The Experts below are selected from a list of 141 Experts worldwide ranked by ideXlab platform
Ajmal Koya Pulikkal - One of the best experts on this subject based on the ideXlab platform.
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amphiphilic Drug Additive systems in aqueous and organic solvent water mixed media a comprehensive account on physicochemical properties
Journal of Molecular Liquids, 2020Co-Authors: Jackson Gurung, Jamsheera Anjudikkal, Ajmal Koya PulikkalAbstract:Abstract The physicochemical properties of Drugs and Drug–Additive interactions have great importance to elucidate the pharmacological effect of the Drug formulations. Plentiful pharmacologically active molecules are amphiphilic in nature. Knowledge about self-assembly, aggregate morphology as well as size and interfacial/micellar properties of such Drugs in presence of pharmaceutical excipients (surfactants, electrolytes, polymers, hydrotropes, etc.) is vital from the fundamental and practical point of view. This article reviews the micellar properties and phase separation of Drugs as well as Drug–Additive systems in aqueous and organic solvent–water mixed media. Results of several pharmaceutical excipients/surfactants assisted Drug mixed systems have been analyzed through thermodynamic parameters which provide a comprehensive account on the physicochemical aspects of Drug/Drug–Additives systems. Along with amphiphilic Drugs, studies of a few non surface-active Drugs have also been reviewed.
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Amphiphilic Drug–Additive systems in aqueous and organic solvent–water mixed media: A comprehensive account on physicochemical properties
Journal of Molecular Liquids, 2020Co-Authors: Jackson Gurung, Jamsheera Anjudikkal, Ajmal Koya PulikkalAbstract:Abstract The physicochemical properties of Drugs and Drug–Additive interactions have great importance to elucidate the pharmacological effect of the Drug formulations. Plentiful pharmacologically active molecules are amphiphilic in nature. Knowledge about self-assembly, aggregate morphology as well as size and interfacial/micellar properties of such Drugs in presence of pharmaceutical excipients (surfactants, electrolytes, polymers, hydrotropes, etc.) is vital from the fundamental and practical point of view. This article reviews the micellar properties and phase separation of Drugs as well as Drug–Additive systems in aqueous and organic solvent–water mixed media. Results of several pharmaceutical excipients/surfactants assisted Drug mixed systems have been analyzed through thermodynamic parameters which provide a comprehensive account on the physicochemical aspects of Drug/Drug–Additives systems. Along with amphiphilic Drugs, studies of a few non surface-active Drugs have also been reviewed.
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clouding behavior of antidepressant Drug Additive system in ethylene glycol glycerol water mixed media and their thermodynamic parameters at cloud point
New Journal of Chemistry, 2018Co-Authors: Ajmal Koya Pulikkal, Jackson GurungAbstract:The influence of ethylene glycol (EG)/glycerol(GL)–water mixed media on clouding action of an amphiphilic Drug, amitriptyline hydrochloride (AMT) at pH 6.7 with inorganic salts (KF, KCl, KBr, LiCl, NaCl, and NH4Cl) in selected compositions of EG–WR and GL–WR mixed media (0%, 5%, 10%, 15%, and 20% of EG/GL, w/w) and their thermodynamic parameters at cloud point (CP) were studied. Experimentally determined critical micellization concentration (cmc) values (up to 25% w/w with an increment of 5% w/w) by conductivity measurements and results of dye solubilization by a UV-visible spectroscopic technique show that the micellization of AMT Drug molecules is affected by an indirect, solvent-mediated mechanism with increasing weight% of EG and GL in their binary mixture due to a diminution in the dielectric constant of mixed media. A rise in CP of the AMT solution was observed with an increase in weight% of organic solvent in the mixed media in the absence and presence of the salts. The results demonstrated that CP behavior depends on the interaction of solvent with the Drug micelles as well as with the hydrated/solvated radii of these ions. F− and Br− co-ions show a prominent effect in higher weight% of the binary mixtures. ΔsG0 values were found to be positive for all the Additives whereas ΔsH0 and TΔsS0 were positive except in presence of KF in 20% EG–WR mixed media. The results are discussed by considering the solvent effect on electrostatic interaction and based on hydrated/solvated sizes of the ions.
