The Experts below are selected from a list of 377436 Experts worldwide ranked by ideXlab platform
Cuixia Cui - One of the best experts on this subject based on the ideXlab platform.
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research on Drug receptor interactions and prediction of Drug Activity via oriented immobilized receptor capillary electrophoresis
Electrophoresis, 2015Co-Authors: Chunye Liu, Xuejiao Zhang, Hui Jing, Yanqing Miao, Lingzhi Zhao, Yan Han, Cuixia CuiAbstract:Oriented covalent immobilized β2 -adrenergic receptor (β2 -AR) CE (OIRCE) was developed to determine the interactions between a set of natural extracts of Radix Paeoniae Rubra (NERPR) and β2 -AR, and to predict the Activity of NERPR. The inner capillary surface is chemically bonded with stable β2 -AR coating via microwave-assisted technical synthesis. The modified capillaries were characterized via infrared spectroscopy and fluorescence microscopy. Furthermore, the bonding amounts of β2 -AR were first obtained via fluorescence spectroscopy method. In determining the amount of bonded β2 -AR, the regression equation A = 576 707C + 35.449 and the correlation coefficient 0.9995 were obtained. This result revealed an excellent linear relationship in the range of 2 × 10(-4) mg/mL to 1 × 10(-3) mg/mL. The normalized capacity factor (KRCE ) was obtained using OIRCE in evaluating Drug-receptor interactions. Related theories and equations were used to calculate KRCE values from apparent migration times of a solute and EOF. The order of KRCE and the binding constant (Kb ) values between Drugs and β2 -AR was well consistent. The results confirmed that the OIRCE and KRCE values can be effectually used to investigate Drug-receptor interactions, and OIRCE has the potential to predict Drug Activity and to select leading compounds from natural chemicals.
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Research on Drug–receptor interactions and prediction of Drug Activity via oriented immobilized receptor capillary electrophoresis
Electrophoresis, 2015Co-Authors: Chunye Liu, Xuejiao Zhang, Hui Jing, Yanqing Miao, Lingzhi Zhao, Yan Han, Cuixia CuiAbstract:Oriented covalent immobilized β2 -adrenergic receptor (β2 -AR) CE (OIRCE) was developed to determine the interactions between a set of natural extracts of Radix Paeoniae Rubra (NERPR) and β2 -AR, and to predict the Activity of NERPR. The inner capillary surface is chemically bonded with stable β2 -AR coating via microwave-assisted technical synthesis. The modified capillaries were characterized via infrared spectroscopy and fluorescence microscopy. Furthermore, the bonding amounts of β2 -AR were first obtained via fluorescence spectroscopy method. In determining the amount of bonded β2 -AR, the regression equation A = 576 707C + 35.449 and the correlation coefficient 0.9995 were obtained. This result revealed an excellent linear relationship in the range of 2 × 10(-4) mg/mL to 1 × 10(-3) mg/mL. The normalized capacity factor (KRCE ) was obtained using OIRCE in evaluating Drug-receptor interactions. Related theories and equations were used to calculate KRCE values from apparent migration times of a solute and EOF. The order of KRCE and the binding constant (Kb ) values between Drugs and β2 -AR was well consistent. The results confirmed that the OIRCE and KRCE values can be effectually used to investigate Drug-receptor interactions, and OIRCE has the potential to predict Drug Activity and to select leading compounds from natural chemicals.
Chunye Liu - One of the best experts on this subject based on the ideXlab platform.
