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Peter J Kertes - One of the best experts on this subject based on the ideXlab platform.
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Retinal ultra-wide-field colour imaging versus Dilated Fundus Examination to screen for sickle cell retinopathy.
The British journal of ophthalmology, 2020Co-Authors: Talal Alabduljalil, Crystal Sy Cheung, Cynthia Vandenhoven, Leslie Mackeen, Melanie Kirby-allen, Peter J KertesAbstract:To compare ultra-wide-field colour Fundus imaging (UWFI) to Dilated Fundus Examination (DFE) for the screening of sickle cell retinopathy (SCR). This study is a prospective, blinded, multicentre case series. This study included two groups: an adult group (n=268 eyes) and a paediatric group (n=168 eyes). Sickle cell disease (SCD) types included haemoglobin S homozygous (HbSS), haemoglobin S and C (HbSC) and Hb S with β-thalassaemia (HbSß-Thal). Participants underwent DFE and UWFI. Each eye received three independent grades (1-4), documented by three graders: clinical grader, image grader 1 and image grader 2. Three clinically relevant diagnostic thresholds were determined. Based on these thresholds, the sensitivity, specificity, positive predictive value and negative predictive value for all three graders were calculated relative to each other as reference tests. HbSC was associated with the most advanced SCR grades. When compared to the clinical grader, image grader 1 and image grader 2 consistently detected more SCR and higher SCR grades in both adult and paediatric groups. In both groups, image grader 1 and image grader 2 identified twice as many cases of capillary occlusion/anastomosis than clinical grader. To detect the presence of any proliferative SCR, image grader 1 and image grader 2 had a sensitivity of 82%, 71% in the paediatrics group and 90% and 72% in the adult group. The clinical grader sensitivity was 52% in the paediatrics group and 53% in the adult group. The UWFI is a sensitive tool to screen for SCR. It is superior to DFE in detecting capillary occlusion or anastomosis. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
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retinal ultra wide field colour imaging versus Dilated Fundus Examination to screen for sickle cell retinopathy
British Journal of Ophthalmology, 2020Co-Authors: Talal Alabduljalil, Crystal Sy Cheung, Cynthia Vandenhoven, Leslie Mackeen, Melanie Kirbyallen, Peter J KertesAbstract:Purpose To compare ultra-wide-field colour Fundus imaging (UWFI) to Dilated Fundus Examination (DFE) for the screening of sickle cell retinopathy (SCR). Design This study is a prospective, blinded, multicentre case series. Participants This study included two groups: an adult group (n=268 eyes) and a paediatric group (n=168 eyes). Sickle cell disease (SCD) types included haemoglobin S homozygous (HbSS), haemoglobin S and C (HbSC) and Hb S with β-thalassaemia (HbSs-Thal). Methods Participants underwent DFE and UWFI. Each eye received three independent grades (1–4), documented by three graders: clinical grader, image grader 1 and image grader 2. Three clinically relevant diagnostic thresholds were determined. Based on these thresholds, the sensitivity, specificity, positive predictive value and negative predictive value for all three graders were calculated relative to each other as reference tests. Results HbSC was associated with the most advanced SCR grades. When compared to the clinical grader, image grader 1 and image grader 2 consistently detected more SCR and higher SCR grades in both adult and paediatric groups. In both groups, image grader 1 and image grader 2 identified twice as many cases of capillary occlusion/anastomosis than clinical grader. To detect the presence of any proliferative SCR, image grader 1 and image grader 2 had a sensitivity of 82%, 71% in the paediatrics group and 90% and 72% in the adult group. The clinical grader sensitivity was 52% in the paediatrics group and 53% in the adult group. Conclusion The UWFI is a sensitive tool to screen for SCR. It is superior to DFE in detecting capillary occlusion or anastomosis.
Talal Alabduljalil - One of the best experts on this subject based on the ideXlab platform.
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Retinal ultra-wide-field colour imaging versus Dilated Fundus Examination to screen for sickle cell retinopathy.
