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John Henderson - One of the best experts on this subject based on the ideXlab platform.

  • household Chemicals persistent wheezing and lung function effect modification by atopy
    European Respiratory Journal, 2008
    Co-Authors: John Henderson, Andrea Sherriff, Alexandra Farrow, J G Ayres
    Abstract:

    The aims of the present study were to assess the effects of maternal use of Domestic Chemicals during pregnancy on wheezing and lung function in children aged ≤8.5 yrs and to explore the potential modifying effect of atopy. In the Avon Longitudinal Study of Parents and Children, a cohort study, a maternal composite household Chemical exposure (CHCE) score was derived. Wheezing phenotypes from birth to age 7 yrs were assigned on the basis of reported wheeze. Lung function (forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced midexpiratory flow between 25 and 75% of FVC (FEF25–75%)) was measured at age 8.5 yrs; and atopy by skin-prick tests at age 7.5 yrs. Multinomial logistic and linear regression models assessed the relationship between wheezing outcomes, lung function and CHCE score, and interactions with atopy. Increased CHCE score was associated with early- ( 30 months) wheezing in nonatopic children (adjusted odds ratio per z-score of CHCE (95% confidence interval) 1.41 (1.13–1.76), 1.43 (1.02–2.13) and 1.69 (1.19–2.41), respectively). Increasing CHCE score was associated with decrements in FEV1 and FEF25–75%. Higher Domestic Chemical exposure during pregnancy was associated with persistent wheeze and lung function abnormalities in nonatopic children. This may result from pre-natal developmental effects or post-natal irritant effects on the developing airway, but is unlikely to be mediated through increased hygiene in the home.

  • Frequent use of Chemical household products is associated with persistent wheezing in pre-school age children
    Thorax, 2005
    Co-Authors: Andrea Sherriff, Alexandra Farrow, Jean Golding, John Henderson
    Abstract:

    Background: In the UK and other developed countries the prevalence of asthma symptoms has increased in recent years. This is likely to be the result of increased exposure to environmental factors. A study was undertaken to investigate the association between maternal use of Chemical based products in the prenatal period and patterns of wheeze in early childhood. Methods: In the population based Avon Longitudinal Study of Parents and Children (ALSPAC), the frequency of use of 11 Chemical based Domestic products was determined from questionnaires completed by women during pregnancy and a total Chemical burden (TCB) score was derived. Four mutually exclusive wheezing patterns were defined for the period from birth to 42 months based on parental questionnaire responses (never wheezed, transient early wheeze, persistent wheeze, and late onset wheeze). Multinomial logistic regression models were used to assess the relationship between these wheezing outcomes and TCB exposure while accounting for numerous potential confounding variables. Complete data for analysis was available for 7019 of 13 971 (50%) children. Results: The mean (SD) TCB score was 9.4 (4.1), range 0–30. Increased use of Domestic Chemical based products was associated with persistent wheezing during early childhood (adjusted odds ratio (OR) per unit increase of TCB 1.06 (95% confidence interval (CI) 1.03 to 1.09)) but not with transient early wheeze or late onset wheeze. Children whose mothers had high TCB scores (>90th centile) were more than twice as likely to wheeze persistently throughout early childhood than children whose mothers had a low TCB score (

  • frequent use of Chemical household products is associated with persistent wheezing in pre school age children
    Thorax, 2005
    Co-Authors: Andrea Sherriff, Alexandra Farrow, Jean Golding, John Henderson
    Abstract:

