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Gerardo Priotto - One of the best experts on this subject based on the ideXlab platform.

  • human african trypanosomiasis in the democratic republic of the congo Disease Distribution and risk
    International Journal of Health Geographics, 2015
    Co-Authors: Crispin Lumbala, Pere P Simarro, Giuliano Cecchi, Massimo Paone, Jose R Franco, Victor Kande Betu Ku Mesu, Jacquies Makabuza, Abdoulaye Diarra, Shampa Chansy, Gerardo Priotto
    Abstract:

    For the past three decades, the Democratic Republic of the Congo (DRC) has been the country reporting the highest number of cases of human African trypanosomiasis (HAT). In 2012, DRC continued to bear the heaviest burden of gambiense HAT, accounting for 84 % of all cases reported at the continental level (i.e., 5,968/7,106). This paper reviews the status of sleeping sickness in DRC between 2000 and 2012, with a focus on spatio-temporal patterns. Epidemiological trends at the national and provincial level are presented. The number of HAT cases reported yearly from DRC decreased by 65 % from 2000 to 2012, i.e., from 16,951 to 5,968. At the provincial level a more complex picture emerges. Whilst HAT control in the Equateur province has had a spectacular impact on the number of cases (97 % reduction), the Disease has proved more difficult to tackle in other provinces, most notably in Bandundu and Kasai, where, despite substantial progress, HAT remains entrenched. HAT prevalence presents its highest values in the northern part of the Province Orientale, where a number of constraints hinder surveillance and control. Significant coordinated efforts by the National Sleeping Sickness Control Programme and the World Health Organization in data collection, reporting, management and mapping, culminating in the Atlas of HAT, have enabled HAT Distribution and risk in DRC to be known with more accuracy than ever before. Over 18,000 locations of epidemiological interest have been geo-referenced (average accuracy ≈ 1.7 km), corresponding to 93.6 % of reported cases (period 2000–2012). The population at risk of contracting sleeping sickness has been calculated for two five-year periods (2003–2007 and 2008–2012), resulting in estimates of 33 and 37 million people respectively. The progressive decrease in HAT cases reported since 2000 in DRC is likely to reflect a real decline in Disease incidence. If this result is to be sustained, and if further progress is to be made towards the goal of HAT elimination, the ongoing integration of HAT control and surveillance into the health system is to be closely monitored and evaluated, and active case-finding activities are to be maintained, especially in those areas where the risk of infection remains high and where resurgence could occur.

  • Human African trypanosomiasis in the Democratic Republic of the Congo: Disease Distribution and risk
    International journal of health geographics, 2015
    Co-Authors: Crispin Lumbala, Pere P Simarro, Giuliano Cecchi, Massimo Paone, Jose R Franco, Victor Kande Betu Ku Mesu, Jacquies Makabuza, Abdoulaye Diarra, Shampa Chansy, Gerardo Priotto
    Abstract:

    For the past three decades, the Democratic Republic of the Congo (DRC) has been the country reporting the highest number of cases of human African trypanosomiasis (HAT). In 2012, DRC continued to bear the heaviest burden of gambiense HAT, accounting for 84 % of all cases reported at the continental level (i.e., 5,968/7,106). This paper reviews the status of sleeping sickness in DRC between 2000 and 2012, with a focus on spatio-temporal patterns. Epidemiological trends at the national and provincial level are presented. The number of HAT cases reported yearly from DRC decreased by 65 % from 2000 to 2012, i.e., from 16,951 to 5,968. At the provincial level a more complex picture emerges. Whilst HAT control in the Equateur province has had a spectacular impact on the number of cases (97 % reduction), the Disease has proved more difficult to tackle in other provinces, most notably in Bandundu and Kasai, where, despite substantial progress, HAT remains entrenched. HAT prevalence presents its highest values in the northern part of the Province Orientale, where a number of constraints hinder surveillance and control. Significant coordinated efforts by the National Sleeping Sickness Control Programme and the World Health Organization in data collection, reporting, management and mapping, culminating in the Atlas of HAT, have enabled HAT Distribution and risk in DRC to be known with more accuracy than ever before. Over 18,000 locations of epidemiological interest have been geo-referenced (average accuracy ≈ 1.7 km), corresponding to 93.6 % of reported cases (period 2000–2012). The population at risk of contracting sleeping sickness has been calculated for two five-year periods (2003–2007 and 2008–2012), resulting in estimates of 33 and 37 million people respectively. The progressive decrease in HAT cases reported since 2000 in DRC is likely to reflect a real decline in Disease incidence. If this result is to be sustained, and if further progress is to be made towards the goal of HAT elimination, the ongoing integration of HAT control and surveillance into the health system is to be closely monitored and evaluated, and active case-finding activities are to be maintained, especially in those areas where the risk of infection remains high and where resurgence could occur.

