The Experts below are selected from a list of 9042 Experts worldwide ranked by ideXlab platform
Satoshi Gando - One of the best experts on this subject based on the ideXlab platform.
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Disseminated Intravascular Coagulation
Nature reviews. Disease primers, 2016Co-Authors: Satoshi Gando, Marcel Levi, Cheng Hock TohAbstract:Disseminated Intravascular Coagulation (DIC) is an acquired syndrome characterized by widespread Intravascular activation of Coagulation that can be caused by infectious insults (such as sepsis) and non-infectious insults (such as trauma). The main pathophysiological mechanisms of DIC are inflammatory cytokine-initiated activation of tissue factor-dependent Coagulation, insufficient control of anticoagulant pathways and plasminogen activator inhibitor 1-mediated suppression of fibrinolysis. Together, these changes give rise to endothelial dysfunction and microvascular thrombosis, which can cause organ dysfunction and seriously affect patient prognosis. Recent observations have pointed to an important role for extracellular DNA and DNA-binding proteins, such as histones, in the pathogenesis of DIC. The International Society on Thrombosis and Haemostasis (ISTH) established a DIC diagnostic scoring system consisting of global haemostatic test parameters. This scoring system has now been well validated in diverse clinical settings. The theoretical cornerstone of DIC management is the specific and vigorous treatment of the underlying conditions, and DIC should be simultaneously managed to improve patient outcomes. The ISTH guidance for the treatment of DIC recommends treatment strategies that are based on current evidence. In this Primer, we provide an updated overview of the pathophysiology, diagnosis and management of DIC and discuss the future directions of basic and clinical research in this field.
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a randomized controlled multicenter trial of the effects of antithrombin on Disseminated Intravascular Coagulation in patients with sepsis
Critical Care, 2013Co-Authors: Satoshi Gando, Toshihiko Mayumi, Hiroyasu Ishikura, Daizoh Saitoh, Masashi Ueyama, Yasuhiro Otomo, Shigeto Oda, Shigeki Kushimoto, Katsuhisa Tanjoh, Toshiaki IkedaAbstract:Introduction To test the hypothesis that the administration of antithrombin concentrate improves Disseminated Intravascular Coagulation (DIC), resulting in recovery from DIC and better outcomes in patients with sepsis, we conducted a prospective, randomized controlled multicenter trial at 13 critical care centers in tertiary care hospitals.
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a multicenter prospective validation study of the japanese association for acute medicine Disseminated Intravascular Coagulation scoring system in patients with severe sepsis
Critical Care, 2013Co-Authors: Satoshi Gando, Hiroshi Ogura, Toshihiko Mayumi, Daizoh Saitoh, Shigeki Kushimoto, Seitaro Fujishima, Tsunetoshi Araki, Hiroto Ikeda, Joji Kotani, Yasuo MikiAbstract:Introduction To validate the Japanese Association for Acute Medicine (JAAM) Disseminated Intravascular Coagulation (DIC) scoring system in patients with severe sepsis, we conducted a multicenter, prospective study at 15 critical care centers in tertiary care hospitals.
