The Experts below are selected from a list of 243 Experts worldwide ranked by ideXlab platform
Florent Marguet - One of the best experts on this subject based on the ideXlab platform.
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Somatic variants in autosomal Dominant Genes are a rare cause of sporadic Alzheimer's disease
Alzheimer's & Dementia: Diagnosis Assessment & Disease Monitoring, 2018Co-Authors: Gaël Nicolas, Rocio Acuna-hidalgo, Michael Keogh, Olivier Quenez, Marloes Steehouwer, Stefan Lelieveld, Stéphane Rousseau, Anne-claire Richard, Manon Oud, Florent MarguetAbstract:Introduction A minority of patients with sporadic early‐onset Alzheimer's disease (AD) exhibit de novo germ line mutations in the autosomal Dominant Genes such as APP PSEN1 , or PSEN2 . We hypothesized that negatively screened patients may harbor somatic variants in these Genes. Methods We applied an ultrasensitive approach based on single‐molecule molecular inversion probes followed by deep next generation sequencing of 11 Genes to 100 brain and 355 blood samples from 445 sporadic patients with AD (>80% exhibited an early onset,
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Somatic variants in autosomal Dominant Genes are a rare cause of sporadic Alzheimer's disease
Alzheimers & Dementia, 2018Co-Authors: Gaël Nicolas, Rocio Acuna-hidalgo, Olivier Quenez, Marloes Steehouwer, Stefan Lelieveld, Stéphane Rousseau, Anne-claire Richard, Michael J. Keogh, Florent MarguetAbstract:Abstract Introduction A minority of patients with sporadic early-onset Alzheimer's disease (AD) exhibit de novo germ line mutations in the autosomal Dominant Genes such as APP , PSEN1 , or PSEN2 . We hypothesized that negatively screened patients may harbor somatic variants in these Genes. Methods We applied an ultrasensitive approach based on single-molecule molecular inversion probes followed by deep next generation sequencing of 11 Genes to 100 brain and 355 blood samples from 445 sporadic patients with AD (>80% exhibited an early onset, Results We identified and confirmed nine somatic variants (allele fractions: 0.2%–10.8%): two APP , five SORL1 , one NCSTN , and one MARK4 variant by independent amplicon-based deep sequencing. Discussion Two of the SORL1 variant might have contributed to the disease, the two APP variants were interpreted as likely benign and the other variants remained of unknown significance. Somatic variants in the autosomal Dominant AD Genes may not be a common cause of sporadic AD, including early onset cases.
Jari P. T. Valkonen - One of the best experts on this subject based on the ideXlab platform.
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Recessive and Dominant Genes interfere with the vascular transport of Potato virus A in diploid potatoes.
Molecular Plant-microbe Interactions, 2000Co-Authors: J. H. Hämäläinen, Tuija Kekarainen, Christiane Gebhardt, Kazuo N. Watanabe, Jari P. T. ValkonenAbstract:Resistance to Potato virus A (PVA) was examined in a diploid cross involving Solanum tuberosum subsp. andigena as a resistance source. Hypersensitive resistance (HR) to PVA cosegregated with extreme resistance (ER) to Potato virus Y conferred by the Dominant gene Ryadg on chromosome XI. Hence, HR to PVA was controlled by a novel, Dominant resistance gene closely linked to Ryadg, or Ryadg recognized both viruses but conferred a different type of resistance to each virus. The HR prevented systemic infection with PVA following mechanical inoculation but not following graft inoculation. Another, recessive gene, ra, that may be linked or even allelic with Ryadg fully blocked vascular transport of PVA in graft-inoculated plants. Hence, a possibility exists that the Genes for the three types of resistance to potyviruses may reside at the same, resistance gene-rich chromosome region syntenic in solanaceous species and might be related. The gene ra acted against all of the three PVA strains tested and, therefore, ...
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recessive and Dominant Genes interfere with the vascular transport of potato virus a in diploid potatoes
Molecular Plant-microbe Interactions, 2000Co-Authors: J. H. Hämäläinen, Tuija Kekarainen, Christiane Gebhardt, Kazuo N. Watanabe, Jari P. T. ValkonenAbstract:Resistance to Potato virus A (PVA) was examined in a diploid cross involving Solanum tuberosum subsp. andigena as a resistance source. Hypersensitive resistance (HR) to PVA cosegregated with extreme resistance (ER) to Potato virus Y conferred by the Dominant gene Ry(adg) on chromosome XI. Hence, HR to PVA was controlled by a novel, Dominant resistance gene closely linked to Ry(adg), or Ry(adg) recognized both viruses but conferred a different type of resistance to each virus. The HR prevented systemic infection with PVA following mechanical inoculation but not following graft inoculation. Another, recessive gene, ra, that may be linked or even allelic with Ry(adg) fully blocked vascular transport of PVA in graft-inoculated plants. Hence, a possibility exists that the Genes for the three types of resistance to potyviruses may reside at the same, resistance gene-rich chromosome region syntenic in solanaceous species and might be related. The gene ra acted against all of the three PVA strains tested and, therefore, the avirulence determinants could not be mapped. However, also, PVA strain-specific resistance was found in the progeny. It was overcome by mutations introduced into the viral genome-linked protein and the helper component proteinase and/or the coat protein.
