The Experts below are selected from a list of 16356 Experts worldwide ranked by ideXlab platform
Ulrike Bingel - One of the best experts on this subject based on the ideXlab platform.
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The effects of treatment failure generalize across different Routes of Drug Administration
Science Translational Medicine, 2017Co-Authors: Matthias Zunhammer, Charlotte Engelbrecht, Johanna Bock, Simon S. Kessner, Markus Ploner, Ulrike BingelAbstract:Failure of medical treatments can hamper responses to subsequent treatments. It has been suggested that changing the Route of Drug Administration could reduce such negative carry-over effects, but direct evidence for this approach is lacking. We therefore investigated in 211 healthy volunteers whether changes in Drug Administration Route reduce such carry-over effects. A positive or negative treatment history with topical analgesic treatments was induced experimentally in a mock clinical trial setting. Subsequently, a different inert Drug was introduced via the same (topical) or another (oral) Route of Administration and its analgesic efficacy was tested. Changing the Route of Drug Administration induced expectations of positive treatment effects in the subjects but did not actually counteract the negative carry-over effects on treatment efficacy. These findings indicate that learned carry-over effects generalize over time and across Routes of Drug Administration—independent of conscious expectations. Other strategies are needed to prevent negative carry-over effects of treatment failure from influencing the results of subsequent treatment attempts.
Ulf Norinder - One of the best experts on this subject based on the ideXlab platform.
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predicting the rate of skin penetration using an aggregated conformal prediction framework
Molecular Pharmaceutics, 2017Co-Authors: Martin Lindh, Anders Karlen, Ulf NorinderAbstract:Skin serves as a Drug Administration Route, and skin permeability of chemicals is of significant interest in the pharmaceutical and cosmetic industries. An aggregated conformal prediction (ACP) framework was used to build models for predicting the permeation rate (log Kp) of chemical compounds through human skin. The conformal prediction method gives as an output the prediction range at a given level of confidence for each compound, which enables the user to make a more informed decision when, for example, suggesting the next compound to prepare. Predictive models were built using both the random forest and the support vector machine methods and were based on experimentally derived permeability data on 211 diverse compounds. The derived models were of similar predictive quality as compared to earlier published models but have the extra advantage of not only presenting a single predicted value for each compound but also a reliable, individually assigned prediction range. The models use calculated descripto...
Rabah Boukherroub - One of the best experts on this subject based on the ideXlab platform.
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Transdermal skin patch based on reduced graphene oxide: A new approach for photothermal triggered permeation of ondansetron across porcine skin
Journal of Controlled Release, 2017Co-Authors: Florina Teodorescu, Gurvan Queniat, Catherine Foulon, Marie Lecoeur, Alexandre Barras, Samia Boulahneche, Mohmaed Salah Medjram, Thomas Hubert, Amar Abderrahmani, Rabah BoukherroubAbstract:The development of a skin-mounted patch capable of controlled transcutaneous delivery of therapeutics through thermal activation provides a unique solution for the controlled release of active principles over long-term periods. Here, we report on a flexible transdermal patch for photothermal triggered release of ondansetron (ODS), a commonly used Drug for the treatment of chemotherapy-induced nausea and vomiting and used as model compound here. To achieve this, a dispersion of ODS-loaded reduced graphene oxide (rGO-ODS) nanosheets were deposited onto Kapton to produce a flexible polyimide-based patch. It is demonstrated that ODS loaded Kapton/rGO patches have a high Drug delivery performance upon irradiation with a continuous laser beam at 980 nm for 10 min due to an induced photothermal heating effect. The ability of ODS impregnated Kapton/rGO patches as transdermal delivery scaffolds for ODS across the skin is in addition investigated using porcine ear skin as a model. We show that the cumulative quantity and flux of ODS passing the skin are highly depending on the laser power density used. At 5 W cm − 2 irradiation, the ODS flux across pig skin was determined to be 1.6 μg cm − 2 h − 1 comparable to other approaches. The use of tween 20 as skin enhancer could significantly increase the ODS flux to 13.2 μg cm − 2 h − 1. While the skin penetration enhancement is comparable to that obtained using other well-known permeation enhancers, the actual superiority and interest of the proposed approach is that the Kapton/rGO photoactivatable skin patch can be loaded with any Drugs and therapeutics of interest, making the approach extremely versatile. The on demand delivery of Drugs upon local laser irradiation and the possibility to reload the interface with the Drug makes this new Drug Administration Route very appealing.
Matthias Zunhammer - One of the best experts on this subject based on the ideXlab platform.
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The effects of treatment failure generalize across different Routes of Drug Administration
Science Translational Medicine, 2017Co-Authors: Matthias Zunhammer, Charlotte Engelbrecht, Johanna Bock, Simon S. Kessner, Markus Ploner, Ulrike BingelAbstract:Failure of medical treatments can hamper responses to subsequent treatments. It has been suggested that changing the Route of Drug Administration could reduce such negative carry-over effects, but direct evidence for this approach is lacking. We therefore investigated in 211 healthy volunteers whether changes in Drug Administration Route reduce such carry-over effects. A positive or negative treatment history with topical analgesic treatments was induced experimentally in a mock clinical trial setting. Subsequently, a different inert Drug was introduced via the same (topical) or another (oral) Route of Administration and its analgesic efficacy was tested. Changing the Route of Drug Administration induced expectations of positive treatment effects in the subjects but did not actually counteract the negative carry-over effects on treatment efficacy. These findings indicate that learned carry-over effects generalize over time and across Routes of Drug Administration—independent of conscious expectations. Other strategies are needed to prevent negative carry-over effects of treatment failure from influencing the results of subsequent treatment attempts.
Martin Lindh - One of the best experts on this subject based on the ideXlab platform.
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predicting the rate of skin penetration using an aggregated conformal prediction framework
Molecular Pharmaceutics, 2017Co-Authors: Martin Lindh, Anders Karlen, Ulf NorinderAbstract:Skin serves as a Drug Administration Route, and skin permeability of chemicals is of significant interest in the pharmaceutical and cosmetic industries. An aggregated conformal prediction (ACP) framework was used to build models for predicting the permeation rate (log Kp) of chemical compounds through human skin. The conformal prediction method gives as an output the prediction range at a given level of confidence for each compound, which enables the user to make a more informed decision when, for example, suggesting the next compound to prepare. Predictive models were built using both the random forest and the support vector machine methods and were based on experimentally derived permeability data on 211 diverse compounds. The derived models were of similar predictive quality as compared to earlier published models but have the extra advantage of not only presenting a single predicted value for each compound but also a reliable, individually assigned prediction range. The models use calculated descripto...