    Background: In the UK and other developed countries the prevalence of asthma symptoms has increased in recent years. This is likely to be the result of increased exposure to environmental factors. A study was undertaken to investigate the association between maternal use of Chemical based products in the prenatal period and patterns of wheeze in early childhood. Methods: In the population based Avon Longitudinal Study of Parents and Children (ALSPAC), the frequency of use of 11 Chemical based Domestic products was determined from questionnaires completed by women during pregnancy and a total Chemical burden (TCB) score was derived. Four mutually exclusive wheezing patterns were defined for the period from birth to 42 months based on parental questionnaire responses (never wheezed, transient early wheeze, persistent wheeze, and late onset wheeze). Multinomial logistic regression models were used to assess the relationship between these wheezing outcomes and TCB exposure while accounting for numerous potential confounding variables. Complete data for analysis was available for 7019 of 13 971 (50%) children. Results: The mean (SD) TCB score was 9.4 (4.1), range 0–30. Increased use of Domestic Chemical based products was associated with persistent wheezing during early childhood (adjusted odds ratio (OR) per unit increase of TCB 1.06 (95% confidence interval (CI) 1.03 to 1.09)) but not with transient early wheeze or late onset wheeze. Children whose mothers had high TCB scores (>90th centile) were more than twice as likely to wheeze persistently throughout early childhood than children whose mothers had a low TCB score (<10th centile) (adjusted OR 2.3 (95% CI 1.2 to 4.4)). Conclusion: These findings suggest that frequent use of Chemical based products in the prenatal period is associated with persistent wheezing in young children. Follow up of this cohort is underway to determine whether TCB is associated with wheezing, asthma, and atopy at later stages in childhood.

Andrea Sherriff - One of the best experts on this subject based on the ideXlab platform.

  • household Chemicals persistent wheezing and lung function effect modification by atopy
    European Respiratory Journal, 2008
    Co-Authors: John Henderson, Andrea Sherriff, Alexandra Farrow, J G Ayres
    Abstract:

    The aims of the present study were to assess the effects of maternal use of Domestic Chemicals during pregnancy on wheezing and lung function in children aged ≤8.5 yrs and to explore the potential modifying effect of atopy. In the Avon Longitudinal Study of Parents and Children, a cohort study, a maternal composite household Chemical exposure (CHCE) score was derived. Wheezing phenotypes from birth to age 7 yrs were assigned on the basis of reported wheeze. Lung function (forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced midexpiratory flow between 25 and 75% of FVC (FEF25–75%)) was measured at age 8.5 yrs; and atopy by skin-prick tests at age 7.5 yrs. Multinomial logistic and linear regression models assessed the relationship between wheezing outcomes, lung function and CHCE score, and interactions with atopy. Increased CHCE score was associated with early- ( 30 months) wheezing in nonatopic children (adjusted odds ratio per z-score of CHCE (95% confidence interval) 1.41 (1.13–1.76), 1.43 (1.02–2.13) and 1.69 (1.19–2.41), respectively). Increasing CHCE score was associated with decrements in FEV1 and FEF25–75%. Higher Domestic Chemical exposure during pregnancy was associated with persistent wheeze and lung function abnormalities in nonatopic children. This may result from pre-natal developmental effects or post-natal irritant effects on the developing airway, but is unlikely to be mediated through increased hygiene in the home.

  • Frequent use of Chemical household products is associated with persistent wheezing in pre-school age children
    Thorax, 2005
    Co-Authors: Andrea Sherriff, Alexandra Farrow, Jean Golding, John Henderson
    Abstract:

    Background: In the UK and other developed countries the prevalence of asthma symptoms has increased in recent years. This is likely to be the result of increased exposure to environmental factors. A study was undertaken to investigate the association between maternal use of Chemical based products in the prenatal period and patterns of wheeze in early childhood. Methods: In the population based Avon Longitudinal Study of Parents and Children (ALSPAC), the frequency of use of 11 Chemical based Domestic products was determined from questionnaires completed by women during pregnancy and a total Chemical burden (TCB) score was derived. Four mutually exclusive wheezing patterns were defined for the period from birth to 42 months based on parental questionnaire responses (never wheezed, transient early wheeze, persistent wheeze, and late onset wheeze). Multinomial logistic regression models were used to assess the relationship between these wheezing outcomes and TCB exposure while accounting for numerous potential confounding variables. Complete data for analysis was available for 7019 of 13 971 (50%) children. Results: The mean (SD) TCB score was 9.4 (4.1), range 0–30. Increased use of Domestic Chemical based products was associated with persistent wheezing during early childhood (adjusted odds ratio (OR) per unit increase of TCB 1.06 (95% confidence interval (CI) 1.03 to 1.09)) but not with transient early wheeze or late onset wheeze. Children whose mothers had high TCB scores (>90th centile) were more than twice as likely to wheeze persistently throughout early childhood than children whose mothers had a low TCB score (

