The Experts below are selected from a list of 24078 Experts worldwide ranked by ideXlab platform
Ecosse L. Lamoureux - One of the best experts on this subject based on the ideXlab platform.
-
a vision bolt on item could increase the Discriminatory Power of the eq 5d index score
Value in Health, 2015Co-Authors: Nan Luo, X. Wang, Marcus Ang, Eric A. Finkelstein, Tin Aung, Tien Yin Wong, Ecosse L. LamoureuxAbstract:Abstract Background Recently, a vision “bolt-on” EuroQol five-dimensional questionnaire (EQ-5D) was developed and tentative utility values (i.e., a “value set”) for this new descriptive system were estimated. Objectives To compare the Discriminatory Power of this bolt-on and standard utility-based EQ-5D health indices. Methods Cross-sectional data on the (3-level) vision bolt-on EQ-5D were collected through face-to-face interviews with 500 and 336 individuals with and without visual impairment, respectively. To assess the Discriminatory Power of the vision bolt-on index relative to the standard EQ-5D index developed in the vision bolt-on valuation study, 16 pairs of mutually exclusive subgroups of individuals defined by the individuals’ visual acuity and responses to the 14-item visual function questionnaire were compared pairwise. The absolute mean difference in the two index scores and the corresponding F statistic derived from the comparisons were used as measures of Discriminatory Power. Results The absolute mean difference in the bolt-on index score was larger than that in the standard EQ-5D index score in 14 of the 16 comparisons. The bolt-on index score exhibited a larger F-statistic value than did the standard EQ-5D index score in all known-group comparisons, with the F-statistic ratio ranging from 0.415 to 0.770. Conclusions The vision bolt-on EQ-5D appears to be more discriminative than the standard EQ-5D in measurement of vision problems. Future studies should investigate the extent to which the vision bolt-on item can increase the sensitivity of the EQ-5D to vision change in interventional studies.
-
A Vision “Bolt-On” Item Could Increase the Discriminatory Power of the EQ-5D Index Score
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 2015Co-Authors: Nan Luo, X. Wang, Marcus Ang, Eric A. Finkelstein, Tin Aung, Tien Yin Wong, Ecosse L. LamoureuxAbstract:Abstract Background Recently, a vision “bolt-on” EuroQol five-dimensional questionnaire (EQ-5D) was developed and tentative utility values (i.e., a “value set”) for this new descriptive system were estimated. Objectives To compare the Discriminatory Power of this bolt-on and standard utility-based EQ-5D health indices. Methods Cross-sectional data on the (3-level) vision bolt-on EQ-5D were collected through face-to-face interviews with 500 and 336 individuals with and without visual impairment, respectively. To assess the Discriminatory Power of the vision bolt-on index relative to the standard EQ-5D index developed in the vision bolt-on valuation study, 16 pairs of mutually exclusive subgroups of individuals defined by the individuals’ visual acuity and responses to the 14-item visual function questionnaire were compared pairwise. The absolute mean difference in the two index scores and the corresponding F statistic derived from the comparisons were used as measures of Discriminatory Power. Results The absolute mean difference in the bolt-on index score was larger than that in the standard EQ-5D index score in 14 of the 16 comparisons. The bolt-on index score exhibited a larger F-statistic value than did the standard EQ-5D index score in all known-group comparisons, with the F-statistic ratio ranging from 0.415 to 0.770. Conclusions The vision bolt-on EQ-5D appears to be more discriminative than the standard EQ-5D in measurement of vision problems. Future studies should investigate the extent to which the vision bolt-on item can increase the sensitivity of the EQ-5D to vision change in interventional studies.
Jakob Zinsstag - One of the best experts on this subject based on the ideXlab platform.
-
Evaluation of the Discriminatory Power of variable number tandem repeat (VNTR) typing of Mycobacterium bovis strains.
Veterinary microbiology, 2005Co-Authors: Markus Hilty, Colette Diguimbaye, Esther Schelling, Franca Baggi, Marcel Tanner, Jakob ZinsstagAbstract:The Discriminatory Power of variable number tandem repeat (VNTR) typing based on 16 known loci (12 MIRUs, 3 ETRs and VNTR 3232) was assessed for Mycobacterium bovis strains collected sequentially at the slaughterhouse of N'Djaména, Chad. Of 67 M. bovis strains analyzed, 67% were clustered. In this study, VNTR typing was highly discriminative with an overall allelic diversity (h(oa)) of 0.922. We defined five loci (ETR A, B, C and MIRU 26, 27) as highly (h>0.25), two loci (MIRU 4, and VNTR 3232) as moderately (0.11
-
Evaluation of the Discriminatory Power of variable number tandem repeat (VNTR) typing of Mycobacterium bovis strains.
