The Experts below are selected from a list of 41814 Experts worldwide ranked by ideXlab platform
Nada Gawad - One of the best experts on this subject based on the ideXlab platform.
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harvesting the sead long term follow up of the surgical exploration and Discovery Program
Journal of Surgical Education, 2020Co-Authors: Linden K. Head, Brittany Greene, Nada Gawad, Stanley J. Hamstra, Tim BrandysAbstract:Objective The Surgical Exploration and Discovery (SEAD) Program was established to facilitate career decision-making by providing preclerkship students with comprehensive exposure to surgical specialties. Our short-term findings demonstrated that, compared to a control group, SEAD participants showed significantly greater career-related learning. The purpose of this study was to understand the long-term impact of the SEAD Program. Design This was a prospective cohort study. One group of students participated in a 2-week surgical curriculum (SEAD group) while another group read only the Program manual (Manual group). Students were surveyed following their residency selection 3 years later. The outcome measures were final specialty preference (medical or surgical), Program utility, and Program satisfaction. Setting Undergraduate Medical Education, Faculty of Medicine, at the University of Ottawa in Ottawa, Ontario, Canada. Participants A total of 18 medical students in the SEAD group, and 18 in the Manual group. Results Survey response rate was 100%. There was no significant difference in the number of students who pursued surgical careers in the SEAD and Manual groups. All students who pursued a surgical residency were ‘very interested’ in surgery prior to SEAD—initial interest in surgery had a significant influence on final residency preference. Ninety-four percent (n = 17) of SEAD participants described the SEAD Program as valuable to facilitating their career decision-making. Conclusions Although SEAD does not generate sustained new interest in surgical disciplines, graduating students believe the Program is valuable in facilitating career decision-making and perceive the Program as a worthwhile time investment. These findings were true for students who selected both surgical and medical specialties, suggesting that early, multifaceted, exposure to surgery is a valuable addition to career exploration even for students who ultimately don't pursue surgical specialties. Going forward, integrating a longitudinal mentorship Program may further improve the value of SEAD.
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branches from the sead sustained and feasible expansion of the surgical exploration and Discovery Program
Journal of Surgical Research, 2019Co-Authors: Nada Gawad, Linden K. Head, Connor Mcguire, Antonio Gangemi, Katie Garland, Kimia Sorouri, Alexander Lachapelle, James T RutkaAbstract:Abstract Problem A predicted shortage of surgeons and attrition among surgical residents has highlighted the need to attract well-suited medical students to surgical specialties. Literature suggests that early exposure may increase interest by addressing misconceptions and allowing students more time to make an informed career decision. Approach The Surgical Exploration and Discovery (SEAD) Program was created in 2012 with the goal of providing medical students with comprehensive and multifaceted exposure to surgical specialties to develop their knowledge and skills, and in turn positively influence their interest in pursuing a surgical career. The purpose of this innovation report is to describe the challenges, successes, and evolution of the SEAD Program. Outcomes Since its inception, SEAD has expanded to include 5 North American institutions and has educated nearly 400 participants in 5 y. Through a replication strategy, SEAD has maintained its basic curriculum, while accommodating the constraints and innovative approaches unique to each institution. Short-term results have demonstrated improved knowledge of curricular objectives, student perception of significant value of the Program, and the generation of interest in a career in surgery. Conclusions Future directions include the evaluation of long-term impact on pursuing a career in surgery and continuing further expansion using the current replication model, while maintaining a high-quality surgical education Program.
