The Experts below are selected from a list of 249 Experts worldwide ranked by ideXlab platform
R. Larsen - One of the best experts on this subject based on the ideXlab platform.
-
High energy phosphates and Direct Calorimetry as predictive parameters for metabolic recovery of the rat liver following ischemia
Acta Anaesthesiologica Scandinavica, 1996Co-Authors: F. Bach, D. Singer, A. Schmiedl, M. Bauer, R. LarsenAbstract:BACKGROUND AND METHODS Alteration of the hepatocellular function following ischemic damage may play a crucial role in the limited recovery after reperfusion. In spite of numerous efforts, finding a simple technique for predicting recovery of the liver after ischemic damage is still an unresolved problem. During ischemic storage of isolated rat livers at 25 degrees C tissue concentrations of high energy phosphates and lactate were determined photometrically and interstitial pH was measured by glass electrodes. In comparison, the metabolic rate was measured continuously by Direct Calorimetry. In a second series of experiments these results were compared with functional recovery after ischemia and reperfusion. Following ischemic storage at 25 degrees C for 60, 120 or 240 min, the isolated livers were reperfused for 30 min in a non-recirculating system with a constant flow rate. During reperfusion functional recovery, as assessed by oxygen consumption and bile flow, was determined. At the end of reperfusion tissue samples were taken for biochemical analysis of adenine nucleotides. Furthermore, morphologic integrity was determined by electron microscopy. RESULTS Whereas the ATP concentration drops within 60 min of ischemia to 6.9% of the control value without further significant change, the continuously measured metabolic rate as assessed by Direct Calorimetry decreases in an exponential manner. Accordingly, a better correlation of hepatocellular secretory function and calorimetrically measured heat output (r2 = 0.85; P < 0.001) was observed than with high energy phosphates (r2 = 0.56; P < 0.001). CONCLUSIONS These data suggest that if the metabolism of the ischemic rat liver falls below a critical level, recovery is incomplete or impossible. Therefore, assessment of the global metabolic rate by Direct Calorimetry seems not only to be a very good predictor of recovery after ischemic damage but also a good tool in the laboratory for studies concerning the sequelae of ischemic metabolism and for improvement of tissue protection.
-
High energy phosphates and Direct Calorimetry as predictive parameters for metabolic recovery of the rat liver following ischemia.
Acta anaesthesiologica Scandinavica, 1996Co-Authors: F. Bach, D. Singer, A. Schmiedl, M. Bauer, R. LarsenAbstract:Alteration of the hepatocellular function following ischemic damage may play a crucial role in the limited recovery after reperfusion. In spite of numerous efforts, finding a simple technique for predicting recovery of the liver after ischemic damage is still an unresolved problem. During ischemic storage of isolated rat livers at 25 degrees C tissue concentrations of high energy phosphates and lactate were determined photometrically and interstitial pH was measured by glass electrodes. In comparison, the metabolic rate was measured continuously by Direct Calorimetry. In a second series of experiments these results were compared with functional recovery after ischemia and reperfusion. Following ischemic storage at 25 degrees C for 60, 120 or 240 min, the isolated livers were reperfused for 30 min in a non-recirculating system with a constant flow rate. During reperfusion functional recovery, as assessed by oxygen consumption and bile flow, was determined. At the end of reperfusion tissue samples were taken for biochemical analysis of adenine nucleotides. Furthermore, morphologic integrity was determined by electron microscopy. Whereas the ATP concentration drops within 60 min of ischemia to 6.9% of the control value without further significant change, the continuously measured metabolic rate as assessed by Direct Calorimetry decreases in an exponential manner. Accordingly, a better correlation of hepatocellular secretory function and calorimetrically measured heat output (r2 = 0.85; P < 0.001) was observed than with high energy phosphates (r2 = 0.56; P < 0.001). These data suggest that if the metabolism of the ischemic rat liver falls below a critical level, recovery is incomplete or impossible. Therefore, assessment of the global metabolic rate by Direct Calorimetry seems not only to be a very good predictor of recovery after ischemic damage but also a good tool in the laboratory for studies concerning the sequelae of ischemic metabolism and for improvement of tissue protection.
