The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform
Jia Miao - One of the best experts on this subject based on the ideXlab platform.
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pharmacokinetics of Dimemorfan Phosphate tablets in healthy chinese volunteers
European Journal of Clinical Pharmacology, 2017Co-Authors: Yali Shen, Zhu Luo, Ying Wang, Jin Xiang, Jia MiaoAbstract:Investigate the pharmacokinetic properties of the antitussive Dimemorfan Phosphate tablets in healthy male and female Chinese volunteers after single and multiple-dose administration; and to evaluate the food-effect on pharmacokinetics of Dimemorfan. 12 subjects received a single dose of 10 mg and 40 mg Dimemorfan Phosphate tablets, respectively in study stage 1. Another 12 subjects received a single dose of 20 mg Dimemorfan Phosphate tablets under fed conditions, a single dose of 20 mg Dimemorfan Phosphate tablets under fasting conditions and multiple-dosing of 20 mg Dimemorfan Phosphate tablets 3 times per day, respectively in study stage 2. The washout between each treatment was 1 week. Plasma Dimemorfan was quantified by a high pressure liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method. After single-dosing of 10 mg, 20 mg and 40 mg Dimemorfan Phosphate tablets, Cmax, AUC0−t and AUC0−∞ were dose proportional, which achievd 6.19 ± 7.61 ng·mL−1, 101 ± 171 and 117 ± 210 ng·mL−1·h, respectively after single-dosing of 40 mg Dimemorfan Phosphate tablets. Tmax ranged from 2.75 to 3.96 h and t1/2 ranged from 10.6 to 11.4 h. After multiple-dosing of 20 mg Dimemorfan Phosphate tablets, the Accumulation Index (AI) was 2.65 ± 1.11. The pharmacokinetic parameters after single-dosing of 20 mg Dimemorfan Phosphate tablets under fed conditions were similar with those under fasting conditions. Sex did not affect the pharmacokinetics of Dimemorfan Phosphate tablets. Single-dosing of Dimemorfan Phosphate tablets exhibited linear kinetic characteristics. Multiple-dosing of 20 mg Dimemorfan Phosphate tablets 3 times per day caused obvious accumulation. No food effect or sex effect on the pharmacokinetics of Dimemorfan Phosphate tablets was observed. Chictr.org identifier: ChiCTR-ONC-14004851.
Yali Shen - One of the best experts on this subject based on the ideXlab platform.
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pharmacokinetics of Dimemorfan Phosphate tablets in healthy chinese volunteers
European Journal of Clinical Pharmacology, 2017Co-Authors: Yali Shen, Zhu Luo, Ying Wang, Jin Xiang, Jia MiaoAbstract:Investigate the pharmacokinetic properties of the antitussive Dimemorfan Phosphate tablets in healthy male and female Chinese volunteers after single and multiple-dose administration; and to evaluate the food-effect on pharmacokinetics of Dimemorfan. 12 subjects received a single dose of 10 mg and 40 mg Dimemorfan Phosphate tablets, respectively in study stage 1. Another 12 subjects received a single dose of 20 mg Dimemorfan Phosphate tablets under fed conditions, a single dose of 20 mg Dimemorfan Phosphate tablets under fasting conditions and multiple-dosing of 20 mg Dimemorfan Phosphate tablets 3 times per day, respectively in study stage 2. The washout between each treatment was 1 week. Plasma Dimemorfan was quantified by a high pressure liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method. After single-dosing of 10 mg, 20 mg and 40 mg Dimemorfan Phosphate tablets, Cmax, AUC0−t and AUC0−∞ were dose proportional, which achievd 6.19 ± 7.61 ng·mL−1, 101 ± 171 and 117 ± 210 ng·mL−1·h, respectively after single-dosing of 40 mg Dimemorfan Phosphate tablets. Tmax ranged from 2.75 to 3.96 h and t1/2 ranged from 10.6 to 11.4 h. After multiple-dosing of 20 mg Dimemorfan Phosphate tablets, the Accumulation Index (AI) was 2.65 ± 1.11. The pharmacokinetic parameters after single-dosing of 20 mg Dimemorfan Phosphate tablets under fed conditions were similar with those under fasting conditions. Sex did not affect the pharmacokinetics of Dimemorfan Phosphate tablets. Single-dosing of Dimemorfan Phosphate tablets exhibited linear kinetic characteristics. Multiple-dosing of 20 mg Dimemorfan Phosphate tablets 3 times per day caused obvious accumulation. No food effect or sex effect on the pharmacokinetics of Dimemorfan Phosphate tablets was observed. Chictr.org identifier: ChiCTR-ONC-14004851.
Zhu Luo - One of the best experts on this subject based on the ideXlab platform.
