The Experts below are selected from a list of 11217 Experts worldwide ranked by ideXlab platform
Siya Zhang - One of the best experts on this subject based on the ideXlab platform.
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lipid acyl chain cis double bond position modulates membrane Domain Registration anti Registration
Journal of the American Chemical Society, 2019Co-Authors: Siya Zhang, Xubo LinAbstract:Inter-leaflet coupling is critical to control the dynamics of membrane Domain Registration/anti-Registration, which is important in maintaining proper biological functions. Factors such as lipid ac...
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the aliphatic chain of cholesterol modulates bilayer interleaflet coupling and Domain Registration
FEBS Letters, 2016Co-Authors: Xubo Lin, Siya Zhang, Hui Ding, Ilya Levental, Alemayehu A GorfeAbstract:Cholesterol is a necessary component and critical regulator of liquid-ordered membrane Domains. However, the structural features that determine its unique physicochemical behaviors are not fully understood. In particular, very little is known about the specific functions of the terminal aliphatic chain of cholesterol, since previous studies have focused mainly on the rigid sterol ring structure and its hydroxyl head. In the current work, we used coarse-grained molecular dynamics simulations to investigate the effect of cholesterol aliphatic chain length on the dynamics and structure of co-existing lipid Domains. We found that the aliphatic chain has no appreciable effect on phase separation per se, but it significantly affects the rate of cholesterol flip-flop and intermonolayer interaction. These effects are accompanied by changes in Domain dynamics, lateral pressure, and interleaflet coupling. Our study provides useful insight into how biological sterols modulate communication between the outer and inner surfaces of the plasma membrane and, therefore, cellular signaling. This article is protected by copyright. All rights reserved.
Sergey A. Akimov - One of the best experts on this subject based on the ideXlab platform.
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Undulations Drive Domain Registration from the Two Membrane Leaflets
Biophysical journal, 2017Co-Authors: Timur R. Galimzyanov, Peter Pohl, Peter I. Kuzmin, Sergey A. AkimovAbstract:Phase separation in biological membranes plays an important role in protein targeting and transmembrane signaling. Its occurrence in both membrane leaflets commonly gives rise to matching liquid or liquid-ordered Domains in the opposing monolayers. The underlying mechanism of such co-localization is not fully understood. The decrease of the line tension around the thicker ordered Domain constitutes an important driving force. Yet, robust Domain coupling requires an additional energy source, which we have now identified as thermal undulations. Our theoretical analysis of elastic deformations in a lipid bilayer shows that stiffer lipid Domains tend to distribute into areas with lower fluctuations of monolayer curvature. These areas naturally align in the opposing monolayers. Thus, coupling requires both membrane leafs to display a heterogeneity in splay rigidities. The heterogeneity may either originate from intrinsic lipid properties or be acquired by adsorption of peripheral molecules. Undulations and line tension act synergistically: the gain in energy due a minimized line tension is proportional to Domain radius and thus primarily fuels the Registration of smaller Domains; whereas the energetic contribution of undulations increases with membrane area and thus primarily acts to coalesce larger Domains.
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Elastic Membrane Deformations Govern Interleaflet Coupling of Lipid-Ordered Domains
Physical review letters, 2015Co-Authors: Timur R. Galimzyanov, R. J. Molotkovsky, Marine E. Bozdaganyan, Fredric S. Cohen, Peter Pohl, Sergey A. AkimovAbstract:The mechanism responsible for Domain Registration in two membrane leaflets has thus far remained enigmatic. Using continuum elasticity theory, we show that minimum line tension is achieved along the rim between thicker (ordered) and thinner (disordered) Domains by shifting the rims in opposing leaflets by a few nanometers relative to each other. Increasing surface tension yields an increase in line tension, resulting in larger Domains. Because Domain Registration is driven by lipid deformation energy, it does not require special lipid components or interactions at the membrane midplane.
G M Cortelazzo - One of the best experts on this subject based on the ideXlab platform.