  • frequent use of Chemical household products is associated with persistent wheezing in pre school age children
    Thorax, 2005
    Co-Authors: Andrea Sherriff, Alexandra Farrow, Jean Golding, John Henderson
    Abstract:

    Background: In the UK and other developed countries the prevalence of asthma symptoms has increased in recent years. This is likely to be the result of increased exposure to environmental factors. A study was undertaken to investigate the association between maternal use of Chemical based products in the prenatal period and patterns of wheeze in early childhood. Methods: In the population based Avon Longitudinal Study of Parents and Children (ALSPAC), the frequency of use of 11 Chemical based Domestic products was determined from questionnaires completed by women during pregnancy and a total Chemical burden (TCB) score was derived. Four mutually exclusive wheezing patterns were defined for the period from birth to 42 months based on parental questionnaire responses (never wheezed, transient early wheeze, persistent wheeze, and late onset wheeze). Multinomial logistic regression models were used to assess the relationship between these wheezing outcomes and TCB exposure while accounting for numerous potential confounding variables. Complete data for analysis was available for 7019 of 13 971 (50%) children. Results: The mean (SD) TCB score was 9.4 (4.1), range 0–30. Increased use of Domestic Chemical based products was associated with persistent wheezing during early childhood (adjusted odds ratio (OR) per unit increase of TCB 1.06 (95% confidence interval (CI) 1.03 to 1.09)) but not with transient early wheeze or late onset wheeze. Children whose mothers had high TCB scores (>90th centile) were more than twice as likely to wheeze persistently throughout early childhood than children whose mothers had a low TCB score (<10th centile) (adjusted OR 2.3 (95% CI 1.2 to 4.4)). Conclusion: These findings suggest that frequent use of Chemical based products in the prenatal period is associated with persistent wheezing in young children. Follow up of this cohort is underway to determine whether TCB is associated with wheezing, asthma, and atopy at later stages in childhood.

Alexandra Farrow - One of the best experts on this subject based on the ideXlab platform.

  • household Chemicals persistent wheezing and lung function effect modification by atopy
    European Respiratory Journal, 2008
    Co-Authors: John Henderson, Andrea Sherriff, Alexandra Farrow, J G Ayres
    Abstract:

    The aims of the present study were to assess the effects of maternal use of Domestic Chemicals during pregnancy on wheezing and lung function in children aged ≤8.5 yrs and to explore the potential modifying effect of atopy. In the Avon Longitudinal Study of Parents and Children, a cohort study, a maternal composite household Chemical exposure (CHCE) score was derived. Wheezing phenotypes from birth to age 7 yrs were assigned on the basis of reported wheeze. Lung function (forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced midexpiratory flow between 25 and 75% of FVC (FEF25–75%)) was measured at age 8.5 yrs; and atopy by skin-prick tests at age 7.5 yrs. Multinomial logistic and linear regression models assessed the relationship between wheezing outcomes, lung function and CHCE score, and interactions with atopy. Increased CHCE score was associated with early- ( 30 months) wheezing in nonatopic children (adjusted odds ratio per z-score of CHCE (95% confidence interval) 1.41 (1.13–1.76), 1.43 (1.02–2.13) and 1.69 (1.19–2.41), respectively). Increasing CHCE score was associated with decrements in FEV1 and FEF25–75%. Higher Domestic Chemical exposure during pregnancy was associated with persistent wheeze and lung function abnormalities in nonatopic children. This may result from pre-natal developmental effects or post-natal irritant effects on the developing airway, but is unlikely to be mediated through increased hygiene in the home.

