The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Kent L Redman - One of the best experts on this subject based on the ideXlab platform.
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british anti lewisite Dimercaprol an amazing history
Annals of Emergency Medicine, 2003Co-Authors: Joel A Vilensky, Kent L RedmanAbstract:Abstract Emergency physicians are familiar with British anti-Lewisite (BAL) because it is a heavy metal-chelating agent that is recommended in some cases of metal poisoning, especially arsenic. Although there are more modern chelating agents, the fact that BAL is still recommended and stocked by hospital pharmacies more than 60 years after its initial synthesis is itself remarkable. During World War II, BAL minimized the risk to the Allied infantry of injury or death from Lewisite, a very potent arsenic-based chemical warfare agent. Once developed, BAL revolutionized the treatment of heavy metal poisonings, both accidental and iatrogenic (eg, toxicity from treatment of arthritis with gold salts). In 1951, BAL was used to treat Wilson's disease with striking success. Today, BAL might again become prominent should terrorists or governments use Lewisite against civilians or military forces. [ Ann Emerg Med. 2003;41:378-383.]
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british anti lewisite Dimercaprol an amazing history
Annals of Emergency Medicine, 2003Co-Authors: Joel A Vilensky, Kent L RedmanAbstract:Emergency physicians are familiar with British anti-Lewisite (BAL) because it is a heavy metal-chelating agent that is recommended in some cases of metal poisoning, especially arsenic. Although there are more modern chelating agents, the fact that BAL is still recommended and stocked by hospital pharmacies more than 60 years after its initial synthesis is itself remarkable. During World War II, BAL minimized the risk to the Allied infantry of injury or death from Lewisite, a very potent arsenic-based chemical warfare agent. Once developed, BAL revolutionized the treatment of heavy metal poisonings, both accidental and iatrogenic (eg, toxicity from treatment of arthritis with gold salts). In 1951, BAL was used to treat Wilson's disease with striking success. Today, BAL might again become prominent should terrorists or governments use Lewisite against civilians or military forces.
Xueping Jia - One of the best experts on this subject based on the ideXlab platform.
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ultrasensitive fluorescent probe for copper ion based on cadmium selenide cadmium sulfide quantum dots capped with Dimercaprol
Spectroscopy Letters, 2018Co-Authors: Qin Zhao, Guanhong Tao, Yan Cai, Qicheng Qiao, Xueping JiaAbstract:A new ultrasensitive copper ion fluorescent probe based on cadmium selenide/cadmium sulfide quantum dots capped with Dimercaprol is described. Dimercaprol was bonded to the quantum dots through a s...
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Ultrasensitive fluorescent probe for copper ion based on cadmium selenide/cadmium sulfide quantum dots capped with Dimercaprol
2018Co-Authors: Qin Zhao, Guanhong Tao, Yan Cai, Qicheng Qiao, Xueping JiaAbstract:A new ultrasensitive copper ion fluorescent probe based on cadmium selenide/cadmium sulfide quantum dots capped with Dimercaprol is described. Dimercaprol was bonded to the quantum dots through a surface ligand exchange to form Dimercaprol-capped quantum dots whose fluorescence could be quenched by the coordination of Dimercaprol on quantum dots’ surface with copper ion. The fluorescent probe based on Dimercaprol-capped quantum dots showed a very good linear response range to copper ion from 0.1 to 50 µg L−1 with the detection limit of 0.087 µg L−1. The proposed method exhibited excellent sensitivity and selectivity due to the specific and strong affinity of Dimercaprol with copper ion and the unique photoluminescence properties of quantum dots. The possible quenching mechanism was discussed and the probe was successfully applied to the determination of ultratrace copper in real samples.
Burke A Cunha - One of the best experts on this subject based on the ideXlab platform.
