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G Brem - One of the best experts on this subject based on the ideXlab platform.
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association between population structure and allele frequencies of the glycogen synthase 1 mutation in the austrian noriker Draft Horse
Animal Genetics, 2017Co-Authors: Thomas Druml, Gertrud Grilzseger, Markus Neuditschko, G BremAbstract:The aim of this study was to determine the allele frequency of the glycogen synthase 1 (GYS1) mutation associated with polysaccharide storage myopathy type 1 in the Austrian Noriker Horse. Furthermore, we examined the influence of population substructures on the allele distribution. The study was based upon a comprehensive population sample (208 breeding stallions and 309 mares) and a complete cohort of unselected offspring from the year 2014 (1553 foals). The mean proportion of GYS1 carrier animals in the foal cohort was 33%, ranging from 15% to 50% according to population substructures based on coat colours. In 517 mature breeding Horses the mutation carrier frequency reached 34%, ranging on a wider scale from 4% to 62% within genetic substructures. We could show that the occurrence of the mutated GYS1 allele is influenced by coat colour; genetic bottlenecks; and assortative, rotating and random mating strategies. Highest GYS1 carrier frequencies were observed in the chestnut sample comprising 50% in foals, 54% in mares and 62% in breeding stallions. The mean inbreeding of homozygous carrier animals reached 4.10%, whereas non-carrier Horses were characterized by an inbreeding coefficient of 3.48%. Lowest GYS1 carrier frequencies were observed in the leopard spotted Noriker subpopulation. Here the mean carrier frequency reached 15% in foals, 17% in mares and 4% in stallions and inbreeding decreased from 3.28% in homozygous non-carrier Horses to 2.70% in heterozygous Horses and 0.94% in homozygous carriers. This study illustrates that lineage breeding and specified mating strategies result in genetic substructures, which affect the frequencies of the GYS1 gene mutation.
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effect of the glycogen synthase 1 gys1 mutation on performance traits in 169 noriker Draft Horse stallions a retrospective study
Archives Animal Breeding, 2016Co-Authors: Thomas Druml, Gertrud Grilzseger, G BremAbstract:Abstract. The aim of this study was to investigate the effect of glycogen synthase 1 (GYS1) mutation on performance traits in Noriker Draft Horse stallions. Individual scores of 32 performance traits and the final performance score were obtained from 169 stallions that took part in the standardized stationary 30-day performance test throughout the years 2002 to 2014. In 2014 the stallions have been genotyped for the GYS1 mutation resulting in 105 non-mutation-carriers, 57 heterozygous, and 7 homozygous animals. The mean frequency of animals carrying the mutation was 38 % (64 of 169). The final performance score and 32 single performance traits were analyzed using a linear model including the GYS1 mutation genotype, the testing year and age as fixed effects. For the final performance score no effect of the GYS1 mutation was found. In three single traits – driving ability, Drafting manner, and kindness in the discipline heavy-load lodging – significantly lower scores for heterozygous Horses than for non-carrier animals were obtained. Homozygous animals did not differ significantly from both groups. Our results from this retrospective study suggest no effect of the GYS1 mutation on performance traits and on the final performance score.
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Effect of the glycogen synthase 1 (GYS1) mutation on performance traits in 169 Noriker Draft Horse stallions – a retrospective study
Copernicus Publications, 2016Co-Authors: Thomas Druml, G. Grilz-seger, G BremAbstract:The aim of this study was to investigate the effect of glycogen synthase 1 (GYS1) mutation on performance traits in Noriker Draft Horse stallions. Individual scores of 32 performance traits and the final performance score were obtained from 169 stallions that took part in the standardized stationary 30-day performance test throughout the years 2002 to 2014. In 2014 the stallions have been genotyped for the GYS1 mutation resulting in 105 non-mutation-carriers, 57 heterozygous, and 7 homozygous animals. The mean frequency of animals carrying the mutation was 38 % (64 of 169). The final performance score and 32 single performance traits were analyzed using a linear model including the GYS1 mutation genotype, the testing year and age as fixed effects. For the final performance score no effect of the GYS1 mutation was found. In three single traits – driving ability, Drafting manner, and kindness in the discipline heavy-load lodging – significantly lower scores for heterozygous Horses than for non-carrier animals were obtained. Homozygous animals did not differ significantly from both groups. Our results from this retrospective study suggest no effect of the GYS1 mutation on performance traits and on the final performance score
Thomas Druml - One of the best experts on this subject based on the ideXlab platform.
