The Experts below are selected from a list of 38445 Experts worldwide ranked by ideXlab platform
James A. Ritter - One of the best experts on this subject based on the ideXlab platform.
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in vitro study of magnetic particle seeding for implant assisted magnetic Drug targeting seed and magnetic Drug Carrier particle capture
Journal of Magnetism and Magnetic Materials, 2009Co-Authors: Misael O Aviles, Armin D. Ebner, James A. RitterAbstract:An implant-assisted-magnetic Drug targeting system using seed particles as the implant to increase the capture of magnetic Drug Carrier particles (MDCPs) in capillary tissue was studied in vitro. Dextran-coated magnetite particles were used as seeds, polydivinylbenzene magnetite particles were used as MDCPs, and a polyethylene porous cylinder was used as surrogate capillary tissue. The results showed that seeds could be magnetically captured first and then used to magnetically capture the MDCPs, causing a significant increase in their collection compared to when the seeds were absent.
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theoretical analysis of a transdermal ferromagnetic implant for retention of magnetic Drug Carrier particles
Journal of Magnetism and Magnetic Materials, 2005Co-Authors: Misael O Aviles, Haitao Chen, Armin D. Ebner, Michael D. Kaminski, Axel J. Rosengart, James A. RitterAbstract:The use of a ferromagnetic wire implant placed near an artery to assist the collection of magnetic Drug Carrier particles (MDCPs) using an external magnet is theoretically studied. Three magnetic Drug targeting (MDT) systems are evaluated in terms of their MDCP collection efficiency (CE): a permanent magnet and wire is better than a permanent magnet alone, which is better than a homogeneous magnetic field and wire.
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analysis of magnetic Drug Carrier particle capture by a magnetizable intravascular stent 2 parametric study with multi wire two dimensional model
Journal of Magnetism and Magnetic Materials, 2005Co-Authors: Haitao Chen, Armin D. Ebner, Michael D. Kaminski, Axel J. Rosengart, James A. RitterAbstract:A 2-D mathematical model was developed and used to examine the capture of magnetic Drug Carrier particles (MDCPs) by a magnetizable intravascular stent (MIS). The roles of both non-stent system parameters, i.e., the blood flow rate, magnetic field strength and direction and MDCP properties, and stent design parameters, i.e., the MIS radius, its wire radius, number of MIS loops, interwire loop spacing and MIS ferromagnetic material were evaluated over a wide range of plausible conditions. The results showed that the MIS could be a very effective magnetic Drug targeting tool with many possible applications.
Paras N. Prasad - One of the best experts on this subject based on the ideXlab platform.
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ceramic based nanoparticles entrapping water insoluble photosensitizing anticancer Drugs a novel Drug Carrier system for photodynamic therapy
Journal of the American Chemical Society, 2003Co-Authors: Indrajit Roy, Haridas E Pudavar, Allan R. Oseroff, Earl J Bergey, Tymish Y. Ohulchanskyy, Janet Morgan, Thomas J. Dougherty, Paras N. PrasadAbstract:A novel nanoparticle-based Drug Carrier for photodynamic therapy is reported which can provide stable aqueous dispersion of hydrophobic photosensitizers, yet preserve the key step of photogeneration of singlet oxygen, necessary for photodynamic action. A multidisciplinary approach is utilized which involves (i) nanochemistry in micellar cavity to produce these Carriers, (ii) spectroscopy to confirm singlet oxygen production, and (iii) in vitro studies using tumor cells to investigate Drug−Carrier uptake and destruction of cancer cells by photodynamic action. Ultrafine organically modified silica-based nanoparticles (diameter ∼30 nm), entrapping water-insoluble photosensitizing anticancer Drug 2-devinyl-2-(1-hexyloxyethyl) pyropheophorbide, have been synthesized in the nonpolar core of micelles by hydrolysis of triethoxyvinylsilane. The resulting Drug-doped nanoparticles are spherical, highly monodispersed, and stable in aqueous system. The entrapped Drug is more fluorescent in aqueous medium than the free...