Gaël Nicolas - One of the best experts on this subject based on the ideXlab platform.
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Somatic variants in autosomal Dominant Genes are a rare cause of sporadic Alzheimer's disease
Alzheimer's & Dementia: Diagnosis Assessment & Disease Monitoring, 2018Co-Authors: Gaël Nicolas, Rocio Acuna-hidalgo, Michael Keogh, Olivier Quenez, Marloes Steehouwer, Stefan Lelieveld, Stéphane Rousseau, Anne-claire Richard, Manon Oud, Florent MarguetAbstract:Introduction A minority of patients with sporadic early‐onset Alzheimer's disease (AD) exhibit de novo germ line mutations in the autosomal Dominant Genes such as APP PSEN1 , or PSEN2 . We hypothesized that negatively screened patients may harbor somatic variants in these Genes. Methods We applied an ultrasensitive approach based on single‐molecule molecular inversion probes followed by deep next generation sequencing of 11 Genes to 100 brain and 355 blood samples from 445 sporadic patients with AD (>80% exhibited an early onset,
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Somatic variants in autosomal Dominant Genes are a rare cause of sporadic Alzheimer's disease
Alzheimers & Dementia, 2018Co-Authors: Gaël Nicolas, Rocio Acuna-hidalgo, Olivier Quenez, Marloes Steehouwer, Stefan Lelieveld, Stéphane Rousseau, Anne-claire Richard, Michael J. Keogh, Florent MarguetAbstract:Abstract Introduction A minority of patients with sporadic early-onset Alzheimer's disease (AD) exhibit de novo germ line mutations in the autosomal Dominant Genes such as APP , PSEN1 , or PSEN2 . We hypothesized that negatively screened patients may harbor somatic variants in these Genes. Methods We applied an ultrasensitive approach based on single-molecule molecular inversion probes followed by deep next generation sequencing of 11 Genes to 100 brain and 355 blood samples from 445 sporadic patients with AD (>80% exhibited an early onset, Results We identified and confirmed nine somatic variants (allele fractions: 0.2%–10.8%): two APP , five SORL1 , one NCSTN , and one MARK4 variant by independent amplicon-based deep sequencing. Discussion Two of the SORL1 variant might have contributed to the disease, the two APP variants were interpreted as likely benign and the other variants remained of unknown significance. Somatic variants in the autosomal Dominant AD Genes may not be a common cause of sporadic AD, including early onset cases.
Christiane Gebhardt - One of the best experts on this subject based on the ideXlab platform.
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Recessive and Dominant Genes interfere with the vascular transport of Potato virus A in diploid potatoes.
Molecular Plant-microbe Interactions, 2000Co-Authors: J. H. Hämäläinen, Tuija Kekarainen, Christiane Gebhardt, Kazuo N. Watanabe, Jari P. T. ValkonenAbstract:Resistance to Potato virus A (PVA) was examined in a diploid cross involving Solanum tuberosum subsp. andigena as a resistance source. Hypersensitive resistance (HR) to PVA cosegregated with extreme resistance (ER) to Potato virus Y conferred by the Dominant gene Ryadg on chromosome XI. Hence, HR to PVA was controlled by a novel, Dominant resistance gene closely linked to Ryadg, or Ryadg recognized both viruses but conferred a different type of resistance to each virus. The HR prevented systemic infection with PVA following mechanical inoculation but not following graft inoculation. Another, recessive gene, ra, that may be linked or even allelic with Ryadg fully blocked vascular transport of PVA in graft-inoculated plants. Hence, a possibility exists that the Genes for the three types of resistance to potyviruses may reside at the same, resistance gene-rich chromosome region syntenic in solanaceous species and might be related. The gene ra acted against all of the three PVA strains tested and, therefore, ...
