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Alexandre Douplik - One of the best experts on this subject based on the ideXlab platform.

  • Optical Nerve Detection by Diffuse Reflectance Spectroscopy for Feedback Controlled Oral and Maxillofacial Laser Surgery
    Journal of translational medicine, 2011
    Co-Authors: Florian Stelzle, Azhar Zam, Katja Tangermann-gerk, Werner Adler, Emeka Nkenke, Alexandre Douplik, Michael Schmidt
    Abstract:

    Background Laser surgery lacks haptic feedback, which is accompanied by the risk of iatrogenic nerve damage. It was the aim of this study to investigate Diffuse Reflectance Spectroscopy for tissue differentiation as the base of a feedback control system to enhance nerve preservation in oral and maxillofacial laser surgery.

  • In vivo soft tissue differentiation by Diffuse Reflectance Spectroscopy: preliminary results
    Physics Procedia, 2010
    Co-Authors: Azhar Zam, Florian Stelzle, Katja Tangermann-gerk, Werner Adler, Emeka Nkenke, Friedrich Wilhelm Neukam, Michael Schmidt, Alexandre Douplik
    Abstract:

    Abstract Remote laser surgery does not provide haptic feedback to operate layer by layer and preserve vulnerable anatomical structures like nerve tissue or blood vessels. The aim of this study is identification of soft tissue in vivo by Diffuse Reflectance Spectroscopy to set the base for a feedback control system to enhance nerve preservation in oral and maxillofacial laser surgery. Various soft tissues can be identified by Diffuse Reflectance Spectroscopy in vivo . The results may set the base for a feedback system to prevent nerve damage during oral and maxillofacial laser surgery.

  • Soft tissue differentiation by Diffuse Reflectance Spectroscopy
    Clinical and Biomedical Spectroscopy, 2009
    Co-Authors: Azhar Zam, Florian Stelzle, Katja Tangermann-gerk, Werner Adler, Emeka Nkenke, Michael Schmidt, Alexandre Douplik
    Abstract:

    Laser surgery gives the possibility to work remotely which leads to high precision, little trauma and high level sterility. However these advantages are coming with the lack of haptic feedback during the laser ablation of tissue. Therefore additional means are required to control tissue-specific ablation during laser surgery supporting the surgeon regardless of experience and skills. Diffuse Reflectance Spectroscopy provides a straightforward and simple approach for optical tissue differentiation. We measured Diffuse Reflectance from four various tissue types ex vivo. We applied Linear Discriminant Analysis (LDA) to differentiate the four tissue types and computed the area under the ROC curve (AUC). Special emphasis was taken on the identification of nerve as the most crucial tissue for maxillofacial surgery. The results show a promise for differentiating soft tissues as guidance for tissue-specific laser surgery by means of the Diffuse Reflectance.

  • Tissue-Specific Laser Surgery: Hard Tissue Differentiation by Diffuse Reflectance Spectroscopy ex vivo
    Frontiers in Optics 2009 Laser Science XXV Fall 2009 OSA Optics & Photonics Technical Digest, 2009
    Co-Authors: Azhar Zam, Florian Stelzle, Katja Tangermann-gerk, Werner Adler, Emeka Nkenke, Michael Schmidt, Alexandre Douplik
    Abstract:

    Diffuse Reflectance Spectroscopy provides a straightforward and simple approach for optical tissue differentiation. The results obtained show a potential for differentiating hard tissues as guidance for tissue-specific laser surgery.

Michael Schmidt - One of the best experts on this subject based on the ideXlab platform.

  • Optical Nerve Detection by Diffuse Reflectance Spectroscopy for Feedback Controlled Oral and Maxillofacial Laser Surgery
    Journal of translational medicine, 2011
    Co-Authors: Florian Stelzle, Azhar Zam, Katja Tangermann-gerk, Werner Adler, Emeka Nkenke, Alexandre Douplik, Michael Schmidt
    Abstract:

    Background Laser surgery lacks haptic feedback, which is accompanied by the risk of iatrogenic nerve damage. It was the aim of this study to investigate Diffuse Reflectance Spectroscopy for tissue differentiation as the base of a feedback control system to enhance nerve preservation in oral and maxillofacial laser surgery.