  • Frequent use of Chemical household products is associated with persistent wheezing in pre-school age children
    Thorax, 2005
    Co-Authors: Andrea Sherriff, Alexandra Farrow, Jean Golding, John Henderson
    Abstract:

    Background: In the UK and other developed countries the prevalence of asthma symptoms has increased in recent years. This is likely to be the result of increased exposure to environmental factors. A study was undertaken to investigate the association between maternal use of Chemical based products in the prenatal period and patterns of wheeze in early childhood. Methods: In the population based Avon Longitudinal Study of Parents and Children (ALSPAC), the frequency of use of 11 Chemical based Domestic products was determined from questionnaires completed by women during pregnancy and a total Chemical burden (TCB) score was derived. Four mutually exclusive wheezing patterns were defined for the period from birth to 42 months based on parental questionnaire responses (never wheezed, transient early wheeze, persistent wheeze, and late onset wheeze). Multinomial logistic regression models were used to assess the relationship between these wheezing outcomes and TCB exposure while accounting for numerous potential confounding variables. Complete data for analysis was available for 7019 of 13 971 (50%) children. Results: The mean (SD) TCB score was 9.4 (4.1), range 0–30. Increased use of Domestic Chemical based products was associated with persistent wheezing during early childhood (adjusted odds ratio (OR) per unit increase of TCB 1.06 (95% confidence interval (CI) 1.03 to 1.09)) but not with transient early wheeze or late onset wheeze. Children whose mothers had high TCB scores (>90th centile) were more than twice as likely to wheeze persistently throughout early childhood than children whose mothers had a low TCB score (

  • frequent use of Chemical household products is associated with persistent wheezing in pre school age children
    Thorax, 2005
    Co-Authors: Andrea Sherriff, Alexandra Farrow, Jean Golding, John Henderson
    Abstract:

    Background: In the UK and other developed countries the prevalence of asthma symptoms has increased in recent years. This is likely to be the result of increased exposure to environmental factors. A study was undertaken to investigate the association between maternal use of Chemical based products in the prenatal period and patterns of wheeze in early childhood. Methods: In the population based Avon Longitudinal Study of Parents and Children (ALSPAC), the frequency of use of 11 Chemical based Domestic products was determined from questionnaires completed by women during pregnancy and a total Chemical burden (TCB) score was derived. Four mutually exclusive wheezing patterns were defined for the period from birth to 42 months based on parental questionnaire responses (never wheezed, transient early wheeze, persistent wheeze, and late onset wheeze). Multinomial logistic regression models were used to assess the relationship between these wheezing outcomes and TCB exposure while accounting for numerous potential confounding variables. Complete data for analysis was available for 7019 of 13 971 (50%) children. Results: The mean (SD) TCB score was 9.4 (4.1), range 0–30. Increased use of Domestic Chemical based products was associated with persistent wheezing during early childhood (adjusted odds ratio (OR) per unit increase of TCB 1.06 (95% confidence interval (CI) 1.03 to 1.09)) but not with transient early wheeze or late onset wheeze. Children whose mothers had high TCB scores (>90th centile) were more than twice as likely to wheeze persistently throughout early childhood than children whose mothers had a low TCB score (<10th centile) (adjusted OR 2.3 (95% CI 1.2 to 4.4)). Conclusion: These findings suggest that frequent use of Chemical based products in the prenatal period is associated with persistent wheezing in young children. Follow up of this cohort is underway to determine whether TCB is associated with wheezing, asthma, and atopy at later stages in childhood.

Jean Golding - One of the best experts on this subject based on the ideXlab platform.

  • Frequent use of Chemical household products is associated with persistent wheezing in pre-school age children
    Thorax, 2005
    Co-Authors: Andrea Sherriff, Alexandra Farrow, Jean Golding, John Henderson
    Abstract:

    Background: In the UK and other developed countries the prevalence of asthma symptoms has increased in recent years. This is likely to be the result of increased exposure to environmental factors. A study was undertaken to investigate the association between maternal use of Chemical based products in the prenatal period and patterns of wheeze in early childhood. Methods: In the population based Avon Longitudinal Study of Parents and Children (ALSPAC), the frequency of use of 11 Chemical based Domestic products was determined from questionnaires completed by women during pregnancy and a total Chemical burden (TCB) score was derived. Four mutually exclusive wheezing patterns were defined for the period from birth to 42 months based on parental questionnaire responses (never wheezed, transient early wheeze, persistent wheeze, and late onset wheeze). Multinomial logistic regression models were used to assess the relationship between these wheezing outcomes and TCB exposure while accounting for numerous potential confounding variables. Complete data for analysis was available for 7019 of 13 971 (50%) children. Results: The mean (SD) TCB score was 9.4 (4.1), range 0–30. Increased use of Domestic Chemical based products was associated with persistent wheezing during early childhood (adjusted odds ratio (OR) per unit increase of TCB 1.06 (95% confidence interval (CI) 1.03 to 1.09)) but not with transient early wheeze or late onset wheeze. Children whose mothers had high TCB scores (>90th centile) were more than twice as likely to wheeze persistently throughout early childhood than children whose mothers had a low TCB score (

