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Toshiyuki Nishio - One of the best experts on this subject based on the ideXlab platform.

  • structure based analysis of Domain Function of chitin oligosaccharide deacetylase from vibrio parahaemolyticus
    FEBS Letters, 2015
    Co-Authors: Takako Hirano, Kanako Sugiyama, Yuta Sakaki, Wataru Hakamata, Samyong Park, Toshiyuki Nishio
    Abstract:

    The X-ray crystal structure of chitin oligosaccharide deacetylase from Vibrio parahaemolyticus (Vp-COD) was determined at an 1.35 A resolution. The amino acid sequence and structure of Vp-COD show that the enzyme comprises one polysaccharide deacetylase Domain (PDD) and two carbohydrate-binding Domains (CBDs). On the basis of a chitin-binding assay with Vp-COD and its CBDs-deleted mutant, it was confirmed that CBDs can adhere to chitin. The catalytic activity of the CBDs-deleted mutant was only mildly depressed compared with that of Vp-COD, indicating that CBDs are unlikely to affect the configuration of the active center residues in active site of PDD.

  • Structure‐based analysis of Domain Function of chitin oligosaccharide deacetylase from Vibrio parahaemolyticus
    FEBS Letters, 2014
    Co-Authors: Takako Hirano, Kanako Sugiyama, Yuta Sakaki, Wataru Hakamata, Samyong Park, Toshiyuki Nishio
    Abstract:

    The X-ray crystal structure of chitin oligosaccharide deacetylase from Vibrio parahaemolyticus (Vp-COD) was determined at an 1.35 A resolution. The amino acid sequence and structure of Vp-COD show that the enzyme comprises one polysaccharide deacetylase Domain (PDD) and two carbohydrate-binding Domains (CBDs). On the basis of a chitin-binding assay with Vp-COD and its CBDs-deleted mutant, it was confirmed that CBDs can adhere to chitin. The catalytic activity of the CBDs-deleted mutant was only mildly depressed compared with that of Vp-COD, indicating that CBDs are unlikely to affect the configuration of the active center residues in active site of PDD.

Richard B. Lipto - One of the best experts on this subject based on the ideXlab platform.

  • Positively worded subscale score of the Perceived Stress Scale is associated with cognitive Domain Function.
    Journal of Behavioral and Brain Science, 2017
    Co-Authors: Julie M. Jiang, Elizabeth K. Seng, Molly E. Zimmerman, Richard B. Lipto
    Abstract:

    Objectives: To examine the cross-sectional associations of the separate subscales of the Perceived Stress Scale (PSS) and tests measuring cognitive Domains in older adults. Methods: 897 adults over the age of 70 free of amnestic mild cognitive impairment and dementia and enrolled in the Einstein Aging Study made up the study sample. The PSS-14 was used to measure stress. Three cognitive Domains (language, episodic memory, and frontal-executive) had previously been found using principle component analysis. Linear regression analyses were used to determine the relationship between the PSS subscales and cognitive Domain Function. Results: The study sample had a mean age of 79.1 years and 62.8% were female. Bivariate correlations show that the PSS-14 positively worded subscale of the PSS (PSS-PW) was significantly associated with all three cognitive Domains (language: r = -0.15, p < 0.001; episodic memory: r = -0.16, p < 0.001; frontal-executive: r = -0.21, p

  • positively worded subscale score of the perceived stress scale is associated with cognitive Domain Function
    Journal of Behavioral and Brain Science, 2017
    Co-Authors: Julie M. Jiang, Elizabeth K. Seng, Molly E. Zimmerman, Richard B. Lipto
    Abstract:

    Objectives: To examine the cross-sectional associations of the separate subscales of the Perceived Stress Scale (PSS) and tests measuring cognitive Domains in older adults. Methods: 897 adults over the age of 70 free of amnestic mild cognitive impairment and dementia and enrolled in the Einstein Aging Study made up the study sample. The PSS-14 was used to measure stress. Three cognitive Domains (language, episodic memory, and frontal-executive) had previously been found using principle component analysis. Linear regression analyses were used to determine the relationship between the PSS subscales and cognitive Domain Function. Results: The study sample had a mean age of 79.1 years and 62.8% were female. Bivariate correlations show that the PSS-14 positively worded subscale of the PSS (PSS-PW) was significantly associated with all three cognitive Domains (language: r = -0.15, p < 0.001; episodic memory: r = -0.16, p < 0.001; frontal-executive: r = -0.21, p <0.001) while the negatively worded subscale of the PSS (PSS-NW) was not significantly associated with any cognitive Domain. In linear regression analyses adjusted for age, white race, gender, years of education, and depressive symptoms, the PSS-PW remained significantly associated with each of the cognitive Domains. The PSS-NW was not associated with any cognitive Domains in any model. The PSS-14 was significantly associated with language and episodic memory, but not the frontal-executive Domain. Conclusion: Worse PSS-PW scores are associated with reduced cognitive Function in the executive, memory, and language Domains in nondemented older adults. The PSS-PW subscale correlated better with cognitive Function than the overall PSS-14. Future research should evaluate the temporality of the association and if stress reduction therapies improve cognitive performance.