-
Prediction of recovery after ischemia. A microcalorimetric and biochemical study of rat liver tissue
Thermochimica Acta, 1995Co-Authors: F. Bach, D. Singer, M. Bauer, H.j. Bretschneider, R. LarsenAbstract:Abstract Alteration of the hepatocellular function following ischemic damage may play a crucial role in the limited recovery after reperfusion. In spite of numerous efforts, finding a simple technique for predicting the recovery of the liver after ischemic damage is still an unresolved problem. During the ischemic storage of isolated rat livers at 25°C, tissue concentrations of high energy phosphates, glycogen and lactate were determined photometrically and, in comparison, the metabolic rate was measured continuously by Direct Calorimetry. In addition, interstitial pH was measured with microelectrodes. In a second series of experiments these results were compared with functional recovery after ischemia and reperfusion. Following ischemic storage at 25°C for 60, 120 and 240 min, the isolated livers were reperfused for 30 min in a non-recirculating system with a constant flow rate. During reperfusion, functional recovery as assessed by oxygen consumption and bile flow was determined. At the end of reperfusion, tissue samples were taken for biochemical analysis of adenine nucleotides and tissue lactate. Though the ATP concentration drops within 60 min of ischemia to 6.94% of the control value without further significant change, the metabolic rate measured continuously by Direct Calorimetry decreases in an exponential manner. According to the calorimetrically measured heat output, functional hepatic metabolism, as assessed by oxygen consumption, bile flow and restoration of high energy phosphates during reperfusion, recovered to an extent depending on the duration of ischemia. It is concluded that the metabolic rate of the ischemic rat liver, as determined continuously by Direct Calorimetry, is a good predictor for recovery after ischemic damage.
F. Bach - One of the best experts on this subject based on the ideXlab platform.
-
High energy phosphates and Direct Calorimetry as predictive parameters for metabolic recovery of the rat liver following ischemia
Acta Anaesthesiologica Scandinavica, 1996Co-Authors: F. Bach, D. Singer, A. Schmiedl, M. Bauer, R. LarsenAbstract:BACKGROUND AND METHODS Alteration of the hepatocellular function following ischemic damage may play a crucial role in the limited recovery after reperfusion. In spite of numerous efforts, finding a simple technique for predicting recovery of the liver after ischemic damage is still an unresolved problem. During ischemic storage of isolated rat livers at 25 degrees C tissue concentrations of high energy phosphates and lactate were determined photometrically and interstitial pH was measured by glass electrodes. In comparison, the metabolic rate was measured continuously by Direct Calorimetry. In a second series of experiments these results were compared with functional recovery after ischemia and reperfusion. Following ischemic storage at 25 degrees C for 60, 120 or 240 min, the isolated livers were reperfused for 30 min in a non-recirculating system with a constant flow rate. During reperfusion functional recovery, as assessed by oxygen consumption and bile flow, was determined. At the end of reperfusion tissue samples were taken for biochemical analysis of adenine nucleotides. Furthermore, morphologic integrity was determined by electron microscopy. RESULTS Whereas the ATP concentration drops within 60 min of ischemia to 6.9% of the control value without further significant change, the continuously measured metabolic rate as assessed by Direct Calorimetry decreases in an exponential manner. Accordingly, a better correlation of hepatocellular secretory function and calorimetrically measured heat output (r2 = 0.85; P < 0.001) was observed than with high energy phosphates (r2 = 0.56; P < 0.001). CONCLUSIONS These data suggest that if the metabolism of the ischemic rat liver falls below a critical level, recovery is incomplete or impossible. Therefore, assessment of the global metabolic rate by Direct Calorimetry seems not only to be a very good predictor of recovery after ischemic damage but also a good tool in the laboratory for studies concerning the sequelae of ischemic metabolism and for improvement of tissue protection.
-
High energy phosphates and Direct Calorimetry as predictive parameters for metabolic recovery of the rat liver following ischemia.