The British journal of ophthalmology, 2020Co-Authors: Talal Alabduljalil, Crystal Sy Cheung, Cynthia Vandenhoven, Leslie Mackeen, Melanie Kirby-allen, Peter J KertesAbstract:To compare ultra-wide-field colour Fundus imaging (UWFI) to Dilated Fundus Examination (DFE) for the screening of sickle cell retinopathy (SCR). This study is a prospective, blinded, multicentre case series. This study included two groups: an adult group (n=268 eyes) and a paediatric group (n=168 eyes). Sickle cell disease (SCD) types included haemoglobin S homozygous (HbSS), haemoglobin S and C (HbSC) and Hb S with β-thalassaemia (HbSß-Thal). Participants underwent DFE and UWFI. Each eye received three independent grades (1-4), documented by three graders: clinical grader, image grader 1 and image grader 2. Three clinically relevant diagnostic thresholds were determined. Based on these thresholds, the sensitivity, specificity, positive predictive value and negative predictive value for all three graders were calculated relative to each other as reference tests. HbSC was associated with the most advanced SCR grades. When compared to the clinical grader, image grader 1 and image grader 2 consistently detected more SCR and higher SCR grades in both adult and paediatric groups. In both groups, image grader 1 and image grader 2 identified twice as many cases of capillary occlusion/anastomosis than clinical grader. To detect the presence of any proliferative SCR, image grader 1 and image grader 2 had a sensitivity of 82%, 71% in the paediatrics group and 90% and 72% in the adult group. The clinical grader sensitivity was 52% in the paediatrics group and 53% in the adult group. The UWFI is a sensitive tool to screen for SCR. It is superior to DFE in detecting capillary occlusion or anastomosis. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
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retinal ultra wide field colour imaging versus Dilated Fundus Examination to screen for sickle cell retinopathy
British Journal of Ophthalmology, 2020Co-Authors: Talal Alabduljalil, Crystal Sy Cheung, Cynthia Vandenhoven, Leslie Mackeen, Melanie Kirbyallen, Peter J KertesAbstract:Purpose To compare ultra-wide-field colour Fundus imaging (UWFI) to Dilated Fundus Examination (DFE) for the screening of sickle cell retinopathy (SCR). Design This study is a prospective, blinded, multicentre case series. Participants This study included two groups: an adult group (n=268 eyes) and a paediatric group (n=168 eyes). Sickle cell disease (SCD) types included haemoglobin S homozygous (HbSS), haemoglobin S and C (HbSC) and Hb S with β-thalassaemia (HbSs-Thal). Methods Participants underwent DFE and UWFI. Each eye received three independent grades (1–4), documented by three graders: clinical grader, image grader 1 and image grader 2. Three clinically relevant diagnostic thresholds were determined. Based on these thresholds, the sensitivity, specificity, positive predictive value and negative predictive value for all three graders were calculated relative to each other as reference tests. Results HbSC was associated with the most advanced SCR grades. When compared to the clinical grader, image grader 1 and image grader 2 consistently detected more SCR and higher SCR grades in both adult and paediatric groups. In both groups, image grader 1 and image grader 2 identified twice as many cases of capillary occlusion/anastomosis than clinical grader. To detect the presence of any proliferative SCR, image grader 1 and image grader 2 had a sensitivity of 82%, 71% in the paediatrics group and 90% and 72% in the adult group. The clinical grader sensitivity was 52% in the paediatrics group and 53% in the adult group. Conclusion The UWFI is a sensitive tool to screen for SCR. It is superior to DFE in detecting capillary occlusion or anastomosis.
Francesco Bandello - One of the best experts on this subject based on the ideXlab platform.