  • In vivo soft tissue differentiation by Diffuse Reflectance Spectroscopy: preliminary results
    Physics Procedia, 2010
    Co-Authors: Azhar Zam, Florian Stelzle, Katja Tangermann-gerk, Werner Adler, Emeka Nkenke, Friedrich Wilhelm Neukam, Michael Schmidt, Alexandre Douplik
    Abstract:

    Abstract Remote laser surgery does not provide haptic feedback to operate layer by layer and preserve vulnerable anatomical structures like nerve tissue or blood vessels. The aim of this study is identification of soft tissue in vivo by Diffuse Reflectance Spectroscopy to set the base for a feedback control system to enhance nerve preservation in oral and maxillofacial laser surgery. Various soft tissues can be identified by Diffuse Reflectance Spectroscopy in vivo . The results may set the base for a feedback system to prevent nerve damage during oral and maxillofacial laser surgery.

  • Soft tissue differentiation by Diffuse Reflectance Spectroscopy
    Clinical and Biomedical Spectroscopy, 2009
    Co-Authors: Azhar Zam, Florian Stelzle, Katja Tangermann-gerk, Werner Adler, Emeka Nkenke, Michael Schmidt, Alexandre Douplik
    Abstract:

    Laser surgery gives the possibility to work remotely which leads to high precision, little trauma and high level sterility. However these advantages are coming with the lack of haptic feedback during the laser ablation of tissue. Therefore additional means are required to control tissue-specific ablation during laser surgery supporting the surgeon regardless of experience and skills. Diffuse Reflectance Spectroscopy provides a straightforward and simple approach for optical tissue differentiation. We measured Diffuse Reflectance from four various tissue types ex vivo. We applied Linear Discriminant Analysis (LDA) to differentiate the four tissue types and computed the area under the ROC curve (AUC). Special emphasis was taken on the identification of nerve as the most crucial tissue for maxillofacial surgery. The results show a promise for differentiating soft tissues as guidance for tissue-specific laser surgery by means of the Diffuse Reflectance.

  • Tissue-Specific Laser Surgery: Hard Tissue Differentiation by Diffuse Reflectance Spectroscopy ex vivo
    Frontiers in Optics 2009 Laser Science XXV Fall 2009 OSA Optics & Photonics Technical Digest, 2009
    Co-Authors: Azhar Zam, Florian Stelzle, Katja Tangermann-gerk, Werner Adler, Emeka Nkenke, Michael Schmidt, Alexandre Douplik
    Abstract:

    Diffuse Reflectance Spectroscopy provides a straightforward and simple approach for optical tissue differentiation. The results obtained show a potential for differentiating hard tissues as guidance for tissue-specific laser surgery.

Theo J.m. Ruers - One of the best experts on this subject based on the ideXlab platform.

  • Towards the use of Diffuse Reflectance Spectroscopy for real-time in vivo detection of breast cancer during surgery.
    Journal of translational medicine, 2018
    Co-Authors: Lisanne L. De Boer, M.j. Vranken Peeters, B.h.w. Hendriks, Torre M. Bydlon, Frederieke Van Duijnhoven, Claudette E. Loo, Gonneke A. O. Winter-warnars, Joyce Sanders, Henricus J. C. M. Sterenborg, Theo J.m. Ruers
    Abstract:

    Background Breast cancer surgeons struggle with differentiating healthy tissue from cancer at the resection margin during surgery. We report on the feasibility of using Diffuse Reflectance Spectroscopy (DRS) for real-time in vivo tissue characterization.

