The Experts below are selected from a list of 756 Experts worldwide ranked by ideXlab platform
Yiqi Yang - One of the best experts on this subject based on the ideXlab platform.
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Correction: Potent and regularizable crosslinking of ultrafine fibrous protein scaffolds for tissue engineering using a cytocompatible Disaccharide Derivative.
Journal of materials chemistry. B, 2020Co-Authors: Peng Liu, Yiqi YangAbstract:Correction for 'Potent and regularizable crosslinking of ultrafine fibrous protein scaffolds for tissue engineering using a cytocompatible Disaccharide Derivative' by Helan Xu et al., J. Mater. Chem. B, 2015, 3, 3609-3616, DOI: 10.1039/C4TB02100B.
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robust and flexible films from 100 starch cross linked by biobased Disaccharide Derivative
ACS Sustainable Chemistry & Engineering, 2015Co-Authors: Hazal Canisag, Yiqi YangAbstract:In this research, oxidized sucrose, a novel aldehyde-based green cross-linker, endowed starch films with substantial improvement in both tensile strength and elongation, whereas many other cross-linkers did not. Starch films are usually weak, brittle, and highly moisture sensitive, and thus have restricted industrial applications. Cross-linking is one of the most common methods to tackle these problems. However, most of the available cross-linkers are either toxic, expensive, or with low cross-linking efficiencies. Oxidized sucrose is a green cross-linker with multiple aldehyde groups per molecule to cross-link starch molecules via forming hemiacetals/acetals. The starch films cross-linked with oxidized sucrose had tensile strength and breaking elongation of 23 MPa and 60%, respectively, exceeding the cross-linking results of many other cross-linkers. Oxidized sucrose cross-linking also substantially increased the stability of starch films in both water and formic acid. With activation energy as low as 33...
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Robust and Flexible Films from 100% Starch Cross-Linked by Biobased Disaccharide Derivative
ACS Sustainable Chemistry & Engineering, 2015Co-Authors: Hazal Canisag, Yiqi YangAbstract:In this research, oxidized sucrose, a novel aldehyde-based green cross-linker, endowed starch films with substantial improvement in both tensile strength and elongation, whereas many other cross-linkers did not. Starch films are usually weak, brittle, and highly moisture sensitive, and thus have restricted industrial applications. Cross-linking is one of the most common methods to tackle these problems. However, most of the available cross-linkers are either toxic, expensive, or with low cross-linking efficiencies. Oxidized sucrose is a green cross-linker with multiple aldehyde groups per molecule to cross-link starch molecules via forming hemiacetals/acetals. The starch films cross-linked with oxidized sucrose had tensile strength and breaking elongation of 23 MPa and 60%, respectively, exceeding the cross-linking results of many other cross-linkers. Oxidized sucrose cross-linking also substantially increased the stability of starch films in both water and formic acid. With activation energy as low as 33...
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potent and regularizable crosslinking of ultrafine fibrous protein scaffolds for tissue engineering using a cytocompatible Disaccharide Derivative
Journal of Materials Chemistry B, 2015Co-Authors: Peng Liu, Yiqi YangAbstract:Sucrose, a naturally-occurring Disaccharide, could be oxidized to polar polyaldehydes to improve the performance properties of tissue engineering scaffolds composed of three-dimensionally arranged ultrafine protein fibers in a controllable manner. With significantly better water stability, an in vitro study demonstrated that the biocompatibility of the oxidized sucrose crosslinked scaffolds was similar to the citric acid crosslinked ones. Due to their structural similarity to the major component in native extracellular matrices (ECMs), proteins had advantages over other macromolecules for development of tissue engineering scaffolds. We have successfully developed three-dimensional (3D) ultrafine fibrous structures from proteins that could mimic the authentic 3D architectures of native ECMs. However, the enlarged contacting area exposed to water worsened the poor water stability of proteins, and thus necessitated potent and non-toxic crosslinking. Citric acid, a biobased crosslinker, was widely recognized as safe and showed good crosslinking efficiency among non-toxic crosslinkers for proteins, though was still less potent than aldehydes. In this research, sucrose was oxidized to non-volatile polyaldehydes with high polarity and low toxicity. Compared to those crosslinked with citric acid, the 3D ultrafine fibrous zein scaffolds crosslinked with oxidized sucrose showed significantly better water stability and similar cytocompatibility via an in vitro study with preosteoblasts. In summary, oxidized sucrose could be a safe and potent crosslinker to improve water stability of macromolecule-based materials for medical and industrial applications.
Peng Liu - One of the best experts on this subject based on the ideXlab platform.
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Correction: Potent and regularizable crosslinking of ultrafine fibrous protein scaffolds for tissue engineering using a cytocompatible Disaccharide Derivative.
