The Experts below are selected from a list of 345237 Experts worldwide ranked by ideXlab platform

Conor Murphy - One of the best experts on this subject based on the ideXlab platform.

  • profiling micro rna expression in patients with primary sjogrens syndrome contribution to Disease Pathogenesis
    BMC Proceedings, 2015
    Co-Authors: Rena Alzubaidy, Joan Ni Gabhann, Qistina Pilson, Conor Murphy
    Abstract:

    Background Sjogrens syndrome (SS) is a chronic autoimmune disorder, characterised by lymphocytic infiltration resulting in exocrine gland destruction and other extra-glandular manifestations [1]. Currently there is no definitive diagnostic test, and the immuno-pathology is not fully understood. Recently focus has shifted to investigating microRNAs (miRs) in an effort to understand the mechanisms contributing to Disease Pathogenesis. MiRs are short non-coding RNA sequences, which regulate gene expression posttranscriptionally [2]. Of note, miRs have been identified as key regulators of immune function in a variety of autoimmune conditions [2]. The hypothesis of this project is that alterations in expression of specific miRs which regulate genes relating to inflammation and immunity may play a role in the pathology of the Disease.

  • Profiling Micro-RNA expression in patients with Primary Sjogrens Syndrome – contribution to Disease Pathogenesis
    BMC Proceedings, 2015
    Co-Authors: Rena Al-zubaidy, Joan Ni Gabhann, Qistina Pilson, Conor Murphy
    Abstract:

    Background Sjogrens syndrome (SS) is a chronic autoimmune disorder, characterised by lymphocytic infiltration resulting in exocrine gland destruction and other extra-glandular manifestations [1]. Currently there is no definitive diagnostic test, and the immuno-pathology is not fully understood. Recently focus has shifted to investigating microRNAs (miRs) in an effort to understand the mechanisms contributing to Disease Pathogenesis. MiRs are short non-coding RNA sequences, which regulate gene expression posttranscriptionally [2]. Of note, miRs have been identified as key regulators of immune function in a variety of autoimmune conditions [2]. The hypothesis of this project is that alterations in expression of specific miRs which regulate genes relating to inflammation and immunity may play a role in the pathology of the Disease.

Siddappa N. Byrareddy - One of the best experts on this subject based on the ideXlab platform.

  • SIV/SHIV-Zika co-infection does not alter Disease Pathogenesis in adult non-pregnant rhesus macaque model.
    PLoS neglected tropical diseases, 2018
    Co-Authors: Mehdi R. M. Bidokhti, Debashis Dutta, Lepakshe S. V. Madduri, Shawna M. Woollard, Robert B. Norgren, Luis D. Giavedoni, Siddappa N. Byrareddy
    Abstract:

    Due to the large geographical overlap of populations exposed to Zika virus (ZIKV) and human immunodeficiency virus (HIV), understanding the Disease Pathogenesis of co-infection is urgently needed. This warrants the development of an animal model for HIV-ZIKV co-infection. In this study, we used adult non-pregnant macaques that were chronically infected with simian immunodeficiency virus/chimeric simian human immunodeficiency virus (SIV/SHIV) and then inoculated with ZIKV. Plasma viral loads of both SIV/SHIV and ZIKV co-infected animals revealed no significant changes as compared to animals that were infected with ZIKV alone or as compared to SIV/SHIV infected animals prior to ZIKV inoculation. ZIKV tissue clearance of co-infected animals was similar to animals that were infected with ZIKV alone. Furthermore, in co-infected macaques, there was no statistically significant difference in plasma cytokines/chemokines levels as compared to prior to ZIKV inoculation. Collectively, these findings suggest that co-infection may not alter Disease Pathogenesis, thus warranting larger HIV-ZIKV epidemiological studies in order to validate these findings.