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ceramic based nanoparticles entrapping water insoluble photosensitizing anticancer Drugs a novel Drug Carrier system for photodynamic therapy
Journal of the American Chemical Society, 2003Co-Authors: Indrajit Roy, Haridas E Pudavar, Allan R. Oseroff, Earl J Bergey, Tymish Y. Ohulchanskyy, Janet Morgan, Thomas J. Dougherty, Paras N. PrasadAbstract:A novel nanoparticle-based Drug Carrier for photodynamic therapy is reported which can provide stable aqueous dispersion of hydrophobic photosensitizers, yet preserve the key step of photogeneration of singlet oxygen, necessary for photodynamic action. A multidisciplinary approach is utilized which involves (i) nanochemistry in micellar cavity to produce these Carriers, (ii) spectroscopy to confirm singlet oxygen production, and (iii) in vitro studies using tumor cells to investigate Drug-Carrier uptake and destruction of cancer cells by photodynamic action. Ultrafine organically modified silica-based nanoparticles (diameter approximately 30 nm), entrapping water-insoluble photosensitizing anticancer Drug 2-devinyl-2-(1-hexyloxyethyl) pyropheophorbide, have been synthesized in the nonpolar core of micelles by hydrolysis of triethoxyvinylsilane. The resulting Drug-doped nanoparticles are spherical, highly monodispersed, and stable in aqueous system. The entrapped Drug is more fluorescent in aqueous medium than the free Drug, permitting use of fluorescence bioimaging studies. Irradiation of the photosensitizing Drug entrapped in nanoparticles with light of suitable wavelength results in efficient generation of singlet oxygen, which is made possible by the inherent porosity of the nanoparticles. In vitro studies have demonstrated the active uptake of Drug-doped nanoparticles into the cytosol of tumor cells. Significant damage to such impregnated tumor cells was observed upon irradiation with light of wavelength 650 nm. Thus, the potential of using ceramic-based nanoparticles as Drug Carriers for photodynamic therapy has been demonstrated.
Hsing-wen Sung - One of the best experts on this subject based on the ideXlab platform.
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genipin crosslinked gelatin microspheres as a Drug Carrier for intramuscular administration in vitro and in vivo studies
Journal of Biomedical Materials Research Part A, 2003Co-Authors: Huangchien Liang, Wenhsiang Chang, Kojung Lin, Hsing-wen SungAbstract:Gelatin microspheres have been widely evaluated as a Drug Carrier. Nevertheless, gelatin dissolves rather rapidly in aqueous environments, making the use of the polymer difficult for the production of long-term delivery systems. This adverse aspect requires the use of a crosslinking agent in forming nonsoluble networks in microspheres. However, the use of crosslinking agents such as formaldehyde and glutaraldehyde can lead to toxic side effects owing to residual crosslinkers. In an attempt to overcome this problem, a naturally occurring crosslinking agent (genipin) was used to crosslink gelatin microspheres as a biodegradable Drug-delivery system for intramuscular administration. Glutaraldehyde was used as a control. In the in vitro study, the morphology, dynamic swelling, and antienzymatic degradation of test microspheres were evaluated. In the in vivo study, the biocompatibility and degradability of test microspheres were implanted in the skeletal muscle of a rat model via intramuscular injection. The results obtained in the study suggested that crosslinking of gelatin microspheres with glutaraldehyde or genipin may produce distinct crosslinking structures. The water transport mechanism in both the glutaraldehyde- and genipin-crosslinked gelatin microspheres exhibit anomalous behavior ranging from Fickian to Case-II extremes. The increase of the swelling diameter for the genipin-crosslinked microspheres was significantly less than that observed for the glutaraldehyde-crosslinked microspheres. In the animal study, it was found that the degree in inflammatory reaction for tissues implanted with the genipin-crosslinked microspheres was significantly less than that implanted with the glutaraldehyde-crosslinked microspheres. Additionally, the degradation rate of the genipin-crosslinked microspheres was significantly slower than their glutaraldehyde-crosslinked counterparts. These results indicated that the genipin-crosslinked gelatin microspheres may be used as a long-acting Drug Carrier for intramuscular administration. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 65A: 271–282, 2003