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Clouding behavior of antidepressant Drug–Additive system in ethylene glycol/glycerol–water mixed media and their thermodynamic parameters at cloud point
New Journal of Chemistry, 2018Co-Authors: Ajmal Koya Pulikkal, Jackson GurungAbstract:The influence of ethylene glycol (EG)/glycerol(GL)–water mixed media on clouding action of an amphiphilic Drug, amitriptyline hydrochloride (AMT) at pH 6.7 with inorganic salts (KF, KCl, KBr, LiCl, NaCl, and NH4Cl) in selected compositions of EG–WR and GL–WR mixed media (0%, 5%, 10%, 15%, and 20% of EG/GL, w/w) and their thermodynamic parameters at cloud point (CP) were studied. Experimentally determined critical micellization concentration (cmc) values (up to 25% w/w with an increment of 5% w/w) by conductivity measurements and results of dye solubilization by a UV-visible spectroscopic technique show that the micellization of AMT Drug molecules is affected by an indirect, solvent-mediated mechanism with increasing weight% of EG and GL in their binary mixture due to a diminution in the dielectric constant of mixed media. A rise in CP of the AMT solution was observed with an increase in weight% of organic solvent in the mixed media in the absence and presence of the salts. The results demonstrated that CP behavior depends on the interaction of solvent with the Drug micelles as well as with the hydrated/solvated radii of these ions. F− and Br− co-ions show a prominent effect in higher weight% of the binary mixtures. ΔsG0 values were found to be positive for all the Additives whereas ΔsH0 and TΔsS0 were positive except in presence of KF in 20% EG–WR mixed media. The results are discussed by considering the solvent effect on electrostatic interaction and based on hydrated/solvated sizes of the ions.
Jackson Gurung - One of the best experts on this subject based on the ideXlab platform.
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amphiphilic Drug Additive systems in aqueous and organic solvent water mixed media a comprehensive account on physicochemical properties
Journal of Molecular Liquids, 2020Co-Authors: Jackson Gurung, Jamsheera Anjudikkal, Ajmal Koya PulikkalAbstract:Abstract The physicochemical properties of Drugs and Drug–Additive interactions have great importance to elucidate the pharmacological effect of the Drug formulations. Plentiful pharmacologically active molecules are amphiphilic in nature. Knowledge about self-assembly, aggregate morphology as well as size and interfacial/micellar properties of such Drugs in presence of pharmaceutical excipients (surfactants, electrolytes, polymers, hydrotropes, etc.) is vital from the fundamental and practical point of view. This article reviews the micellar properties and phase separation of Drugs as well as Drug–Additive systems in aqueous and organic solvent–water mixed media. Results of several pharmaceutical excipients/surfactants assisted Drug mixed systems have been analyzed through thermodynamic parameters which provide a comprehensive account on the physicochemical aspects of Drug/Drug–Additives systems. Along with amphiphilic Drugs, studies of a few non surface-active Drugs have also been reviewed.
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Amphiphilic Drug–Additive systems in aqueous and organic solvent–water mixed media: A comprehensive account on physicochemical properties
Journal of Molecular Liquids, 2020Co-Authors: Jackson Gurung, Jamsheera Anjudikkal, Ajmal Koya PulikkalAbstract:Abstract The physicochemical properties of Drugs and Drug–Additive interactions have great importance to elucidate the pharmacological effect of the Drug formulations. Plentiful pharmacologically active molecules are amphiphilic in nature. Knowledge about self-assembly, aggregate morphology as well as size and interfacial/micellar properties of such Drugs in presence of pharmaceutical excipients (surfactants, electrolytes, polymers, hydrotropes, etc.) is vital from the fundamental and practical point of view. This article reviews the micellar properties and phase separation of Drugs as well as Drug–Additive systems in aqueous and organic solvent–water mixed media. Results of several pharmaceutical excipients/surfactants assisted Drug mixed systems have been analyzed through thermodynamic parameters which provide a comprehensive account on the physicochemical aspects of Drug/Drug–Additives systems. Along with amphiphilic Drugs, studies of a few non surface-active Drugs have also been reviewed.