Veterinary Microbiology, 2005Co-Authors: Markus Hilty, Colette Diguimbaye, Esther Schelling, Franca Baggi, Marcel Tanner, Jakob ZinsstagAbstract:Abstract The Discriminatory Power of variable number tandem repeat (VNTR) typing based on 16 known loci (12 MIRUs, 3 ETRs and VNTR 3232) was assessed for Mycobacterium bovis strains collected sequentially at the slaughterhouse of N’Djamena, Chad. Of 67 M. bovis strains analyzed, 67% were clustered. In this study, VNTR typing was highly discriminative with an overall allelic diversity ( h oa ) of 0.922. We defined five loci (ETR A, B, C and MIRU 26, 27) as highly ( h > 0.25), two loci (MIRU 4, and VNTR 3232) as moderately (0.11 h h h = 0.917) proved to be most appropriate for first line typing of M. bovis strains of Chad and superior than spoligotyping ( h sp = 0.789). In contrast to Mycobacterium tuberculosis strains, a consensus on VNTR loci needs to be found for M. bovis strains. The selection of a generally agreed set of VNTR loci for molecular discrimination of M. bovis in different geographical settings is discussed.
Nan Luo - One of the best experts on this subject based on the ideXlab platform.
-
a vision bolt on item could increase the Discriminatory Power of the eq 5d index score
Value in Health, 2015Co-Authors: Nan Luo, X. Wang, Marcus Ang, Eric A. Finkelstein, Tin Aung, Tien Yin Wong, Ecosse L. LamoureuxAbstract:Abstract Background Recently, a vision “bolt-on” EuroQol five-dimensional questionnaire (EQ-5D) was developed and tentative utility values (i.e., a “value set”) for this new descriptive system were estimated. Objectives To compare the Discriminatory Power of this bolt-on and standard utility-based EQ-5D health indices. Methods Cross-sectional data on the (3-level) vision bolt-on EQ-5D were collected through face-to-face interviews with 500 and 336 individuals with and without visual impairment, respectively. To assess the Discriminatory Power of the vision bolt-on index relative to the standard EQ-5D index developed in the vision bolt-on valuation study, 16 pairs of mutually exclusive subgroups of individuals defined by the individuals’ visual acuity and responses to the 14-item visual function questionnaire were compared pairwise. The absolute mean difference in the two index scores and the corresponding F statistic derived from the comparisons were used as measures of Discriminatory Power. Results The absolute mean difference in the bolt-on index score was larger than that in the standard EQ-5D index score in 14 of the 16 comparisons. The bolt-on index score exhibited a larger F-statistic value than did the standard EQ-5D index score in all known-group comparisons, with the F-statistic ratio ranging from 0.415 to 0.770. Conclusions The vision bolt-on EQ-5D appears to be more discriminative than the standard EQ-5D in measurement of vision problems. Future studies should investigate the extent to which the vision bolt-on item can increase the sensitivity of the EQ-5D to vision change in interventional studies.
-
A Vision “Bolt-On” Item Could Increase the Discriminatory Power of the EQ-5D Index Score
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 2015Co-Authors: Nan Luo, X. Wang, Marcus Ang, Eric A. Finkelstein, Tin Aung, Tien Yin Wong, Ecosse L. LamoureuxAbstract:Abstract Background Recently, a vision “bolt-on” EuroQol five-dimensional questionnaire (EQ-5D) was developed and tentative utility values (i.e., a “value set”) for this new descriptive system were estimated. Objectives To compare the Discriminatory Power of this bolt-on and standard utility-based EQ-5D health indices. Methods Cross-sectional data on the (3-level) vision bolt-on EQ-5D were collected through face-to-face interviews with 500 and 336 individuals with and without visual impairment, respectively. To assess the Discriminatory Power of the vision bolt-on index relative to the standard EQ-5D index developed in the vision bolt-on valuation study, 16 pairs of mutually exclusive subgroups of individuals defined by the individuals’ visual acuity and responses to the 14-item visual function questionnaire were compared pairwise. The absolute mean difference in the two index scores and the corresponding F statistic derived from the comparisons were used as measures of Discriminatory Power. Results The absolute mean difference in the bolt-on index score was larger than that in the standard EQ-5D index score in 14 of the 16 comparisons. The bolt-on index score exhibited a larger F-statistic value than did the standard EQ-5D index score in all known-group comparisons, with the F-statistic ratio ranging from 0.415 to 0.770. Conclusions The vision bolt-on EQ-5D appears to be more discriminative than the standard EQ-5D in measurement of vision problems. Future studies should investigate the extent to which the vision bolt-on item can increase the sensitivity of the EQ-5D to vision change in interventional studies.