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Growing the 'SEAD': Expansion of the Surgical Exploration and Discovery Program
Journal of Surgical Education, 2016Co-Authors: Linden K. Head, Brittany Greene, Nada Gawad, Christine Seabrook, Kim Tardioli, Stanley J. Hamstra, Tim BrandysAbstract:Background The declining popularity of surgical specialties among North American medical students has been attributed partially to limited early exposure and minimal involvement of surgeons in preclerkship education; in response, the Surgical Exploration and Discovery (SEAD) Program was developed at the University of Toronto in 2012. SEAD is a 2-week curriculum that provides first-year medical students comprehensive exposure to surgical specialties through operating room observerships, simulation workshops, and career discussions. This study is the first to examine implementation of the SEAD Program at another site. Methods This prospective cohort study evaluated the effectiveness of the SEAD Program in improving surgical knowledge and facilitating career decision making when compared with a control group. In all, 18 students participated in the SEAD Program, and 18 students from the same class read only the Program's instructional manual; both the groups completed multiple-choice tests and questionnaires at baseline and at completion to assess knowledge acquisition and career-related learning. Results Both the groups significantly improved their surgical knowledge, but there was no difference between groups. SEAD participants made significantly greater progress in refining their career decisions when compared with the control group; all but one SEAD participant either gained interest in or ruled out a surgical specialty as a potential career choice compared with only 10 of the participants reading the manual only. Conclusions The SEAD Program provides a meaningful opportunity for medical students to explore surgical careers during preclerkship and to make better-informed career decisions. This expansion demonstrates that the Program can be successfully reproduced at another institution.
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surgical exploration and Discovery Program inaugural involvement of otolaryngology head and neck surgery
Journal of Otolaryngology-head & Neck Surgery, 2015Co-Authors: Brittany Greene, Linden K. Head, Nada Gawad, Stanley J. Hamstra, Laurie McleanAbstract:Background There is significant variability in undergraduate Otolaryngology – Head and Neck Surgery (OTOHNS) curricula across Canadian medical schools. As part of an extracurricular Program delivered jointly with other surgical specialties, the Surgical Exploration and Discovery (SEAD) Program presents an opportunity for medical students to experience OTOHNS. The purpose of this study is to review the participation and outcome of OTOHNS in the SEAD Program.
Linden K. Head - One of the best experts on this subject based on the ideXlab platform.
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harvesting the sead long term follow up of the surgical exploration and Discovery Program
Journal of Surgical Education, 2020Co-Authors: Linden K. Head, Brittany Greene, Nada Gawad, Stanley J. Hamstra, Tim BrandysAbstract:Objective The Surgical Exploration and Discovery (SEAD) Program was established to facilitate career decision-making by providing preclerkship students with comprehensive exposure to surgical specialties. Our short-term findings demonstrated that, compared to a control group, SEAD participants showed significantly greater career-related learning. The purpose of this study was to understand the long-term impact of the SEAD Program. Design This was a prospective cohort study. One group of students participated in a 2-week surgical curriculum (SEAD group) while another group read only the Program manual (Manual group). Students were surveyed following their residency selection 3 years later. The outcome measures were final specialty preference (medical or surgical), Program utility, and Program satisfaction. Setting Undergraduate Medical Education, Faculty of Medicine, at the University of Ottawa in Ottawa, Ontario, Canada. Participants A total of 18 medical students in the SEAD group, and 18 in the Manual group. Results Survey response rate was 100%. There was no significant difference in the number of students who pursued surgical careers in the SEAD and Manual groups. All students who pursued a surgical residency were ‘very interested’ in surgery prior to SEAD—initial interest in surgery had a significant influence on final residency preference. Ninety-four percent (n = 17) of SEAD participants described the SEAD Program as valuable to facilitating their career decision-making. Conclusions Although SEAD does not generate sustained new interest in surgical disciplines, graduating students believe the Program is valuable in facilitating career decision-making and perceive the Program as a worthwhile time investment. These findings were true for students who selected both surgical and medical specialties, suggesting that early, multifaceted, exposure to surgery is a valuable addition to career exploration even for students who ultimately don't pursue surgical specialties. Going forward, integrating a longitudinal mentorship Program may further improve the value of SEAD.