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clouding behavior of antidepressant Drug Additive system in ethylene glycol glycerol water mixed media and their thermodynamic parameters at cloud point
New Journal of Chemistry, 2018Co-Authors: Ajmal Koya Pulikkal, Jackson GurungAbstract:The influence of ethylene glycol (EG)/glycerol(GL)–water mixed media on clouding action of an amphiphilic Drug, amitriptyline hydrochloride (AMT) at pH 6.7 with inorganic salts (KF, KCl, KBr, LiCl, NaCl, and NH4Cl) in selected compositions of EG–WR and GL–WR mixed media (0%, 5%, 10%, 15%, and 20% of EG/GL, w/w) and their thermodynamic parameters at cloud point (CP) were studied. Experimentally determined critical micellization concentration (cmc) values (up to 25% w/w with an increment of 5% w/w) by conductivity measurements and results of dye solubilization by a UV-visible spectroscopic technique show that the micellization of AMT Drug molecules is affected by an indirect, solvent-mediated mechanism with increasing weight% of EG and GL in their binary mixture due to a diminution in the dielectric constant of mixed media. A rise in CP of the AMT solution was observed with an increase in weight% of organic solvent in the mixed media in the absence and presence of the salts. The results demonstrated that CP behavior depends on the interaction of solvent with the Drug micelles as well as with the hydrated/solvated radii of these ions. F− and Br− co-ions show a prominent effect in higher weight% of the binary mixtures. ΔsG0 values were found to be positive for all the Additives whereas ΔsH0 and TΔsS0 were positive except in presence of KF in 20% EG–WR mixed media. The results are discussed by considering the solvent effect on electrostatic interaction and based on hydrated/solvated sizes of the ions.
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Clouding behavior of antidepressant Drug–Additive system in ethylene glycol/glycerol–water mixed media and their thermodynamic parameters at cloud point
New Journal of Chemistry, 2018Co-Authors: Ajmal Koya Pulikkal, Jackson GurungAbstract:The influence of ethylene glycol (EG)/glycerol(GL)–water mixed media on clouding action of an amphiphilic Drug, amitriptyline hydrochloride (AMT) at pH 6.7 with inorganic salts (KF, KCl, KBr, LiCl, NaCl, and NH4Cl) in selected compositions of EG–WR and GL–WR mixed media (0%, 5%, 10%, 15%, and 20% of EG/GL, w/w) and their thermodynamic parameters at cloud point (CP) were studied. Experimentally determined critical micellization concentration (cmc) values (up to 25% w/w with an increment of 5% w/w) by conductivity measurements and results of dye solubilization by a UV-visible spectroscopic technique show that the micellization of AMT Drug molecules is affected by an indirect, solvent-mediated mechanism with increasing weight% of EG and GL in their binary mixture due to a diminution in the dielectric constant of mixed media. A rise in CP of the AMT solution was observed with an increase in weight% of organic solvent in the mixed media in the absence and presence of the salts. The results demonstrated that CP behavior depends on the interaction of solvent with the Drug micelles as well as with the hydrated/solvated radii of these ions. F− and Br− co-ions show a prominent effect in higher weight% of the binary mixtures. ΔsG0 values were found to be positive for all the Additives whereas ΔsH0 and TΔsS0 were positive except in presence of KF in 20% EG–WR mixed media. The results are discussed by considering the solvent effect on electrostatic interaction and based on hydrated/solvated sizes of the ions.
Liang Fang - One of the best experts on this subject based on the ideXlab platform.
