The Experts below are selected from a list of 23274 Experts worldwide ranked by ideXlab platform
Cyrill Seillet - One of the best experts on this subject based on the ideXlab platform.
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ccr2 defines in vivo development and homing of il 23 Driven gm csf producing th17 cells
Nature Communications, 2015Co-Authors: Ervin E Kara, Duncan R Mckenzie, Cameron R Bastow, Carly E Gregor, Kevin A Fenix, Abiodun D Ogunniyi, James C Paton, Matthias Mack, Diana Pombal, Cyrill SeilletAbstract:IL-17-producing helper T (Th17) cells are critical for host defense against extracellular pathogens but also drive numerous autoimmune diseases. Th17 cells that differ in their inflammatory potential have been described including IL-10-producing Th17 cells that are weak inducers of inflammation and highly inflammatory, IL-23-Driven, GM-CSF/IFNγ-producing Th17 cells. However, their distinct developmental requirements, functions and trafficking mechanisms in vivo remain poorly understood. Here we identify a temporally regulated IL-23-dependent switch from CCR6 to CCR2 usage by developing Th17 cells that is critical for pathogenic Th17 cell-Driven inflammation in experimental autoimmune encephalomyelitis (EAE). This switch defines a unique in vivo cell surface signature (CCR6(-)CCR2(+)) of GM-CSF/IFNγ-producing Th17 cells in EAE and experimental persistent extracellular bacterial infection, and in humans. Using this signature, we identify an IL-23/IL-1/IFNγ/TNFα/T-bet/Eomesodermin-Driven Circuit driving GM-CSF/IFNγ-producing Th17 cell formation in vivo. Thus, our data identify a unique cell surface signature, trafficking mechanism and T-cell intrinsic regulators of GM-CSF/IFNγ-producing Th17 cells.
Xianlong Hong - One of the best experts on this subject based on the ideXlab platform.
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cdctree novel obstacle avoiding routing tree construction based on current Driven Circuit model
Asia and South Pacific Design Automation Conference, 2006Co-Authors: Tong Jing, Lei He, Zhe Feng, Xianlong HongAbstract:Routing tree construction is a fundamental problem in modern VLSI design. In this paper we propose CDC-Tree, an Obstacle-Avoiding Rectilinear Steiner Minimum Tree (OARSMT) heuristic algorithm to construct an OARSMT. CDC-Tree is based on the current Driven Circuit (CDC) model mapped from an escape graph. The Circuit structure comes from the topology of the escape graph, with each edge replaced by a resistor indicating the wirelength of that edge. By performing DC analysis on the Circuit and selecting the edges according to the current distribution to construct an OARSMT, the wirelength of the resulting tree is short. The algorithm has been implemented and tested on cases of different scales and with different shapes of obstacles. Experiments show that CDCTree can achieve shorter wirelength than the existing best algorithm, An-OARSMan, when the terminal number of a net is less than 50.
Tsuyoshi Yamamoto - One of the best experts on this subject based on the ideXlab platform.
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microwave down conversion with an impedance matched λ system in Driven Circuit qed
Physical Review Letters, 2014Co-Authors: K Inomata, Kazuki Koshino, Zhirong Lin, William D Oliver, J S Tsai, Yasunobu Nakamura, Tsuyoshi YamamotoAbstract:Japan Society for the Promotion of Science (World-Leading Innovative R&D on Science and Technology)
Luis A. Tarazona D. - One of the best experts on this subject based on the ideXlab platform.
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Asynchronous data-Driven Circuit synthesis
IEEE Transactions on Very Large Scale Integration (VLSI) Systems, 2010Co-Authors: Sam Taylor, Luis A. Plana, Doug Edwards, Luis A. Tarazona D.Abstract:A method is described for synthesizing asynchronous Circuits based on the Handshake Circuit paradigm but employing a data-Driven, rather than a control-Driven, style. This approach attempts to combine the performance advantages of data-Driven asynchronous design styles with the handshake Circuit style of construction used in existing syntax-directed synthesis. The method is demonstrated on a significant design-a 32-bit microprocessor. This example shows that the data-Driven Circuit style provides better performance than control-Driven synthesized Circuits. This paper extends previous reported work by illustrating how conditional execution, oft-cited as a problem for data-Driven descriptions, is handled within the system, and by a more detailed analysis of the design example.
Ervin E Kara - One of the best experts on this subject based on the ideXlab platform.
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ccr2 defines in vivo development and homing of il 23 Driven gm csf producing th17 cells
Nature Communications, 2015Co-Authors: Ervin E Kara, Duncan R Mckenzie, Cameron R Bastow, Carly E Gregor, Kevin A Fenix, Abiodun D Ogunniyi, James C Paton, Matthias Mack, Diana Pombal, Cyrill SeilletAbstract:IL-17-producing helper T (Th17) cells are critical for host defense against extracellular pathogens but also drive numerous autoimmune diseases. Th17 cells that differ in their inflammatory potential have been described including IL-10-producing Th17 cells that are weak inducers of inflammation and highly inflammatory, IL-23-Driven, GM-CSF/IFNγ-producing Th17 cells. However, their distinct developmental requirements, functions and trafficking mechanisms in vivo remain poorly understood. Here we identify a temporally regulated IL-23-dependent switch from CCR6 to CCR2 usage by developing Th17 cells that is critical for pathogenic Th17 cell-Driven inflammation in experimental autoimmune encephalomyelitis (EAE). This switch defines a unique in vivo cell surface signature (CCR6(-)CCR2(+)) of GM-CSF/IFNγ-producing Th17 cells in EAE and experimental persistent extracellular bacterial infection, and in humans. Using this signature, we identify an IL-23/IL-1/IFNγ/TNFα/T-bet/Eomesodermin-Driven Circuit driving GM-CSF/IFNγ-producing Th17 cell formation in vivo. Thus, our data identify a unique cell surface signature, trafficking mechanism and T-cell intrinsic regulators of GM-CSF/IFNγ-producing Th17 cells.