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branches from the sead sustained and feasible expansion of the surgical exploration and Discovery Program
Journal of Surgical Research, 2019Co-Authors: Nada Gawad, Linden K. Head, Connor Mcguire, Antonio Gangemi, Katie Garland, Kimia Sorouri, Alexander Lachapelle, James T RutkaAbstract:Abstract Problem A predicted shortage of surgeons and attrition among surgical residents has highlighted the need to attract well-suited medical students to surgical specialties. Literature suggests that early exposure may increase interest by addressing misconceptions and allowing students more time to make an informed career decision. Approach The Surgical Exploration and Discovery (SEAD) Program was created in 2012 with the goal of providing medical students with comprehensive and multifaceted exposure to surgical specialties to develop their knowledge and skills, and in turn positively influence their interest in pursuing a surgical career. The purpose of this innovation report is to describe the challenges, successes, and evolution of the SEAD Program. Outcomes Since its inception, SEAD has expanded to include 5 North American institutions and has educated nearly 400 participants in 5 y. Through a replication strategy, SEAD has maintained its basic curriculum, while accommodating the constraints and innovative approaches unique to each institution. Short-term results have demonstrated improved knowledge of curricular objectives, student perception of significant value of the Program, and the generation of interest in a career in surgery. Conclusions Future directions include the evaluation of long-term impact on pursuing a career in surgery and continuing further expansion using the current replication model, while maintaining a high-quality surgical education Program.
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Growing the 'SEAD': Expansion of the Surgical Exploration and Discovery Program
Journal of Surgical Education, 2016Co-Authors: Linden K. Head, Brittany Greene, Nada Gawad, Christine Seabrook, Kim Tardioli, Stanley J. Hamstra, Tim BrandysAbstract:Background The declining popularity of surgical specialties among North American medical students has been attributed partially to limited early exposure and minimal involvement of surgeons in preclerkship education; in response, the Surgical Exploration and Discovery (SEAD) Program was developed at the University of Toronto in 2012. SEAD is a 2-week curriculum that provides first-year medical students comprehensive exposure to surgical specialties through operating room observerships, simulation workshops, and career discussions. This study is the first to examine implementation of the SEAD Program at another site. Methods This prospective cohort study evaluated the effectiveness of the SEAD Program in improving surgical knowledge and facilitating career decision making when compared with a control group. In all, 18 students participated in the SEAD Program, and 18 students from the same class read only the Program's instructional manual; both the groups completed multiple-choice tests and questionnaires at baseline and at completion to assess knowledge acquisition and career-related learning. Results Both the groups significantly improved their surgical knowledge, but there was no difference between groups. SEAD participants made significantly greater progress in refining their career decisions when compared with the control group; all but one SEAD participant either gained interest in or ruled out a surgical specialty as a potential career choice compared with only 10 of the participants reading the manual only. Conclusions The SEAD Program provides a meaningful opportunity for medical students to explore surgical careers during preclerkship and to make better-informed career decisions. This expansion demonstrates that the Program can be successfully reproduced at another institution.
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surgical exploration and Discovery Program inaugural involvement of otolaryngology head and neck surgery
Journal of Otolaryngology-head & Neck Surgery, 2015Co-Authors: Brittany Greene, Linden K. Head, Nada Gawad, Stanley J. Hamstra, Laurie McleanAbstract:Background There is significant variability in undergraduate Otolaryngology – Head and Neck Surgery (OTOHNS) curricula across Canadian medical schools. As part of an extracurricular Program delivered jointly with other surgical specialties, the Surgical Exploration and Discovery (SEAD) Program presents an opportunity for medical students to experience OTOHNS. The purpose of this study is to review the participation and outcome of OTOHNS in the SEAD Program.
James T Rutka - One of the best experts on this subject based on the ideXlab platform.