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genipin crosslinked gelatin microspheres as a Drug Carrier for intramuscular administration in vitro and in vivo studies
Journal of Biomedical Materials Research Part A, 2003Co-Authors: Huangchien Liang, Wenhsiang Chang, Kojung Lin, Hsing-wen SungAbstract:Gelatin microspheres have been widely evaluated as a Drug Carrier. Nevertheless, gelatin dissolves rather rapidly in aqueous environments, making the use of the polymer difficult for the production of long-term delivery systems. This adverse aspect requires the use of a crosslinking agent in forming nonsoluble networks in microspheres. However, the use of crosslinking agents such as formaldehyde and glutaraldehyde can lead to toxic side effects owing to residual crosslinkers. In an attempt to overcome this problem, a naturally occurring crosslinking agent (genipin) was used to crosslink gelatin microspheres as a biodegradable Drug-delivery system for intramuscular administration. Glutaraldehyde was used as a control. In the in vitro study, the morphology, dynamic swelling, and antienzymatic degradation of test microspheres were evaluated. In the in vivo study, the biocompatibility and degradability of test microspheres were implanted in the skeletal muscle of a rat model via intramuscular injection. The results obtained in the study suggested that crosslinking of gelatin microspheres with glutaraldehyde or genipin may produce distinct crosslinking structures. The water transport mechanism in both the glutaraldehyde- and genipin-crosslinked gelatin microspheres exhibit anomalous behavior ranging from Fickian to Case-II extremes. The increase of the swelling diameter for the genipin-crosslinked microspheres was significantly less than that observed for the glutaraldehyde-crosslinked microspheres. In the animal study, it was found that the degree in inflammatory reaction for tissues implanted with the genipin-crosslinked microspheres was significantly less than that implanted with the glutaraldehyde-crosslinked microspheres. Additionally, the degradation rate of the genipin-crosslinked microspheres was significantly slower than their glutaraldehyde-crosslinked counterparts. These results indicated that the genipin-crosslinked gelatin microspheres may be used as a long-acting Drug Carrier for intramuscular administration.
Yu Chen Chien - One of the best experts on this subject based on the ideXlab platform.
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Hyaluronic acid-based nano-sized Drug Carrier-containing Gellan gum microspheres as potential multifunctional embolic agent
Scientific Reports, 2018Co-Authors: Ming Fang Hsu, Yen Sheng Tyan, Yu Chen Chien, Ming Wei LeeAbstract:The purpose of this study was to develop a gellan gum-based multifunctional embolic agent. Calibrated spherical gellan gum and nanoparticle-containing gellan gum microspheres were prepared via water-in oil emulsification method. Self-assembled nanoparticles composed of short-chain hyaluronic acid and polyethylenimine as the doxorubicin Carrier were prepared. The short-chain hyaluronic acid/polyethylenimine/ doxorubicin (sHH/PH/Dox) with the mean size was 140 ± 8 nm. To examine sHH/PH/Dox nanoparticle uptake into cells, the results confirmed that sHH/PH nanoparticles as Drug Carrier can facilitate the transport of doxorubicin into HepG2 liver cancer cells. Subsequently, sHH/PH/Dox merged into the gellan gum (GG) microspheres forming GG/sHH/PH/Dox microsphere. After a Drug release experiment lasting 45 days, the amount of released doxorubicin from 285, 388, and 481 μm GG/sHH/PH/Dox microspheres were approximately 4.8, 1.8 and 1.1-fold above the IC50 value of the HepG2 cell. GG/sHH/PH/Dox microspheres were performed in rabbit ear embolization model and ischemic necrosis on ear was visible due to the vascular after 8 days. Regarding the application of this device in the future, we aim to provide better embolization agents for transcatheter arterial chemoembolization (TACE).
