The Experts below are selected from a list of 930 Experts worldwide ranked by ideXlab platform
Anatoli I Yashin - One of the best experts on this subject based on the ideXlab platform.
-
association between apoe ɛ2 ɛ3 ɛ4 polymorphism and Disability Severity in a national long term care survey sample
Age and Ageing, 2008Co-Authors: Alexander M Kulminski, Svetlana V Ukraintseva, Konstantin G Arbeev, Kenneth G Manton, Junko Oshima, George M Martin, Anatoli I YashinAbstract:Background: early studies reported controversial findings on association of apolipoprotein E (APOE) polymorphism with Disability. Objective: to analyse sex-specific associations of APOE genotypes with impairments in (instrumental) activities of daily living [(I)ADL] and mortality. Design: population-based 1999 National Long Term Care Survey (NLTCS) of the US older (65+) individuals. Participants: genetic data are available for 1,805 individuals. Methods: each of six genotypes of three common alleles of the APOE locus (e2, e 3a nde4) was tested on the association with a Disability index or mortality. Results: APOE e3/e3 genotype significantly decreases odds ratio (OR) for IADL Disability in males [OR = 0.48; 95% Confidence Interval (CI) 0.31‐0.76] while it exhibits no association in females. The OR for ADL Disability is 0.19 (CI 0.04‐0.99) for e4/e4 female carriers. The e2/e3 genotype increases the chances of IADL Disability for males (OR = 2.33; CI 1.28‐4.25). No significant association between APOE polymorphism and mortality was found. A surprising observation was that e4/e4 female carriers have a 5.3 times lower chance of having ADL Disability than non-e4/e4-carriers. Conclusions: association of the APOE polymorphism with Disability and lack of association with mortality support the view that APOE gene actions may be more significant as modulators of frailty than of longevity.
-
Association between APOE ɛ2/ɛ3/ɛ4 polymorphism and Disability Severity in a national long-term care survey sample
Age and Ageing, 2008Co-Authors: Alexander M Kulminski, Svetlana V Ukraintseva, Konstantin G Arbeev, Kenneth G Manton, Junko Oshima, George M Martin, Anatoli I YashinAbstract:Background: early studies reported controversial findings on association of apolipoprotein E (APOE) polymorphism with Disability. Objective: to analyse sex-specific associations of APOE genotypes with impairments in (instrumental) activities of daily living [(I)ADL] and mortality. Design: population-based 1999 National Long Term Care Survey (NLTCS) of the US older (65+) individuals. Participants: genetic data are available for 1,805 individuals. Methods: each of six genotypes of three common alleles of the APOE locus (e2, e 3a nde4) was tested on the association with a Disability index or mortality. Results: APOE e3/e3 genotype significantly decreases odds ratio (OR) for IADL Disability in males [OR = 0.48; 95% Confidence Interval (CI) 0.31‐0.76] while it exhibits no association in females. The OR for ADL Disability is 0.19 (CI 0.04‐0.99) for e4/e4 female carriers. The e2/e3 genotype increases the chances of IADL Disability for males (OR = 2.33; CI 1.28‐4.25). No significant association between APOE polymorphism and mortality was found. A surprising observation was that e4/e4 female carriers have a 5.3 times lower chance of having ADL Disability than non-e4/e4-carriers. Conclusions: association of the APOE polymorphism with Disability and lack of association with mortality support the view that APOE gene actions may be more significant as modulators of frailty than of longevity.
Vicki L Kristman - One of the best experts on this subject based on the ideXlab platform.
-
Disability Severity, Leader-Member Exchange, and Attitudinal Outcomes: Considering the Employee and Supervisor Perspectives.
Journal of occupational rehabilitation, 2020Co-Authors: Zhanna Lyubykh, Mahfooz A Ansari, Kelly Williams-whitt, Vicki L KristmanAbstract:Purpose Although the effects of Disability on employee work outcomes are well-documented, the mechanism that explain these relationship remains unclear. We propose that the quality of relationships employees with disabilities develop with their supervisors explains the link between Disability Severity and employee work outcomes. More specifically, we examine the mediating role of leader-member exchange (LMX) in the relationship between employee Disability Severity and presenteeism, job accommodation, supervisor-rated performance, job satisfaction, and resilience. We test this proposition from two perspectives: employees with disabilities and supervisors who had supervised employees with disabilities. Method We collected data from employees with musculoskeletal disabilities (Sample 1, N = 264) and supervisors who had supervised employees with musculoskeletal disabilities in the past two years (Sample 2, N = 224). Results From the perspective of employees with disabilities (Sample 1), Disability Severity was negatively related to LMX quality (R2 = .28). Contrary to our hypothesis, we found a positive relationship between supervisor perceptions of employee Disability Severity and LMX in Sample 2 (R2 = .27). After adjusting for Disability Severity, LMX quality was related to improved outcomes in both samples: higher employee job satisfaction (Sample 1: R2 = .36), provision of job accommodations (Sample 1: R2 = .16; Sample 2: R2= .15), resilience (Sample 1: R2 = .18), lower levels of presenteeism (Sample 1: R2 = .20), and higher performance evaluations for employees with disabilities (Sample 2: R2 = .49). Conclusion By collecting two separate samples, we revealed similarities and differences in employee and supervisor perspectives. Our findings demonstrated the need for including both perspectives when considering implications of employee Disability Severity.