Acta anaesthesiologica Scandinavica, 1996Co-Authors: F. Bach, D. Singer, A. Schmiedl, M. Bauer, R. LarsenAbstract:Alteration of the hepatocellular function following ischemic damage may play a crucial role in the limited recovery after reperfusion. In spite of numerous efforts, finding a simple technique for predicting recovery of the liver after ischemic damage is still an unresolved problem. During ischemic storage of isolated rat livers at 25 degrees C tissue concentrations of high energy phosphates and lactate were determined photometrically and interstitial pH was measured by glass electrodes. In comparison, the metabolic rate was measured continuously by Direct Calorimetry. In a second series of experiments these results were compared with functional recovery after ischemia and reperfusion. Following ischemic storage at 25 degrees C for 60, 120 or 240 min, the isolated livers were reperfused for 30 min in a non-recirculating system with a constant flow rate. During reperfusion functional recovery, as assessed by oxygen consumption and bile flow, was determined. At the end of reperfusion tissue samples were taken for biochemical analysis of adenine nucleotides. Furthermore, morphologic integrity was determined by electron microscopy. Whereas the ATP concentration drops within 60 min of ischemia to 6.9% of the control value without further significant change, the continuously measured metabolic rate as assessed by Direct Calorimetry decreases in an exponential manner. Accordingly, a better correlation of hepatocellular secretory function and calorimetrically measured heat output (r2 = 0.85; P < 0.001) was observed than with high energy phosphates (r2 = 0.56; P < 0.001). These data suggest that if the metabolism of the ischemic rat liver falls below a critical level, recovery is incomplete or impossible. Therefore, assessment of the global metabolic rate by Direct Calorimetry seems not only to be a very good predictor of recovery after ischemic damage but also a good tool in the laboratory for studies concerning the sequelae of ischemic metabolism and for improvement of tissue protection.
-
Prediction of recovery after ischemia. A microcalorimetric and biochemical study of rat liver tissue
Thermochimica Acta, 1995Co-Authors: F. Bach, D. Singer, M. Bauer, H.j. Bretschneider, R. LarsenAbstract:Abstract Alteration of the hepatocellular function following ischemic damage may play a crucial role in the limited recovery after reperfusion. In spite of numerous efforts, finding a simple technique for predicting the recovery of the liver after ischemic damage is still an unresolved problem. During the ischemic storage of isolated rat livers at 25°C, tissue concentrations of high energy phosphates, glycogen and lactate were determined photometrically and, in comparison, the metabolic rate was measured continuously by Direct Calorimetry. In addition, interstitial pH was measured with microelectrodes. In a second series of experiments these results were compared with functional recovery after ischemia and reperfusion. Following ischemic storage at 25°C for 60, 120 and 240 min, the isolated livers were reperfused for 30 min in a non-recirculating system with a constant flow rate. During reperfusion, functional recovery as assessed by oxygen consumption and bile flow was determined. At the end of reperfusion, tissue samples were taken for biochemical analysis of adenine nucleotides and tissue lactate. Though the ATP concentration drops within 60 min of ischemia to 6.94% of the control value without further significant change, the metabolic rate measured continuously by Direct Calorimetry decreases in an exponential manner. According to the calorimetrically measured heat output, functional hepatic metabolism, as assessed by oxygen consumption, bile flow and restoration of high energy phosphates during reperfusion, recovered to an extent depending on the duration of ischemia. It is concluded that the metabolic rate of the ischemic rat liver, as determined continuously by Direct Calorimetry, is a good predictor for recovery after ischemic damage.
M. Bauer - One of the best experts on this subject based on the ideXlab platform.
-
High energy phosphates and Direct Calorimetry as predictive parameters for metabolic recovery of the rat liver following ischemia
Acta Anaesthesiologica Scandinavica, 1996Co-Authors: F. Bach, D. Singer, A. Schmiedl, M. Bauer, R. LarsenAbstract:BACKGROUND AND METHODS Alteration of the hepatocellular function following ischemic damage may play a crucial role in the limited recovery after reperfusion. In spite of numerous efforts, finding a simple technique for predicting recovery of the liver after ischemic damage is still an unresolved problem. During ischemic storage of isolated rat livers at 25 degrees C tissue concentrations of high energy phosphates and lactate were determined photometrically and interstitial pH was measured by glass electrodes. In comparison, the metabolic rate was measured continuously by Direct Calorimetry. In a second series of experiments these results were compared with functional recovery after ischemia and reperfusion. Following ischemic storage at 25 degrees C for 60, 120 or 240 min, the isolated livers were reperfused for 30 min in a non-recirculating system with a constant flow rate. During reperfusion functional recovery, as assessed by oxygen consumption and bile flow, was determined. At the end of reperfusion tissue samples were taken for biochemical analysis of adenine nucleotides. Furthermore, morphologic integrity was determined by electron microscopy. RESULTS Whereas the ATP concentration drops within 60 min of ischemia to 6.9% of the control value without further significant change, the continuously measured metabolic rate as assessed by Direct Calorimetry decreases in an exponential manner. Accordingly, a better correlation of hepatocellular secretory function and calorimetrically measured heat output (r2 = 0.85; P < 0.001) was observed than with high energy phosphates (r2 = 0.56; P < 0.001). CONCLUSIONS These data suggest that if the metabolism of the ischemic rat liver falls below a critical level, recovery is incomplete or impossible. Therefore, assessment of the global metabolic rate by Direct Calorimetry seems not only to be a very good predictor of recovery after ischemic damage but also a good tool in the laboratory for studies concerning the sequelae of ischemic metabolism and for improvement of tissue protection.