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association between population structure and allele frequencies of the glycogen synthase 1 mutation in the austrian noriker Draft Horse
Animal Genetics, 2017Co-Authors: Thomas Druml, Gertrud Grilzseger, Markus Neuditschko, G BremAbstract:The aim of this study was to determine the allele frequency of the glycogen synthase 1 (GYS1) mutation associated with polysaccharide storage myopathy type 1 in the Austrian Noriker Horse. Furthermore, we examined the influence of population substructures on the allele distribution. The study was based upon a comprehensive population sample (208 breeding stallions and 309 mares) and a complete cohort of unselected offspring from the year 2014 (1553 foals). The mean proportion of GYS1 carrier animals in the foal cohort was 33%, ranging from 15% to 50% according to population substructures based on coat colours. In 517 mature breeding Horses the mutation carrier frequency reached 34%, ranging on a wider scale from 4% to 62% within genetic substructures. We could show that the occurrence of the mutated GYS1 allele is influenced by coat colour; genetic bottlenecks; and assortative, rotating and random mating strategies. Highest GYS1 carrier frequencies were observed in the chestnut sample comprising 50% in foals, 54% in mares and 62% in breeding stallions. The mean inbreeding of homozygous carrier animals reached 4.10%, whereas non-carrier Horses were characterized by an inbreeding coefficient of 3.48%. Lowest GYS1 carrier frequencies were observed in the leopard spotted Noriker subpopulation. Here the mean carrier frequency reached 15% in foals, 17% in mares and 4% in stallions and inbreeding decreased from 3.28% in homozygous non-carrier Horses to 2.70% in heterozygous Horses and 0.94% in homozygous carriers. This study illustrates that lineage breeding and specified mating strategies result in genetic substructures, which affect the frequencies of the GYS1 gene mutation.
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effect of the glycogen synthase 1 gys1 mutation on performance traits in 169 noriker Draft Horse stallions a retrospective study
Archives Animal Breeding, 2016Co-Authors: Thomas Druml, Gertrud Grilzseger, G BremAbstract:Abstract. The aim of this study was to investigate the effect of glycogen synthase 1 (GYS1) mutation on performance traits in Noriker Draft Horse stallions. Individual scores of 32 performance traits and the final performance score were obtained from 169 stallions that took part in the standardized stationary 30-day performance test throughout the years 2002 to 2014. In 2014 the stallions have been genotyped for the GYS1 mutation resulting in 105 non-mutation-carriers, 57 heterozygous, and 7 homozygous animals. The mean frequency of animals carrying the mutation was 38 % (64 of 169). The final performance score and 32 single performance traits were analyzed using a linear model including the GYS1 mutation genotype, the testing year and age as fixed effects. For the final performance score no effect of the GYS1 mutation was found. In three single traits – driving ability, Drafting manner, and kindness in the discipline heavy-load lodging – significantly lower scores for heterozygous Horses than for non-carrier animals were obtained. Homozygous animals did not differ significantly from both groups. Our results from this retrospective study suggest no effect of the GYS1 mutation on performance traits and on the final performance score.
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Effect of the glycogen synthase 1 (GYS1) mutation on performance traits in 169 Noriker Draft Horse stallions – a retrospective study
Copernicus Publications, 2016Co-Authors: Thomas Druml, G. Grilz-seger, G BremAbstract:The aim of this study was to investigate the effect of glycogen synthase 1 (GYS1) mutation on performance traits in Noriker Draft Horse stallions. Individual scores of 32 performance traits and the final performance score were obtained from 169 stallions that took part in the standardized stationary 30-day performance test throughout the years 2002 to 2014. In 2014 the stallions have been genotyped for the GYS1 mutation resulting in 105 non-mutation-carriers, 57 heterozygous, and 7 homozygous animals. The mean frequency of animals carrying the mutation was 38 % (64 of 169). The final performance score and 32 single performance traits were analyzed using a linear model including the GYS1 mutation genotype, the testing year and age as fixed effects. For the final performance score no effect of the GYS1 mutation was found. In three single traits – driving ability, Drafting manner, and kindness in the discipline heavy-load lodging – significantly lower scores for heterozygous Horses than for non-carrier animals were obtained. Homozygous animals did not differ significantly from both groups. Our results from this retrospective study suggest no effect of the GYS1 mutation on performance traits and on the final performance score
Alessandra Tateo - One of the best experts on this subject based on the ideXlab platform.
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Application of Wood's model to lactation curve of Italian Heavy Draft Horse mares.
Journal of dairy science, 2012Co-Authors: Pasquale Centoducati, Aristide Maggiolino, P. De Palo, Alessandra TateoAbstract:The aim of this work was to study, using Wood's model, the lactation curve in Italian Heavy Draft Horse (IHDH) mares, both for milk yield and composition. Interest in mare's milk has grown for use in human nutrition, as a substitute for human and cow milk for premature newborns and allergic children. For this study, 7 IHDH mares were used. Milk yield was evaluated from d 15 to 180 postpartum (every 15 d). Wood's lactation model was used to describe milk yield, fat, protein, and lactose lactation curves in the first 180 d in milk (DIM), with a prediction to 210 DIM. Mean values recorded across the considered lactation period for milk yield and constituents were 16.11 kg of milk/d, 11.38 g of fat/kg, 15.54 g of protein/kg, and 69.72 g of lactose/kg. The lactation curve showed a peak at 69 DIM, with a persistence index of 6.26. Fat (g/kg) and protein (g/kg) lactation curves decreased during the lactation period; instead, the lactose (g/kg) curve increased from the first to the last DIM. The coefficient of determination values indicated a good model fit by Wood's model application to IHDH mare lactation. The research showed good aptitude of a heavy Horse breed, such as IHDH, for milk production.