-
Disability Severity, Leader–Member Exchange, and Attitudinal Outcomes: Considering the Employee and Supervisor Perspectives
Journal of Occupational Rehabilitation, 2020Co-Authors: Zhanna Lyubykh, Mahfooz A Ansari, Kelly Williams-whitt, Vicki L KristmanAbstract:Purpose Although the effects of Disability on employee work outcomes are well-documented, the mechanism that explain these relationship remains unclear. We propose that the quality of relationships employees with disabilities develop with their supervisors explains the link between Disability Severity and employee work outcomes. More specifically, we examine the mediating role of leader–member exchange (LMX) in the relationship between employee Disability Severity and presenteeism, job accommodation, supervisor-rated performance, job satisfaction, and resilience. We test this proposition from two perspectives: employees with disabilities and supervisors who had supervised employees with disabilities. Method We collected data from employees with musculoskeletal disabilities (Sample 1, N = 264) and supervisors who had supervised employees with musculoskeletal disabilities in the past two years (Sample 2, N = 224). Results From the perspective of employees with disabilities (Sample 1), Disability Severity was negatively related to LMX quality ( R ^2 = .28). Contrary to our hypothesis, we found a positive relationship between supervisor perceptions of employee Disability Severity and LMX in Sample 2 ( R ^2 = .27). After adjusting for Disability Severity, LMX quality was related to improved outcomes in both samples: higher employee job satisfaction (Sample 1: R ^2 = .36), provision of job accommodations (Sample 1: R ^2 = .16; Sample 2: R ^2= .15), resilience (Sample 1: R ^2 = .18), lower levels of presenteeism (Sample 1: R ^2 = .20), and higher performance evaluations for employees with disabilities (Sample 2: R ^2 = .49). Conclusion By collecting two separate samples, we revealed similarities and differences in employee and supervisor perspectives. Our findings demonstrated the need for including both perspectives when considering implications of employee Disability Severity.
Yasmeen Iqbal - One of the best experts on this subject based on the ideXlab platform.
-
hoarding Severity predicts Disability in late life hoarding disorder patients
Hawai'i journal of medicine & public health, 2014Co-Authors: Princeton Ly, Catherine R Ayers, Ian Howard, Tina L Mayes, Ben Porter, Yasmeen IqbalAbstract:Objective: Late-life hoarding is a serious psychiatric condition with significant implications in health and functioning. Geriatric hoarding patients show greater impairment in activities of daily living and have a greater number of medical conditions compared to same-aged non-hoarders. This study examined the relationship between geriatric hoarding Severity and Disability Severity.
-
hoarding Severity predicts functional Disability in late life hoarding disorder patients
International Journal of Geriatric Psychiatry, 2014Co-Authors: Catherine R Ayers, Princeton Ly, Ian Howard, Tina L Mayes, Ben Porter, Yasmeen IqbalAbstract:Objective Late-life hoarding is a serious psychiatric condition with significant implications in health and functioning. Geriatric hoarding patients show greater impairment in activities of daily living and have a greater number of medical conditions compared with same-aged nonhoarders. This study examined the relationship between geriatric hoarding Severity and functional Disability Severity. Methods Sixty-five subjects age 60 or older with hoarding disorder (HD) participated in the current study. Participants were assessed with measures of hoarding Severity, psychiatric symptoms, and general Disability. Hierarchical regression was used to test the unique association of hoarding symptoms with functional Disability beyond the effects of demographic factors, anxiety, and depression. Results When controlling for demographics (age and gender) and psychiatric symptoms (anxiety and depression), hoarding Severity predicts functional Disability Severity. Analyses also show that clinician-administered measures of hoarding are stronger predictors of Disability than patient self-report measures. Conclusions When treating older adults with HD, clinicians must consider symptom impact on daily life. A multidisciplinary team must be utilized to address the wide-ranging consequences of hoarding symptoms. Future work should examine how psychiatric treatment of HD affects functional Disability. Copyright © 2013 John Wiley & Sons, Ltd.
Alexander M Kulminski - One of the best experts on this subject based on the ideXlab platform.