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Disseminated Intravascular Coagulation at an early phase of trauma is associated with consumption coagulopathy and excessive fibrinolysis both by plasmin and neutrophil elastase
Surgery, 2011Co-Authors: Mineji Hayakawa, Atsushi Sawamura, Satoshi Gando, Nobuhiko Kubota, Shinji Uegaki, Hidekazu Shimojima, Masahiro Sugano, Masahiro IekoAbstract:Background The aims of the present study were to confirm the consumption coagulopathy of Disseminated Intravascular Coagulation with the fibrinolytic phenotype at an early phase of trauma and to test the hypothesis that thrombin-activatable fibrinolysis inhibitor, neutrophil elastase, and plasmin contribute to the increased fibrinolysis of this type of Disseminated Intravascular Coagulation. Furthermore, we hypothesized that Disseminated Intravascular Coagulation at an early phase of trauma progresses dependently to Disseminated Intravascular Coagulation with a thorombotic phenotype from 3 to 5 days after injury. Methods Fifty-seven trauma patients, including 30 patients with Disseminated Intravascular Coagulation and 27 patients without Disseminated Intravascular Coagulation, were studied prospectively. Levels of thrombin-activatable fibrinolysis inhibitor, tissue-type plasminogen activator plasminogen activator inhibitor-1 complex, plasmin alpha2 plasmin inhibitor complex, D-dimer, neutrophil elastase, and fibrin degradation product by neutrophil elastase were measured on days 1, 3, and 5 after trauma. The prothrombin time, fibrinogen, fibrin/fibrinogen degradation product, antithrombin, and lactate also were measured. Results Independent of the lactate levels, Disseminated Intravascular Coagulation patients showed a prolonged prothrombin time, lesser fibrinogen and antithrombin levels, and increased levels of fibrin/fibrinogen degradation product on day 1. Disseminated Intravascular Coagulation diagnosed on day 1 continued to late-phase Disseminated Intravascular Coagulation on days 3 and 5 after trauma. Increased levels of tissue-type plasminogen activator plasminogen activator inhibitor-1 complex, plasmin alpha2 plasmin inhibitor complex, D-dimer, neutrophil elastase, and fibrin degradation product by neutrophil elastase but not thrombin-activatable fibrinolysis inhibitor were observed in the Disseminated Intravascular Coagulation patients. No correlation was observed between plasmin alpha2 plasmin inhibitor complex and fibrin degradation product by neutrophil elastase in Disseminated Intravascular Coagulation patients. Multiple regression analysis showed the Disseminated Intravascular Coagulation score and the tissue-type plasminogen activator plasminogen activator inhibitor-1 complex levels on day 1 to correlate with the total volume of transfused blood. Patient prognosis deteriorated in accordance with the increasing Disseminated Intravascular Coagulation severity. Conclusion Disseminated Intravascular Coagulation at an early phase of trauma is associated with consumption coagulopathy and excessive fibrinolysis both by plasmin and neutrophil elastase independent of hypoperfusion and continues to Disseminated Intravascular Coagulation at a late phase of trauma. Increased fibrinolysis requires more blood transfusions, contributing to a poor patient outcome.
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a multicenter prospective validation of Disseminated Intravascular Coagulation diagnostic criteria for critically ill patients comparing current criteria
Critical Care Medicine, 2006Co-Authors: Satoshi Gando, Toshiaki Iba, Yutaka Eguchi, Yasuhiro Ohtomo, Kohji Okamoto, Kazuhide Koseki, Toshihiko Mayumi, Atsuo Murata, Toshiaki Ikeda, Hiroyasu IshikuraAbstract:Objectives:To validate scoring algorithm criteria established by the Japanese Association for Acute Medicine (JAAM) for Disseminated Intravascular Coagulation (DIC) and to evaluate its diagnostic property by comparing the two leading scoring systems for DIC, from the Japanese Ministry of Health and
Kazuma Yamakawa - One of the best experts on this subject based on the ideXlab platform.
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recombinant human soluble thrombomodulin in sepsis induced Disseminated Intravascular Coagulation a multicenter propensity score analysis
Intensive Care Medicine, 2013Co-Authors: Kazuma Yamakawa, Hiroshi Ogura, Satoshi Fujimi, Miki Morikawa, Yoshihito Ogawa, Tomoyoshi Mohri, Yasushi Nakamori, Yoshiaki InoueAbstract:Purpose Evidence of efficacy and safety of, and especially mortality related to, recombinant human thrombomodulin (rhTM) treatment for sepsis-induced Disseminated Intravascular Coagulation (DIC) is limited. We hypothesized that patients with sepsis-induced DIC receiving treatment with rhTM would have improved mortality compared with those with similar acuity who did not.
Hiroshi Ogura - One of the best experts on this subject based on the ideXlab platform.
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a multicenter prospective validation study of the japanese association for acute medicine Disseminated Intravascular Coagulation scoring system in patients with severe sepsis
Critical Care, 2013Co-Authors: Satoshi Gando, Hiroshi Ogura, Toshihiko Mayumi, Daizoh Saitoh, Shigeki Kushimoto, Seitaro Fujishima, Tsunetoshi Araki, Hiroto Ikeda, Joji Kotani, Yasuo MikiAbstract:Introduction To validate the Japanese Association for Acute Medicine (JAAM) Disseminated Intravascular Coagulation (DIC) scoring system in patients with severe sepsis, we conducted a multicenter, prospective study at 15 critical care centers in tertiary care hospitals.