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Design of a Drug-in-Adhesive Transdermal Patch for Risperidone: Effect of Drug-Additive Interactions on the Crystallization Inhibition and In Vitro/In Vivo Correlation Study
Journal of Pharmaceutical Sciences, 2016Co-Authors: Wei Weng, Peng Quan, Hanqing Zhao, Liang FangAbstract:Abstract The purpose of this work was to develop and design an appropriate Drug-in-adhesive patch for transdermal delivery of risperidone (RISP). Various formulation factors were investigated by in vitro permeation study using excised rabbit skin. Increasing the Drug concentration in the pressure sensitive adhesive (PSA) was used to enhance the Drug permeation. To overcome the high crystallization tendency of the patch, several crystallization inhibitors such as PVP, PEG, and surfactants and fatty acids were evaluated by microscopy study. The mechanism of crystallization inhibition was investigated by differential scanning calorimetry, nuclear magnetic resonance spectrometer, and FT-IR studies. RISP and its active metabolite were determined after topical application of the optimized transdermal patch, and the in vivo pharmacokinetic parameters were compared with the intravenous administration group. The microscopy study indicated that fatty acid greatly inhibited the crystallization of RISP in PSA. The inhibition was attributed to the Drug-Additive interaction between amino group of RISP and the carboxyl group of fatty acid which was further confirmed by 1 H-NMR and FT-IR studies. The optimal permeation profile was obtained with the patches containing 5% RISP and 5% oleic acid in Duro-Tak ® 87-2287. The in vivo pharmacokinetic study exhibited a sustained absorption and metabolism profile and well correlated with the in vitro permeation data.
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Pharmaceutics, Drug Delivery and Pharmaceutical Technology Design of a Drug-in-Adhesive Transdermal Patch for Risperidone: Effect of Drug-Additive Interactions on the Crystallization Inhibition and In Vitro/In Vivo Correlation Study
2016Co-Authors: Wei Weng, Peng Quan, Hanqing Zhao, Chao Liu, Liang FangAbstract:The purpose of this work was to develop and design an appropriate Drug-in-adhesive patch for transdermal delivery of risperidone (RISP). Various formulation factors were investigated by in vitro permeation study using excised rabbit skin. Increasing the Drug concentration in the pressure sensitive adhesive (PSA) was used to enhance the Drug permeation. To overcome the high crystallization tendency of the patch, several crystallization inhibitors such as PVP, PEG, and surfactants and fatty acids were evaluated by microscopy study. The mechanism of crystallization inhibition was investigated by differential scanning calorimetry, nuclear magnetic resonance spectrometer, and FT-IR studies. RISP and its active metabolite were determined after topical application of the optimized transdermal patch, and the in vivo pharmacokinetic parameters were compared with the intravenous administration group. The microscopy study indicated that fatty acid greatly inhibited the crystallization of RISP in PSA. The inhibition was attributed to the Drug-Additive interaction between amino group of RISP and the carboxyl group of fatty acid which was further confirmed by 1 H-NMR and FT-IR studies. The optimal permeation profile was obtained with the patches containing 5% RISP and 5% oleic acid in Duro-Tak ® 87-2287. The in vivo pharmacokinetic study exhibited a
Jamsheera Anjudikkal - One of the best experts on this subject based on the ideXlab platform.
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amphiphilic Drug Additive systems in aqueous and organic solvent water mixed media a comprehensive account on physicochemical properties
Journal of Molecular Liquids, 2020Co-Authors: Jackson Gurung, Jamsheera Anjudikkal, Ajmal Koya PulikkalAbstract:Abstract The physicochemical properties of Drugs and Drug–Additive interactions have great importance to elucidate the pharmacological effect of the Drug formulations. Plentiful pharmacologically active molecules are amphiphilic in nature. Knowledge about self-assembly, aggregate morphology as well as size and interfacial/micellar properties of such Drugs in presence of pharmaceutical excipients (surfactants, electrolytes, polymers, hydrotropes, etc.) is vital from the fundamental and practical point of view. This article reviews the micellar properties and phase separation of Drugs as well as Drug–Additive systems in aqueous and organic solvent–water mixed media. Results of several pharmaceutical excipients/surfactants assisted Drug mixed systems have been analyzed through thermodynamic parameters which provide a comprehensive account on the physicochemical aspects of Drug/Drug–Additives systems. Along with amphiphilic Drugs, studies of a few non surface-active Drugs have also been reviewed.