Journal of materials chemistry. B, 2020Co-Authors: Peng Liu, Yiqi YangAbstract:Correction for 'Potent and regularizable crosslinking of ultrafine fibrous protein scaffolds for tissue engineering using a cytocompatible Disaccharide Derivative' by Helan Xu et al., J. Mater. Chem. B, 2015, 3, 3609-3616, DOI: 10.1039/C4TB02100B.
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potent and regularizable crosslinking of ultrafine fibrous protein scaffolds for tissue engineering using a cytocompatible Disaccharide Derivative
Journal of Materials Chemistry B, 2015Co-Authors: Peng Liu, Yiqi YangAbstract:Sucrose, a naturally-occurring Disaccharide, could be oxidized to polar polyaldehydes to improve the performance properties of tissue engineering scaffolds composed of three-dimensionally arranged ultrafine protein fibers in a controllable manner. With significantly better water stability, an in vitro study demonstrated that the biocompatibility of the oxidized sucrose crosslinked scaffolds was similar to the citric acid crosslinked ones. Due to their structural similarity to the major component in native extracellular matrices (ECMs), proteins had advantages over other macromolecules for development of tissue engineering scaffolds. We have successfully developed three-dimensional (3D) ultrafine fibrous structures from proteins that could mimic the authentic 3D architectures of native ECMs. However, the enlarged contacting area exposed to water worsened the poor water stability of proteins, and thus necessitated potent and non-toxic crosslinking. Citric acid, a biobased crosslinker, was widely recognized as safe and showed good crosslinking efficiency among non-toxic crosslinkers for proteins, though was still less potent than aldehydes. In this research, sucrose was oxidized to non-volatile polyaldehydes with high polarity and low toxicity. Compared to those crosslinked with citric acid, the 3D ultrafine fibrous zein scaffolds crosslinked with oxidized sucrose showed significantly better water stability and similar cytocompatibility via an in vitro study with preosteoblasts. In summary, oxidized sucrose could be a safe and potent crosslinker to improve water stability of macromolecule-based materials for medical and industrial applications.
Sabu Thomas - One of the best experts on this subject based on the ideXlab platform.
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Thermal, biodegradation and theoretical perspectives on nanoscale confinement in starch/cellulose nanocomposite modified via green crosslinker
International Journal of Biological Macromolecules, 2019Co-Authors: Preetha Balakrishnan, V.g. Geethamma, Sreerag Gopi, Martin George Thomas, Matjaž Kunaver, Miroslav Huskić, Nandakumar Kalarikkal, Tatiana Volova, Didier Rouxel, Sabu ThomasAbstract:In this research work, we propose a synergistic effect of a green crosslinker and cellulose nanomaterial on the crystallinity, viscoelastic, and thermal properties of starch nanocomposites. A Disaccharide Derivative was used as a bio crosslinker and nanofiber from pineapple leaf as a reinforcing phase for starch. Sucrose was oxidised using periodate, that can selectively oxidise the vicinal hydroxyl group of sucrose and form tetra aldehyde Derivative. Crystallinity of films after crosslinking decreased with successive addition of crosslinker. The melting temperature of films increased because of formation of more dense structure after crosslinking. Morphological investigations were analysed by atomic force microscopy. Polymer chain confinement and mechanics were quantified. The crosslink densities of the films were calculated using two models, phantom model and affine model, using storage modulus data. By using very low amount of crosslinker and nanoreinforcement, the properties of thermoplastic starch were significantly improved.
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thermal biodegradation and theoretical perspectives on nanoscale confinement in starch cellulose nanocomposite modified via green crosslinker
International Journal of Biological Macromolecules, 2019Co-Authors: Preetha Balakrishnan, V.g. Geethamma, Sreerag Gopi, Martin George Thomas, Matjaž Kunaver, Nandakumar Kalarikkal, Tatiana Volova, Didier Rouxel, Miroslav Huskic, Sabu ThomasAbstract:In this research work, we propose a synergistic effect of a green crosslinker and cellulose nanomaterial on the crystallinity, viscoelastic, and thermal properties of starch nanocomposites. A Disaccharide Derivative was used as a bio crosslinker and nanofiber from pineapple leaf as a reinforcing phase for starch. Sucrose was oxidised using periodate, that can selectively oxidise the vicinal hydroxyl group of sucrose and form tetra aldehyde Derivative. Crystallinity of films after crosslinking decreased with successive addition of crosslinker. The melting temperature of films increased because of formation of more dense structure after crosslinking. Morphological investigations were analysed by atomic force microscopy. Polymer chain confinement and mechanics were quantified. The crosslink densities of the films were calculated using two models, phantom model and affine model, using storage modulus data. By using very low amount of crosslinker and nanoreinforcement, the properties of thermoplastic starch were significantly improved.
