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S. Saarikoski - One of the best experts on this subject based on the ideXlab platform.

  • PLACENTAL TRANSFER OF 14C-Dimethyltubocurarine DURING CAESAREAN SECTION
    2016
    Co-Authors: I Klvalo, S. Saarikoski
    Abstract:

    Placental transfer of 14C-Dimethyltubocurarine (14C-dmtc) was studied during Caesarean section. Liquid scintillation counting was used for determination of 14C activity from the maternal and foetal blood samples. Paper chromatography was used to confirm the stability of 14C-dmtc. In all cases 14C-dmtc was able to cross the placenta. Detectable amounts of 14C-dmtc were found in umbilical blood 2 min after injection into the mother. Six and 10 min after injection, the 14C con-centration in the umbilical blood was 12 % of the corresponding maternal value. In an earlier study of placental transmission and foetal uptake of 14C-Dimethyltubocurarine (14C-dmtc) during the first trimester of pregnancy, it was found that 14C foetal plasma concentration was approxi-mately one-tenth of the maternal value 20 min after the injection of the substance to the mother (Kivalo and Saarikoski, 1972). The result was in agreement with the findings of Elert and Cohen (1962), who reported that the concentration of tubocurarine in th

I Klvalo - One of the best experts on this subject based on the ideXlab platform.

  • PLACENTAL TRANSFER OF 14C-Dimethyltubocurarine DURING CAESAREAN SECTION
    2016
    Co-Authors: I Klvalo, S. Saarikoski
    Abstract:

    Placental transfer of 14C-Dimethyltubocurarine (14C-dmtc) was studied during Caesarean section. Liquid scintillation counting was used for determination of 14C activity from the maternal and foetal blood samples. Paper chromatography was used to confirm the stability of 14C-dmtc. In all cases 14C-dmtc was able to cross the placenta. Detectable amounts of 14C-dmtc were found in umbilical blood 2 min after injection into the mother. Six and 10 min after injection, the 14C con-centration in the umbilical blood was 12 % of the corresponding maternal value. In an earlier study of placental transmission and foetal uptake of 14C-Dimethyltubocurarine (14C-dmtc) during the first trimester of pregnancy, it was found that 14C foetal plasma concentration was approxi-mately one-tenth of the maternal value 20 min after the injection of the substance to the mother (Kivalo and Saarikoski, 1972). The result was in agreement with the findings of Elert and Cohen (1962), who reported that the concentration of tubocurarine in th