Yasuo Ikeda - One of the best experts on this subject based on the ideXlab platform.

  • Disease Distribution of β2-glycoprotein I-dependent anticardiolipin antibodies in rheumatic Diseases
    Lupus, 1995
    Co-Authors: Junichi Kaburaki, Masataka Kuwana, Mihoko Yamamoto, Shinichi Kawai, Eiji Matsuura, Yasuo Ikeda
    Abstract:

    We investigated the clinical significance of IgG β2-glycoprotein I (GPI)-dependent anticardiolipin antibodies (aCL) in rheumatic Diseases. Three hundred and seventeen patients were entered. They consisted of 133 patients with SLE, 60 with RA, 45 with SSc, 37 with PM, 23 with overlap syndrome (overlap), and 19 with unclassified connective tissue Disease (UCTD). IgG β2-GPI-dependent aCL were examined by ELISA. While IgG β2-GPI-dependent aCL were detected in 13% of patients with SLE, these aCL were positive in two patients with SSc, two with overlap and 14 with UCTD. A significant association between IgG β2-GPI-dependent aCL and thrombosis was found. Clinical manifestations were studied in 32 patients with secondary APS based on SLE and 14 with primary APS (PAPS). Incidences of malar rash, arthritis, renal disorder, leucopenia, immunological disorders and hypocomplementemia were significantly less frequent in patients with PAPS. IgG β2-GPI-dependent aCL were detected in all patients with PAPS and in 34% of s...

  • Disease Distribution of beta 2-glycoprotein I-dependent anticardiolipin antibodies in rheumatic Diseases.
    Lupus, 1995
    Co-Authors: Junichi Kaburaki, Masataka Kuwana, Mihoko Yamamoto, Shinichi Kawai, Eiji Matsuura, Yasuo Ikeda
    Abstract:

    We investigated the clinical significance of IgG beta 2-glycoprotein I (GPI)-dependent anticardiolipin antibodies (aCL) in rheumatic Diseases. Three hundred and seventeen patients were entered. They consisted of 133 patients with SLE, 60 with RA, 45 with SSc, 37 with PM, 23 with overlap syndrome (overlap), and 19 with unclassified connective tissue Disease (UCTD). IgG beta 2-GPI-dependent aCL were examined by ELISA. While IgG beta 2-GPI-dependent aCL were detected in 13% of patients with SLE, these aCL were positive in two patients with SSc, two with overlap and 14 with UCTD. A significant association between IgG beta 2-GPI-dependent aCL and thrombosis was found. Clinical manifestations were studied in 32 patients with secondary APS based on SLE and 14 with primary APS (PAPS). Incidence of malar rash, arthritis, renal disorder, leucopenia, immunological disorders and hypocomplementemia were significantly less frequent in patients with PAPS. IgG beta 2-GPI-dependent aCL were detected in all patients with PAPS and in 34% of secondary APS. This difference was significant. These data suggest that IgG beta 2-dependent aCL are useful for identifying a subset in patients with APS.

Crispin Lumbala - One of the best experts on this subject based on the ideXlab platform.