Michael A Caligiuri - One of the best experts on this subject based on the ideXlab platform.
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a synthetic Disaccharide Derivative of diphyllin taard activates human natural killer cells to secrete interferon gamma via toll like receptor mediated nf κb and stat3 signaling pathways
Frontiers in Immunology, 2018Co-Authors: Luxi Che, Xiaofeng Guo, Haixia Wang, Jianying Zhang, Douglas A Kingho, Xiaohua Huang, Lishu Wang, Michael A CaligiuriAbstract:Natural products and their Derivatives have long been used as pharmacological agents in the fight against cancer. Human natural killer (NK) cells are critical in our immune system in that they are capable of destroying tumor cells directly. However, there are few reports that elucidate the role of natural products in activating NK cells. In this study, we discovered that a synthetic Disaccharide Derivative of diphyllin, 4-O-{[2”,3”,4”-tri-O-acetyl-α-D-arabinopyranosyl-(1”→4’)]-2’,3’-di-O-acetyl-α-L-rhamnopyranosyl}diphyllin (TAARD), can alone stimulate interferon (IFN)- secretion in primary human NK cells and the NKL cell line. Additionally, it had an additive effect with IL-12 or IL-15 on IFN- production but little adverse effects on NK cells. Mechanistically, TAARD induced the phosphorylation of NF-B and STAT3, resulting in their binding on the IFNG promoter, which was dependent on TLR1 and TLR3 signaling, respectively. STAT3 and NF-B knockdown with lentivirus shRNA as well as the NF-B specific inhibitor, N-tosyl-L-phenylalaninechloromethyl ketone (TPCK), significantly suppressed TAARD-induced IFN- generation in primary NK cells. Blockade of TLR1 and TLR3 with neutralizing antibodies considerably decreased TAARD-induced activation of NF-B and STAT3, respectively, as well as IFN- generation in NK cells. Collectively, our data suggest that TAARD can induce NK cell IFN- production through TLR1-NF-B and TLR3-STAT3 signaling pathways, rendering its potential use as an agent for cancer prevention or treatment.
Preetha Balakrishnan - One of the best experts on this subject based on the ideXlab platform.
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Thermal, biodegradation and theoretical perspectives on nanoscale confinement in starch/cellulose nanocomposite modified via green crosslinker
International Journal of Biological Macromolecules, 2019Co-Authors: Preetha Balakrishnan, V.g. Geethamma, Sreerag Gopi, Martin George Thomas, Matjaž Kunaver, Miroslav Huskić, Nandakumar Kalarikkal, Tatiana Volova, Didier Rouxel, Sabu ThomasAbstract:In this research work, we propose a synergistic effect of a green crosslinker and cellulose nanomaterial on the crystallinity, viscoelastic, and thermal properties of starch nanocomposites. A Disaccharide Derivative was used as a bio crosslinker and nanofiber from pineapple leaf as a reinforcing phase for starch. Sucrose was oxidised using periodate, that can selectively oxidise the vicinal hydroxyl group of sucrose and form tetra aldehyde Derivative. Crystallinity of films after crosslinking decreased with successive addition of crosslinker. The melting temperature of films increased because of formation of more dense structure after crosslinking. Morphological investigations were analysed by atomic force microscopy. Polymer chain confinement and mechanics were quantified. The crosslink densities of the films were calculated using two models, phantom model and affine model, using storage modulus data. By using very low amount of crosslinker and nanoreinforcement, the properties of thermoplastic starch were significantly improved.
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thermal biodegradation and theoretical perspectives on nanoscale confinement in starch cellulose nanocomposite modified via green crosslinker
International Journal of Biological Macromolecules, 2019Co-Authors: Preetha Balakrishnan, V.g. Geethamma, Sreerag Gopi, Martin George Thomas, Matjaž Kunaver, Nandakumar Kalarikkal, Tatiana Volova, Didier Rouxel, Miroslav Huskic, Sabu ThomasAbstract:In this research work, we propose a synergistic effect of a green crosslinker and cellulose nanomaterial on the crystallinity, viscoelastic, and thermal properties of starch nanocomposites. A Disaccharide Derivative was used as a bio crosslinker and nanofiber from pineapple leaf as a reinforcing phase for starch. Sucrose was oxidised using periodate, that can selectively oxidise the vicinal hydroxyl group of sucrose and form tetra aldehyde Derivative. Crystallinity of films after crosslinking decreased with successive addition of crosslinker. The melting temperature of films increased because of formation of more dense structure after crosslinking. Morphological investigations were analysed by atomic force microscopy. Polymer chain confinement and mechanics were quantified. The crosslink densities of the films were calculated using two models, phantom model and affine model, using storage modulus data. By using very low amount of crosslinker and nanoreinforcement, the properties of thermoplastic starch were significantly improved.