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Gianni Tognoni - One of the best experts on this subject based on the ideXlab platform.
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the prognostic value of preDischarge quantitative two dimensional echocardiographic measurements and the effects of early lisinopril treatment on left ventricular structure and function after acute myocardial infarction in the gissi 3 trial
European Heart Journal, 1996Co-Authors: G L Nicolosi, Roberto Latini, Paolo Marino, A P Maggioni, Simona Barlera, M G Franzosi, Enrico Geraci, L Santoro, Luigi Tavazzi, Gianni TognoniAbstract:Background Left ventricular dilatation and a low ejection fraction after acute myocardial infarction are indepEndent indicators of a poor prognosis. ACE inhibitors have been shown to decrease left ventricular dilatation after myocardial infarction. In the GISSI-3 trial, patients were randomly assigned, within 24 h of onset of myocardial infarction symptoms, to 6 weeks of treatment with lisinopnl, nitroglycerin, both or neither, in an open, 2x2 factorial design. The study showed that early treatment in relatively unselected patients with lisinopril decreases mortality at 6 weeks and severe left ventricular dysfunction. We assessed (1) the prognostic value of pre-Discharge 2-D echocardiographic variables, and (2) the effects of lisinopril on the progression of left ventricular dilatation. Methods and results 2-D echocardiograms were available pre-Discharge in 8619 GISSI-3 trial patients Discharged alive. In 6405 of these patients, a 2-D echocardiographic study was also available at 6 weeks, and at 6 months. Pre-Discharge End-diastolic and End-systolic volumes, and ejection fraction predicted 6-month mortality and non-fatal clinical congestive heart failure (/" 27%. Patients with wall motion asynergy <27% showed no dilatation and lisinopril did not affect volumes at 6 months. Patients randomized to lisinopril also had smaller volumes after withdrawal of treatment at 6 weeks. Lisinopril did not affect left ventricular ejection fraction. Conclusions 2-D echocardiography indepEndently contributes to pre-Discharge risk stratification in terms of 6-month mortality and clinical heart failure after myocardial infarction, and early, short-term treatment with lisinopril in unselected myocardial infarction patients attenuates left ventricular dilatation; an effect evident in patients with larger infarcts. These results probably only partly explain the effect of lisinopril on total mortality concentrated in the first week after infarction. (Eur Heart J 1996; 17: 1646-1656)
G L Nicolosi - One of the best experts on this subject based on the ideXlab platform.
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the prognostic value of preDischarge quantitative two dimensional echocardiographic measurements and the effects of early lisinopril treatment on left ventricular structure and function after acute myocardial infarction in the gissi 3 trial
European Heart Journal, 1996Co-Authors: G L Nicolosi, Roberto Latini, Paolo Marino, A P Maggioni, Simona Barlera, M G Franzosi, Enrico Geraci, L Santoro, Luigi Tavazzi, Gianni TognoniAbstract:Background Left ventricular dilatation and a low ejection fraction after acute myocardial infarction are indepEndent indicators of a poor prognosis. ACE inhibitors have been shown to decrease left ventricular dilatation after myocardial infarction. In the GISSI-3 trial, patients were randomly assigned, within 24 h of onset of myocardial infarction symptoms, to 6 weeks of treatment with lisinopnl, nitroglycerin, both or neither, in an open, 2x2 factorial design. The study showed that early treatment in relatively unselected patients with lisinopril decreases mortality at 6 weeks and severe left ventricular dysfunction. We assessed (1) the prognostic value of pre-Discharge 2-D echocardiographic variables, and (2) the effects of lisinopril on the progression of left ventricular dilatation. Methods and results 2-D echocardiograms were available pre-Discharge in 8619 GISSI-3 trial patients Discharged alive. In 6405 of these patients, a 2-D echocardiographic study was also available at 6 weeks, and at 6 months. Pre-Discharge End-diastolic and End-systolic volumes, and ejection fraction predicted 6-month mortality and non-fatal clinical congestive heart failure (/" 27%. Patients with wall motion asynergy <27% showed no dilatation and lisinopril did not affect volumes at 6 months. Patients randomized to lisinopril also had smaller volumes after withdrawal of treatment at 6 weeks. Lisinopril did not affect left ventricular ejection fraction. Conclusions 2-D echocardiography indepEndently contributes to pre-Discharge risk stratification in terms of 6-month mortality and clinical heart failure after myocardial infarction, and early, short-term treatment with lisinopril in unselected myocardial infarction patients attenuates left ventricular dilatation; an effect evident in patients with larger infarcts. These results probably only partly explain the effect of lisinopril on total mortality concentrated in the first week after infarction. (Eur Heart J 1996; 17: 1646-1656)
Uwe Sprinz - One of the best experts on this subject based on the ideXlab platform.
