The Experts below are selected from a list of 321 Experts worldwide ranked by ideXlab platform
Christian Brenneis - One of the best experts on this subject based on the ideXlab platform.
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a widespread Distinct Pattern of cerebral atrophy in patients with alcohol addiction revealed by voxel based morphometry
Journal of Neurology Neurosurgery and Psychiatry, 2007Co-Authors: Sergei Mechtcheriakov, Christian Brenneis, Michael Schocke, Karl Egger, Florian Koppelstaetter, Josef MarksteinerAbstract:Background: Patients with alcohol addiction show a number of transient or persistent neurological and psychiatric deficits. The complexity of these brain alterations suggests that several brain areas are involved, although the definition of the brain alteration Patterns is not yet accomplished. Aim: To determine brain atrophy Patterns in patients with alcohol dependence. Methods: Voxel-based morphometry (VBM) of grey matter (GM) and white matter (WM) was performed in 22 patients with alcohol dependence and in 22 healthy controls matched for age and sex. Results: In patients with alcohol dependence, VBM of GM revealed a significant decrease in density (p Conclusions: Our findings provide evidence that alcohol addiction is associated with altered density of GM and WM of specific brain regions. This supports the assumption that alcohol dependence is associated with both local GM dysfunction and altered brain connectivity. Also, VBM is an effective tool for in vivo investigation of cerebral atrophy in patients with alcohol addiction.
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voxel based morphometry reveals a Distinct Pattern of frontal atrophy in progressive supranuclear palsy
Journal of Neurology Neurosurgery and Psychiatry, 2004Co-Authors: Christian Brenneis, K Seppi, Michael Schocke, Thomas Benke, Gregor K Wenning, W PoeweAbstract:Background: Frontal lobe atrophy is a well known neuropathological feature of progressive supranuclear palsy (PSP), accompanied by characteristic neuropsychological deficits. Objective: To determine subregional frontal lobe atrophy Patterns in patients with PSP using voxel based morphometry (VBM). Methods: VBM is an observer unbiased volumetry which allows the investigation of the entire brain. An optimised protocol for normalisation, segmentation, and correction for volume changes in preprocessing was used. Grey matter, white matter, and cerebrospinal fluid (CSF) partitions in 12 patients with probable PSP were compared with 12 healthy controls matched for age and sex. Results: In PSP patients, the following cortical areas were decreased in volume (p corr Conclusions: Frontal atrophy in PSP predominantly involves mesio-frontal targets of striatal projections. This atrophy Pattern probably accounts for cardinal PSP associated behavioural deficits.
Michael Schocke - One of the best experts on this subject based on the ideXlab platform.
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a widespread Distinct Pattern of cerebral atrophy in patients with alcohol addiction revealed by voxel based morphometry
Journal of Neurology Neurosurgery and Psychiatry, 2007Co-Authors: Sergei Mechtcheriakov, Christian Brenneis, Michael Schocke, Karl Egger, Florian Koppelstaetter, Josef MarksteinerAbstract:Background: Patients with alcohol addiction show a number of transient or persistent neurological and psychiatric deficits. The complexity of these brain alterations suggests that several brain areas are involved, although the definition of the brain alteration Patterns is not yet accomplished. Aim: To determine brain atrophy Patterns in patients with alcohol dependence. Methods: Voxel-based morphometry (VBM) of grey matter (GM) and white matter (WM) was performed in 22 patients with alcohol dependence and in 22 healthy controls matched for age and sex. Results: In patients with alcohol dependence, VBM of GM revealed a significant decrease in density (p Conclusions: Our findings provide evidence that alcohol addiction is associated with altered density of GM and WM of specific brain regions. This supports the assumption that alcohol dependence is associated with both local GM dysfunction and altered brain connectivity. Also, VBM is an effective tool for in vivo investigation of cerebral atrophy in patients with alcohol addiction.
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voxel based morphometry reveals a Distinct Pattern of frontal atrophy in progressive supranuclear palsy
Journal of Neurology Neurosurgery and Psychiatry, 2004Co-Authors: Christian Brenneis, K Seppi, Michael Schocke, Thomas Benke, Gregor K Wenning, W PoeweAbstract:Background: Frontal lobe atrophy is a well known neuropathological feature of progressive supranuclear palsy (PSP), accompanied by characteristic neuropsychological deficits. Objective: To determine subregional frontal lobe atrophy Patterns in patients with PSP using voxel based morphometry (VBM). Methods: VBM is an observer unbiased volumetry which allows the investigation of the entire brain. An optimised protocol for normalisation, segmentation, and correction for volume changes in preprocessing was used. Grey matter, white matter, and cerebrospinal fluid (CSF) partitions in 12 patients with probable PSP were compared with 12 healthy controls matched for age and sex. Results: In PSP patients, the following cortical areas were decreased in volume (p corr Conclusions: Frontal atrophy in PSP predominantly involves mesio-frontal targets of striatal projections. This atrophy Pattern probably accounts for cardinal PSP associated behavioural deficits.