-
High energy phosphates and Direct Calorimetry as predictive parameters for metabolic recovery of the rat liver following ischemia.
Acta anaesthesiologica Scandinavica, 1996Co-Authors: F. Bach, D. Singer, A. Schmiedl, M. Bauer, R. LarsenAbstract:Alteration of the hepatocellular function following ischemic damage may play a crucial role in the limited recovery after reperfusion. In spite of numerous efforts, finding a simple technique for predicting recovery of the liver after ischemic damage is still an unresolved problem. During ischemic storage of isolated rat livers at 25 degrees C tissue concentrations of high energy phosphates and lactate were determined photometrically and interstitial pH was measured by glass electrodes. In comparison, the metabolic rate was measured continuously by Direct Calorimetry. In a second series of experiments these results were compared with functional recovery after ischemia and reperfusion. Following ischemic storage at 25 degrees C for 60, 120 or 240 min, the isolated livers were reperfused for 30 min in a non-recirculating system with a constant flow rate. During reperfusion functional recovery, as assessed by oxygen consumption and bile flow, was determined. At the end of reperfusion tissue samples were taken for biochemical analysis of adenine nucleotides. Furthermore, morphologic integrity was determined by electron microscopy. Whereas the ATP concentration drops within 60 min of ischemia to 6.9% of the control value without further significant change, the continuously measured metabolic rate as assessed by Direct Calorimetry decreases in an exponential manner. Accordingly, a better correlation of hepatocellular secretory function and calorimetrically measured heat output (r2 = 0.85; P < 0.001) was observed than with high energy phosphates (r2 = 0.56; P < 0.001). These data suggest that if the metabolism of the ischemic rat liver falls below a critical level, recovery is incomplete or impossible. Therefore, assessment of the global metabolic rate by Direct Calorimetry seems not only to be a very good predictor of recovery after ischemic damage but also a good tool in the laboratory for studies concerning the sequelae of ischemic metabolism and for improvement of tissue protection.
-
Prediction of recovery after ischemia. A microcalorimetric and biochemical study of rat liver tissue
Thermochimica Acta, 1995Co-Authors: F. Bach, D. Singer, M. Bauer, H.j. Bretschneider, R. LarsenAbstract:Abstract Alteration of the hepatocellular function following ischemic damage may play a crucial role in the limited recovery after reperfusion. In spite of numerous efforts, finding a simple technique for predicting the recovery of the liver after ischemic damage is still an unresolved problem. During the ischemic storage of isolated rat livers at 25°C, tissue concentrations of high energy phosphates, glycogen and lactate were determined photometrically and, in comparison, the metabolic rate was measured continuously by Direct Calorimetry. In addition, interstitial pH was measured with microelectrodes. In a second series of experiments these results were compared with functional recovery after ischemia and reperfusion. Following ischemic storage at 25°C for 60, 120 and 240 min, the isolated livers were reperfused for 30 min in a non-recirculating system with a constant flow rate. During reperfusion, functional recovery as assessed by oxygen consumption and bile flow was determined. At the end of reperfusion, tissue samples were taken for biochemical analysis of adenine nucleotides and tissue lactate. Though the ATP concentration drops within 60 min of ischemia to 6.94% of the control value without further significant change, the metabolic rate measured continuously by Direct Calorimetry decreases in an exponential manner. According to the calorimetrically measured heat output, functional hepatic metabolism, as assessed by oxygen consumption, bile flow and restoration of high energy phosphates during reperfusion, recovered to an extent depending on the duration of ischemia. It is concluded that the metabolic rate of the ischemic rat liver, as determined continuously by Direct Calorimetry, is a good predictor for recovery after ischemic damage.