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research on Drug receptor interactions and prediction of Drug Activity via oriented immobilized receptor capillary electrophoresis
Electrophoresis, 2015Co-Authors: Chunye Liu, Xuejiao Zhang, Hui Jing, Yanqing Miao, Lingzhi Zhao, Yan Han, Cuixia CuiAbstract:Oriented covalent immobilized β2 -adrenergic receptor (β2 -AR) CE (OIRCE) was developed to determine the interactions between a set of natural extracts of Radix Paeoniae Rubra (NERPR) and β2 -AR, and to predict the Activity of NERPR. The inner capillary surface is chemically bonded with stable β2 -AR coating via microwave-assisted technical synthesis. The modified capillaries were characterized via infrared spectroscopy and fluorescence microscopy. Furthermore, the bonding amounts of β2 -AR were first obtained via fluorescence spectroscopy method. In determining the amount of bonded β2 -AR, the regression equation A = 576 707C + 35.449 and the correlation coefficient 0.9995 were obtained. This result revealed an excellent linear relationship in the range of 2 × 10(-4) mg/mL to 1 × 10(-3) mg/mL. The normalized capacity factor (KRCE ) was obtained using OIRCE in evaluating Drug-receptor interactions. Related theories and equations were used to calculate KRCE values from apparent migration times of a solute and EOF. The order of KRCE and the binding constant (Kb ) values between Drugs and β2 -AR was well consistent. The results confirmed that the OIRCE and KRCE values can be effectually used to investigate Drug-receptor interactions, and OIRCE has the potential to predict Drug Activity and to select leading compounds from natural chemicals.
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Research on Drug–receptor interactions and prediction of Drug Activity via oriented immobilized receptor capillary electrophoresis
Electrophoresis, 2015Co-Authors: Chunye Liu, Xuejiao Zhang, Hui Jing, Yanqing Miao, Lingzhi Zhao, Yan Han, Cuixia CuiAbstract:Oriented covalent immobilized β2 -adrenergic receptor (β2 -AR) CE (OIRCE) was developed to determine the interactions between a set of natural extracts of Radix Paeoniae Rubra (NERPR) and β2 -AR, and to predict the Activity of NERPR. The inner capillary surface is chemically bonded with stable β2 -AR coating via microwave-assisted technical synthesis. The modified capillaries were characterized via infrared spectroscopy and fluorescence microscopy. Furthermore, the bonding amounts of β2 -AR were first obtained via fluorescence spectroscopy method. In determining the amount of bonded β2 -AR, the regression equation A = 576 707C + 35.449 and the correlation coefficient 0.9995 were obtained. This result revealed an excellent linear relationship in the range of 2 × 10(-4) mg/mL to 1 × 10(-3) mg/mL. The normalized capacity factor (KRCE ) was obtained using OIRCE in evaluating Drug-receptor interactions. Related theories and equations were used to calculate KRCE values from apparent migration times of a solute and EOF. The order of KRCE and the binding constant (Kb ) values between Drugs and β2 -AR was well consistent. The results confirmed that the OIRCE and KRCE values can be effectually used to investigate Drug-receptor interactions, and OIRCE has the potential to predict Drug Activity and to select leading compounds from natural chemicals.
Xuejiao Zhang - One of the best experts on this subject based on the ideXlab platform.
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research on Drug receptor interactions and prediction of Drug Activity via oriented immobilized receptor capillary electrophoresis
Electrophoresis, 2015Co-Authors: Chunye Liu, Xuejiao Zhang, Hui Jing, Yanqing Miao, Lingzhi Zhao, Yan Han, Cuixia CuiAbstract:Oriented covalent immobilized β2 -adrenergic receptor (β2 -AR) CE (OIRCE) was developed to determine the interactions between a set of natural extracts of Radix Paeoniae Rubra (NERPR) and β2 -AR, and to predict the Activity of NERPR. The inner capillary surface is chemically bonded with stable β2 -AR coating via microwave-assisted technical synthesis. The modified capillaries were characterized via infrared spectroscopy and fluorescence microscopy. Furthermore, the bonding amounts of β2 -AR were first obtained via fluorescence spectroscopy method. In determining the amount of bonded β2 -AR, the regression equation A = 576 707C + 35.449 and the correlation coefficient 0.9995 were obtained. This result revealed an excellent linear relationship in the range of 2 × 10(-4) mg/mL to 1 × 10(-3) mg/mL. The normalized capacity factor (KRCE ) was obtained using OIRCE in evaluating Drug-receptor interactions. Related theories and equations were used to calculate KRCE values from apparent migration times of a solute and EOF. The order of KRCE and the binding constant (Kb ) values between Drugs and β2 -AR was well consistent. The results confirmed that the OIRCE and KRCE values can be effectually used to investigate Drug-receptor interactions, and OIRCE has the potential to predict Drug Activity and to select leading compounds from natural chemicals.