Gertrud Grilzseger - One of the best experts on this subject based on the ideXlab platform.
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association between population structure and allele frequencies of the glycogen synthase 1 mutation in the austrian noriker Draft Horse
Animal Genetics, 2017Co-Authors: Thomas Druml, Gertrud Grilzseger, Markus Neuditschko, G BremAbstract:The aim of this study was to determine the allele frequency of the glycogen synthase 1 (GYS1) mutation associated with polysaccharide storage myopathy type 1 in the Austrian Noriker Horse. Furthermore, we examined the influence of population substructures on the allele distribution. The study was based upon a comprehensive population sample (208 breeding stallions and 309 mares) and a complete cohort of unselected offspring from the year 2014 (1553 foals). The mean proportion of GYS1 carrier animals in the foal cohort was 33%, ranging from 15% to 50% according to population substructures based on coat colours. In 517 mature breeding Horses the mutation carrier frequency reached 34%, ranging on a wider scale from 4% to 62% within genetic substructures. We could show that the occurrence of the mutated GYS1 allele is influenced by coat colour; genetic bottlenecks; and assortative, rotating and random mating strategies. Highest GYS1 carrier frequencies were observed in the chestnut sample comprising 50% in foals, 54% in mares and 62% in breeding stallions. The mean inbreeding of homozygous carrier animals reached 4.10%, whereas non-carrier Horses were characterized by an inbreeding coefficient of 3.48%. Lowest GYS1 carrier frequencies were observed in the leopard spotted Noriker subpopulation. Here the mean carrier frequency reached 15% in foals, 17% in mares and 4% in stallions and inbreeding decreased from 3.28% in homozygous non-carrier Horses to 2.70% in heterozygous Horses and 0.94% in homozygous carriers. This study illustrates that lineage breeding and specified mating strategies result in genetic substructures, which affect the frequencies of the GYS1 gene mutation.
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effect of the glycogen synthase 1 gys1 mutation on performance traits in 169 noriker Draft Horse stallions a retrospective study
Archives Animal Breeding, 2016Co-Authors: Thomas Druml, Gertrud Grilzseger, G BremAbstract:Abstract. The aim of this study was to investigate the effect of glycogen synthase 1 (GYS1) mutation on performance traits in Noriker Draft Horse stallions. Individual scores of 32 performance traits and the final performance score were obtained from 169 stallions that took part in the standardized stationary 30-day performance test throughout the years 2002 to 2014. In 2014 the stallions have been genotyped for the GYS1 mutation resulting in 105 non-mutation-carriers, 57 heterozygous, and 7 homozygous animals. The mean frequency of animals carrying the mutation was 38 % (64 of 169). The final performance score and 32 single performance traits were analyzed using a linear model including the GYS1 mutation genotype, the testing year and age as fixed effects. For the final performance score no effect of the GYS1 mutation was found. In three single traits – driving ability, Drafting manner, and kindness in the discipline heavy-load lodging – significantly lower scores for heterozygous Horses than for non-carrier animals were obtained. Homozygous animals did not differ significantly from both groups. Our results from this retrospective study suggest no effect of the GYS1 mutation on performance traits and on the final performance score.
Szilvia Kusza - One of the best experts on this subject based on the ideXlab platform.
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Genetic analysis of the Hungarian Draft Horse population using partial mitochondrial DNA D-loop sequencing
PeerJ, 2018Co-Authors: Nikolett Csizmár, Sándor Mihók, András Jávor, Szilvia KuszaAbstract:Background The Hungarian Draft is a Horse breed with a recent mixed ancestry created in the 1920s by crossing local mares with draught Horses imported from France and Belgium. The interest in its conservation and characterization has increased over the last few years. The aim of this work is to contribute to the characterization of the endangered Hungarian heavy Draft Horse populations in order to obtain useful information to implement conservation strategies for these genetic stocks. Methods To genetically characterize the breed and to set up the basis for a conservation program, in the present study a hypervariable region of the mitochrondial DNA (D-loop) was used to assess genetic diversity in Hungarian Draft Horses. Two hundred and eighty five sequences obtained in our laboratory and 419 downloaded sequences available from Genbank were analyzed. Results One hundred and sixty-four haplotypes and thirty-six polymorphic sites were observed. High haplotype and nucleotide diversity values (Hd = 0.954 ± 0.004; π = 0.028 ± 0.0004) were identified in Hungarian population, although they were higher within than among the different populations (Hd = 0.972 ± 0.002; π = 0.03097 ± 0.002). Fourteen of the previously observed seventeen haplogroups were detected. Discussion Our samples showed a large intra- and interbreed variation. There was no clear clustering on the median joining network figure. The overall information collected in this work led us to consider that the genetic scenario observed for Hungarian Draft breed is more likely the result of contributions from ‘ancestrally’ different genetic backgrounds. This study could contribute to the development of a breeding plan for Hungarian Draft Horses and help to formulate a genetic conservation plan, avoiding inbreeding while.