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Amphiphilic Drug–Additive systems in aqueous and organic solvent–water mixed media: A comprehensive account on physicochemical properties
Journal of Molecular Liquids, 2020Co-Authors: Jackson Gurung, Jamsheera Anjudikkal, Ajmal Koya PulikkalAbstract:Abstract The physicochemical properties of Drugs and Drug–Additive interactions have great importance to elucidate the pharmacological effect of the Drug formulations. Plentiful pharmacologically active molecules are amphiphilic in nature. Knowledge about self-assembly, aggregate morphology as well as size and interfacial/micellar properties of such Drugs in presence of pharmaceutical excipients (surfactants, electrolytes, polymers, hydrotropes, etc.) is vital from the fundamental and practical point of view. This article reviews the micellar properties and phase separation of Drugs as well as Drug–Additive systems in aqueous and organic solvent–water mixed media. Results of several pharmaceutical excipients/surfactants assisted Drug mixed systems have been analyzed through thermodynamic parameters which provide a comprehensive account on the physicochemical aspects of Drug/Drug–Additives systems. Along with amphiphilic Drugs, studies of a few non surface-active Drugs have also been reviewed.
Wei Weng - One of the best experts on this subject based on the ideXlab platform.
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Design of a Drug-in-Adhesive Transdermal Patch for Risperidone: Effect of Drug-Additive Interactions on the Crystallization Inhibition and In Vitro/In Vivo Correlation Study
Journal of Pharmaceutical Sciences, 2016Co-Authors: Wei Weng, Peng Quan, Hanqing Zhao, Liang FangAbstract:Abstract The purpose of this work was to develop and design an appropriate Drug-in-adhesive patch for transdermal delivery of risperidone (RISP). Various formulation factors were investigated by in vitro permeation study using excised rabbit skin. Increasing the Drug concentration in the pressure sensitive adhesive (PSA) was used to enhance the Drug permeation. To overcome the high crystallization tendency of the patch, several crystallization inhibitors such as PVP, PEG, and surfactants and fatty acids were evaluated by microscopy study. The mechanism of crystallization inhibition was investigated by differential scanning calorimetry, nuclear magnetic resonance spectrometer, and FT-IR studies. RISP and its active metabolite were determined after topical application of the optimized transdermal patch, and the in vivo pharmacokinetic parameters were compared with the intravenous administration group. The microscopy study indicated that fatty acid greatly inhibited the crystallization of RISP in PSA. The inhibition was attributed to the Drug-Additive interaction between amino group of RISP and the carboxyl group of fatty acid which was further confirmed by 1 H-NMR and FT-IR studies. The optimal permeation profile was obtained with the patches containing 5% RISP and 5% oleic acid in Duro-Tak ® 87-2287. The in vivo pharmacokinetic study exhibited a sustained absorption and metabolism profile and well correlated with the in vitro permeation data.
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Pharmaceutics, Drug Delivery and Pharmaceutical Technology Design of a Drug-in-Adhesive Transdermal Patch for Risperidone: Effect of Drug-Additive Interactions on the Crystallization Inhibition and In Vitro/In Vivo Correlation Study
2016Co-Authors: Wei Weng, Peng Quan, Hanqing Zhao, Chao Liu, Liang FangAbstract:The purpose of this work was to develop and design an appropriate Drug-in-adhesive patch for transdermal delivery of risperidone (RISP). Various formulation factors were investigated by in vitro permeation study using excised rabbit skin. Increasing the Drug concentration in the pressure sensitive adhesive (PSA) was used to enhance the Drug permeation. To overcome the high crystallization tendency of the patch, several crystallization inhibitors such as PVP, PEG, and surfactants and fatty acids were evaluated by microscopy study. The mechanism of crystallization inhibition was investigated by differential scanning calorimetry, nuclear magnetic resonance spectrometer, and FT-IR studies. RISP and its active metabolite were determined after topical application of the optimized transdermal patch, and the in vivo pharmacokinetic parameters were compared with the intravenous administration group. The microscopy study indicated that fatty acid greatly inhibited the crystallization of RISP in PSA. The inhibition was attributed to the Drug-Additive interaction between amino group of RISP and the carboxyl group of fatty acid which was further confirmed by 1 H-NMR and FT-IR studies. The optimal permeation profile was obtained with the patches containing 5% RISP and 5% oleic acid in Duro-Tak ® 87-2287. The in vivo pharmacokinetic study exhibited a
