AAD) of the vapor-phase mole fraction Δy between the experimental and the calculated values for all of the measured systems are less than 0.01.
Yang Feng - One of the best experts on this subject based on the ideXlab platform.
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Isobaric Vapor–Liquid Equilibrium for the Binary Systems (Diethylamine + Ethanol), (Ethanol + N,N-Diethylethanolamine), and (Diethylamine + N,N-Diethylethanolamine) at p = (80.0 and 40.0) kPa
Journal of Chemical & Engineering Data, 2014Co-Authors: Changsheng Yang, Ping Zhang, Yang Feng, Hao ZengAbstract:In this work, isobaric vapor–liquid equilibrium (VLE) data for the three binary systems composed of Diethylamine (1) + ethanol (2), ethanol (1) + N,N-diethylethanolamine (2), and Diethylamine (1) + N,N-diethylethanolamine (2) at p = (80.0 and 40.0) kPa have been measured using a modified Rose–Williams still. All of the experimental data passed thermodynamic consistency tests, including the area test of Herington and the point test of Van Ness and co-workers. No azeotropic behavior was observed at the two reduced pressures. The Wilson, NRTL, and UNIQUAC activity coefficient models were used to correlate the experimental data. The obtained results indicated that the UNIQUAC model was more suitable than the Wilson and NRTL models for correlating the measured isobaric VLE data.
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isobaric vapor liquid equilibrium for the binary systems Diethylamine ethanol ethanol n n diethylethanolamine and Diethylamine n n diethylethanolamine at p 80 0 and 40 0 kpa
Journal of Chemical & Engineering Data, 2014Co-Authors: Changsheng Yang, Ping Zhang, Yang Feng, Hao ZengAbstract:In this work, isobaric vapor–liquid equilibrium (VLE) data for the three binary systems composed of Diethylamine (1) + ethanol (2), ethanol (1) + N,N-diethylethanolamine (2), and Diethylamine (1) + N,N-diethylethanolamine (2) at p = (80.0 and 40.0) kPa have been measured using a modified Rose–Williams still. All of the experimental data passed thermodynamic consistency tests, including the area test of Herington and the point test of Van Ness and co-workers. No azeotropic behavior was observed at the two reduced pressures. The Wilson, NRTL, and UNIQUAC activity coefficient models were used to correlate the experimental data. The obtained results indicated that the UNIQUAC model was more suitable than the Wilson and NRTL models for correlating the measured isobaric VLE data.
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isobaric vapor liquid equilibrium for the binary systems of methanol Diethylamine and n n diethylethanolamine at p 60 0 and 101 3 kpa
Journal of Chemical & Engineering Data, 2013Co-Authors: Changsheng Yang, Yali Xu, Hao Zeng, Ping Zhang, Yang FengAbstract:Isobaric vapor–liquid equilibrium (VLE) data have been measured with a modified Rose–Williams still for the binary systems of methanol (1) + Diethylamine (2), methanol (1) + N,N-diethylethanolamine (2), and N,N-diethylethanolamine (1) + Diethylamine (2) at p = (60.0 and 101.3) kPa. All of the experimental data pass the thermodynamic consistency test by the method of Herington and the point test of Van Ness. The system of methanol + Diethylamine (DEA) at two pressures exhibits a maximum temperature azeotrope. The other two systems did not show that behavior. The experimental VLE data were well-correlated with the Wilson and universal quasichemical (UNIQUAC) activity coefficient models, and the average absolute deviations (AAD) of the vapor-phase mole fraction Δy between the experimental and the calculated values for all of the measured systems are less than 0.01.