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surface antigen exposure by bismuth Dimercaprol suppression of klebsiella pneumoniae capsular polysaccharide
Infection and Immunity, 1999Co-Authors: Philip Domenico, Juan M Tomas, Susana Merino, Xavier Rubires, Burke A CunhaAbstract:The bacterial capsule is an important virulence determinant in animal and plant disease. Bacterial capsule and slime can be inhibited by bismuth compounds, especially when complexed with lipophilic thiol chelators. Bismuth Dimercaprol (BisBAL) at 1 ppm of Bi3+ repressed Klebsiella pneumoniae capsule expression in defined medium by nearly 90%, which exposed subsurface structures. The phagocytic index for BisBAL-treated bacteria increased from <10 to 360 bacteria per 100 neutrophils in the presence of complement and anticapsular or anti-O antigen antiserum. BisBAL treatment also enhanced the reactivity of monoclonal antibodies (MAbs) specific for the O1-antigen lipopolysaccharide (LPS) or the LPS core in a dose-dependent manner as indicated by the results of enzyme-linked immunosorbent assays. When anti-O1 MAb was used, the reactivity increased significantly for fully encapsulated O1:K1 or O1:K2 cells but not for O1:K- cells. Deposition of C3b also increased significantly for BisBAL-treated O1:K1 or O1:K2 cells but not for O1:K- cells. Survival of a serum-sensitive strain was <0.1% when nonimmune human serum absorbed with O1:K1 cells was used and 107% when BisBAL-treated cells were used for absorption. Outer membrane proteins were also more accessible on the surface of K. pneumoniae after BisBAL treatment. Thus, at subinhibitory levels, BisBAL inhibited capsule expression, which promoted phagocytosis, enhanced the reactivity of specific antibodies for LPS O antigen, LPS core epitopes, or outer-membrane proteins, and enhanced complement interaction with encapsulated K. pneumoniae. By unmasking bacterial surface structures and enhancing the immune system reactivity to bacteria, bismuth thiols may prove useful as adjuncts for vaccination.
Joel A Vilensky - One of the best experts on this subject based on the ideXlab platform.
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british anti lewisite Dimercaprol an amazing history
Annals of Emergency Medicine, 2003Co-Authors: Joel A Vilensky, Kent L RedmanAbstract:Abstract Emergency physicians are familiar with British anti-Lewisite (BAL) because it is a heavy metal-chelating agent that is recommended in some cases of metal poisoning, especially arsenic. Although there are more modern chelating agents, the fact that BAL is still recommended and stocked by hospital pharmacies more than 60 years after its initial synthesis is itself remarkable. During World War II, BAL minimized the risk to the Allied infantry of injury or death from Lewisite, a very potent arsenic-based chemical warfare agent. Once developed, BAL revolutionized the treatment of heavy metal poisonings, both accidental and iatrogenic (eg, toxicity from treatment of arthritis with gold salts). In 1951, BAL was used to treat Wilson's disease with striking success. Today, BAL might again become prominent should terrorists or governments use Lewisite against civilians or military forces. [ Ann Emerg Med. 2003;41:378-383.]
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british anti lewisite Dimercaprol an amazing history
Annals of Emergency Medicine, 2003Co-Authors: Joel A Vilensky, Kent L RedmanAbstract:Emergency physicians are familiar with British anti-Lewisite (BAL) because it is a heavy metal-chelating agent that is recommended in some cases of metal poisoning, especially arsenic. Although there are more modern chelating agents, the fact that BAL is still recommended and stocked by hospital pharmacies more than 60 years after its initial synthesis is itself remarkable. During World War II, BAL minimized the risk to the Allied infantry of injury or death from Lewisite, a very potent arsenic-based chemical warfare agent. Once developed, BAL revolutionized the treatment of heavy metal poisonings, both accidental and iatrogenic (eg, toxicity from treatment of arthritis with gold salts). In 1951, BAL was used to treat Wilson's disease with striking success. Today, BAL might again become prominent should terrorists or governments use Lewisite against civilians or military forces.
Qin Zhao - One of the best experts on this subject based on the ideXlab platform.
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ultrasensitive fluorescent probe for copper ion based on cadmium selenide cadmium sulfide quantum dots capped with Dimercaprol
Spectroscopy Letters, 2018Co-Authors: Qin Zhao, Guanhong Tao, Yan Cai, Qicheng Qiao, Xueping JiaAbstract:A new ultrasensitive copper ion fluorescent probe based on cadmium selenide/cadmium sulfide quantum dots capped with Dimercaprol is described. Dimercaprol was bonded to the quantum dots through a s...
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Ultrasensitive fluorescent probe for copper ion based on cadmium selenide/cadmium sulfide quantum dots capped with Dimercaprol
2018Co-Authors: Qin Zhao, Guanhong Tao, Yan Cai, Qicheng Qiao, Xueping JiaAbstract:A new ultrasensitive copper ion fluorescent probe based on cadmium selenide/cadmium sulfide quantum dots capped with Dimercaprol is described. Dimercaprol was bonded to the quantum dots through a surface ligand exchange to form Dimercaprol-capped quantum dots whose fluorescence could be quenched by the coordination of Dimercaprol on quantum dots’ surface with copper ion. The fluorescent probe based on Dimercaprol-capped quantum dots showed a very good linear response range to copper ion from 0.1 to 50 µg L−1 with the detection limit of 0.087 µg L−1. The proposed method exhibited excellent sensitivity and selectivity due to the specific and strong affinity of Dimercaprol with copper ion and the unique photoluminescence properties of quantum dots. The possible quenching mechanism was discussed and the probe was successfully applied to the determination of ultratrace copper in real samples.