The Experts below are selected from a list of 273 Experts worldwide ranked by ideXlab platform

Xuesi Chen - One of the best experts on this subject based on the ideXlab platform.

  • polypeptide Doxorubicin Hydrochloride polymersomes prepared through organic solvent free technique as a smart drug delivery platform
    Macromolecular Bioscience, 2013
    Co-Authors: Zhaohui Tang, Wantong Song, Hai Sun, Huaiyu Liu, Xuesi Chen
    Abstract:

    Rapid and efficient side-chain functionalization of polypeptide with neighboring carboxylgroups is achieved via the combination of ring-opening polymerization and subsequent thiol-yne click chemistry. The spontaneous formation of polymersomes with uniform size is found to occur in aqueous medium via electrostatic interaction between the anionic polypeptide and cationic Doxorubicin Hydrochloride (DOX·HCl). The polymersomes are taken up by A549 cells via endocytosis, with a slightly lower cytotoxicity compared with free DOX ·HCl. Moreover, the drug-loaded polymersomes exhibit the enhanced therapeutic efficacy, increase apoptosis in tumor tissues, and reduce systemic toxicity in nude mice bearing A549 lung cancer xenograft, in comparison with free DOX ·HCl.

  • Polypeptide/Doxorubicin Hydrochloride Polymersomes Prepared Through Organic Solvent-free Technique as a Smart Drug Delivery Platform
    Macromolecular bioscience, 2013
    Co-Authors: Zhaohui Tang, Wantong Song, Hai Sun, Huaiyu Liu, Xuesi Chen
    Abstract:

    Rapid and efficient side-chain functionalization of polypeptide with neighboring carboxylgroups is achieved via the combination of ring-opening polymerization and subsequent thiol-yne click chemistry. The spontaneous formation of polymersomes with uniform size is found to occur in aqueous medium via electrostatic interaction between the anionic polypeptide and cationic Doxorubicin Hydrochloride (DOX·HCl). The polymersomes are taken up by A549 cells via endocytosis, with a slightly lower cytotoxicity compared with free DOX ·HCl. Moreover, the drug-loaded polymersomes exhibit the enhanced therapeutic efficacy, increase apoptosis in tumor tissues, and reduce systemic toxicity in nude mice bearing A549 lung cancer xenograft, in comparison with free DOX ·HCl.

  • Ultrafine PEG-PLA fibers loaded with both paclitaxel and Doxorubicin Hydrochloride and their in vitro cytotoxicity.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2008
    Co-Authors: Xuesi Chen, Zhanfeng Wang, Xiabin Jing
    Abstract:

    By means of "emulsion-electrospinning", both hydrophobic and hydrophilic drugs, paclitaxel (PTX) and Doxorubicin Hydrochloride (DOX), were successfully loaded into PEG-PLA nanofiber mats to realize multi-drug delivery. The release behaviors of both the drugs from the same fiber mats were ascribed to their solubility properties and distribution status in the fibers. Due to its high hydrophilicity, DOX was easy to diffuse out from the fibers, and its release rate was always faster than that of hydrophobic PTX. Moreover, the release rate of PTX was accelerated by DOX's release from the same drug-loaded fibers. In vitro cytotoxicity against rat Glioma C6 cells indicated that the dual drug combination showed a higher inhibition and apoptosis against C6 cells than a single drug-loaded system, which suggests the promise for multi-drug delivery on combination therapy.

  • the release behavior of Doxorubicin Hydrochloride from medicated fibers prepared by emulsion electrospinning
    European Journal of Pharmaceutics and Biopharmaceutics, 2008
    Co-Authors: Xiuling Xu, Xuesi Chen, Xinri Wang, Xiabin Jing
    Abstract:

    Abstract The release behavior of a water-soluble small molecule drug from the drug-loaded nanofibers prepared by emulsion-electrospinning was investigated. Doxorubicin Hydrochloride (Dox), a water-soluble anticancer agent, was used as the model drug. The laser scanning confocal microscopic images indicated that the drug was well incorporated into amphiphilic poly(ethylene glycol)–poly( l -lactic acid) (PEG–PLA) diblock copolymer nanofibers, forming “core-sheath” structured drug-loaded nanofibers. The drug release behavior of this drug-loaded system showed a three-stage diffusion-controlled mechanism, in which the release rate of the first stage was slower than that of the second stage, but both obeyed Fick’s second law. Based on these results, it is concluded that the Dox-loaded fibers prepared by emulsion-electrospinning represent a reservoir-type delivery system in which the Dox release rate decreases with the increasing Dox content in the fibers.

K Harada - One of the best experts on this subject based on the ideXlab platform.

M Imamura - One of the best experts on this subject based on the ideXlab platform.

Zhaohui Tang - One of the best experts on this subject based on the ideXlab platform.

  • polypeptide Doxorubicin Hydrochloride polymersomes prepared through organic solvent free technique as a smart drug delivery platform
    Macromolecular Bioscience, 2013
    Co-Authors: Zhaohui Tang, Wantong Song, Hai Sun, Huaiyu Liu, Xuesi Chen
    Abstract:

    Rapid and efficient side-chain functionalization of polypeptide with neighboring carboxylgroups is achieved via the combination of ring-opening polymerization and subsequent thiol-yne click chemistry. The spontaneous formation of polymersomes with uniform size is found to occur in aqueous medium via electrostatic interaction between the anionic polypeptide and cationic Doxorubicin Hydrochloride (DOX·HCl). The polymersomes are taken up by A549 cells via endocytosis, with a slightly lower cytotoxicity compared with free DOX ·HCl. Moreover, the drug-loaded polymersomes exhibit the enhanced therapeutic efficacy, increase apoptosis in tumor tissues, and reduce systemic toxicity in nude mice bearing A549 lung cancer xenograft, in comparison with free DOX ·HCl.

  • Polypeptide/Doxorubicin Hydrochloride Polymersomes Prepared Through Organic Solvent-free Technique as a Smart Drug Delivery Platform
    Macromolecular bioscience, 2013
    Co-Authors: Zhaohui Tang, Wantong Song, Hai Sun, Huaiyu Liu, Xuesi Chen
    Abstract:

    Rapid and efficient side-chain functionalization of polypeptide with neighboring carboxylgroups is achieved via the combination of ring-opening polymerization and subsequent thiol-yne click chemistry. The spontaneous formation of polymersomes with uniform size is found to occur in aqueous medium via electrostatic interaction between the anionic polypeptide and cationic Doxorubicin Hydrochloride (DOX·HCl). The polymersomes are taken up by A549 cells via endocytosis, with a slightly lower cytotoxicity compared with free DOX ·HCl. Moreover, the drug-loaded polymersomes exhibit the enhanced therapeutic efficacy, increase apoptosis in tumor tissues, and reduce systemic toxicity in nude mice bearing A549 lung cancer xenograft, in comparison with free DOX ·HCl.

Toshihito Seki - One of the best experts on this subject based on the ideXlab platform.