-
association between apoe ɛ2 ɛ3 ɛ4 polymorphism and Disability Severity in a national long term care survey sample
Age and Ageing, 2008Co-Authors: Alexander M Kulminski, Svetlana V Ukraintseva, Konstantin G Arbeev, Kenneth G Manton, Junko Oshima, George M Martin, Anatoli I YashinAbstract:Background: early studies reported controversial findings on association of apolipoprotein E (APOE) polymorphism with Disability. Objective: to analyse sex-specific associations of APOE genotypes with impairments in (instrumental) activities of daily living [(I)ADL] and mortality. Design: population-based 1999 National Long Term Care Survey (NLTCS) of the US older (65+) individuals. Participants: genetic data are available for 1,805 individuals. Methods: each of six genotypes of three common alleles of the APOE locus (e2, e 3a nde4) was tested on the association with a Disability index or mortality. Results: APOE e3/e3 genotype significantly decreases odds ratio (OR) for IADL Disability in males [OR = 0.48; 95% Confidence Interval (CI) 0.31‐0.76] while it exhibits no association in females. The OR for ADL Disability is 0.19 (CI 0.04‐0.99) for e4/e4 female carriers. The e2/e3 genotype increases the chances of IADL Disability for males (OR = 2.33; CI 1.28‐4.25). No significant association between APOE polymorphism and mortality was found. A surprising observation was that e4/e4 female carriers have a 5.3 times lower chance of having ADL Disability than non-e4/e4-carriers. Conclusions: association of the APOE polymorphism with Disability and lack of association with mortality support the view that APOE gene actions may be more significant as modulators of frailty than of longevity.
-
Association between APOE ɛ2/ɛ3/ɛ4 polymorphism and Disability Severity in a national long-term care survey sample
Age and Ageing, 2008Co-Authors: Alexander M Kulminski, Svetlana V Ukraintseva, Konstantin G Arbeev, Kenneth G Manton, Junko Oshima, George M Martin, Anatoli I YashinAbstract:Background: early studies reported controversial findings on association of apolipoprotein E (APOE) polymorphism with Disability. Objective: to analyse sex-specific associations of APOE genotypes with impairments in (instrumental) activities of daily living [(I)ADL] and mortality. Design: population-based 1999 National Long Term Care Survey (NLTCS) of the US older (65+) individuals. Participants: genetic data are available for 1,805 individuals. Methods: each of six genotypes of three common alleles of the APOE locus (e2, e 3a nde4) was tested on the association with a Disability index or mortality. Results: APOE e3/e3 genotype significantly decreases odds ratio (OR) for IADL Disability in males [OR = 0.48; 95% Confidence Interval (CI) 0.31‐0.76] while it exhibits no association in females. The OR for ADL Disability is 0.19 (CI 0.04‐0.99) for e4/e4 female carriers. The e2/e3 genotype increases the chances of IADL Disability for males (OR = 2.33; CI 1.28‐4.25). No significant association between APOE polymorphism and mortality was found. A surprising observation was that e4/e4 female carriers have a 5.3 times lower chance of having ADL Disability than non-e4/e4-carriers. Conclusions: association of the APOE polymorphism with Disability and lack of association with mortality support the view that APOE gene actions may be more significant as modulators of frailty than of longevity.
Daan Kromhout - One of the best experts on this subject based on the ideXlab platform.
-
the contribution of self rated health and depressive symptoms to Disability Severity as a predictor of 10 year mortality in european elderly men
American Journal of Public Health, 2005Co-Authors: Carolien L Van Den Brink, Marja Tijhuis, Simona Giampaoli, Aulikki Nissinen, Daan KromhoutAbstract:Objectives. To investigate the effect of Disability Severity and the contribution of self-rated health and depressive symptoms to 10-year mortality. Methods. Longitudinal data were collected from 1141 men aged 70 to 89 years from the Finland, Italy, and the Netherlands Elderly Study from 1990 to 2000. Disability Severity was classified into 4 categories: no Disability, instrumental activities, mobility, and basic activities of daily living. Self-rated health and depressive symptoms were classified into 2 and 3 categories, respectively. Multivariate Cox proportional hazard models were used to calculate mortality risks. Results. Men with severe Disability had a risk of mortality that was more than 2-fold higher (hazard ratio [HR] = 2.41; 95% confidence interval [CI] = 1.84, 3.16) than that of men without Disability. Men who had severe Disability and did not feel healthy had the highest mortality risk (HR = 3.30; 95% CI = 2.52, 4.33). This risk was lower at lower levels of Disability and higher levels of self-rated health. The same trend was observed for depressive symptoms. Conclusions. For adequate prognoses on mortality or for developing intervention strategies, not only physical aspects of health but also other health outcomes should be taken into account.
-
Duration and intensity of physical activity and Disability among European elderly men
Disability and Rehabilitation, 2005Co-Authors: Carolien L Van Den Brink, Simona Giampaoli, Aulikki Nissinen, Hsusanj Picavet, Daan KromhoutAbstract:Purpose. To investigate the relationship between duration and intensity of physical activity and Disability 10 years later, and to investigate the possible effect of selective mortality.Method. Longitudinal data of 560 men aged 70 – 89 years, without Disability at baseline from the Finland, Italy and The Netherlands Elderly (FINE) Study was used. Physical activity in 1990 was based on activities like walking, bicycling and gardening. Disability Severity (three categories) in 1990 and 2000 was based on instrumental activities, mobility and basic activities of daily living.Results. Men in the highest tertile of total physical activity had a lower risk of Disability than men in the lowest tertile (odds ratio (OR) 0.46; 95% confidence interval (CI): 0.26 – 0.84). This was due to duration of physical activity (OR highest tertile 0.42; 95% CI: 0.23 – 0.78 compared to the lowest tertile). Intensity of physical activity was not associated with Disability. Addition of deceased men as fourth category leaded to weak...