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Rajendra K Prasad - One of the best experts on this subject based on the ideXlab platform.
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surgical technique and systemic inflammation influences long term Disease Free Survival following hepatic resection for colorectal metastasis
Journal of Surgical Oncology, 2008Co-Authors: Dhanwant Gomez, Gareth Morrisstiff, Judy Wyatt, G J Toogood, Peter J A Lodge, Rajendra K PrasadAbstract:BACKGROUND: To date, there is limited data available on prognostic factors that influence long-term Disease-Free Survival following hepatic resection for colorectal liver metastasis (CRLM). The aim of the study was to identify prognostic factors that were associated with long-term Disease-Free Survival (>5 years) following resection for CRLM. METHODS: Patients undergoing resection for CRLM from January 1993 to March 2007 were identified from the hepatobiliary database. Data analyzed included demographics, laboratory results, operative findings and histopathological data. RESULTS: Seven hundred five curative primary hepatic resections were performed, of which 434 patients developed Disease recurrence within 5 years and 67 patients were Disease-Free more than 5 years. There was a significant association between systemic inflammatory response (raised neutrophil to lymphocyte ratio and/or C-reactive protein), blood transfusion, >2 tumors, bilobar Disease and resection margin involvement with developing recurrence during the follow-up period. On multivariate analysis, three independent predictors for recurrent Disease within the 5-year follow-up were identified: pre-operative inflammatory response; blood transfusion requirement; and status of resection margin. CONCLUSION: Absence of a systemic inflammatory response and surgical technique to minimize transfusion requirements and obtain a R0 resection margin, are associated with long-term Disease-Free Survival.
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surgical technique and systemic inflammation influences long term Disease Free Survival following hepatic resection for colorectal metastasis
Journal of Surgical Oncology, 2008Co-Authors: Dhanwant Gomez, Gareth Morrisstiff, Judy Wyatt, G J Toogood, Peter J A Lodge, Rajendra K PrasadAbstract:Background To date, there is limited data available on prognostic factors that influence long-term Disease-Free Survival following hepatic resection for colorectal liver metastasis (CRLM). The aim of the study was to identify prognostic factors that were associated with long-term Disease-Free Survival (>5 years) following resection for CRLM. Methods Patients undergoing resection for CRLM from January 1993 to March 2007 were identified from the hepatobiliary database. Data analyzed included demographics, laboratory results, operative findings and histopathological data. Results Seven hundred five curative primary hepatic resections were performed, of which 434 patients developed Disease recurrence within 5 years and 67 patients were Disease-Free more than 5 years. There was a significant association between systemic inflammatory response (raised neutrophil to lymphocyte ratio and/or C-reactive protein), blood transfusion, >2 tumors, bilobar Disease and resection margin involvement with developing recurrence during the follow-up period. On multivariate analysis, three independent predictors for recurrent Disease within the 5-year follow-up were identified: pre-operative inflammatory response; blood transfusion requirement; and status of resection margin. Conclusion Absence of a systemic inflammatory response and surgical technique to minimize transfusion requirements and obtain a R0 resection margin, are associated with long-term Disease-Free Survival. J. Surg. Oncol. 2008;98:371–376. © 2008 Wiley-Liss, Inc.
Dhanwant Gomez - One of the best experts on this subject based on the ideXlab platform.
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surgical technique and systemic inflammation influences long term Disease Free Survival following hepatic resection for colorectal metastasis
Journal of Surgical Oncology, 2008Co-Authors: Dhanwant Gomez, Gareth Morrisstiff, Judy Wyatt, G J Toogood, Peter J A Lodge, Rajendra K PrasadAbstract:BACKGROUND: To date, there is limited data available on prognostic factors that influence long-term Disease-Free Survival following hepatic resection for colorectal liver metastasis (CRLM). The aim of the study was to identify prognostic factors that were associated with long-term Disease-Free Survival (>5 years) following resection for CRLM. METHODS: Patients undergoing resection for CRLM from January 1993 to March 2007 were identified from the hepatobiliary database. Data analyzed included demographics, laboratory results, operative findings and histopathological data. RESULTS: Seven hundred five curative primary hepatic resections were performed, of which 434 patients developed Disease recurrence within 5 years and 67 patients were Disease-Free more than 5 years. There was a significant association between systemic inflammatory response (raised neutrophil to lymphocyte ratio and/or C-reactive protein), blood transfusion, >2 tumors, bilobar Disease and resection margin involvement with developing recurrence during the follow-up period. On multivariate analysis, three independent predictors for recurrent Disease within the 5-year follow-up were identified: pre-operative inflammatory response; blood transfusion requirement; and status of resection margin. CONCLUSION: Absence of a systemic inflammatory response and surgical technique to minimize transfusion requirements and obtain a R0 resection margin, are associated with long-term Disease-Free Survival.