  • frequent use of Chemical household products is associated with persistent wheezing in pre school age children
    Thorax, 2005
    Co-Authors: Andrea Sherriff, Alexandra Farrow, Jean Golding, John Henderson
    Abstract:

    Background: In the UK and other developed countries the prevalence of asthma symptoms has increased in recent years. This is likely to be the result of increased exposure to environmental factors. A study was undertaken to investigate the association between maternal use of Chemical based products in the prenatal period and patterns of wheeze in early childhood. Methods: In the population based Avon Longitudinal Study of Parents and Children (ALSPAC), the frequency of use of 11 Chemical based Domestic products was determined from questionnaires completed by women during pregnancy and a total Chemical burden (TCB) score was derived. Four mutually exclusive wheezing patterns were defined for the period from birth to 42 months based on parental questionnaire responses (never wheezed, transient early wheeze, persistent wheeze, and late onset wheeze). Multinomial logistic regression models were used to assess the relationship between these wheezing outcomes and TCB exposure while accounting for numerous potential confounding variables. Complete data for analysis was available for 7019 of 13 971 (50%) children. Results: The mean (SD) TCB score was 9.4 (4.1), range 0–30. Increased use of Domestic Chemical based products was associated with persistent wheezing during early childhood (adjusted odds ratio (OR) per unit increase of TCB 1.06 (95% confidence interval (CI) 1.03 to 1.09)) but not with transient early wheeze or late onset wheeze. Children whose mothers had high TCB scores (>90th centile) were more than twice as likely to wheeze persistently throughout early childhood than children whose mothers had a low TCB score (<10th centile) (adjusted OR 2.3 (95% CI 1.2 to 4.4)). Conclusion: These findings suggest that frequent use of Chemical based products in the prenatal period is associated with persistent wheezing in young children. Follow up of this cohort is underway to determine whether TCB is associated with wheezing, asthma, and atopy at later stages in childhood.

Liudmyla Koval - One of the best experts on this subject based on the ideXlab platform.

  • DEVELOPMENT OF Chemical INDUSTRY IN UKRAINE AND THE WORLD: COMPARATIVE ESTIMATION
    Vol 18 No 2 (2019), 2019
    Co-Authors: Svitlana Ishchuk, Liudmyla Koval
    Abstract:

    The main trends of the Chemical industry development in globalization changes terms are investigated. The share of Ukraine in Chemical products export of TOP-10 world Chemical market participants and the European Union countries is determined. A comparative estimation of Chemicals and pharmaceuticals production dynamics, as well as the structure of foreign trade (export / import) of these products in Ukraine and the EU-28 is conducted. The prospects for the Domestic Chemical industry development are outlined based on the calculation of Ukrainian and the EU members Chemical enterprises main functioning indicators. The measures for innovation activity activation and the institutional reforms in Ukraine on purpose of the Chemical production competitiveness increasing are proposed.

  • DEVELOPMENT OF Chemical INDUSTRY IN UKRAINE AND THE WORLD: COMPARATIVE ESTIMATION
    2019
    Co-Authors: Svitlana Ishchuk, Liudmyla Koval
    Abstract:

    The main trends of the Chemical industry development in globalization changes terms are investigated. The share of Ukraine in Chemical products export of TOP-10 world Chemical market participants and the European Union countries is determined. A comparative estimation of Chemicals and pharmaceuticals production dynamics, as well as the structure of foreign trade (export / import) of these products in Ukraine and the EU-28 is conducted. The prospects for the Domestic Chemical industry development are outlined based on the calculation of Ukrainian and the EU members Chemical enterprises main functioning indicators. The measures for innovation activity activation and the institutional reforms in Ukraine on purpose of the Chemical production competitiveness increasing are proposed. JEL: L690, O570.