  • Positively worded subscale score of the Perceived Stress Scale is associated with cognitive Domain Function.
    Journal of Behavioral and Brain Science, 2017
    Co-Authors: Julie M. Jiang, Elizabeth K. Seng, Molly E. Zimmerman, Mimi Kim, Richard B. Lipto
    Abstract:

    Objectives: To examine the cross-sectional associations of the separate subscales of the Perceived Stress Scale (PSS) and tests measuring cognitive Domains in older adults. Methods: 897 adults over the age of 70 free of amnestic mild cognitive impairment and dementia and enrolled in the Einstein Aging Study made up the study sample. The PSS-14 was used to measure stress. Three cognitive Domains (language, episodic memory, and frontal-executive) had previously been found using principle component analysis. Linear regression analyses were used to determine the relationship between the PSS subscales and cognitive Domain Function. Results: The study sample had a mean age of 79.1 years and 62.8% were female. Bivariate correlations show that the PSS-14 positively worded subscale of the PSS (PSS-PW) was significantly associated with all three cognitive Domains (language: r = -0.15, p Conclusion: Worse PSS-PW scores are associated with reduced cognitive Function in the executive, memory, and language Domains in nondemented older adults. The PSS-PW subscale correlated better with cognitive Function than the overall PSS-14. Future research should evaluate the temporality of the association and if stress reduction therapies improve cognitive performance.

Takako Hirano - One of the best experts on this subject based on the ideXlab platform.

  • structure based analysis of Domain Function of chitin oligosaccharide deacetylase from vibrio parahaemolyticus
    FEBS Letters, 2015
    Co-Authors: Takako Hirano, Kanako Sugiyama, Yuta Sakaki, Wataru Hakamata, Samyong Park, Toshiyuki Nishio
    Abstract:

    The X-ray crystal structure of chitin oligosaccharide deacetylase from Vibrio parahaemolyticus (Vp-COD) was determined at an 1.35 A resolution. The amino acid sequence and structure of Vp-COD show that the enzyme comprises one polysaccharide deacetylase Domain (PDD) and two carbohydrate-binding Domains (CBDs). On the basis of a chitin-binding assay with Vp-COD and its CBDs-deleted mutant, it was confirmed that CBDs can adhere to chitin. The catalytic activity of the CBDs-deleted mutant was only mildly depressed compared with that of Vp-COD, indicating that CBDs are unlikely to affect the configuration of the active center residues in active site of PDD.

  • Structure‐based analysis of Domain Function of chitin oligosaccharide deacetylase from Vibrio parahaemolyticus
    FEBS Letters, 2014
    Co-Authors: Takako Hirano, Kanako Sugiyama, Yuta Sakaki, Wataru Hakamata, Samyong Park, Toshiyuki Nishio
    Abstract:

    The X-ray crystal structure of chitin oligosaccharide deacetylase from Vibrio parahaemolyticus (Vp-COD) was determined at an 1.35 A resolution. The amino acid sequence and structure of Vp-COD show that the enzyme comprises one polysaccharide deacetylase Domain (PDD) and two carbohydrate-binding Domains (CBDs). On the basis of a chitin-binding assay with Vp-COD and its CBDs-deleted mutant, it was confirmed that CBDs can adhere to chitin. The catalytic activity of the CBDs-deleted mutant was only mildly depressed compared with that of Vp-COD, indicating that CBDs are unlikely to affect the configuration of the active center residues in active site of PDD.

Julie M. Jiang - One of the best experts on this subject based on the ideXlab platform.

  • Positively worded subscale score of the Perceived Stress Scale is associated with cognitive Domain Function.
    Journal of Behavioral and Brain Science, 2017
    Co-Authors: Julie M. Jiang, Elizabeth K. Seng, Molly E. Zimmerman, Richard B. Lipto
    Abstract:

    Objectives: To examine the cross-sectional associations of the separate subscales of the Perceived Stress Scale (PSS) and tests measuring cognitive Domains in older adults. Methods: 897 adults over the age of 70 free of amnestic mild cognitive impairment and dementia and enrolled in the Einstein Aging Study made up the study sample. The PSS-14 was used to measure stress. Three cognitive Domains (language, episodic memory, and frontal-executive) had previously been found using principle component analysis. Linear regression analyses were used to determine the relationship between the PSS subscales and cognitive Domain Function. Results: The study sample had a mean age of 79.1 years and 62.8% were female. Bivariate correlations show that the PSS-14 positively worded subscale of the PSS (PSS-PW) was significantly associated with all three cognitive Domains (language: r = -0.15, p < 0.001; episodic memory: r = -0.16, p < 0.001; frontal-executive: r = -0.21, p

  • positively worded subscale score of the perceived stress scale is associated with cognitive Domain Function
    Journal of Behavioral and Brain Science, 2017
    Co-Authors: Julie M. Jiang, Elizabeth K. Seng, Molly E. Zimmerman, Richard B. Lipto
    Abstract:

    Objectives: To examine the cross-sectional associations of the separate subscales of the Perceived Stress Scale (PSS) and tests measuring cognitive Domains in older adults. Methods: 897 adults over the age of 70 free of amnestic mild cognitive impairment and dementia and enrolled in the Einstein Aging Study made up the study sample. The PSS-14 was used to measure stress. Three cognitive Domains (language, episodic memory, and frontal-executive) had previously been found using principle component analysis. Linear regression analyses were used to determine the relationship between the PSS subscales and cognitive Domain Function. Results: The study sample had a mean age of 79.1 years and 62.8% were female. Bivariate correlations show that the PSS-14 positively worded subscale of the PSS (PSS-PW) was significantly associated with all three cognitive Domains (language: r = -0.15, p < 0.001; episodic memory: r = -0.16, p < 0.001; frontal-executive: r = -0.21, p <0.001) while the negatively worded subscale of the PSS (PSS-NW) was not significantly associated with any cognitive Domain. In linear regression analyses adjusted for age, white race, gender, years of education, and depressive symptoms, the PSS-PW remained significantly associated with each of the cognitive Domains. The PSS-NW was not associated with any cognitive Domains in any model. The PSS-14 was significantly associated with language and episodic memory, but not the frontal-executive Domain. Conclusion: Worse PSS-PW scores are associated with reduced cognitive Function in the executive, memory, and language Domains in nondemented older adults. The PSS-PW subscale correlated better with cognitive Function than the overall PSS-14. Future research should evaluate the temporality of the association and if stress reduction therapies improve cognitive performance.

  • Positively worded subscale score of the Perceived Stress Scale is associated with cognitive Domain Function.
    Journal of Behavioral and Brain Science, 2017
    Co-Authors: Julie M. Jiang, Elizabeth K. Seng, Molly E. Zimmerman, Mimi Kim, Richard B. Lipto
    Abstract:

    Objectives: To examine the cross-sectional associations of the separate subscales of the Perceived Stress Scale (PSS) and tests measuring cognitive Domains in older adults. Methods: 897 adults over the age of 70 free of amnestic mild cognitive impairment and dementia and enrolled in the Einstein Aging Study made up the study sample. The PSS-14 was used to measure stress. Three cognitive Domains (language, episodic memory, and frontal-executive) had previously been found using principle component analysis. Linear regression analyses were used to determine the relationship between the PSS subscales and cognitive Domain Function. Results: The study sample had a mean age of 79.1 years and 62.8% were female. Bivariate correlations show that the PSS-14 positively worded subscale of the PSS (PSS-PW) was significantly associated with all three cognitive Domains (language: r = -0.15, p Conclusion: Worse PSS-PW scores are associated with reduced cognitive Function in the executive, memory, and language Domains in nondemented older adults. The PSS-PW subscale correlated better with cognitive Function than the overall PSS-14. Future research should evaluate the temporality of the association and if stress reduction therapies improve cognitive performance.

Yuta Sakaki - One of the best experts on this subject based on the ideXlab platform.

  • structure based analysis of Domain Function of chitin oligosaccharide deacetylase from vibrio parahaemolyticus
    FEBS Letters, 2015
    Co-Authors: Takako Hirano, Kanako Sugiyama, Yuta Sakaki, Wataru Hakamata, Samyong Park, Toshiyuki Nishio
    Abstract:

    The X-ray crystal structure of chitin oligosaccharide deacetylase from Vibrio parahaemolyticus (Vp-COD) was determined at an 1.35 A resolution. The amino acid sequence and structure of Vp-COD show that the enzyme comprises one polysaccharide deacetylase Domain (PDD) and two carbohydrate-binding Domains (CBDs). On the basis of a chitin-binding assay with Vp-COD and its CBDs-deleted mutant, it was confirmed that CBDs can adhere to chitin. The catalytic activity of the CBDs-deleted mutant was only mildly depressed compared with that of Vp-COD, indicating that CBDs are unlikely to affect the configuration of the active center residues in active site of PDD.

  • Structure‐based analysis of Domain Function of chitin oligosaccharide deacetylase from Vibrio parahaemolyticus
    FEBS Letters, 2014
    Co-Authors: Takako Hirano, Kanako Sugiyama, Yuta Sakaki, Wataru Hakamata, Samyong Park, Toshiyuki Nishio
    Abstract:

    The X-ray crystal structure of chitin oligosaccharide deacetylase from Vibrio parahaemolyticus (Vp-COD) was determined at an 1.35 A resolution. The amino acid sequence and structure of Vp-COD show that the enzyme comprises one polysaccharide deacetylase Domain (PDD) and two carbohydrate-binding Domains (CBDs). On the basis of a chitin-binding assay with Vp-COD and its CBDs-deleted mutant, it was confirmed that CBDs can adhere to chitin. The catalytic activity of the CBDs-deleted mutant was only mildly depressed compared with that of Vp-COD, indicating that CBDs are unlikely to affect the configuration of the active center residues in active site of PDD.