  • human african trypanosomiasis in the democratic republic of the congo Disease Distribution and risk
    International Journal of Health Geographics, 2015
    Co-Authors: Crispin Lumbala, Pere P Simarro, Giuliano Cecchi, Massimo Paone, Jose R Franco, Victor Kande Betu Ku Mesu, Jacquies Makabuza, Abdoulaye Diarra, Shampa Chansy, Gerardo Priotto
    Abstract:

    For the past three decades, the Democratic Republic of the Congo (DRC) has been the country reporting the highest number of cases of human African trypanosomiasis (HAT). In 2012, DRC continued to bear the heaviest burden of gambiense HAT, accounting for 84 % of all cases reported at the continental level (i.e., 5,968/7,106). This paper reviews the status of sleeping sickness in DRC between 2000 and 2012, with a focus on spatio-temporal patterns. Epidemiological trends at the national and provincial level are presented. The number of HAT cases reported yearly from DRC decreased by 65 % from 2000 to 2012, i.e., from 16,951 to 5,968. At the provincial level a more complex picture emerges. Whilst HAT control in the Equateur province has had a spectacular impact on the number of cases (97 % reduction), the Disease has proved more difficult to tackle in other provinces, most notably in Bandundu and Kasai, where, despite substantial progress, HAT remains entrenched. HAT prevalence presents its highest values in the northern part of the Province Orientale, where a number of constraints hinder surveillance and control. Significant coordinated efforts by the National Sleeping Sickness Control Programme and the World Health Organization in data collection, reporting, management and mapping, culminating in the Atlas of HAT, have enabled HAT Distribution and risk in DRC to be known with more accuracy than ever before. Over 18,000 locations of epidemiological interest have been geo-referenced (average accuracy ≈ 1.7 km), corresponding to 93.6 % of reported cases (period 2000–2012). The population at risk of contracting sleeping sickness has been calculated for two five-year periods (2003–2007 and 2008–2012), resulting in estimates of 33 and 37 million people respectively. The progressive decrease in HAT cases reported since 2000 in DRC is likely to reflect a real decline in Disease incidence. If this result is to be sustained, and if further progress is to be made towards the goal of HAT elimination, the ongoing integration of HAT control and surveillance into the health system is to be closely monitored and evaluated, and active case-finding activities are to be maintained, especially in those areas where the risk of infection remains high and where resurgence could occur.

  • Human African trypanosomiasis in the Democratic Republic of the Congo: Disease Distribution and risk
    International journal of health geographics, 2015
    Co-Authors: Crispin Lumbala, Pere P Simarro, Giuliano Cecchi, Massimo Paone, Jose R Franco, Victor Kande Betu Ku Mesu, Jacquies Makabuza, Abdoulaye Diarra, Shampa Chansy, Gerardo Priotto
    Abstract:

    For the past three decades, the Democratic Republic of the Congo (DRC) has been the country reporting the highest number of cases of human African trypanosomiasis (HAT). In 2012, DRC continued to bear the heaviest burden of gambiense HAT, accounting for 84 % of all cases reported at the continental level (i.e., 5,968/7,106). This paper reviews the status of sleeping sickness in DRC between 2000 and 2012, with a focus on spatio-temporal patterns. Epidemiological trends at the national and provincial level are presented. The number of HAT cases reported yearly from DRC decreased by 65 % from 2000 to 2012, i.e., from 16,951 to 5,968. At the provincial level a more complex picture emerges. Whilst HAT control in the Equateur province has had a spectacular impact on the number of cases (97 % reduction), the Disease has proved more difficult to tackle in other provinces, most notably in Bandundu and Kasai, where, despite substantial progress, HAT remains entrenched. HAT prevalence presents its highest values in the northern part of the Province Orientale, where a number of constraints hinder surveillance and control. Significant coordinated efforts by the National Sleeping Sickness Control Programme and the World Health Organization in data collection, reporting, management and mapping, culminating in the Atlas of HAT, have enabled HAT Distribution and risk in DRC to be known with more accuracy than ever before. Over 18,000 locations of epidemiological interest have been geo-referenced (average accuracy ≈ 1.7 km), corresponding to 93.6 % of reported cases (period 2000–2012). The population at risk of contracting sleeping sickness has been calculated for two five-year periods (2003–2007 and 2008–2012), resulting in estimates of 33 and 37 million people respectively. The progressive decrease in HAT cases reported since 2000 in DRC is likely to reflect a real decline in Disease incidence. If this result is to be sustained, and if further progress is to be made towards the goal of HAT elimination, the ongoing integration of HAT control and surveillance into the health system is to be closely monitored and evaluated, and active case-finding activities are to be maintained, especially in those areas where the risk of infection remains high and where resurgence could occur.