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Nonmydriatic widefield retinal imaging with an automatic white LED confocal imaging system compared with Dilated ophthalmoscopy in screening for diabetic retinopathy
Acta Diabetologica, 2020Co-Authors: Enrico Borrelli, Lea Querques, Rosangela Lattanzio, Michele Cavalleri, Alessio Grazioli Moretti, Carlo Di Biase, Alberto Signorino, Francesco Gelormini, Riccardo Sacconi, Francesco BandelloAbstract:Purpose To compare nonmydriatic montage widefield images with Dilated Fundus ophthalmoscopy for determining diabetic retinopathy (DR) severity. Materials and methods In this prospective, observational, cross-sectional study, patients with a previous diagnosis of diabetes and without history of diabetes-associated ocular disease were screened for DR. Montage widefield imaging was obtained with a system that combines confocal technology with white-light emitting diode (LED) illumination (DRSplus, Centervue, Padua, Italy). Dilated Fundus Examination was performed by a retina specialist. Results Thirty-seven eyes (20 patients, 8 females) were finally included in the analysis. Mean age of the patients enrolled was 58.0 ± 11.6 years [range 31–80 years]. The level of DR identified on montage widefield images agreed exactly with indirect ophthalmoscopy in 97.3% (36) of eyes and was within 1 step in 100% (37) of eyes. Cohen's kappa coefficient ( κ ) was 0.96, this suggesting an almost perfect agreement between the two modalities in DR screening. Nonmydriatic montage widefield imaging acquisition time was significantly shorter than that of Dilated clinical Examination ( p = 0.010). Conclusion Nonmydriatic montage widefield images were compared favorably with Dilated Fundus Examination in defining DR severity; however, they are acquired more rapidly.
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Nonmydriatic widefield retinal imaging with an automatic white LED confocal imaging system compared with Dilated ophthalmoscopy in screening for diabetic retinopathy.
Acta Diabetologica, 2020Co-Authors: Enrico Borrelli, Lea Querques, Rosangela Lattanzio, Michele Cavalleri, Carlo Di Biase, Alberto Signorino, Francesco Gelormini, Riccardo Sacconi, Alessio Grazioli Moretti, Francesco BandelloAbstract:PURPOSE To compare nonmydriatic montage widefield images with Dilated Fundus ophthalmoscopy for determining diabetic retinopathy (DR) severity. MATERIALS AND METHODS In this prospective, observational, cross-sectional study, patients with a previous diagnosis of diabetes and without history of diabetes-associated ocular disease were screened for DR. Montage widefield imaging was obtained with a system that combines confocal technology with white-light emitting diode (LED) illumination (DRSplus, Centervue, Padua, Italy). Dilated Fundus Examination was performed by a retina specialist. RESULTS Thirty-seven eyes (20 patients, 8 females) were finally included in the analysis. Mean age of the patients enrolled was 58.0 ± 11.6 years [range 31-80 years]. The level of DR identified on montage widefield images agreed exactly with indirect ophthalmoscopy in 97.3% (36) of eyes and was within 1 step in 100% (37) of eyes. Cohen's kappa coefficient (κ) was 0.96, this suggesting an almost perfect agreement between the two modalities in DR screening. Nonmydriatic montage widefield imaging acquisition time was significantly shorter than that of Dilated clinical Examination (p = 0.010). CONCLUSION Nonmydriatic montage widefield images were compared favorably with Dilated Fundus Examination in defining DR severity; however, they are acquired more rapidly.
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Comparison Between Ultra-Widefield Pseudocolor Imaging and Indirect Ophthalmoscopy in the Detection of Peripheral Retinal Lesions
Ophthalmic Surgery and Lasers, 2019Co-Authors: Giovanni Fogliato, Enrico Borrelli, Lea Querques, Francesco Bandello, Lorenzo Iuliano, Andrea Ramoni, Alessandro Rabiolo, Giuseppe QuerquesAbstract:BACKGROUND AND OBJECTIVE To systematically compare the intermodality and inter-rater agreement for indirect ophthalmoscopy and ultra-widefield (UWF) imaging in detecting peripheral retinal lesions predisposing to retinal rhegmatogenous detachment. PATIENTS AND METHODS In this prospective, observational, cross-sectional study, patients with a previous diagnosis of peripheral retinal lesions were enrolled. UWF pseudocolor imaging and Dilated Fundus Examination were obtained. RESULTS Thirty-seven eyes (20 patients, 12 females) were enrolled. The level of inter-rater agreement was excellent in both the ophthalmoscopy-based and UWF-based assessment. The overall agreement in the UWF-based assessment was found to be Kappa = 0.874 (P < .0001). The UWF-based evaluation was demonstrated to have a sensitivity of 89.2% in detecting peripheral retinal lesions. In the sectorial analysis, the UWF-based reading had a lower sensitivity in the inferior sector. CONCLUSION The identification of peripheral retinal lesions with UWF imaging allowed for an accurate and reproducible assessment. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:544-549.].