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branches from the sead sustained and feasible expansion of the surgical exploration and Discovery Program
Journal of Surgical Research, 2019Co-Authors: Nada Gawad, Linden K. Head, Connor Mcguire, Antonio Gangemi, Katie Garland, Kimia Sorouri, Alexander Lachapelle, James T RutkaAbstract:Abstract Problem A predicted shortage of surgeons and attrition among surgical residents has highlighted the need to attract well-suited medical students to surgical specialties. Literature suggests that early exposure may increase interest by addressing misconceptions and allowing students more time to make an informed career decision. Approach The Surgical Exploration and Discovery (SEAD) Program was created in 2012 with the goal of providing medical students with comprehensive and multifaceted exposure to surgical specialties to develop their knowledge and skills, and in turn positively influence their interest in pursuing a surgical career. The purpose of this innovation report is to describe the challenges, successes, and evolution of the SEAD Program. Outcomes Since its inception, SEAD has expanded to include 5 North American institutions and has educated nearly 400 participants in 5 y. Through a replication strategy, SEAD has maintained its basic curriculum, while accommodating the constraints and innovative approaches unique to each institution. Short-term results have demonstrated improved knowledge of curricular objectives, student perception of significant value of the Program, and the generation of interest in a career in surgery. Conclusions Future directions include the evaluation of long-term impact on pursuing a career in surgery and continuing further expansion using the current replication model, while maintaining a high-quality surgical education Program.
Carlotta Ferrando - One of the best experts on this subject based on the ideXlab platform.
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international ocean Discovery Program expedition 360 preliminary report southwest indian ridge lower crust and moho the nature of the lower crust and moho at slower spreading ridges slomo leg 1
Integrated Ocean Drilling Program: Preliminary Reports, 2016Co-Authors: Henry J. B. Dick, Christopher J. Macleod, Donna K. Blackman, Julie Bowles, Michael J. Cheadle, Jakub Ciązela, P Blum, Jeremy R Deans, Virginia P Edgcomb, Carlotta FerrandoAbstract:International Ocean Discovery Program (IODP) Expedition 360 was the first leg of Phase I of the SloMo (shorthand for "The nature of the lower crust and Moho at slower spreading ridges") Project, a multiphase drilling Program that proposes to drill through the outermost of the global seismic velocity discontinuities, the Mohorovicic seismic discontinuity (Moho). The Moho corresponds to a compressional wave velocity increase, typically at ∼7 km beneath the oceans, and has generally been regarded as the boundary between crust and mantle. An alternative model, that the Moho is a hydration front in the mantle, has recently gained credence upon the Discovery of abundant partially serpentinized peridotite on the seafloor and on the walls of fracture zones, such as at Atlantis Bank, an 11-13 My old elevated oceanic core complex massif adjacent to the Atlantis II Transform on the Southwest Indian Ridge. Hole U1473A was drilled on the summit of Atlantis Bank during IODP Expedition 360, 1-2 km away from two previous Ocean Drilling Program (ODP) holes: Hole 735B (drilled during ODP Leg 118 in 1987 and ODP Leg 176 in 1997) and Hole 1105A (drilled during ODP Leg 179 in 1998). A mantle peridotite/gabbro contact has been traced by dredging and diving along the transform wall for 40 km. The contact is located at ∼4200 m depth at the drill sites but shoals considerably 20 km to the south, where it was observed in outcrop at 2563 m depth. Moho reflections have, however, been found at ∼5-6 km beneath Atlantis Bank and <4 km beneath the transform wall, leading to the suggestion that the seismic discontinuity may not represent the crust/mantle boundary but rather an alteration (serpentinization) front. This then raises the interesting possibility that a whole new planetary biosphere may thrive due to methanogenesis associated with serpentinization. The SloMo Project seeks to test these two hypotheses at Atlantis Bank and evaluate carbon sequestration in the lower crust and uppermost mantle. A primary objective of SloMo Leg 1 was to explore the lateral variability of the stratigraphy established in Hole 735B. Comparison of Hole U1473A with Holes 735B and 1105A allows us to demonstrate a continuity of process and complex interplay of magmatic accretion and steady-state detachment faulting over a time period of ∼128 ky. Preliminary assessment indicates that these sections of lower crust are constructed by repeated cycles of intrusion, represented in Hole U1473A by approximately three upwardly differentiated hundreds of meter-scale bodies of olivine gabbro broadly similar to those encountered in the deeper parts of Hole 735B. Specific aims of Expedition 360 focused on gaining an understanding of how magmatism and tectonism interact in accommodating seafloor spreading, how magnetic reversal boundaries are expressed in the lower crust, assessing the role of the lower crust and shallow mantle in the global carbon cycle, and constraining the extent and nature of life at deep levels within the ocean lithosphere.