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Research on Drug–receptor interactions and prediction of Drug Activity via oriented immobilized receptor capillary electrophoresis
Electrophoresis, 2015Co-Authors: Chunye Liu, Xuejiao Zhang, Hui Jing, Yanqing Miao, Lingzhi Zhao, Yan Han, Cuixia CuiAbstract:Oriented covalent immobilized β2 -adrenergic receptor (β2 -AR) CE (OIRCE) was developed to determine the interactions between a set of natural extracts of Radix Paeoniae Rubra (NERPR) and β2 -AR, and to predict the Activity of NERPR. The inner capillary surface is chemically bonded with stable β2 -AR coating via microwave-assisted technical synthesis. The modified capillaries were characterized via infrared spectroscopy and fluorescence microscopy. Furthermore, the bonding amounts of β2 -AR were first obtained via fluorescence spectroscopy method. In determining the amount of bonded β2 -AR, the regression equation A = 576 707C + 35.449 and the correlation coefficient 0.9995 were obtained. This result revealed an excellent linear relationship in the range of 2 × 10(-4) mg/mL to 1 × 10(-3) mg/mL. The normalized capacity factor (KRCE ) was obtained using OIRCE in evaluating Drug-receptor interactions. Related theories and equations were used to calculate KRCE values from apparent migration times of a solute and EOF. The order of KRCE and the binding constant (Kb ) values between Drugs and β2 -AR was well consistent. The results confirmed that the OIRCE and KRCE values can be effectually used to investigate Drug-receptor interactions, and OIRCE has the potential to predict Drug Activity and to select leading compounds from natural chemicals.
Hui Jing - One of the best experts on this subject based on the ideXlab platform.
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research on Drug receptor interactions and prediction of Drug Activity via oriented immobilized receptor capillary electrophoresis
Electrophoresis, 2015Co-Authors: Chunye Liu, Xuejiao Zhang, Hui Jing, Yanqing Miao, Lingzhi Zhao, Yan Han, Cuixia CuiAbstract:Oriented covalent immobilized β2 -adrenergic receptor (β2 -AR) CE (OIRCE) was developed to determine the interactions between a set of natural extracts of Radix Paeoniae Rubra (NERPR) and β2 -AR, and to predict the Activity of NERPR. The inner capillary surface is chemically bonded with stable β2 -AR coating via microwave-assisted technical synthesis. The modified capillaries were characterized via infrared spectroscopy and fluorescence microscopy. Furthermore, the bonding amounts of β2 -AR were first obtained via fluorescence spectroscopy method. In determining the amount of bonded β2 -AR, the regression equation A = 576 707C + 35.449 and the correlation coefficient 0.9995 were obtained. This result revealed an excellent linear relationship in the range of 2 × 10(-4) mg/mL to 1 × 10(-3) mg/mL. The normalized capacity factor (KRCE ) was obtained using OIRCE in evaluating Drug-receptor interactions. Related theories and equations were used to calculate KRCE values from apparent migration times of a solute and EOF. The order of KRCE and the binding constant (Kb ) values between Drugs and β2 -AR was well consistent. The results confirmed that the OIRCE and KRCE values can be effectually used to investigate Drug-receptor interactions, and OIRCE has the potential to predict Drug Activity and to select leading compounds from natural chemicals.