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surgical technique and systemic inflammation influences long term Disease Free Survival following hepatic resection for colorectal metastasis
Journal of Surgical Oncology, 2008Co-Authors: Dhanwant Gomez, Gareth Morrisstiff, Judy Wyatt, G J Toogood, Peter J A Lodge, Rajendra K PrasadAbstract:Background To date, there is limited data available on prognostic factors that influence long-term Disease-Free Survival following hepatic resection for colorectal liver metastasis (CRLM). The aim of the study was to identify prognostic factors that were associated with long-term Disease-Free Survival (>5 years) following resection for CRLM. Methods Patients undergoing resection for CRLM from January 1993 to March 2007 were identified from the hepatobiliary database. Data analyzed included demographics, laboratory results, operative findings and histopathological data. Results Seven hundred five curative primary hepatic resections were performed, of which 434 patients developed Disease recurrence within 5 years and 67 patients were Disease-Free more than 5 years. There was a significant association between systemic inflammatory response (raised neutrophil to lymphocyte ratio and/or C-reactive protein), blood transfusion, >2 tumors, bilobar Disease and resection margin involvement with developing recurrence during the follow-up period. On multivariate analysis, three independent predictors for recurrent Disease within the 5-year follow-up were identified: pre-operative inflammatory response; blood transfusion requirement; and status of resection margin. Conclusion Absence of a systemic inflammatory response and surgical technique to minimize transfusion requirements and obtain a R0 resection margin, are associated with long-term Disease-Free Survival. J. Surg. Oncol. 2008;98:371–376. © 2008 Wiley-Liss, Inc.
Hong Chu-yuan - One of the best experts on this subject based on the ideXlab platform.
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Analysis of Survival Rate and the Disease Free Survival in Patients with Dukes' Stage A or B Colorectal Cancers
Chinese Journal of General Practice, 2011Co-Authors: Hong Chu-yuanAbstract:Objective To investigate Survival rate and the Disease Free Survival in patients with Dukes' Stage A or B colorectal cancers and analyze the prognosis related factors.Methods Sixty-five patients with Dukes' Stage A or B colorectal cancer of 2000.2-2003.2 and follow-up visit to 2008.2 were enrolled.Cox ratio risk pattern analysis was used.Results The 5-year Survival rate and the Disease Free Survival rate of group were 89.6% and 80.9%.The Survival rate and the Disease Free Survival rate in Dukes' A was superior to that of Dukes' B(P0.01).Univariate analysis showed that the relative factors of the Disease Free Survival rate in Dukes' A and Dukes' B were age(P=0.008),histological differentiation(P=0.025),tumor size(P=0.036),tumor location(P=0.040),chemotherapy(P=0.005).Multivariate analysis based on a COX proportional hazard model showed that invasive depth and metastasis were independent prognostic factors about the Disease Free Survival rate of patients with Dukes' stage A or B colorectal cancers.Conclusion Invasive depth and metastasis were independent prognostic factors about the Disease Free Survival rate of patients with Dukes' stage A or B colorectal cancers.Postoperative chemotherapy was helpful to patients.
Georg Rutishauser - One of the best experts on this subject based on the ideXlab platform.