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a frequency Domain technique for range data Registration
IEEE Transactions on Pattern Analysis and Machine Intelligence, 2002Co-Authors: L. Lucchese, Gianfranco Doretto, G M CortelazzoAbstract:This work introduces an original method for registering pairs of 3D views consisting of range data sets which operates in the frequency Domain. The Fourier transform allows the decoupling of the estimate of the rotation parameters from the estimate of the translation parameters, our algorithm exploits this well-known property by suggesting a three-step procedure. The rotation parameters are estimated by the first two steps through convenient representations and projections of the Fourier transforms' magnitudes and the translational displacement is recovered by the third step by means of a standard phase correlation technique after compensating one of the two views for rotation. The performance of the algorithm, which is well-suited for unsupervised Registration, is clearly assessed through extensive testing with several objects and shows that good and robust estimates of 3D rigid motion are achievable. Our algorithm can be used as a prealignment tool for more accurate space-Domain Registration techniques, like the ICP algorithm.
Xubo Lin - One of the best experts on this subject based on the ideXlab platform.
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lipid acyl chain cis double bond position modulates membrane Domain Registration anti Registration
Journal of the American Chemical Society, 2019Co-Authors: Siya Zhang, Xubo LinAbstract:Inter-leaflet coupling is critical to control the dynamics of membrane Domain Registration/anti-Registration, which is important in maintaining proper biological functions. Factors such as lipid ac...
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the aliphatic chain of cholesterol modulates bilayer interleaflet coupling and Domain Registration
FEBS Letters, 2016Co-Authors: Xubo Lin, Siya Zhang, Hui Ding, Ilya Levental, Alemayehu A GorfeAbstract:Cholesterol is a necessary component and critical regulator of liquid-ordered membrane Domains. However, the structural features that determine its unique physicochemical behaviors are not fully understood. In particular, very little is known about the specific functions of the terminal aliphatic chain of cholesterol, since previous studies have focused mainly on the rigid sterol ring structure and its hydroxyl head. In the current work, we used coarse-grained molecular dynamics simulations to investigate the effect of cholesterol aliphatic chain length on the dynamics and structure of co-existing lipid Domains. We found that the aliphatic chain has no appreciable effect on phase separation per se, but it significantly affects the rate of cholesterol flip-flop and intermonolayer interaction. These effects are accompanied by changes in Domain dynamics, lateral pressure, and interleaflet coupling. Our study provides useful insight into how biological sterols modulate communication between the outer and inner surfaces of the plasma membrane and, therefore, cellular signaling. This article is protected by copyright. All rights reserved.
Timur R. Galimzyanov - One of the best experts on this subject based on the ideXlab platform.
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Undulations Drive Domain Registration from the Two Membrane Leaflets
Biophysical journal, 2017Co-Authors: Timur R. Galimzyanov, Peter Pohl, Peter I. Kuzmin, Sergey A. AkimovAbstract:Phase separation in biological membranes plays an important role in protein targeting and transmembrane signaling. Its occurrence in both membrane leaflets commonly gives rise to matching liquid or liquid-ordered Domains in the opposing monolayers. The underlying mechanism of such co-localization is not fully understood. The decrease of the line tension around the thicker ordered Domain constitutes an important driving force. Yet, robust Domain coupling requires an additional energy source, which we have now identified as thermal undulations. Our theoretical analysis of elastic deformations in a lipid bilayer shows that stiffer lipid Domains tend to distribute into areas with lower fluctuations of monolayer curvature. These areas naturally align in the opposing monolayers. Thus, coupling requires both membrane leafs to display a heterogeneity in splay rigidities. The heterogeneity may either originate from intrinsic lipid properties or be acquired by adsorption of peripheral molecules. Undulations and line tension act synergistically: the gain in energy due a minimized line tension is proportional to Domain radius and thus primarily fuels the Registration of smaller Domains; whereas the energetic contribution of undulations increases with membrane area and thus primarily acts to coalesce larger Domains.
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Elastic Membrane Deformations Govern Interleaflet Coupling of Lipid-Ordered Domains
Physical review letters, 2015Co-Authors: Timur R. Galimzyanov, R. J. Molotkovsky, Marine E. Bozdaganyan, Fredric S. Cohen, Peter Pohl, Sergey A. AkimovAbstract:The mechanism responsible for Domain Registration in two membrane leaflets has thus far remained enigmatic. Using continuum elasticity theory, we show that minimum line tension is achieved along the rim between thicker (ordered) and thinner (disordered) Domains by shifting the rims in opposing leaflets by a few nanometers relative to each other. Increasing surface tension yields an increase in line tension, resulting in larger Domains. Because Domain Registration is driven by lipid deformation energy, it does not require special lipid components or interactions at the membrane midplane.