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International Ocean Discovery Program Expedition 360 Scientific Prospectus Southwest Indian Ridge Lower Crust and Moho The nature of the lower crust and Moho at slower spreading ridges (SloMo-Leg 1)
2015Co-Authors: Henry Dick, Peter Blum, Christopher Macleod, Benoit Ildefonse, Carlotta FerrandoAbstract:International Ocean Discovery Program (IODP) Expedition 360 will form the first leg of a multiphase drilling project that aims to drill through the crust/mantle boundary at the ultraslow-spreading Southwest Indian Ridge and investigate the nature of the Mohorovičić seismic discontinuity (Moho). Expedition 360 is expected to drill ~1300 m into lower crustal gabbro and is unlikely to penetrate the crust–mantle transition or recover a significant amount of peridotite. Drilling will be sited at Atlantis Bank, on an elevated wave-cut platform on the east flank of the Atlantis II Transform. Previous drilling and mapping shows that Atlantis Bank is a large oceanic core complex, exposing a tectonic window of deep crustal and lithospheric mantle exhumed on the footwall of an oceanic detachment fault. The shallowest part of Atlantis Bank, at 700 m water depth, consists of a ~25 km2 wave-cut platform rimmed by a thin bioclastic limestone cap. The platform is part of a continuous gabbro massif ~40 km long by 30 km wide, overlying granular mantle peridotite that forms the lower slopes of the eastern wall of the Atlantis II Transform. Mapping shows that basement on the wave-cut platform consists largely of shallow-dipping amphibolitized gabbro mylonite generated by detachment faulting. This fault rooted near-continuously into partially crystalline gabbro for >4 million years. The mylonite exposed on the platform, and by cross-faulting and landslips on the sides of Atlantis Bank, both cut and are cut by steeply north dipping greenschist-facies diabase dikes. Thus, the gabbro crystallized at depth was uplifted into the zone of diking at the ridge axis, creating, in effect, the equivalent to the base of a dike–gabbro transition seen in many ophiolites. Previous Ocean Drilling Program (ODP) operations at Atlantis Bank drilled the 1508 m deep Hole 735B and 150 m deep Hole 1105A, both recovering long sections of gabbro. During Expedition 360, we propose to drill to a nominal depth of 1.3 km at a site on the northern edge of the Atlantis Bank platform, ~1 km north-northeast of Hole 1105A and ~2 km northeast of Hole 735B. A future drilling expedition, SloMo-Leg 2, aims to deepen the hole to ~3 km, with the overall goal of penetrating the crust–mantle transition, which is believed to be ~2.5 km above the seismically determined Moho. Specific objectives of Expedition 360 include establishing the lateral continuity of the igneous, metamorphic, and structural stratigraphies previously drilled to the southwest, testing the nature of a magnetic polarity transition, and investigating the biogeochemistry of the lower crust.
Ronald J Quinn - One of the best experts on this subject based on the ideXlab platform.
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antimalarial benzylisoquinoline alkaloid from the rainforest tree doryphora sassafras
Journal of Natural Products, 2009Co-Authors: Malcolm Stewart Buchanan, Vicky M Avery, Sandra Duffy, Rohan Andrew Davis, Ronald J QuinnAbstract:Mass-directed isolation of the CH2Cl2/MeOH extract of Doryphora sassafras resulted in the purification of a new benzylisoquinoline alkaloid, 1-(4-hydroxybenzyl)-6,7-methylenedioxy-2-methylisoquinolinium trifluoroacetate (1), and the known aporphine alkaloid (S)-isocorydine (2). The structures of 1 and 2 were determined by 1D and 2D NMR and MS data analyses. The compounds were isolated during a drug Discovery Program aimed at identifying new antimalarial leads from a prefractionated natural product library. When tested against two different strains of the parasite Plasmodium falciparum (3D7 and Dd2), 1 displayed IC50 values of 3.0 and 4.4 μM, respectively. Compound 1 was tested for cytotoxicity toward a human embryonic kidney cell line (HEK293) and displayed no activity at 120 μM.