Markus Hilty - One of the best experts on this subject based on the ideXlab platform.
-
Evaluation of the Discriminatory Power of variable number tandem repeat (VNTR) typing of Mycobacterium bovis strains.
Veterinary microbiology, 2005Co-Authors: Markus Hilty, Colette Diguimbaye, Esther Schelling, Franca Baggi, Marcel Tanner, Jakob ZinsstagAbstract:The Discriminatory Power of variable number tandem repeat (VNTR) typing based on 16 known loci (12 MIRUs, 3 ETRs and VNTR 3232) was assessed for Mycobacterium bovis strains collected sequentially at the slaughterhouse of N'Djaména, Chad. Of 67 M. bovis strains analyzed, 67% were clustered. In this study, VNTR typing was highly discriminative with an overall allelic diversity (h(oa)) of 0.922. We defined five loci (ETR A, B, C and MIRU 26, 27) as highly (h>0.25), two loci (MIRU 4, and VNTR 3232) as moderately (0.11
-
Evaluation of the Discriminatory Power of variable number tandem repeat (VNTR) typing of Mycobacterium bovis strains.
Veterinary Microbiology, 2005Co-Authors: Markus Hilty, Colette Diguimbaye, Esther Schelling, Franca Baggi, Marcel Tanner, Jakob ZinsstagAbstract:Abstract The Discriminatory Power of variable number tandem repeat (VNTR) typing based on 16 known loci (12 MIRUs, 3 ETRs and VNTR 3232) was assessed for Mycobacterium bovis strains collected sequentially at the slaughterhouse of N’Djamena, Chad. Of 67 M. bovis strains analyzed, 67% were clustered. In this study, VNTR typing was highly discriminative with an overall allelic diversity ( h oa ) of 0.922. We defined five loci (ETR A, B, C and MIRU 26, 27) as highly ( h > 0.25), two loci (MIRU 4, and VNTR 3232) as moderately (0.11 h h h = 0.917) proved to be most appropriate for first line typing of M. bovis strains of Chad and superior than spoligotyping ( h sp = 0.789). In contrast to Mycobacterium tuberculosis strains, a consensus on VNTR loci needs to be found for M. bovis strains. The selection of a generally agreed set of VNTR loci for molecular discrimination of M. bovis in different geographical settings is discussed.
Fanni Rencz - One of the best experts on this subject based on the ideXlab platform.
