The Experts below are selected from a list of 513399 Experts worldwide ranked by ideXlab platform
Yunjiang Qiu - One of the best experts on this subject based on the ideXlab platform.
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common DNA Sequence variation influences 3 dimensional conformation of the human genome
Genome Biology, 2019Co-Authors: David U Gorkin, Yunjiang Qiu, Kipper Fletezbrant, Tristin Liu, Anthony D Schmitt, Amina Noor, Joshua Chiou, Kyle J Gaulton, Jonathan SebatAbstract:The 3-dimensional (3D) conformation of chromatin inside the nucleus is integral to a variety of nuclear processes including transcriptional regulation, DNA replication, and DNA damage repair. Aberrations in 3D chromatin conformation have been implicated in developmental abnormalities and cancer. Despite the importance of 3D chromatin conformation to cellular function and human health, little is known about how 3D chromatin conformation varies in the human population, or whether DNA Sequence variation between individuals influences 3D chromatin conformation. To address these questions, we perform Hi-C on lymphoblastoid cell lines from 20 individuals. We identify thousands of regions across the genome where 3D chromatin conformation varies between individuals and find that this variation is often accompanied by variation in gene expression, histone modifications, and transcription factor binding. Moreover, we find that DNA Sequence variation influences several features of 3D chromatin conformation including loop strength, contact insulation, contact directionality, and density of local cis contacts. We map hundreds of quantitative trait loci associated with 3D chromatin features and find evidence that some of these same variants are associated at modest levels with other molecular phenotypes as well as complex disease risk. Our results demonstrate that common DNA Sequence variants can influence 3D chromatin conformation, pointing to a more pervasive role for 3D chromatin conformation in human phenotypic variation than previously recognized.
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common DNA Sequence variation influences 3 dimensional conformation of the human genome
bioRxiv, 2019Co-Authors: David U Gorkin, Yunjiang Qiu, Kipper Fletezbrant, Tristin Liu, Anthony D Schmitt, Amina Noor, Joshua Chiou, Kyle J GaultonAbstract:ABSTRACT The 3-dimensional (3D) conformation of chromatin inside the nucleus is integral to a variety of nuclear processes including transcriptional regulation, DNA replication, and DNA damage repair. Aberrations in 3D chromatin conformation have been implicated in developmental abnormalities and cancer. Despite the importance of 3D chromatin conformation to cellular function and human health, little is known about how 3D chromatin conformation varies in the human population, or whether DNA Sequence variation between individuals influences 3D chromatin conformation. To address these questions, we performed Hi-C on Lymphoblastoid Cell Lines (LCLs) from 20 individuals. We identified thousands of regions across the genome where 3D chromatin conformation varies between individuals and found that this conformational variation is often accompanied by variation in gene expression, histone modifications, and transcription factor (TF) binding. Moreover, we found that DNA Sequence variation influences several features of 3D chromatin conformation including loop strength, contact insulation, contact directionality and density of local cis contacts. We mapped hundreds of Quantitative Trait Loci (QTLs) associated with 3D chromatin features and found evidence that some of these same variants are associated at modest levels with other molecular phenotypes as well as complex disease risk. Our results demonstrate that common DNA Sequence variants can influence 3D chromatin conformation, pointing to a more pervasive role for 3D chromatin conformation in human phenotypic variation than previously recognized.
Jonathan Sebat - One of the best experts on this subject based on the ideXlab platform.
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common DNA Sequence variation influences 3 dimensional conformation of the human genome
Genome Biology, 2019Co-Authors: David U Gorkin, Yunjiang Qiu, Kipper Fletezbrant, Tristin Liu, Anthony D Schmitt, Amina Noor, Joshua Chiou, Kyle J Gaulton, Jonathan SebatAbstract:The 3-dimensional (3D) conformation of chromatin inside the nucleus is integral to a variety of nuclear processes including transcriptional regulation, DNA replication, and DNA damage repair. Aberrations in 3D chromatin conformation have been implicated in developmental abnormalities and cancer. Despite the importance of 3D chromatin conformation to cellular function and human health, little is known about how 3D chromatin conformation varies in the human population, or whether DNA Sequence variation between individuals influences 3D chromatin conformation. To address these questions, we perform Hi-C on lymphoblastoid cell lines from 20 individuals. We identify thousands of regions across the genome where 3D chromatin conformation varies between individuals and find that this variation is often accompanied by variation in gene expression, histone modifications, and transcription factor binding. Moreover, we find that DNA Sequence variation influences several features of 3D chromatin conformation including loop strength, contact insulation, contact directionality, and density of local cis contacts. We map hundreds of quantitative trait loci associated with 3D chromatin features and find evidence that some of these same variants are associated at modest levels with other molecular phenotypes as well as complex disease risk. Our results demonstrate that common DNA Sequence variants can influence 3D chromatin conformation, pointing to a more pervasive role for 3D chromatin conformation in human phenotypic variation than previously recognized.
Shiguo Lian - One of the best experts on this subject based on the ideXlab platform.