Bimal K Baidya - One of the best experts on this subject based on the ideXlab platform.

  • Malaria transmission in Tripura: Disease Distribution & determinants.
    Indian Journal of Medical Research, 2015
    Co-Authors: Vas Dev, Tridibes Adak, Om Singh, Nutan Nanda, Bimal K Baidya
    Abstract:

    Background & objectives: Malaria is a major public health problem in Tripura and focal Disease outbreaks are of frequent occurrence. The s0 tate is co-endemic for both Plasmodium falciparum and P. vivax and transmission is perennial and persistent. The present study was aimed to review data on Disease Distribution to prioritize high-risk districts, and to study seasonal prevalence of Disease vectors and their bionomical characteristics to help formulate vector species-specific interventions for malaria control. Methods: Data on malaria morbidity in the State were reviewed retrospectively (2008-2012) for understanding Disease Distribution and transmission dynamics. Cross-sectional mass blood surveys were conducted in malaria endemic villages of South Tripura district to ascertain the prevalence of malaria and proportions of parasite species. Mosquito collections were made in human dwellings of malaria endemic villages aiming at vector incrimination and to study relative abundance, resting and feeding preferences, and their present susceptibility status to DDT. Results: The study showed that malaria was widely prevalent and P. falciparum was the predominant infection (>90%), the remaining were P. vivax cases. The Disease Distribution, however, was uneven with large concentration of cases in districts of South Tripura and Dhalai coinciding with vast forest cover and tribal populations. Both Anopheles minimus s.s. and An. baimaii were recorded to be prevalent and observed to be highly anthropophagic and susceptible to DDT. Of these, An. minimus was incriminated (sporozoite infection rate 4.92%), and its bionomical characteristics revealed this species to be largely indoor resting and endophagic. Interpretation & conclusions: For effective control of malaria in the s0 tate, it is recommended that Diseases surveillance should be robust, and vector control interventions including DDT spray coverage, mass Distribution of insecticide-treated nets/ long-lasting insecticidal nets should be intensified prioritizing population groups most at risk to avert impending Disease outbreaks and spread of drug-resistant malaria.

  • Malaria transmission in Tripura: Disease Distribution & determinants.
    The Indian journal of medical research, 2015
    Co-Authors: Vas Dev, Tridibes Adak, Nutan Nanda, Om P Singh, Bimal K Baidya
    Abstract:

    Malaria is a major public health problem in Tripura and focal Disease outbreaks are of frequent occurrence. The state is co-endemic for both Plasmodium falciparum and P. vivax and transmission is perennial and persistent. The present study was aimed to review data on Disease Distribution to prioritize high-risk districts, and to study seasonal prevalence of Disease vectors and their bionomical characteristics to help formulate vector species-specific interventions for malaria control. Data on malaria morbidity in the State were reviewed retrospectively (2008-2012) for understanding Disease Distribution and transmission dynamics. Cross-sectional mass blood surveys were conducted in malaria endemic villages of South Tripura district to ascertain the prevalence of malaria and proportions of parasite species. Mosquito collections were made in human dwellings of malaria endemic villages aiming at vector incrimination and to study relative abundance, resting and feeding preferences, and their present susceptibility status to DDT. The study showed that malaria was widely prevalent and P. falciparum was the predominant infection (>90%), the remaining were P. vivax cases. The Disease Distribution, however, was uneven with large concentration of cases in districts of South Tripura and Dhalai coinciding with vast forest cover and tribal populations. Both Anopheles minimus s.s. and An. baimaii were recorded to be prevalent and observed to be highly anthropophagic and susceptible to DDT. Of these, An. minimus was incriminated (sporozoite infection rate 4.92%), and its bionomical characteristics revealed this species to be largely indoor resting and endophagic. For effective control of malaria in the state, it is recommended that Diseases surveillance should be robust, and vector control interventions including DDT spray coverage, mass Distribution of insecticide-treated nets/ long-lasting insecticidal nets should be intensified prioritizing population groups most at risk to avert impending Disease outbreaks and spread of drug-resistant malaria.

Junichi Kaburaki - One of the best experts on this subject based on the ideXlab platform.

  • Disease Distribution of β2-glycoprotein I-dependent anticardiolipin antibodies in rheumatic Diseases
    Lupus, 1995
    Co-Authors: Junichi Kaburaki, Masataka Kuwana, Mihoko Yamamoto, Shinichi Kawai, Eiji Matsuura, Yasuo Ikeda
    Abstract:

    We investigated the clinical significance of IgG β2-glycoprotein I (GPI)-dependent anticardiolipin antibodies (aCL) in rheumatic Diseases. Three hundred and seventeen patients were entered. They consisted of 133 patients with SLE, 60 with RA, 45 with SSc, 37 with PM, 23 with overlap syndrome (overlap), and 19 with unclassified connective tissue Disease (UCTD). IgG β2-GPI-dependent aCL were examined by ELISA. While IgG β2-GPI-dependent aCL were detected in 13% of patients with SLE, these aCL were positive in two patients with SSc, two with overlap and 14 with UCTD. A significant association between IgG β2-GPI-dependent aCL and thrombosis was found. Clinical manifestations were studied in 32 patients with secondary APS based on SLE and 14 with primary APS (PAPS). Incidences of malar rash, arthritis, renal disorder, leucopenia, immunological disorders and hypocomplementemia were significantly less frequent in patients with PAPS. IgG β2-GPI-dependent aCL were detected in all patients with PAPS and in 34% of s...

  • Disease Distribution of beta 2-glycoprotein I-dependent anticardiolipin antibodies in rheumatic Diseases.
    Lupus, 1995
    Co-Authors: Junichi Kaburaki, Masataka Kuwana, Mihoko Yamamoto, Shinichi Kawai, Eiji Matsuura, Yasuo Ikeda
    Abstract:

    We investigated the clinical significance of IgG beta 2-glycoprotein I (GPI)-dependent anticardiolipin antibodies (aCL) in rheumatic Diseases. Three hundred and seventeen patients were entered. They consisted of 133 patients with SLE, 60 with RA, 45 with SSc, 37 with PM, 23 with overlap syndrome (overlap), and 19 with unclassified connective tissue Disease (UCTD). IgG beta 2-GPI-dependent aCL were examined by ELISA. While IgG beta 2-GPI-dependent aCL were detected in 13% of patients with SLE, these aCL were positive in two patients with SSc, two with overlap and 14 with UCTD. A significant association between IgG beta 2-GPI-dependent aCL and thrombosis was found. Clinical manifestations were studied in 32 patients with secondary APS based on SLE and 14 with primary APS (PAPS). Incidence of malar rash, arthritis, renal disorder, leucopenia, immunological disorders and hypocomplementemia were significantly less frequent in patients with PAPS. IgG beta 2-GPI-dependent aCL were detected in all patients with PAPS and in 34% of secondary APS. This difference was significant. These data suggest that IgG beta 2-dependent aCL are useful for identifying a subset in patients with APS.