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Research on Drug–receptor interactions and prediction of Drug Activity via oriented immobilized receptor capillary electrophoresis
Electrophoresis, 2015Co-Authors: Chunye Liu, Xuejiao Zhang, Hui Jing, Yanqing Miao, Lingzhi Zhao, Yan Han, Cuixia CuiAbstract:Oriented covalent immobilized β2 -adrenergic receptor (β2 -AR) CE (OIRCE) was developed to determine the interactions between a set of natural extracts of Radix Paeoniae Rubra (NERPR) and β2 -AR, and to predict the Activity of NERPR. The inner capillary surface is chemically bonded with stable β2 -AR coating via microwave-assisted technical synthesis. The modified capillaries were characterized via infrared spectroscopy and fluorescence microscopy. Furthermore, the bonding amounts of β2 -AR were first obtained via fluorescence spectroscopy method. In determining the amount of bonded β2 -AR, the regression equation A = 576 707C + 35.449 and the correlation coefficient 0.9995 were obtained. This result revealed an excellent linear relationship in the range of 2 × 10(-4) mg/mL to 1 × 10(-3) mg/mL. The normalized capacity factor (KRCE ) was obtained using OIRCE in evaluating Drug-receptor interactions. Related theories and equations were used to calculate KRCE values from apparent migration times of a solute and EOF. The order of KRCE and the binding constant (Kb ) values between Drugs and β2 -AR was well consistent. The results confirmed that the OIRCE and KRCE values can be effectually used to investigate Drug-receptor interactions, and OIRCE has the potential to predict Drug Activity and to select leading compounds from natural chemicals.
Yanqing Miao - One of the best experts on this subject based on the ideXlab platform.
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research on Drug receptor interactions and prediction of Drug Activity via oriented immobilized receptor capillary electrophoresis
Electrophoresis, 2015Co-Authors: Chunye Liu, Xuejiao Zhang, Hui Jing, Yanqing Miao, Lingzhi Zhao, Yan Han, Cuixia CuiAbstract:Oriented covalent immobilized β2 -adrenergic receptor (β2 -AR) CE (OIRCE) was developed to determine the interactions between a set of natural extracts of Radix Paeoniae Rubra (NERPR) and β2 -AR, and to predict the Activity of NERPR. The inner capillary surface is chemically bonded with stable β2 -AR coating via microwave-assisted technical synthesis. The modified capillaries were characterized via infrared spectroscopy and fluorescence microscopy. Furthermore, the bonding amounts of β2 -AR were first obtained via fluorescence spectroscopy method. In determining the amount of bonded β2 -AR, the regression equation A = 576 707C + 35.449 and the correlation coefficient 0.9995 were obtained. This result revealed an excellent linear relationship in the range of 2 × 10(-4) mg/mL to 1 × 10(-3) mg/mL. The normalized capacity factor (KRCE ) was obtained using OIRCE in evaluating Drug-receptor interactions. Related theories and equations were used to calculate KRCE values from apparent migration times of a solute and EOF. The order of KRCE and the binding constant (Kb ) values between Drugs and β2 -AR was well consistent. The results confirmed that the OIRCE and KRCE values can be effectually used to investigate Drug-receptor interactions, and OIRCE has the potential to predict Drug Activity and to select leading compounds from natural chemicals.
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Research on Drug–receptor interactions and prediction of Drug Activity via oriented immobilized receptor capillary electrophoresis
Electrophoresis, 2015Co-Authors: Chunye Liu, Xuejiao Zhang, Hui Jing, Yanqing Miao, Lingzhi Zhao, Yan Han, Cuixia CuiAbstract:Oriented covalent immobilized β2 -adrenergic receptor (β2 -AR) CE (OIRCE) was developed to determine the interactions between a set of natural extracts of Radix Paeoniae Rubra (NERPR) and β2 -AR, and to predict the Activity of NERPR. The inner capillary surface is chemically bonded with stable β2 -AR coating via microwave-assisted technical synthesis. The modified capillaries were characterized via infrared spectroscopy and fluorescence microscopy. Furthermore, the bonding amounts of β2 -AR were first obtained via fluorescence spectroscopy method. In determining the amount of bonded β2 -AR, the regression equation A = 576 707C + 35.449 and the correlation coefficient 0.9995 were obtained. This result revealed an excellent linear relationship in the range of 2 × 10(-4) mg/mL to 1 × 10(-3) mg/mL. The normalized capacity factor (KRCE ) was obtained using OIRCE in evaluating Drug-receptor interactions. Related theories and equations were used to calculate KRCE values from apparent migration times of a solute and EOF. The order of KRCE and the binding constant (Kb ) values between Drugs and β2 -AR was well consistent. The results confirmed that the OIRCE and KRCE values can be effectually used to investigate Drug-receptor interactions, and OIRCE has the potential to predict Drug Activity and to select leading compounds from natural chemicals.