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Swept source optical coherence tomography of a vitreal pocket entrapped in myelinated retinal nerve fibers
International Ophthalmology, 2015Co-Authors: Luisa Pierro, Maria Vittoria Cicinelli, Gagliardi Marco, Giorgia Carlotta Albertini, Francesco BandelloAbstract:A 53-year-old women, 20/20 visual acuity in both eyes, showed after Dilated Fundus Examination myelinated retinal nerve fibers (MRNF) on 360 around optic disk in left eye, sparing the macula (A). Swept source optical coherence tomography (SS-OCT) scanning line centered on the optic nerve head (B), showed two vitreous pockets (*) entrapped between highly hyperreflective MRNF and posterior hyaloid; posterior hyaloid appears thickened by hyperreflective tissue that can be interpreted as residual of innermost layer of myelin remained attached after posterior hyaloid separation.
Leslie Mackeen - One of the best experts on this subject based on the ideXlab platform.
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Retinal ultra-wide-field colour imaging versus Dilated Fundus Examination to screen for sickle cell retinopathy.
The British journal of ophthalmology, 2020Co-Authors: Talal Alabduljalil, Crystal Sy Cheung, Cynthia Vandenhoven, Leslie Mackeen, Melanie Kirby-allen, Peter J KertesAbstract:To compare ultra-wide-field colour Fundus imaging (UWFI) to Dilated Fundus Examination (DFE) for the screening of sickle cell retinopathy (SCR). This study is a prospective, blinded, multicentre case series. This study included two groups: an adult group (n=268 eyes) and a paediatric group (n=168 eyes). Sickle cell disease (SCD) types included haemoglobin S homozygous (HbSS), haemoglobin S and C (HbSC) and Hb S with β-thalassaemia (HbSß-Thal). Participants underwent DFE and UWFI. Each eye received three independent grades (1-4), documented by three graders: clinical grader, image grader 1 and image grader 2. Three clinically relevant diagnostic thresholds were determined. Based on these thresholds, the sensitivity, specificity, positive predictive value and negative predictive value for all three graders were calculated relative to each other as reference tests. HbSC was associated with the most advanced SCR grades. When compared to the clinical grader, image grader 1 and image grader 2 consistently detected more SCR and higher SCR grades in both adult and paediatric groups. In both groups, image grader 1 and image grader 2 identified twice as many cases of capillary occlusion/anastomosis than clinical grader. To detect the presence of any proliferative SCR, image grader 1 and image grader 2 had a sensitivity of 82%, 71% in the paediatrics group and 90% and 72% in the adult group. The clinical grader sensitivity was 52% in the paediatrics group and 53% in the adult group. The UWFI is a sensitive tool to screen for SCR. It is superior to DFE in detecting capillary occlusion or anastomosis. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
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retinal ultra wide field colour imaging versus Dilated Fundus Examination to screen for sickle cell retinopathy
British Journal of Ophthalmology, 2020Co-Authors: Talal Alabduljalil, Crystal Sy Cheung, Cynthia Vandenhoven, Leslie Mackeen, Melanie Kirbyallen, Peter J KertesAbstract:Purpose To compare ultra-wide-field colour Fundus imaging (UWFI) to Dilated Fundus Examination (DFE) for the screening of sickle cell retinopathy (SCR). Design This study is a prospective, blinded, multicentre case series. Participants This study included two groups: an adult group (n=268 eyes) and a paediatric group (n=168 eyes). Sickle cell disease (SCD) types included haemoglobin S homozygous (HbSS), haemoglobin S and C (HbSC) and Hb S with β-thalassaemia (HbSs-Thal). Methods Participants underwent DFE and UWFI. Each eye received three independent grades (1–4), documented by three graders: clinical grader, image grader 1 and image grader 2. Three clinically relevant diagnostic thresholds were determined. Based on these thresholds, the sensitivity, specificity, positive predictive value and negative predictive value for all three graders were calculated relative to each other as reference tests. Results HbSC was associated with the most advanced SCR grades. When compared to the clinical grader, image grader 1 and image grader 2 consistently detected more SCR and higher SCR grades in both adult and paediatric groups. In both groups, image grader 1 and image grader 2 identified twice as many cases of capillary occlusion/anastomosis than clinical grader. To detect the presence of any proliferative SCR, image grader 1 and image grader 2 had a sensitivity of 82%, 71% in the paediatrics group and 90% and 72% in the adult group. The clinical grader sensitivity was 52% in the paediatrics group and 53% in the adult group. Conclusion The UWFI is a sensitive tool to screen for SCR. It is superior to DFE in detecting capillary occlusion or anastomosis.