D. Singer - One of the best experts on this subject based on the ideXlab platform.
-
High energy phosphates and Direct Calorimetry as predictive parameters for metabolic recovery of the rat liver following ischemia
Acta Anaesthesiologica Scandinavica, 1996Co-Authors: F. Bach, D. Singer, A. Schmiedl, M. Bauer, R. LarsenAbstract:BACKGROUND AND METHODS Alteration of the hepatocellular function following ischemic damage may play a crucial role in the limited recovery after reperfusion. In spite of numerous efforts, finding a simple technique for predicting recovery of the liver after ischemic damage is still an unresolved problem. During ischemic storage of isolated rat livers at 25 degrees C tissue concentrations of high energy phosphates and lactate were determined photometrically and interstitial pH was measured by glass electrodes. In comparison, the metabolic rate was measured continuously by Direct Calorimetry. In a second series of experiments these results were compared with functional recovery after ischemia and reperfusion. Following ischemic storage at 25 degrees C for 60, 120 or 240 min, the isolated livers were reperfused for 30 min in a non-recirculating system with a constant flow rate. During reperfusion functional recovery, as assessed by oxygen consumption and bile flow, was determined. At the end of reperfusion tissue samples were taken for biochemical analysis of adenine nucleotides. Furthermore, morphologic integrity was determined by electron microscopy. RESULTS Whereas the ATP concentration drops within 60 min of ischemia to 6.9% of the control value without further significant change, the continuously measured metabolic rate as assessed by Direct Calorimetry decreases in an exponential manner. Accordingly, a better correlation of hepatocellular secretory function and calorimetrically measured heat output (r2 = 0.85; P < 0.001) was observed than with high energy phosphates (r2 = 0.56; P < 0.001). CONCLUSIONS These data suggest that if the metabolism of the ischemic rat liver falls below a critical level, recovery is incomplete or impossible. Therefore, assessment of the global metabolic rate by Direct Calorimetry seems not only to be a very good predictor of recovery after ischemic damage but also a good tool in the laboratory for studies concerning the sequelae of ischemic metabolism and for improvement of tissue protection.
-
High energy phosphates and Direct Calorimetry as predictive parameters for metabolic recovery of the rat liver following ischemia.
Acta anaesthesiologica Scandinavica, 1996Co-Authors: F. Bach, D. Singer, A. Schmiedl, M. Bauer, R. LarsenAbstract:Alteration of the hepatocellular function following ischemic damage may play a crucial role in the limited recovery after reperfusion. In spite of numerous efforts, finding a simple technique for predicting recovery of the liver after ischemic damage is still an unresolved problem. During ischemic storage of isolated rat livers at 25 degrees C tissue concentrations of high energy phosphates and lactate were determined photometrically and interstitial pH was measured by glass electrodes. In comparison, the metabolic rate was measured continuously by Direct Calorimetry. In a second series of experiments these results were compared with functional recovery after ischemia and reperfusion. Following ischemic storage at 25 degrees C for 60, 120 or 240 min, the isolated livers were reperfused for 30 min in a non-recirculating system with a constant flow rate. During reperfusion functional recovery, as assessed by oxygen consumption and bile flow, was determined. At the end of reperfusion tissue samples were taken for biochemical analysis of adenine nucleotides. Furthermore, morphologic integrity was determined by electron microscopy. Whereas the ATP concentration drops within 60 min of ischemia to 6.9% of the control value without further significant change, the continuously measured metabolic rate as assessed by Direct Calorimetry decreases in an exponential manner. Accordingly, a better correlation of hepatocellular secretory function and calorimetrically measured heat output (r2 = 0.85; P < 0.001) was observed than with high energy phosphates (r2 = 0.56; P < 0.001). These data suggest that if the metabolism of the ischemic rat liver falls below a critical level, recovery is incomplete or impossible. Therefore, assessment of the global metabolic rate by Direct Calorimetry seems not only to be a very good predictor of recovery after ischemic damage but also a good tool in the laboratory for studies concerning the sequelae of ischemic metabolism and for improvement of tissue protection.