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a novel color image encryption algorithm based on DNA Sequence operation and hyper chaotic system
Journal of Systems and Software, 2012Co-Authors: Xiaopeng Wei, Qiang Zhang, Ling Guo, Jianxin Zhang, Shiguo LianAbstract:A new color image encryption algorithm based on DNA (Deoxyribonucleic acid) Sequence addition operation is presented. Firstly, three DNA Sequence matrices are obtained by encoding the original color image which can be converted into three matrices R, G and B. Secondly, we use the chaotic Sequences generated by Chen's hyper-chaotic maps to scramble the locations of elements from three DNA Sequence matrices, and then divide three DNA Sequence matrices into some equal blocks respectively. Thirdly, we add these blocks by using DNA Sequence addition operation and Chen's hyper-chaotic maps. At last, by decoding the DNA Sequence matrices and recombining the three channels R, G and B, we get the encrypted color image. The simulation results and security analysis show that our algorithm not only has good encryption effect, but also has the ability of resisting exhaustive attack, statistical attack and differential attack.
David U Gorkin - One of the best experts on this subject based on the ideXlab platform.
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common DNA Sequence variation influences 3 dimensional conformation of the human genome
Genome Biology, 2019Co-Authors: David U Gorkin, Yunjiang Qiu, Kipper Fletezbrant, Tristin Liu, Anthony D Schmitt, Amina Noor, Joshua Chiou, Kyle J Gaulton, Jonathan SebatAbstract:The 3-dimensional (3D) conformation of chromatin inside the nucleus is integral to a variety of nuclear processes including transcriptional regulation, DNA replication, and DNA damage repair. Aberrations in 3D chromatin conformation have been implicated in developmental abnormalities and cancer. Despite the importance of 3D chromatin conformation to cellular function and human health, little is known about how 3D chromatin conformation varies in the human population, or whether DNA Sequence variation between individuals influences 3D chromatin conformation. To address these questions, we perform Hi-C on lymphoblastoid cell lines from 20 individuals. We identify thousands of regions across the genome where 3D chromatin conformation varies between individuals and find that this variation is often accompanied by variation in gene expression, histone modifications, and transcription factor binding. Moreover, we find that DNA Sequence variation influences several features of 3D chromatin conformation including loop strength, contact insulation, contact directionality, and density of local cis contacts. We map hundreds of quantitative trait loci associated with 3D chromatin features and find evidence that some of these same variants are associated at modest levels with other molecular phenotypes as well as complex disease risk. Our results demonstrate that common DNA Sequence variants can influence 3D chromatin conformation, pointing to a more pervasive role for 3D chromatin conformation in human phenotypic variation than previously recognized.
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common DNA Sequence variation influences 3 dimensional conformation of the human genome
bioRxiv, 2019Co-Authors: David U Gorkin, Yunjiang Qiu, Kipper Fletezbrant, Tristin Liu, Anthony D Schmitt, Amina Noor, Joshua Chiou, Kyle J GaultonAbstract:ABSTRACT The 3-dimensional (3D) conformation of chromatin inside the nucleus is integral to a variety of nuclear processes including transcriptional regulation, DNA replication, and DNA damage repair. Aberrations in 3D chromatin conformation have been implicated in developmental abnormalities and cancer. Despite the importance of 3D chromatin conformation to cellular function and human health, little is known about how 3D chromatin conformation varies in the human population, or whether DNA Sequence variation between individuals influences 3D chromatin conformation. To address these questions, we performed Hi-C on Lymphoblastoid Cell Lines (LCLs) from 20 individuals. We identified thousands of regions across the genome where 3D chromatin conformation varies between individuals and found that this conformational variation is often accompanied by variation in gene expression, histone modifications, and transcription factor (TF) binding. Moreover, we found that DNA Sequence variation influences several features of 3D chromatin conformation including loop strength, contact insulation, contact directionality and density of local cis contacts. We mapped hundreds of Quantitative Trait Loci (QTLs) associated with 3D chromatin features and found evidence that some of these same variants are associated at modest levels with other molecular phenotypes as well as complex disease risk. Our results demonstrate that common DNA Sequence variants can influence 3D chromatin conformation, pointing to a more pervasive role for 3D chromatin conformation in human phenotypic variation than previously recognized.
Xiaopeng Wei - One of the best experts on this subject based on the ideXlab platform.
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a novel color image encryption algorithm based on DNA Sequence operation and hyper chaotic system
Journal of Systems and Software, 2012Co-Authors: Xiaopeng Wei, Qiang Zhang, Ling Guo, Jianxin Zhang, Shiguo LianAbstract:A new color image encryption algorithm based on DNA (Deoxyribonucleic acid) Sequence addition operation is presented. Firstly, three DNA Sequence matrices are obtained by encoding the original color image which can be converted into three matrices R, G and B. Secondly, we use the chaotic Sequences generated by Chen's hyper-chaotic maps to scramble the locations of elements from three DNA Sequence matrices, and then divide three DNA Sequence matrices into some equal blocks respectively. Thirdly, we add these blocks by using DNA Sequence addition operation and Chen's hyper-chaotic maps. At last, by decoding the DNA Sequence matrices and recombining the three channels R, G and B, we get the encrypted color image. The simulation results and security analysis show that our algorithm not only has good encryption effect, but also has the ability of resisting exhaustive attack, statistical attack and differential attack.
