The Experts below are selected from a list of 153 Experts worldwide ranked by ideXlab platform

Michael H Criqui - One of the best experts on this subject based on the ideXlab platform.

  • a high ankle brachial index is associated with increased cardiovascular disease morbidity and lower quality of life
    Journal of the American College of Cardiology, 2008
    Co-Authors: Matthew A Allison, William R Hiatt, Alan T Hirsch, Joseph R Coll, Michael H Criqui
    Abstract:

    Objectives The purpose of this study is to determine if an ankle-brachial index (ABI) ≥1.40 is associated with reduced quality of life (QoL). Background Ankle-brachial index values ≥1.40 have been associated with some cardiovascular disease (CVD) risk factors and increased mortality, but the relationship to other disease morbidity such as reduced QoL has not been previously evaluated. Methods The PARTNERS (PAD Awareness, Risk and Treatment: New Resources for Survival) program was a national cross-sectional study of 7,155 patients age >50 years recruited from 350 primary care sites. All sites performed the ABI using a Doppler Device and a standardized technique. Results A total of 296 subjects had an ABI ≥1.40 in at least 1 leg, and 4,420 had an ABI between 0.90 and 1.40. Diabetes, male gender, and waist circumference were positively associated with a high ABI, and smoking and dyslipidemia were inversely associated with a high ABI. After adjustment for age, gender, and the traditional CVD risk factors, and accounting for multiple comparisons, the high ABI group had significantly higher odds for foot ulcers (p Conclusion Individuals with a high ABI have higher odds for foot ulcers and neuropathy, as well as lower scores on some physical functioning QoL domains.

  • a high ankle brachial index is associated with increased cardiovascular disease morbidity and lower quality of life
    Journal of the American College of Cardiology, 2008
    Co-Authors: Matthew A Allison, William R Hiatt, Alan T Hirsch, Joseph R Coll, Michael H Criqui
    Abstract:

    Objectives The purpose of this study is to determine if an ankle-brachial index (ABI) ≥1.40 is associated with reduced quality of life (QoL). Background Ankle-brachial index values ≥1.40 have been associated with some cardiovascular disease (CVD) risk factors and increased mortality, but the relationship to other disease morbidity such as reduced QoL has not been previously evaluated. Methods The PARTNERS (PAD Awareness, Risk and Treatment: New Resources for Survival) program was a national cross-sectional study of 7,155 patients age >50 years recruited from 350 primary care sites. All sites performed the ABI using a Doppler Device and a standardized technique. Results A total of 296 subjects had an ABI ≥1.40 in at least 1 leg, and 4,420 had an ABI between 0.90 and 1.40. Diabetes, male gender, and waist circumference were positively associated with a high ABI, and smoking and dyslipidemia were inversely associated with a high ABI. After adjustment for age, gender, and the traditional CVD risk factors, and accounting for multiple comparisons, the high ABI group had significantly higher odds for foot ulcers (p < 0.005) and borderline associations with heart failure, stroke, and neuropathy. After the same adjustments and adjusting for patients with other CVD, the high ABI group scored 2.0 points lower on the physical component scale on the Medical Outcomes Study Standard Form–36 and 5.5 points lower on the Walking Impairment Questionnaire walking distance domain (p < 0.05 for both). Conclusion Individuals with a high ABI have higher odds for foot ulcers and neuropathy, as well as lower scores on some physical functioning QoL domains.

Martin Berghoff - One of the best experts on this subject based on the ideXlab platform.

  • differential impairment of the sudomotor and nociceptor axon reflex in diabetic peripheral neuropathy
    Muscle & Nerve, 2006
    Co-Authors: Max J Hilz, Martin Berghoff, Sonja Kilo, Roy Freeman
    Abstract:

    It is not known whether C-fiber functional subclasses are differentially affected by diabetes mellitus or whether the patterns of C-fiber dysfunction are different between type 1 and type 2 diabetes. We therefore examined efferent sympathetic sudomotor and primary afferent nociceptor C-fiber function in diabetic patients. Acetylcholine (10%) was used to evoke C-fiber (axon-reflex)–mediated responses. The nociceptor (flare) response was measured using a laser Doppler Device. The sudomotor response was quantified with silastic imprints. The nociceptor C-fiber–mediated flare response was reduced in type 2 diabetic patients (P < 0.008) but was similar to controls in type 1 diabetic patients. The sympathetic C-fiber–mediated responses, including sweat volume (P < 0.05) and the number of activated sweat glands (P = 0.003), were increased in patients with type 1 diabetes. There also was a trend toward a larger axon-reflex sweat area in patients with type 1 diabetes (P = 0.09). No differences in these sweat responses were found in patients with type 2 diabetes compared to controls. These findings suggest that the functional abnormalities in diabetic peripheral neuropathy are not homogeneous and that C-fiber subclasses are differentially affected in type 1 and 2 diabetes mellitus. Muscle Nerve, 2006