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Adverse effect of transurethral resection on Disease-Free Survival in locally advanced prostatic cancer treated with irradiation
International journal of radiation oncology biology physics, 1993Co-Authors: Christine Landmann, Reinhard Hunig, Georg RutishauserAbstract:Abstract Purpose: The purpose of this study was to analyze the impact of transurethral resection of the prostate on prognosis in patients with localized prostate cancer who received definitive external beam radiotherapy. Methods and Materials: Out of the 431 patients treated diagnosis was established by needle biopsy in 198 and by transurethral resection of the prostate in 233 cases. Disease-Free Survival and relative Survival as a function of transurethral resection of the prostate and needle biopsy were calculated for all stages and within each tumor stage and grade. Results: An adverse effect of transurethral resection of the prostate on Disease-Free Survival was observed only in patients with T3 T4 tumors of intermediate and poor differentiation ( p Conclusion: We conclude that transurethral resection of the prostate has an adverse effect on Disease-Free Survival in a selected group of patients and discuss the implications of this finding.
Peter J A Lodge - One of the best experts on this subject based on the ideXlab platform.
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surgical technique and systemic inflammation influences long term Disease Free Survival following hepatic resection for colorectal metastasis
Journal of Surgical Oncology, 2008Co-Authors: Dhanwant Gomez, Gareth Morrisstiff, Judy Wyatt, G J Toogood, Peter J A Lodge, Rajendra K PrasadAbstract:BACKGROUND: To date, there is limited data available on prognostic factors that influence long-term Disease-Free Survival following hepatic resection for colorectal liver metastasis (CRLM). The aim of the study was to identify prognostic factors that were associated with long-term Disease-Free Survival (>5 years) following resection for CRLM. METHODS: Patients undergoing resection for CRLM from January 1993 to March 2007 were identified from the hepatobiliary database. Data analyzed included demographics, laboratory results, operative findings and histopathological data. RESULTS: Seven hundred five curative primary hepatic resections were performed, of which 434 patients developed Disease recurrence within 5 years and 67 patients were Disease-Free more than 5 years. There was a significant association between systemic inflammatory response (raised neutrophil to lymphocyte ratio and/or C-reactive protein), blood transfusion, >2 tumors, bilobar Disease and resection margin involvement with developing recurrence during the follow-up period. On multivariate analysis, three independent predictors for recurrent Disease within the 5-year follow-up were identified: pre-operative inflammatory response; blood transfusion requirement; and status of resection margin. CONCLUSION: Absence of a systemic inflammatory response and surgical technique to minimize transfusion requirements and obtain a R0 resection margin, are associated with long-term Disease-Free Survival.
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surgical technique and systemic inflammation influences long term Disease Free Survival following hepatic resection for colorectal metastasis
Journal of Surgical Oncology, 2008Co-Authors: Dhanwant Gomez, Gareth Morrisstiff, Judy Wyatt, G J Toogood, Peter J A Lodge, Rajendra K PrasadAbstract:Background To date, there is limited data available on prognostic factors that influence long-term Disease-Free Survival following hepatic resection for colorectal liver metastasis (CRLM). The aim of the study was to identify prognostic factors that were associated with long-term Disease-Free Survival (>5 years) following resection for CRLM. Methods Patients undergoing resection for CRLM from January 1993 to March 2007 were identified from the hepatobiliary database. Data analyzed included demographics, laboratory results, operative findings and histopathological data. Results Seven hundred five curative primary hepatic resections were performed, of which 434 patients developed Disease recurrence within 5 years and 67 patients were Disease-Free more than 5 years. There was a significant association between systemic inflammatory response (raised neutrophil to lymphocyte ratio and/or C-reactive protein), blood transfusion, >2 tumors, bilobar Disease and resection margin involvement with developing recurrence during the follow-up period. On multivariate analysis, three independent predictors for recurrent Disease within the 5-year follow-up were identified: pre-operative inflammatory response; blood transfusion requirement; and status of resection margin. Conclusion Absence of a systemic inflammatory response and surgical technique to minimize transfusion requirements and obtain a R0 resection margin, are associated with long-term Disease-Free Survival. J. Surg. Oncol. 2008;98:371–376. © 2008 Wiley-Liss, Inc.