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experimental investigation of solid bed depth at the Discharge End of rotary kilns
Powder Technology, 2010Co-Authors: Eckehard Specht, Yichun Shi, Herrmann Woche, Joern Knabbe, Uwe SprinzAbstract:Abstract The solid bed depth at the Discharge End of rotary kilns was experimentally investigated for different mass flow rates, rotational speeds, inclination angles and materials using two lab kilns with sizes of 0.4 m (ID) ⁎ 5 m (L) and 0.25 m (ID) ⁎ 6.7 m (L), respectively. The solid depth at the Discharge was found to be several more times higher than the particle diameter. All parameters according to Saeman's model were combined in a newly developed dimensionless ‘Bed depth number’ designated as ‘Bd’. The filling degree of a solid bed at the Discharge can be correlated with F0 = 1.75 ⁎ Bd0.5 (for an inclination angle between 1° and 4°). The range of the researched Bed depth number (Bd) is suitable for all industrial kilns. These values should be used as the initial condition, which was still unknown before, to solve the differential equation for the profile of the solid bed depth through the cylinder.
Jh Kingma - One of the best experts on this subject based on the ideXlab platform.
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association between reduced heart rate variability and left ventricular dilatation in patients with a first anterior myocardial infarction cats investigators captopril and thrombolysis study
Heart, 1994Co-Authors: Janhenk E Dambrink, Ype S Tuininga, W H Van Gilst, Kathinka H Peels, K I Lie, Jh KingmaAbstract:BACKGROUND--Reduced heart rate variability has been identified as an important prognostic factor after myocardial infarction. This factor is thought to reflect an imbalance between sympathetic and parasympathetic activity, which may lead to unfavourable loading conditions and thus promote left ventricular dilatation. PATIENTS AND METHODS--298 patients in a multicentre clinical trial were randomised to captopril or placebo after a first anterior myocardial infarction. All patients were treated with streptokinase before randomisation. In the present substudy full data including heart rate variability and echocardiographic measurements were available from 80 patients. Patients were divided into two groups: those with a reduced ( 25). Heart rate variability was evaluated by 24 h Holter monitoring before Discharge. Left ventricular volumes were assessed by echocardiography before Discharge and three and 12 months after myocardial infarction. Extent of myocardial injury, severity of coronary artery disease, functional class, haemodynamic variables, and medication were also considered as possible determinants of left ventricular dilatation. RESULTS--Before Discharge End systolic and End diastolic volumes were not different in the two groups. After 12 months in patients with a reduced heart rate variability, End systolic volume (mean (SD)) had increased by 6 (14) ml/m2 (P = 0.043) and End diastolic volume had increased by 8 (17) ml/m2 (P = 0.024). Left ventricular volumes were unchanged in patients with a normal heart rate variability. Also, patients with left ventricular dilatation had a larger enzymatic infarct size and higher heart rates and rate-pressure products. A reduced heart rate variability index before Discharge was an indepEndent risk factor for left ventricular dilatation during follow up. Measurement of heart rate variability after three months had no predictive value for this event. CONCLUSION--Assessment of the heart rate variability index before Discharge, but not at three months, gave important additional information for identifying patients at risk of left ventricular dilatation.
Paolo Marino - One of the best experts on this subject based on the ideXlab platform.
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the prognostic value of preDischarge quantitative two dimensional echocardiographic measurements and the effects of early lisinopril treatment on left ventricular structure and function after acute myocardial infarction in the gissi 3 trial
European Heart Journal, 1996Co-Authors: G L Nicolosi, Roberto Latini, Paolo Marino, A P Maggioni, Simona Barlera, M G Franzosi, Enrico Geraci, L Santoro, Luigi Tavazzi, Gianni TognoniAbstract:Background Left ventricular dilatation and a low ejection fraction after acute myocardial infarction are indepEndent indicators of a poor prognosis. ACE inhibitors have been shown to decrease left ventricular dilatation after myocardial infarction. In the GISSI-3 trial, patients were randomly assigned, within 24 h of onset of myocardial infarction symptoms, to 6 weeks of treatment with lisinopnl, nitroglycerin, both or neither, in an open, 2x2 factorial design. The study showed that early treatment in relatively unselected patients with lisinopril decreases mortality at 6 weeks and severe left ventricular dysfunction. We assessed (1) the prognostic value of pre-Discharge 2-D echocardiographic variables, and (2) the effects of lisinopril on the progression of left ventricular dilatation. Methods and results 2-D echocardiograms were available pre-Discharge in 8619 GISSI-3 trial patients Discharged alive. In 6405 of these patients, a 2-D echocardiographic study was also available at 6 weeks, and at 6 months. Pre-Discharge End-diastolic and End-systolic volumes, and ejection fraction predicted 6-month mortality and non-fatal clinical congestive heart failure (/" 27%. Patients with wall motion asynergy <27% showed no dilatation and lisinopril did not affect volumes at 6 months. Patients randomized to lisinopril also had smaller volumes after withdrawal of treatment at 6 weeks. Lisinopril did not affect left ventricular ejection fraction. Conclusions 2-D echocardiography indepEndently contributes to pre-Discharge risk stratification in terms of 6-month mortality and clinical heart failure after myocardial infarction, and early, short-term treatment with lisinopril in unselected myocardial infarction patients attenuates left ventricular dilatation; an effect evident in patients with larger infarcts. These results probably only partly explain the effect of lisinopril on total mortality concentrated in the first week after infarction. (Eur Heart J 1996; 17: 1646-1656)