  • differential impairment of the sudomotor and nociceptor axon reflex in diabetic peripheral neuropathy
    Annual meeting of the American Academy of Neurology, 2006
    Co-Authors: Max J Hilz, Martin Berghoff, Sonja Kilo, Roy Freeman
    Abstract:

    It is not known whether C-fiber functional subclasses are differentially affected by diabetes mellitus or whether the patterns of C-fiber dysfunction are different between type 1 and type 2 diabetes. We therefore examined efferent sympathetic sudomotor and primary afferent nociceptor C-fiber function in diabetic patients. Acetylcholine (10%) was used to evoke C-fiber (axon-reflex)-mediated responses. The nociceptor (flare) response was measured using a laser Doppler Device. The sudomotor response was quantified with silastic imprints. The nociceptor C-fiber-mediated flare response was reduced in type 2 diabetic patients (P < 0.008) but was similar to controls in type 1 diabetic patients. The sympathetic C-fiber-mediated responses, including sweat volume (P < 0.05) and the number of activated sweat glands (P = 0.003), were increased in patients with type 1 diabetes. There also was a trend toward a larger axon-reflex sweat area in patients with type 1 diabetes (P = 0.09). No differences in these sweat responses were found in patients with type 2 diabetes compared to controls. These findings suggest that the functional abnormalities in diabetic peripheral neuropathy are not homogeneous and that C-fiber subclasses are differentially affected in type 1 and 2 diabetes mellitus.

Matthew A Allison - One of the best experts on this subject based on the ideXlab platform.

  • a high ankle brachial index is associated with increased cardiovascular disease morbidity and lower quality of life
    Journal of the American College of Cardiology, 2008
    Co-Authors: Matthew A Allison, William R Hiatt, Alan T Hirsch, Joseph R Coll, Michael H Criqui
    Abstract:

    Objectives The purpose of this study is to determine if an ankle-brachial index (ABI) ≥1.40 is associated with reduced quality of life (QoL). Background Ankle-brachial index values ≥1.40 have been associated with some cardiovascular disease (CVD) risk factors and increased mortality, but the relationship to other disease morbidity such as reduced QoL has not been previously evaluated. Methods The PARTNERS (PAD Awareness, Risk and Treatment: New Resources for Survival) program was a national cross-sectional study of 7,155 patients age >50 years recruited from 350 primary care sites. All sites performed the ABI using a Doppler Device and a standardized technique. Results A total of 296 subjects had an ABI ≥1.40 in at least 1 leg, and 4,420 had an ABI between 0.90 and 1.40. Diabetes, male gender, and waist circumference were positively associated with a high ABI, and smoking and dyslipidemia were inversely associated with a high ABI. After adjustment for age, gender, and the traditional CVD risk factors, and accounting for multiple comparisons, the high ABI group had significantly higher odds for foot ulcers (p Conclusion Individuals with a high ABI have higher odds for foot ulcers and neuropathy, as well as lower scores on some physical functioning QoL domains.

  • a high ankle brachial index is associated with increased cardiovascular disease morbidity and lower quality of life
    Journal of the American College of Cardiology, 2008
    Co-Authors: Matthew A Allison, William R Hiatt, Alan T Hirsch, Joseph R Coll, Michael H Criqui
    Abstract:

    Objectives The purpose of this study is to determine if an ankle-brachial index (ABI) ≥1.40 is associated with reduced quality of life (QoL). Background Ankle-brachial index values ≥1.40 have been associated with some cardiovascular disease (CVD) risk factors and increased mortality, but the relationship to other disease morbidity such as reduced QoL has not been previously evaluated. Methods The PARTNERS (PAD Awareness, Risk and Treatment: New Resources for Survival) program was a national cross-sectional study of 7,155 patients age >50 years recruited from 350 primary care sites. All sites performed the ABI using a Doppler Device and a standardized technique. Results A total of 296 subjects had an ABI ≥1.40 in at least 1 leg, and 4,420 had an ABI between 0.90 and 1.40. Diabetes, male gender, and waist circumference were positively associated with a high ABI, and smoking and dyslipidemia were inversely associated with a high ABI. After adjustment for age, gender, and the traditional CVD risk factors, and accounting for multiple comparisons, the high ABI group had significantly higher odds for foot ulcers (p < 0.005) and borderline associations with heart failure, stroke, and neuropathy. After the same adjustments and adjusting for patients with other CVD, the high ABI group scored 2.0 points lower on the physical component scale on the Medical Outcomes Study Standard Form–36 and 5.5 points lower on the Walking Impairment Questionnaire walking distance domain (p < 0.05 for both). Conclusion Individuals with a high ABI have higher odds for foot ulcers and neuropathy, as well as lower scores on some physical functioning QoL domains.