  • Diffuse Reflectance Spectroscopy; Towards Clinical Application in Breast Cancer
    Annals of Oncology, 2012
    Co-Authors: Theo J.m. Ruers, Daniel J. Evers, Rami Nachabe, M.j. Vranken Peeters, J. A. Van Der Hage, Hester S. A. Oldenburg, E.j.t. Rutgers, Gerhardus Wilhelmus Lucassen, B.h.w. Hendriks, Jelle Wesseling
    Abstract:

    ABSTRACT Background Diffuse Reflectance Spectroscopy (DRS) is a promising new technique for breast cancer diagnosis. During DRS tissue is illuminated by a selected light spectrum. By specific absorption and scattering characteristics of the tissue an ‘optical fingerprint’ is obtained which represents specific morphological information. In this way DRS is able to differentiate normal tissue from tumor tissue. Here we compared the diagnostic accuracy of DRS in a cohort of patients and each patient individually to the pathology analysis of normal and malignant breast tissue. Methods Breast tissue from 47 female patients was analysed ex-vivo by DRS. A total of 1073 optical spectra were collected from fat, glandular tissue and fibroadenoma lesions as well as from (pre)-malignant tissue samples. These spectra were analyzed for each patient individually as well as for all patients collectively. Results were compared to the pathology analysis of biopsies from each measurement location. Results Collective patient data analysis for discrimination between normal and malignant breast tissue resulted in a sensitivity of 90%, a specificity of 88% and an overall accuracy of 89%. For individual analysis all measurements per patient were categorized as either benign or malignant. The discriminative accuracy of this individual analysis was nearly 100%. When an arbitrary threshold was used of a 90% agreement between all DRS measurements and the pathology analysis for each individual patient to ascertain a diagnosis, only in one patient the diagnosis was classified as uncertain. Conclusions Our results demonstrate that Diffuse Reflectance Spectroscopy can be considered as an important new optical sensing technique that could improve the diagnostic workflow in breast cancer. Disclosure All authors have declared no conflicts of interest.

Florian Stelzle - One of the best experts on this subject based on the ideXlab platform.

  • Optical Nerve Detection by Diffuse Reflectance Spectroscopy for Feedback Controlled Oral and Maxillofacial Laser Surgery
    Journal of translational medicine, 2011
    Co-Authors: Florian Stelzle, Azhar Zam, Katja Tangermann-gerk, Werner Adler, Emeka Nkenke, Alexandre Douplik, Michael Schmidt
    Abstract:

    Background Laser surgery lacks haptic feedback, which is accompanied by the risk of iatrogenic nerve damage. It was the aim of this study to investigate Diffuse Reflectance Spectroscopy for tissue differentiation as the base of a feedback control system to enhance nerve preservation in oral and maxillofacial laser surgery.

  • In vivo soft tissue differentiation by Diffuse Reflectance Spectroscopy: preliminary results
    Physics Procedia, 2010
    Co-Authors: Azhar Zam, Florian Stelzle, Katja Tangermann-gerk, Werner Adler, Emeka Nkenke, Friedrich Wilhelm Neukam, Michael Schmidt, Alexandre Douplik
    Abstract:

    Abstract Remote laser surgery does not provide haptic feedback to operate layer by layer and preserve vulnerable anatomical structures like nerve tissue or blood vessels. The aim of this study is identification of soft tissue in vivo by Diffuse Reflectance Spectroscopy to set the base for a feedback control system to enhance nerve preservation in oral and maxillofacial laser surgery. Various soft tissues can be identified by Diffuse Reflectance Spectroscopy in vivo . The results may set the base for a feedback system to prevent nerve damage during oral and maxillofacial laser surgery.

  • Soft tissue differentiation by Diffuse Reflectance Spectroscopy
    Clinical and Biomedical Spectroscopy, 2009
    Co-Authors: Azhar Zam, Florian Stelzle, Katja Tangermann-gerk, Werner Adler, Emeka Nkenke, Michael Schmidt, Alexandre Douplik
    Abstract:

    Laser surgery gives the possibility to work remotely which leads to high precision, little trauma and high level sterility. However these advantages are coming with the lack of haptic feedback during the laser ablation of tissue. Therefore additional means are required to control tissue-specific ablation during laser surgery supporting the surgeon regardless of experience and skills. Diffuse Reflectance Spectroscopy provides a straightforward and simple approach for optical tissue differentiation. We measured Diffuse Reflectance from four various tissue types ex vivo. We applied Linear Discriminant Analysis (LDA) to differentiate the four tissue types and computed the area under the ROC curve (AUC). Special emphasis was taken on the identification of nerve as the most crucial tissue for maxillofacial surgery. The results show a promise for differentiating soft tissues as guidance for tissue-specific laser surgery by means of the Diffuse Reflectance.