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recessive and Dominant Genes interfere with the vascular transport of potato virus a in diploid potatoes
Molecular Plant-microbe Interactions, 2000Co-Authors: J. H. Hämäläinen, Tuija Kekarainen, Christiane Gebhardt, Kazuo N. Watanabe, Jari P. T. ValkonenAbstract:Resistance to Potato virus A (PVA) was examined in a diploid cross involving Solanum tuberosum subsp. andigena as a resistance source. Hypersensitive resistance (HR) to PVA cosegregated with extreme resistance (ER) to Potato virus Y conferred by the Dominant gene Ry(adg) on chromosome XI. Hence, HR to PVA was controlled by a novel, Dominant resistance gene closely linked to Ry(adg), or Ry(adg) recognized both viruses but conferred a different type of resistance to each virus. The HR prevented systemic infection with PVA following mechanical inoculation but not following graft inoculation. Another, recessive gene, ra, that may be linked or even allelic with Ry(adg) fully blocked vascular transport of PVA in graft-inoculated plants. Hence, a possibility exists that the Genes for the three types of resistance to potyviruses may reside at the same, resistance gene-rich chromosome region syntenic in solanaceous species and might be related. The gene ra acted against all of the three PVA strains tested and, therefore, the avirulence determinants could not be mapped. However, also, PVA strain-specific resistance was found in the progeny. It was overcome by mutations introduced into the viral genome-linked protein and the helper component proteinase and/or the coat protein.
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identification of rflp markers closely linked to the h1 gene conferring resistance to globodera rostochiensis in potato
Theoretical and Applied Genetics, 1993Co-Authors: Christiane Gebhardt, D Mugniery, Enrique Ritter, Francesco Salamini, E BonnelAbstract:Resistance to the root cyst nematode Globodera rostochiensis is an agronomic trait that is at present incorporated into most new potato varieties. Major Dominant Genes are available that originate from wild and cultivated Solanum species closely related to the cultivated European potato (Solanum tuberosum ssp. tuberosum). One of those Genes, H1, from S. Tuberosum ssp. andigena, was mapped to a distal position on potato chromosome V using restriction fragment length polymorphism (RFLP) markers. The H1 locus segregates independently from Gro1, a second Dominant gene presumably from S. Spegazzinii that confers resistance to G. Rostochiensis and which has been mapped to chromosome VII. One marker, CP113, was linked without recombination to the H1 locus.
J. H. Hämäläinen - One of the best experts on this subject based on the ideXlab platform.
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Recessive and Dominant Genes interfere with the vascular transport of Potato virus A in diploid potatoes.
Molecular Plant-microbe Interactions, 2000Co-Authors: J. H. Hämäläinen, Tuija Kekarainen, Christiane Gebhardt, Kazuo N. Watanabe, Jari P. T. ValkonenAbstract:Resistance to Potato virus A (PVA) was examined in a diploid cross involving Solanum tuberosum subsp. andigena as a resistance source. Hypersensitive resistance (HR) to PVA cosegregated with extreme resistance (ER) to Potato virus Y conferred by the Dominant gene Ryadg on chromosome XI. Hence, HR to PVA was controlled by a novel, Dominant resistance gene closely linked to Ryadg, or Ryadg recognized both viruses but conferred a different type of resistance to each virus. The HR prevented systemic infection with PVA following mechanical inoculation but not following graft inoculation. Another, recessive gene, ra, that may be linked or even allelic with Ryadg fully blocked vascular transport of PVA in graft-inoculated plants. Hence, a possibility exists that the Genes for the three types of resistance to potyviruses may reside at the same, resistance gene-rich chromosome region syntenic in solanaceous species and might be related. The gene ra acted against all of the three PVA strains tested and, therefore, ...
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recessive and Dominant Genes interfere with the vascular transport of potato virus a in diploid potatoes
Molecular Plant-microbe Interactions, 2000Co-Authors: J. H. Hämäläinen, Tuija Kekarainen, Christiane Gebhardt, Kazuo N. Watanabe, Jari P. T. ValkonenAbstract:Resistance to Potato virus A (PVA) was examined in a diploid cross involving Solanum tuberosum subsp. andigena as a resistance source. Hypersensitive resistance (HR) to PVA cosegregated with extreme resistance (ER) to Potato virus Y conferred by the Dominant gene Ry(adg) on chromosome XI. Hence, HR to PVA was controlled by a novel, Dominant resistance gene closely linked to Ry(adg), or Ry(adg) recognized both viruses but conferred a different type of resistance to each virus. The HR prevented systemic infection with PVA following mechanical inoculation but not following graft inoculation. Another, recessive gene, ra, that may be linked or even allelic with Ry(adg) fully blocked vascular transport of PVA in graft-inoculated plants. Hence, a possibility exists that the Genes for the three types of resistance to potyviruses may reside at the same, resistance gene-rich chromosome region syntenic in solanaceous species and might be related. The gene ra acted against all of the three PVA strains tested and, therefore, the avirulence determinants could not be mapped. However, also, PVA strain-specific resistance was found in the progeny. It was overcome by mutations introduced into the viral genome-linked protein and the helper component proteinase and/or the coat protein.