The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform
Pat Sandra - One of the best experts on this subject based on the ideXlab platform.
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determination of the rodenticides warfarin Diphenadione and chlorophacinone in soil samples by hplc dad
Talanta, 1997Co-Authors: Andrei Medvedovici, Frank David, Pat SandraAbstract:A HPLC-DAD method is described for the analysis of the rodenticides warfarin, Diphenadione and chlorophacinone, together with the phenylurea herbicides isoproturon and diuron, in soil samples. The HPLC parameters have been optimised to provide baseline separation with symmetrical peakshapes in short analysis times. The sample preparation consists of Soxhlet extraction followed by SPE clean-up on cyanopropyl silica.
Andrei Medvedovici - One of the best experts on this subject based on the ideXlab platform.
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determination of the rodenticides warfarin Diphenadione and chlorophacinone in soil samples by hplc dad
Talanta, 1997Co-Authors: Andrei Medvedovici, Frank David, Pat SandraAbstract:A HPLC-DAD method is described for the analysis of the rodenticides warfarin, Diphenadione and chlorophacinone, together with the phenylurea herbicides isoproturon and diuron, in soil samples. The HPLC parameters have been optimised to provide baseline separation with symmetrical peakshapes in short analysis times. The sample preparation consists of Soxhlet extraction followed by SPE clean-up on cyanopropyl silica.
Frank David - One of the best experts on this subject based on the ideXlab platform.
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determination of the rodenticides warfarin Diphenadione and chlorophacinone in soil samples by hplc dad
Talanta, 1997Co-Authors: Andrei Medvedovici, Frank David, Pat SandraAbstract:A HPLC-DAD method is described for the analysis of the rodenticides warfarin, Diphenadione and chlorophacinone, together with the phenylurea herbicides isoproturon and diuron, in soil samples. The HPLC parameters have been optimised to provide baseline separation with symmetrical peakshapes in short analysis times. The sample preparation consists of Soxhlet extraction followed by SPE clean-up on cyanopropyl silica.
Boyages Steven - One of the best experts on this subject based on the ideXlab platform.
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Warfarin Toxicity and Individual Variability—Clinical Case
MDPI, 2026Co-Authors: Piatkov Irina, Rochester Colin, Jones Trudi, Boyages StevenAbstract:Warfarin is a widely used anticoagulant in the treatment and prevention of thrombosis, in the treatment for chronic atrial fibrillation, mechanical valves, pulmonary embolism, and dilated cardiomyopathy. It is tasteless and colorless, was used as a poison, and is still marketed as a pesticide against rats and mice. Several long-acting warfarin derivatives—superwarfarin anticoagulants—such as brodifacoum, Diphenadione, chlorophacinone, bromadiolone, are used as pesticides and can produce profound and prolonged anticoagulation. Several factors increase the risk of warfarin toxicity. However, polymorphisms in cytochrome P450 genes and drug interactions account for most of the risk for toxicity complications. Each person is unique in their degree of susceptibility to toxic agents. The toxicity interpretation and the health risk of most toxic substances are a subject of uncertainty. Genetically determined low metabolic capacity in an individual can dramatically alter the toxin and metabolite levels from those normally expected, which is crucial for drugs with a narrow therapeutic index, like warfarin. Personalized approaches in interpretation have the potential to remove some of the scientific uncertainties in toxicity cases
Piatkov Irina - One of the best experts on this subject based on the ideXlab platform.
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Warfarin Toxicity and Individual Variability—Clinical Case
MDPI, 2026Co-Authors: Piatkov Irina, Rochester Colin, Jones Trudi, Boyages StevenAbstract:Warfarin is a widely used anticoagulant in the treatment and prevention of thrombosis, in the treatment for chronic atrial fibrillation, mechanical valves, pulmonary embolism, and dilated cardiomyopathy. It is tasteless and colorless, was used as a poison, and is still marketed as a pesticide against rats and mice. Several long-acting warfarin derivatives—superwarfarin anticoagulants—such as brodifacoum, Diphenadione, chlorophacinone, bromadiolone, are used as pesticides and can produce profound and prolonged anticoagulation. Several factors increase the risk of warfarin toxicity. However, polymorphisms in cytochrome P450 genes and drug interactions account for most of the risk for toxicity complications. Each person is unique in their degree of susceptibility to toxic agents. The toxicity interpretation and the health risk of most toxic substances are a subject of uncertainty. Genetically determined low metabolic capacity in an individual can dramatically alter the toxin and metabolite levels from those normally expected, which is crucial for drugs with a narrow therapeutic index, like warfarin. Personalized approaches in interpretation have the potential to remove some of the scientific uncertainties in toxicity cases