  • Tissue-Specific Laser Surgery: Hard Tissue Differentiation by Diffuse Reflectance Spectroscopy ex vivo
    Frontiers in Optics 2009 Laser Science XXV Fall 2009 OSA Optics & Photonics Technical Digest, 2009
    Co-Authors: Azhar Zam, Florian Stelzle, Katja Tangermann-gerk, Werner Adler, Emeka Nkenke, Michael Schmidt, Alexandre Douplik
    Abstract:

    Diffuse Reflectance Spectroscopy provides a straightforward and simple approach for optical tissue differentiation. The results obtained show a potential for differentiating hard tissues as guidance for tissue-specific laser surgery.

Azhar Zam - One of the best experts on this subject based on the ideXlab platform.

  • Optical Nerve Detection by Diffuse Reflectance Spectroscopy for Feedback Controlled Oral and Maxillofacial Laser Surgery
    Journal of translational medicine, 2011
    Co-Authors: Florian Stelzle, Azhar Zam, Katja Tangermann-gerk, Werner Adler, Emeka Nkenke, Alexandre Douplik, Michael Schmidt
    Abstract:

    Background Laser surgery lacks haptic feedback, which is accompanied by the risk of iatrogenic nerve damage. It was the aim of this study to investigate Diffuse Reflectance Spectroscopy for tissue differentiation as the base of a feedback control system to enhance nerve preservation in oral and maxillofacial laser surgery.

  • In vivo soft tissue differentiation by Diffuse Reflectance Spectroscopy: preliminary results
    Physics Procedia, 2010
    Co-Authors: Azhar Zam, Florian Stelzle, Katja Tangermann-gerk, Werner Adler, Emeka Nkenke, Friedrich Wilhelm Neukam, Michael Schmidt, Alexandre Douplik
    Abstract:

    Abstract Remote laser surgery does not provide haptic feedback to operate layer by layer and preserve vulnerable anatomical structures like nerve tissue or blood vessels. The aim of this study is identification of soft tissue in vivo by Diffuse Reflectance Spectroscopy to set the base for a feedback control system to enhance nerve preservation in oral and maxillofacial laser surgery. Various soft tissues can be identified by Diffuse Reflectance Spectroscopy in vivo . The results may set the base for a feedback system to prevent nerve damage during oral and maxillofacial laser surgery.

  • Soft tissue differentiation by Diffuse Reflectance Spectroscopy
    Clinical and Biomedical Spectroscopy, 2009
    Co-Authors: Azhar Zam, Florian Stelzle, Katja Tangermann-gerk, Werner Adler, Emeka Nkenke, Michael Schmidt, Alexandre Douplik
    Abstract:

    Laser surgery gives the possibility to work remotely which leads to high precision, little trauma and high level sterility. However these advantages are coming with the lack of haptic feedback during the laser ablation of tissue. Therefore additional means are required to control tissue-specific ablation during laser surgery supporting the surgeon regardless of experience and skills. Diffuse Reflectance Spectroscopy provides a straightforward and simple approach for optical tissue differentiation. We measured Diffuse Reflectance from four various tissue types ex vivo. We applied Linear Discriminant Analysis (LDA) to differentiate the four tissue types and computed the area under the ROC curve (AUC). Special emphasis was taken on the identification of nerve as the most crucial tissue for maxillofacial surgery. The results show a promise for differentiating soft tissues as guidance for tissue-specific laser surgery by means of the Diffuse Reflectance.

  • Tissue-Specific Laser Surgery: Hard Tissue Differentiation by Diffuse Reflectance Spectroscopy ex vivo
    Frontiers in Optics 2009 Laser Science XXV Fall 2009 OSA Optics & Photonics Technical Digest, 2009
    Co-Authors: Azhar Zam, Florian Stelzle, Katja Tangermann-gerk, Werner Adler, Emeka Nkenke, Michael Schmidt, Alexandre Douplik
    Abstract:

    Diffuse Reflectance Spectroscopy provides a straightforward and simple approach for optical tissue differentiation. The results obtained show a potential for differentiating hard tissues as guidance for tissue-specific laser surgery.