Ten Feizi - One of the best experts on this subject based on the ideXlab platform.
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Collectin-43 is a serum lectin with a Distinct Pattern of carbohydrate recognition.
Immunology, 1995Co-Authors: R W Loveless, Uffe Holmskov, Ten FeiziAbstract:Collectin-43 (CL-43) is a C-type serum lectin and a member of the collectin family of soluble proteins that are effector molecules in innate immunity. We have investigated the binding specificity of CL-43 using as model systems a panel of structurally defined oligosaccharides in the form of neoglycolipids, and several glycoproteins derived from the complement glycoprotein C3 during activation of the complement cascade. A specificity is revealed towards fucose as part of the Lea oligosaccharide sequence, and towards mannose as found on high mannose-type chains. These are features shared with other serum collectins, conglutinin and mannan-binding proteins; a major difference is the lack of detectable binding by CL-43 to N-glycosidic oligosaccharides terminating in N-acetylglucosamine. CL-43 has a unique Pattern of reactivity towards high mannose-type oligosaccharides on the two glycosylation sites of C3 and derived glycoproteins: it binds to C3c (not bound by conglutinin and mannan-binding protein) but not to hydrolysed C3 [C3(H2O)], C3b or iC3b immobilized on microwells (all bound by conglutinin but not by mannan-binding protein). When these glycoproteins are sodium dodecyl sulphate (SDS)-treated and immobilized on nitrocellulose, CL-43 (but not conglutinin nor mannan-binding protein) binds strongly to C3(H2O), iC3b and C3c. The salient conclusions are, first, that there are remarkable positive or negative effects of carrier protein on oligosaccharide presentation and these differ for the individual collectins. Second, the different though partially overlapping binding Patterns among the collectins may be important for their function as circulating effector molecules with broad surveillance capabilities.
Victor D. Martinez - One of the best experts on this subject based on the ideXlab platform.
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Transcriptomic analysis of spleen infected with infectious salmon anemia virus reveals Distinct Pattern of viral replication on resistant and susceptible Atlantic salmon (Salmo salar)
Fish & shellfish immunology, 2017Co-Authors: Phillip Dettleff, Thomas Moen, Nina Santi, Victor D. MartinezAbstract:The infectious salmon anemia virus (ISAv) produces a systemic infection in salmonids, causing large losses in salmon production. However, little is known regarding the mechanisms exerting disease resistance. In this paper, we perform an RNA-seq analysis in Atlantic salmon challenged with ISAv (using individuals coming from families that were highly susceptible or highly resistant to ISAv infection). We evaluated the differential expression of both host and ISAv genes in a target organ for the virus, i.e. the spleen. The results showed differential expression of host genes related to response to stress, immune response and protein folding (genes such as; atf3, mhc, mx1-3, cd276, cd2, cocs1, c7, il10, il10rb, il13ra2, ubl-1, ifng, ifngr1, hivep2, sigle14 and sigle5). An increased protein processing activity was found in susceptible fish, which generates a subsequent unfolded protein response. We observed extreme differences in the expression of viral segments between susceptible and resistant groups, demonstrating the capacity of resistant fish to overcome the virus replication, generating a very low viral load. This phenomenon and survival of this higher resistant fish seem to be related to differences in immune and translational process, as well as to the increase of HIV-EP2 (hivep2) transcript in resistant fish, although the causal mechanism is yet to be discovered. This study provides valuable information about disease resistance mechanisms in Atlantic salmon from a host-pathogen interaction point of view.
Josef Marksteiner - One of the best experts on this subject based on the ideXlab platform.
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a widespread Distinct Pattern of cerebral atrophy in patients with alcohol addiction revealed by voxel based morphometry
Journal of Neurology Neurosurgery and Psychiatry, 2007Co-Authors: Sergei Mechtcheriakov, Christian Brenneis, Michael Schocke, Karl Egger, Florian Koppelstaetter, Josef MarksteinerAbstract:Background: Patients with alcohol addiction show a number of transient or persistent neurological and psychiatric deficits. The complexity of these brain alterations suggests that several brain areas are involved, although the definition of the brain alteration Patterns is not yet accomplished. Aim: To determine brain atrophy Patterns in patients with alcohol dependence. Methods: Voxel-based morphometry (VBM) of grey matter (GM) and white matter (WM) was performed in 22 patients with alcohol dependence and in 22 healthy controls matched for age and sex. Results: In patients with alcohol dependence, VBM of GM revealed a significant decrease in density (p Conclusions: Our findings provide evidence that alcohol addiction is associated with altered density of GM and WM of specific brain regions. This supports the assumption that alcohol dependence is associated with both local GM dysfunction and altered brain connectivity. Also, VBM is an effective tool for in vivo investigation of cerebral atrophy in patients with alcohol addiction.