Paul P M Van Zuijlen - One of the best experts on this subject based on the ideXlab platform.

  • the hand held Doppler Device for the detection of perforators in reconstructive surgery what you hear is not always what you get
    Burns, 2014
    Co-Authors: Carlijn M Stekelenburg, Pia M D G Sonneveld, Markbram Bouman, Martijn B A Van Der Wal, Dirk L Knol, Henrica C W De Vet, Paul P M Van Zuijlen
    Abstract:

    Abstract Background Perforator-based flaps have become indispensable in the treatment of burn scars. Pre-operative perforator mapping is often performed by use of the hand held Doppler Device, partly due to its convenience and the low costs. We expected to find sufficient evidence in literature to support the use of the Device, however available literature showed a distinct lack of clinimetric studies that adequately tested the reliability. Methods To assess reliability, perforator locations were mapped independently by two clinicians using an 8 MHz Doppler Device. In healthy volunteers the elbow region or the peri-umbilical region were randomly chosen to be the measurement areas of predefined squares (7 cm × 7 cm). Subsequently, the perforators within the area were mapped with Duplex to establish the validity by means of the positive predictive value. Results 20 volunteers were included. The hand held Doppler technique showed moderate reliability with a mean Dice coefficient of 0.56. Also, poor validity was found expressed by a mean positive predictive value of 55%. Conclusions Surprisingly, this study has shown that performance of the hand held Doppler Device was moderate. The Doppler should not be used alone for the detection of perforators.

Roy Freeman - One of the best experts on this subject based on the ideXlab platform.

  • differential impairment of the sudomotor and nociceptor axon reflex in diabetic peripheral neuropathy
    Muscle & Nerve, 2006
    Co-Authors: Max J Hilz, Martin Berghoff, Sonja Kilo, Roy Freeman
    Abstract:

    It is not known whether C-fiber functional subclasses are differentially affected by diabetes mellitus or whether the patterns of C-fiber dysfunction are different between type 1 and type 2 diabetes. We therefore examined efferent sympathetic sudomotor and primary afferent nociceptor C-fiber function in diabetic patients. Acetylcholine (10%) was used to evoke C-fiber (axon-reflex)–mediated responses. The nociceptor (flare) response was measured using a laser Doppler Device. The sudomotor response was quantified with silastic imprints. The nociceptor C-fiber–mediated flare response was reduced in type 2 diabetic patients (P < 0.008) but was similar to controls in type 1 diabetic patients. The sympathetic C-fiber–mediated responses, including sweat volume (P < 0.05) and the number of activated sweat glands (P = 0.003), were increased in patients with type 1 diabetes. There also was a trend toward a larger axon-reflex sweat area in patients with type 1 diabetes (P = 0.09). No differences in these sweat responses were found in patients with type 2 diabetes compared to controls. These findings suggest that the functional abnormalities in diabetic peripheral neuropathy are not homogeneous and that C-fiber subclasses are differentially affected in type 1 and 2 diabetes mellitus. Muscle Nerve, 2006

  • differential impairment of the sudomotor and nociceptor axon reflex in diabetic peripheral neuropathy
    Annual meeting of the American Academy of Neurology, 2006
    Co-Authors: Max J Hilz, Martin Berghoff, Sonja Kilo, Roy Freeman
    Abstract:

    It is not known whether C-fiber functional subclasses are differentially affected by diabetes mellitus or whether the patterns of C-fiber dysfunction are different between type 1 and type 2 diabetes. We therefore examined efferent sympathetic sudomotor and primary afferent nociceptor C-fiber function in diabetic patients. Acetylcholine (10%) was used to evoke C-fiber (axon-reflex)-mediated responses. The nociceptor (flare) response was measured using a laser Doppler Device. The sudomotor response was quantified with silastic imprints. The nociceptor C-fiber-mediated flare response was reduced in type 2 diabetic patients (P < 0.008) but was similar to controls in type 1 diabetic patients. The sympathetic C-fiber-mediated responses, including sweat volume (P < 0.05) and the number of activated sweat glands (P = 0.003), were increased in patients with type 1 diabetes. There also was a trend toward a larger axon-reflex sweat area in patients with type 1 diabetes (P = 0.09). No differences in these sweat responses were found in patients with type 2 diabetes compared to controls. These findings suggest that the functional abnormalities in diabetic peripheral neuropathy are not homogeneous and that C-fiber subclasses are differentially affected in type 1 and 2 diabetes mellitus.