-
Prediction of recovery after ischemia. A microcalorimetric and biochemical study of rat liver tissue
Thermochimica Acta, 1995Co-Authors: F. Bach, D. Singer, M. Bauer, H.j. Bretschneider, R. LarsenAbstract:Abstract Alteration of the hepatocellular function following ischemic damage may play a crucial role in the limited recovery after reperfusion. In spite of numerous efforts, finding a simple technique for predicting the recovery of the liver after ischemic damage is still an unresolved problem. During the ischemic storage of isolated rat livers at 25°C, tissue concentrations of high energy phosphates, glycogen and lactate were determined photometrically and, in comparison, the metabolic rate was measured continuously by Direct Calorimetry. In addition, interstitial pH was measured with microelectrodes. In a second series of experiments these results were compared with functional recovery after ischemia and reperfusion. Following ischemic storage at 25°C for 60, 120 and 240 min, the isolated livers were reperfused for 30 min in a non-recirculating system with a constant flow rate. During reperfusion, functional recovery as assessed by oxygen consumption and bile flow was determined. At the end of reperfusion, tissue samples were taken for biochemical analysis of adenine nucleotides and tissue lactate. Though the ATP concentration drops within 60 min of ischemia to 6.94% of the control value without further significant change, the metabolic rate measured continuously by Direct Calorimetry decreases in an exponential manner. According to the calorimetrically measured heat output, functional hepatic metabolism, as assessed by oxygen consumption, bile flow and restoration of high energy phosphates during reperfusion, recovered to an extent depending on the duration of ischemia. It is concluded that the metabolic rate of the ischemic rat liver, as determined continuously by Direct Calorimetry, is a good predictor for recovery after ischemic damage.
S. N. Gridchin - One of the best experts on this subject based on the ideXlab platform.
-
Thermodynamic characteristics of the acid–base equilibria of ethylenediamine- N , N ′-diglutaric acid in aqueous solutions using calorimetric data
Russian Journal of Physical Chemistry A, 2017Co-Authors: S. N. Gridchin, V. M. Nikol’skiiAbstract:The enthalpies of reaction of betaine group neutralization of ethylenediamine-N,N'-diglutaric acid (H4L) at 298.15 K and at different values of ionic strength of 0.1, 0.5, 1.0 (KNO3) is measured by Direct Calorimetry. The standard thermodynamic characteristics of the protolytic equilibria of H4L are calculated.
-
Thermodynamic Parameters of Protolytic Equilibria of Selected Dipeptides in Aqueous Solutions
Russian Journal of General Chemistry, 2015Co-Authors: S. N. GridchinAbstract:Heat effects of stepwise dissociation of D,L-valyl-D,L-leucine, L-leucyl-L-leucine, D,L-leucylglycine, and glycyl-D,L-leucine (298.15 K; 0.1, 0.5, or 1.0 mol/L KNO3) have been determined by Direct Calorimetry. Standard thermodynamic parameters of the studied equilibria have been calculated.
-
Thermodynamic characteristics of the acid-base equilibria of taurine in aqueous solutions, according to Calorimetry data
Russian Journal of Physical Chemistry A, 2014Co-Authors: S. N. Gridchin, R. F. Shekhanov, Dmitrii PyreuAbstract:Enthalpies of the neutralization and protonation of taurine (HL) are measured by Direct Calorimetry at 298.15 K and ionic strengths of 0.3, 0.5, and 1.0 (KNO3). The standard thermodynamic characteristics of HL protolytic equilibria are calculated.
-
thermodynamic characteristics of protolytic equilibria of hexamethylenediamine n n n n tetraacetic acid
Russian Journal of Physical Chemistry A, 2011Co-Authors: S. N. Gridchin, Dmitrii PyreuAbstract:The heats of dissociation of betaine groups of hexamethylenediamine-N,N,N′,N′-tetraacetic acid (H4L) at 298.15 K and the ionic strengths of 0.1, 0.5, and 1.0 (KNO3) were determined by Direct Calorimetry. The standard thermodynamic characteristics of the ptotolytic equilidria of H4L were calculated using the results from thermochemical and potentiometric measurements made under identical test conditions.
-
Thermodynamics of nickel(II) complexing with trimethylenediamine-N,N,N′,N′-tetraacetic acid
Russian Journal of Inorganic Chemistry, 2008Co-Authors: S. N. Gridchin, G. G. GorboletovaAbstract:The heats of nickel(II) trimethylenediaminetetraacetate formation were determined by Direct Calorimetry at 298.15 K and ionic strength I =0.1, 0.5, and 1.0 (KNO3). The corresponding thermodynamic characteristics were calculated. The results were compared to literature data on the related compounds.