-
dlqi r scoring improves the Discriminatory Power of the dermatology life quality index in patients with psoriasis pemphigus and morphea
British Journal of Dermatology, 2020Co-Authors: Fanni Rencz, László Gulácsi, Márta Péntek, Andrea Szegedi, Éva Remenyik, Gábor Bali, Bernadett Hidvégi, Zsuzsanna Batacsorgő, Béla TamásiAbstract:BACKGROUND The Dermatology Life Quality Index (DLQI) rates 'not relevant' responses (NRRs) as the item on the questionnaire having no impact on the patients' lives at all. The DLQI-Relevant (DLQI-R) is a recently developed scoring that adjusts the total score of the questionnaire for the number of NRRs indicated by a patient. OBJECTIVES To compare the Discriminatory Power of the original and DLQI-R scoring approaches in terms of absolute and relative informativity. METHODS Cross-sectional data from 637 patients with morphea, pemphigus and psoriasis were used for the analyses. To assess absolute and relative informativity, Shannon's index and Shannon's evenness index were calculated for the 10 items on the questionnaire and for DLQI and DLQI-R total scores. RESULTS Mean DLQI and DLQI-R scores of patients were 6·13 vs. 6·91. In the subset of patients with NRRs (n = 261, 41%), absolute informativity was higher with the DLQI-R scoring for all eight items with NRR options in all three conditions. The DLQI-R exhibited a better relative informativity in 8, 8 and 6 items in pemphigus, morphea and psoriasis, respectively. The DLQI-R led to an improvement in average item-level informativity in all DLQI score bands up to 20 points. Regarding total scores, the DLQI-R produced both a higher absolute and relative informativity in all three conditions. CONCLUSIONS In patients with morphea, pemphigus and psoriasis, DLQI-R scoring improves the Discriminatory Power of the questionnaire by benefiting from the additional information in NRRs. DLQI-R scoring may be useful both in clinical practice and research. A scoring chart has been developed to aid physicians with scoring. What's already known about this topic? The original scoring of the Dermatology Life Quality Index (DLQI) rates 'not relevant' responses as the item of the questionnaire having no impact on the patients' lives at all. DLQI-Relevant (DLQI-R) is a new scoring developed in 2018 that adjusts the total score of the questionnaire for the number of 'not relevant' responses indicated by patients. The Discriminatory Power of the DLQI-R compared with the DLQI has not yet been investigated. What does this study add? In patients with psoriasis, pemphigus and morphea, DLQI-R scoring improves the Discriminatory Power of the questionnaire by benefiting from the additional information in 'not relevant' responses. What are the clinical implications of this work? DLQI-R scoring may help to more accurately quantify patients' health-related quality of life both in clinical practice and research. A scoring chart has been developed to aid physicians with scoring.
-
DLQI‐R scoring improves the Discriminatory Power of the Dermatology Life Quality Index in patients with psoriasis, pemphigus and morphea
The British journal of dermatology, 2019Co-Authors: Fanni Rencz, László Gulácsi, Márta Péntek, Andrea Szegedi, Éva Remenyik, Zsuzsanna Bata-csörgő, Gábor Bali, Bernadett Hidvégi, Béla Tamási, A.k. PoórAbstract:BACKGROUND The Dermatology Life Quality Index (DLQI) rates 'not relevant' responses (NRRs) as the item on the questionnaire having no impact on the patients' lives at all. The DLQI-Relevant (DLQI-R) is a recently developed scoring that adjusts the total score of the questionnaire for the number of NRRs indicated by a patient. OBJECTIVES To compare the Discriminatory Power of the original and DLQI-R scoring approaches in terms of absolute and relative informativity. METHODS Cross-sectional data from 637 patients with morphea, pemphigus and psoriasis were used for the analyses. To assess absolute and relative informativity, Shannon's index and Shannon's evenness index were calculated for the 10 items on the questionnaire and for DLQI and DLQI-R total scores. RESULTS Mean DLQI and DLQI-R scores of patients were 6·13 vs. 6·91. In the subset of patients with NRRs (n = 261, 41%), absolute informativity was higher with the DLQI-R scoring for all eight items with NRR options in all three conditions. The DLQI-R exhibited a better relative informativity in 8, 8 and 6 items in pemphigus, morphea and psoriasis, respectively. The DLQI-R led to an improvement in average item-level informativity in all DLQI score bands up to 20 points. Regarding total scores, the DLQI-R produced both a higher absolute and relative informativity in all three conditions. CONCLUSIONS In patients with morphea, pemphigus and psoriasis, DLQI-R scoring improves the Discriminatory Power of the questionnaire by benefiting from the additional information in NRRs. DLQI-R scoring may be useful both in clinical practice and research. A scoring chart has been developed to aid physicians with scoring. What's already known about this topic? The original scoring of the Dermatology Life Quality Index (DLQI) rates 'not relevant' responses as the item of the questionnaire having no impact on the patients' lives at all. DLQI-Relevant (DLQI-R) is a new scoring developed in 2018 that adjusts the total score of the questionnaire for the number of 'not relevant' responses indicated by patients. The Discriminatory Power of the DLQI-R compared with the DLQI has not yet been investigated. What does this study add? In patients with psoriasis, pemphigus and morphea, DLQI-R scoring improves the Discriminatory Power of the questionnaire by benefiting from the additional information in 'not relevant' responses. What are the clinical implications of this work? DLQI-R scoring may help to more accurately quantify patients' health-related quality of life both in clinical practice and research. A scoring chart has been developed to aid physicians with scoring.