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pharmacokinetics of Dimemorfan Phosphate tablets in healthy chinese volunteers
European Journal of Clinical Pharmacology, 2017Co-Authors: Yali Shen, Zhu Luo, Ying Wang, Jin Xiang, Jia MiaoAbstract:Investigate the pharmacokinetic properties of the antitussive Dimemorfan Phosphate tablets in healthy male and female Chinese volunteers after single and multiple-dose administration; and to evaluate the food-effect on pharmacokinetics of Dimemorfan. 12 subjects received a single dose of 10 mg and 40 mg Dimemorfan Phosphate tablets, respectively in study stage 1. Another 12 subjects received a single dose of 20 mg Dimemorfan Phosphate tablets under fed conditions, a single dose of 20 mg Dimemorfan Phosphate tablets under fasting conditions and multiple-dosing of 20 mg Dimemorfan Phosphate tablets 3 times per day, respectively in study stage 2. The washout between each treatment was 1 week. Plasma Dimemorfan was quantified by a high pressure liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method. After single-dosing of 10 mg, 20 mg and 40 mg Dimemorfan Phosphate tablets, Cmax, AUC0−t and AUC0−∞ were dose proportional, which achievd 6.19 ± 7.61 ng·mL−1, 101 ± 171 and 117 ± 210 ng·mL−1·h, respectively after single-dosing of 40 mg Dimemorfan Phosphate tablets. Tmax ranged from 2.75 to 3.96 h and t1/2 ranged from 10.6 to 11.4 h. After multiple-dosing of 20 mg Dimemorfan Phosphate tablets, the Accumulation Index (AI) was 2.65 ± 1.11. The pharmacokinetic parameters after single-dosing of 20 mg Dimemorfan Phosphate tablets under fed conditions were similar with those under fasting conditions. Sex did not affect the pharmacokinetics of Dimemorfan Phosphate tablets. Single-dosing of Dimemorfan Phosphate tablets exhibited linear kinetic characteristics. Multiple-dosing of 20 mg Dimemorfan Phosphate tablets 3 times per day caused obvious accumulation. No food effect or sex effect on the pharmacokinetics of Dimemorfan Phosphate tablets was observed. Chictr.org identifier: ChiCTR-ONC-14004851.
Ying Wang - One of the best experts on this subject based on the ideXlab platform.
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pharmacokinetics of Dimemorfan Phosphate tablets in healthy chinese volunteers
European Journal of Clinical Pharmacology, 2017Co-Authors: Yali Shen, Zhu Luo, Ying Wang, Jin Xiang, Jia MiaoAbstract:Investigate the pharmacokinetic properties of the antitussive Dimemorfan Phosphate tablets in healthy male and female Chinese volunteers after single and multiple-dose administration; and to evaluate the food-effect on pharmacokinetics of Dimemorfan. 12 subjects received a single dose of 10 mg and 40 mg Dimemorfan Phosphate tablets, respectively in study stage 1. Another 12 subjects received a single dose of 20 mg Dimemorfan Phosphate tablets under fed conditions, a single dose of 20 mg Dimemorfan Phosphate tablets under fasting conditions and multiple-dosing of 20 mg Dimemorfan Phosphate tablets 3 times per day, respectively in study stage 2. The washout between each treatment was 1 week. Plasma Dimemorfan was quantified by a high pressure liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method. After single-dosing of 10 mg, 20 mg and 40 mg Dimemorfan Phosphate tablets, Cmax, AUC0−t and AUC0−∞ were dose proportional, which achievd 6.19 ± 7.61 ng·mL−1, 101 ± 171 and 117 ± 210 ng·mL−1·h, respectively after single-dosing of 40 mg Dimemorfan Phosphate tablets. Tmax ranged from 2.75 to 3.96 h and t1/2 ranged from 10.6 to 11.4 h. After multiple-dosing of 20 mg Dimemorfan Phosphate tablets, the Accumulation Index (AI) was 2.65 ± 1.11. The pharmacokinetic parameters after single-dosing of 20 mg Dimemorfan Phosphate tablets under fed conditions were similar with those under fasting conditions. Sex did not affect the pharmacokinetics of Dimemorfan Phosphate tablets. Single-dosing of Dimemorfan Phosphate tablets exhibited linear kinetic characteristics. Multiple-dosing of 20 mg Dimemorfan Phosphate tablets 3 times per day caused obvious accumulation. No food effect or sex effect on the pharmacokinetics of Dimemorfan Phosphate tablets was observed. Chictr.org identifier: ChiCTR-ONC-14004851.
Jin Xiang - One of the best experts on this subject based on the ideXlab platform.
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pharmacokinetics of Dimemorfan Phosphate tablets in healthy chinese volunteers
European Journal of Clinical Pharmacology, 2017Co-Authors: Yali Shen, Zhu Luo, Ying Wang, Jin Xiang, Jia MiaoAbstract:Investigate the pharmacokinetic properties of the antitussive Dimemorfan Phosphate tablets in healthy male and female Chinese volunteers after single and multiple-dose administration; and to evaluate the food-effect on pharmacokinetics of Dimemorfan. 12 subjects received a single dose of 10 mg and 40 mg Dimemorfan Phosphate tablets, respectively in study stage 1. Another 12 subjects received a single dose of 20 mg Dimemorfan Phosphate tablets under fed conditions, a single dose of 20 mg Dimemorfan Phosphate tablets under fasting conditions and multiple-dosing of 20 mg Dimemorfan Phosphate tablets 3 times per day, respectively in study stage 2. The washout between each treatment was 1 week. Plasma Dimemorfan was quantified by a high pressure liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method. After single-dosing of 10 mg, 20 mg and 40 mg Dimemorfan Phosphate tablets, Cmax, AUC0−t and AUC0−∞ were dose proportional, which achievd 6.19 ± 7.61 ng·mL−1, 101 ± 171 and 117 ± 210 ng·mL−1·h, respectively after single-dosing of 40 mg Dimemorfan Phosphate tablets. Tmax ranged from 2.75 to 3.96 h and t1/2 ranged from 10.6 to 11.4 h. After multiple-dosing of 20 mg Dimemorfan Phosphate tablets, the Accumulation Index (AI) was 2.65 ± 1.11. The pharmacokinetic parameters after single-dosing of 20 mg Dimemorfan Phosphate tablets under fed conditions were similar with those under fasting conditions. Sex did not affect the pharmacokinetics of Dimemorfan Phosphate tablets. Single-dosing of Dimemorfan Phosphate tablets exhibited linear kinetic characteristics. Multiple-dosing of 20 mg Dimemorfan Phosphate tablets 3 times per day caused obvious accumulation. No food effect or sex effect on the pharmacokinetics of Dimemorfan Phosphate tablets was observed. Chictr.org identifier: ChiCTR-ONC-14004851.