  • SIV/SHIV-Zika coinfection does not alter Disease Pathogenesis in adult non-pregnant Rhesus Macaques
    2018
    Co-Authors: Mehdi R. M. Bidokhti, Debashis Dutta, Lepakshe S. V. Madduri, Shawna M. Woollard, Robert B. Norgren, Luis D. Giavedoni, Siddappa N. Byrareddy
    Abstract:

    Due to the large geographical overlap of populations exposed to Zika virus (ZIKV) and human immunodeficiency virus (HIV), understanding Disease Pathogenesis in such coinfections is urgently needed. We used chronically infected simian immunodeficiency virus and chimeric simian human immunodeficiency virus (SIV/SHIV) macaques and inoculated with ZIKV. Plasma viral loads of both SIV/SHIV and ZIKV showed no significant changes as compared to ZIKV alone-infected animals. Tissue clearance of ZIKV was observed similarly. Furthermore, minimal changes in cytokines/chemokines were observed. Collectively, these data suggest that coinfection may not alter Disease Pathogenesis and warrants large HIV-ZIKV epidemiological studies to validate these findings.

Mehdi R. M. Bidokhti - One of the best experts on this subject based on the ideXlab platform.

  • SIV/SHIV-Zika co-infection does not alter Disease Pathogenesis in adult non-pregnant rhesus macaque model.
    PLoS neglected tropical diseases, 2018
    Co-Authors: Mehdi R. M. Bidokhti, Debashis Dutta, Lepakshe S. V. Madduri, Shawna M. Woollard, Robert B. Norgren, Luis D. Giavedoni, Siddappa N. Byrareddy
    Abstract:

    Due to the large geographical overlap of populations exposed to Zika virus (ZIKV) and human immunodeficiency virus (HIV), understanding the Disease Pathogenesis of co-infection is urgently needed. This warrants the development of an animal model for HIV-ZIKV co-infection. In this study, we used adult non-pregnant macaques that were chronically infected with simian immunodeficiency virus/chimeric simian human immunodeficiency virus (SIV/SHIV) and then inoculated with ZIKV. Plasma viral loads of both SIV/SHIV and ZIKV co-infected animals revealed no significant changes as compared to animals that were infected with ZIKV alone or as compared to SIV/SHIV infected animals prior to ZIKV inoculation. ZIKV tissue clearance of co-infected animals was similar to animals that were infected with ZIKV alone. Furthermore, in co-infected macaques, there was no statistically significant difference in plasma cytokines/chemokines levels as compared to prior to ZIKV inoculation. Collectively, these findings suggest that co-infection may not alter Disease Pathogenesis, thus warranting larger HIV-ZIKV epidemiological studies in order to validate these findings.

  • SIV/SHIV-Zika coinfection does not alter Disease Pathogenesis in adult non-pregnant Rhesus Macaques
    2018
    Co-Authors: Mehdi R. M. Bidokhti, Debashis Dutta, Lepakshe S. V. Madduri, Shawna M. Woollard, Robert B. Norgren, Luis D. Giavedoni, Siddappa N. Byrareddy
    Abstract:

    Due to the large geographical overlap of populations exposed to Zika virus (ZIKV) and human immunodeficiency virus (HIV), understanding Disease Pathogenesis in such coinfections is urgently needed. We used chronically infected simian immunodeficiency virus and chimeric simian human immunodeficiency virus (SIV/SHIV) macaques and inoculated with ZIKV. Plasma viral loads of both SIV/SHIV and ZIKV showed no significant changes as compared to ZIKV alone-infected animals. Tissue clearance of ZIKV was observed similarly. Furthermore, minimal changes in cytokines/chemokines were observed. Collectively, these data suggest that coinfection may not alter Disease Pathogenesis and warrants large HIV-ZIKV epidemiological studies to validate these findings.

Joan Ni Gabhann - One of the best experts on this subject based on the ideXlab platform.