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recombinant human soluble thrombomodulin in sepsis induced Disseminated Intravascular Coagulation a multicenter propensity score analysis
Intensive Care Medicine, 2013Co-Authors: Kazuma Yamakawa, Hiroshi Ogura, Satoshi Fujimi, Miki Morikawa, Yoshihito Ogawa, Tomoyoshi Mohri, Yasushi Nakamori, Yoshiaki InoueAbstract:Purpose Evidence of efficacy and safety of, and especially mortality related to, recombinant human thrombomodulin (rhTM) treatment for sepsis-induced Disseminated Intravascular Coagulation (DIC) is limited. We hypothesized that patients with sepsis-induced DIC receiving treatment with rhTM would have improved mortality compared with those with similar acuity who did not.
Toshihiko Mayumi - One of the best experts on this subject based on the ideXlab platform.
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a randomized controlled multicenter trial of the effects of antithrombin on Disseminated Intravascular Coagulation in patients with sepsis
Critical Care, 2013Co-Authors: Satoshi Gando, Toshihiko Mayumi, Hiroyasu Ishikura, Daizoh Saitoh, Masashi Ueyama, Yasuhiro Otomo, Shigeto Oda, Shigeki Kushimoto, Katsuhisa Tanjoh, Toshiaki IkedaAbstract:Introduction To test the hypothesis that the administration of antithrombin concentrate improves Disseminated Intravascular Coagulation (DIC), resulting in recovery from DIC and better outcomes in patients with sepsis, we conducted a prospective, randomized controlled multicenter trial at 13 critical care centers in tertiary care hospitals.
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a multicenter prospective validation study of the japanese association for acute medicine Disseminated Intravascular Coagulation scoring system in patients with severe sepsis
Critical Care, 2013Co-Authors: Satoshi Gando, Hiroshi Ogura, Toshihiko Mayumi, Daizoh Saitoh, Shigeki Kushimoto, Seitaro Fujishima, Tsunetoshi Araki, Hiroto Ikeda, Joji Kotani, Yasuo MikiAbstract:Introduction To validate the Japanese Association for Acute Medicine (JAAM) Disseminated Intravascular Coagulation (DIC) scoring system in patients with severe sepsis, we conducted a multicenter, prospective study at 15 critical care centers in tertiary care hospitals.
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a multicenter prospective validation of Disseminated Intravascular Coagulation diagnostic criteria for critically ill patients comparing current criteria
Critical Care Medicine, 2006Co-Authors: Satoshi Gando, Toshiaki Iba, Yutaka Eguchi, Yasuhiro Ohtomo, Kohji Okamoto, Kazuhide Koseki, Toshihiko Mayumi, Atsuo Murata, Toshiaki Ikeda, Hiroyasu IshikuraAbstract:Objectives:To validate scoring algorithm criteria established by the Japanese Association for Acute Medicine (JAAM) for Disseminated Intravascular Coagulation (DIC) and to evaluate its diagnostic property by comparing the two leading scoring systems for DIC, from the Japanese Ministry of Health and
Yoshiaki Inoue - One of the best experts on this subject based on the ideXlab platform.
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recombinant human soluble thrombomodulin in sepsis induced Disseminated Intravascular Coagulation a multicenter propensity score analysis
Intensive Care Medicine, 2013Co-Authors: Kazuma Yamakawa, Hiroshi Ogura, Satoshi Fujimi, Miki Morikawa, Yoshihito Ogawa, Tomoyoshi Mohri, Yasushi Nakamori, Yoshiaki InoueAbstract:Purpose Evidence of efficacy and safety of, and especially mortality related to, recombinant human thrombomodulin (rhTM) treatment for sepsis-induced Disseminated Intravascular Coagulation (DIC) is limited. We hypothesized that patients with sepsis-induced DIC receiving treatment with rhTM would have improved mortality compared with those with similar acuity who did not.