Cynthia Vandenhoven - One of the best experts on this subject based on the ideXlab platform.
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Retinal ultra-wide-field colour imaging versus Dilated Fundus Examination to screen for sickle cell retinopathy.
The British journal of ophthalmology, 2020Co-Authors: Talal Alabduljalil, Crystal Sy Cheung, Cynthia Vandenhoven, Leslie Mackeen, Melanie Kirby-allen, Peter J KertesAbstract:To compare ultra-wide-field colour Fundus imaging (UWFI) to Dilated Fundus Examination (DFE) for the screening of sickle cell retinopathy (SCR). This study is a prospective, blinded, multicentre case series. This study included two groups: an adult group (n=268 eyes) and a paediatric group (n=168 eyes). Sickle cell disease (SCD) types included haemoglobin S homozygous (HbSS), haemoglobin S and C (HbSC) and Hb S with β-thalassaemia (HbSß-Thal). Participants underwent DFE and UWFI. Each eye received three independent grades (1-4), documented by three graders: clinical grader, image grader 1 and image grader 2. Three clinically relevant diagnostic thresholds were determined. Based on these thresholds, the sensitivity, specificity, positive predictive value and negative predictive value for all three graders were calculated relative to each other as reference tests. HbSC was associated with the most advanced SCR grades. When compared to the clinical grader, image grader 1 and image grader 2 consistently detected more SCR and higher SCR grades in both adult and paediatric groups. In both groups, image grader 1 and image grader 2 identified twice as many cases of capillary occlusion/anastomosis than clinical grader. To detect the presence of any proliferative SCR, image grader 1 and image grader 2 had a sensitivity of 82%, 71% in the paediatrics group and 90% and 72% in the adult group. The clinical grader sensitivity was 52% in the paediatrics group and 53% in the adult group. The UWFI is a sensitive tool to screen for SCR. It is superior to DFE in detecting capillary occlusion or anastomosis. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
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retinal ultra wide field colour imaging versus Dilated Fundus Examination to screen for sickle cell retinopathy
British Journal of Ophthalmology, 2020Co-Authors: Talal Alabduljalil, Crystal Sy Cheung, Cynthia Vandenhoven, Leslie Mackeen, Melanie Kirbyallen, Peter J KertesAbstract:Purpose To compare ultra-wide-field colour Fundus imaging (UWFI) to Dilated Fundus Examination (DFE) for the screening of sickle cell retinopathy (SCR). Design This study is a prospective, blinded, multicentre case series. Participants This study included two groups: an adult group (n=268 eyes) and a paediatric group (n=168 eyes). Sickle cell disease (SCD) types included haemoglobin S homozygous (HbSS), haemoglobin S and C (HbSC) and Hb S with β-thalassaemia (HbSs-Thal). Methods Participants underwent DFE and UWFI. Each eye received three independent grades (1–4), documented by three graders: clinical grader, image grader 1 and image grader 2. Three clinically relevant diagnostic thresholds were determined. Based on these thresholds, the sensitivity, specificity, positive predictive value and negative predictive value for all three graders were calculated relative to each other as reference tests. Results HbSC was associated with the most advanced SCR grades. When compared to the clinical grader, image grader 1 and image grader 2 consistently detected more SCR and higher SCR grades in both adult and paediatric groups. In both groups, image grader 1 and image grader 2 identified twice as many cases of capillary occlusion/anastomosis than clinical grader. To detect the presence of any proliferative SCR, image grader 1 and image grader 2 had a sensitivity of 82%, 71% in the paediatrics group and 90% and 72% in the adult group. The clinical grader sensitivity was 52% in the paediatrics group and 53% in the adult group. Conclusion The UWFI is a sensitive tool to screen for SCR. It is superior to DFE in detecting capillary occlusion or anastomosis.