  • profiling micro rna expression in patients with primary sjogrens syndrome contribution to Disease Pathogenesis
    BMC Proceedings, 2015
    Co-Authors: Rena Alzubaidy, Joan Ni Gabhann, Qistina Pilson, Conor Murphy
    Abstract:

    Background Sjogrens syndrome (SS) is a chronic autoimmune disorder, characterised by lymphocytic infiltration resulting in exocrine gland destruction and other extra-glandular manifestations [1]. Currently there is no definitive diagnostic test, and the immuno-pathology is not fully understood. Recently focus has shifted to investigating microRNAs (miRs) in an effort to understand the mechanisms contributing to Disease Pathogenesis. MiRs are short non-coding RNA sequences, which regulate gene expression posttranscriptionally [2]. Of note, miRs have been identified as key regulators of immune function in a variety of autoimmune conditions [2]. The hypothesis of this project is that alterations in expression of specific miRs which regulate genes relating to inflammation and immunity may play a role in the pathology of the Disease.

  • Profiling Micro-RNA expression in patients with Primary Sjogrens Syndrome – contribution to Disease Pathogenesis
    BMC Proceedings, 2015
    Co-Authors: Rena Al-zubaidy, Joan Ni Gabhann, Qistina Pilson, Conor Murphy
    Abstract:

    Background Sjogrens syndrome (SS) is a chronic autoimmune disorder, characterised by lymphocytic infiltration resulting in exocrine gland destruction and other extra-glandular manifestations [1]. Currently there is no definitive diagnostic test, and the immuno-pathology is not fully understood. Recently focus has shifted to investigating microRNAs (miRs) in an effort to understand the mechanisms contributing to Disease Pathogenesis. MiRs are short non-coding RNA sequences, which regulate gene expression posttranscriptionally [2]. Of note, miRs have been identified as key regulators of immune function in a variety of autoimmune conditions [2]. The hypothesis of this project is that alterations in expression of specific miRs which regulate genes relating to inflammation and immunity may play a role in the pathology of the Disease.

Qistina Pilson - One of the best experts on this subject based on the ideXlab platform.

  • profiling micro rna expression in patients with primary sjogrens syndrome contribution to Disease Pathogenesis
    BMC Proceedings, 2015
    Co-Authors: Rena Alzubaidy, Joan Ni Gabhann, Qistina Pilson, Conor Murphy
    Abstract:

    Background Sjogrens syndrome (SS) is a chronic autoimmune disorder, characterised by lymphocytic infiltration resulting in exocrine gland destruction and other extra-glandular manifestations [1]. Currently there is no definitive diagnostic test, and the immuno-pathology is not fully understood. Recently focus has shifted to investigating microRNAs (miRs) in an effort to understand the mechanisms contributing to Disease Pathogenesis. MiRs are short non-coding RNA sequences, which regulate gene expression posttranscriptionally [2]. Of note, miRs have been identified as key regulators of immune function in a variety of autoimmune conditions [2]. The hypothesis of this project is that alterations in expression of specific miRs which regulate genes relating to inflammation and immunity may play a role in the pathology of the Disease.

  • Profiling Micro-RNA expression in patients with Primary Sjogrens Syndrome – contribution to Disease Pathogenesis
    BMC Proceedings, 2015
    Co-Authors: Rena Al-zubaidy, Joan Ni Gabhann, Qistina Pilson, Conor Murphy
    Abstract:

    Background Sjogrens syndrome (SS) is a chronic autoimmune disorder, characterised by lymphocytic infiltration resulting in exocrine gland destruction and other extra-glandular manifestations [1]. Currently there is no definitive diagnostic test, and the immuno-pathology is not fully understood. Recently focus has shifted to investigating microRNAs (miRs) in an effort to understand the mechanisms contributing to Disease Pathogenesis. MiRs are short non-coding RNA sequences, which regulate gene expression posttranscriptionally [2]. Of note, miRs have been identified as key regulators of immune function in a variety of autoimmune conditions [2]. The hypothesis of this project is that alterations in expression of specific miRs which regulate genes relating to inflammation and immunity may play a role in the pathology of the Disease.