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hyaluronic acid based nano sized Drug Carrier containing gellan gum microspheres as potential multifunctional embolic agent
Scientific Reports, 2018Co-Authors: Yen Sheng Tyan, Yu Chen ChienAbstract:The purpose of this study was to develop a gellan gum-based multifunctional embolic agent. Calibrated spherical gellan gum and nanoparticle-containing gellan gum microspheres were prepared via water-in oil emulsification method. Self-assembled nanoparticles composed of short-chain hyaluronic acid and polyethylenimine as the doxorubicin Carrier were prepared. The short-chain hyaluronic acid/polyethylenimine/ doxorubicin (sHH/PH/Dox) with the mean size was 140 ± 8 nm. To examine sHH/PH/Dox nanoparticle uptake into cells, the results confirmed that sHH/PH nanoparticles as Drug Carrier can facilitate the transport of doxorubicin into HepG2 liver cancer cells. Subsequently, sHH/PH/Dox merged into the gellan gum (GG) microspheres forming GG/sHH/PH/Dox microsphere. After a Drug release experiment lasting 45 days, the amount of released doxorubicin from 285, 388, and 481 μm GG/sHH/PH/Dox microspheres were approximately 4.8, 1.8 and 1.1-fold above the IC50 value of the HepG2 cell. GG/sHH/PH/Dox microspheres were performed in rabbit ear embolization model and ischemic necrosis on ear was visible due to the vascular after 8 days. Regarding the application of this device in the future, we aim to provide better embolization agents for transcatheter arterial chemoembolization (TACE).
Indrajit Roy - One of the best experts on this subject based on the ideXlab platform.
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ceramic based nanoparticles entrapping water insoluble photosensitizing anticancer Drugs a novel Drug Carrier system for photodynamic therapy
Journal of the American Chemical Society, 2003Co-Authors: Indrajit Roy, Haridas E Pudavar, Allan R. Oseroff, Earl J Bergey, Tymish Y. Ohulchanskyy, Janet Morgan, Thomas J. Dougherty, Paras N. PrasadAbstract:A novel nanoparticle-based Drug Carrier for photodynamic therapy is reported which can provide stable aqueous dispersion of hydrophobic photosensitizers, yet preserve the key step of photogeneration of singlet oxygen, necessary for photodynamic action. A multidisciplinary approach is utilized which involves (i) nanochemistry in micellar cavity to produce these Carriers, (ii) spectroscopy to confirm singlet oxygen production, and (iii) in vitro studies using tumor cells to investigate Drug−Carrier uptake and destruction of cancer cells by photodynamic action. Ultrafine organically modified silica-based nanoparticles (diameter ∼30 nm), entrapping water-insoluble photosensitizing anticancer Drug 2-devinyl-2-(1-hexyloxyethyl) pyropheophorbide, have been synthesized in the nonpolar core of micelles by hydrolysis of triethoxyvinylsilane. The resulting Drug-doped nanoparticles are spherical, highly monodispersed, and stable in aqueous system. The entrapped Drug is more fluorescent in aqueous medium than the free...
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ceramic based nanoparticles entrapping water insoluble photosensitizing anticancer Drugs a novel Drug Carrier system for photodynamic therapy
Journal of the American Chemical Society, 2003Co-Authors: Indrajit Roy, Haridas E Pudavar, Allan R. Oseroff, Earl J Bergey, Tymish Y. Ohulchanskyy, Janet Morgan, Thomas J. Dougherty, Paras N. PrasadAbstract:A novel nanoparticle-based Drug Carrier for photodynamic therapy is reported which can provide stable aqueous dispersion of hydrophobic photosensitizers, yet preserve the key step of photogeneration of singlet oxygen, necessary for photodynamic action. A multidisciplinary approach is utilized which involves (i) nanochemistry in micellar cavity to produce these Carriers, (ii) spectroscopy to confirm singlet oxygen production, and (iii) in vitro studies using tumor cells to investigate Drug-Carrier uptake and destruction of cancer cells by photodynamic action. Ultrafine organically modified silica-based nanoparticles (diameter approximately 30 nm), entrapping water-insoluble photosensitizing anticancer Drug 2-devinyl-2-(1-hexyloxyethyl) pyropheophorbide, have been synthesized in the nonpolar core of micelles by hydrolysis of triethoxyvinylsilane. The resulting Drug-doped nanoparticles are spherical, highly monodispersed, and stable in aqueous system. The entrapped Drug is more fluorescent in aqueous medium than the free Drug, permitting use of fluorescence bioimaging studies. Irradiation of the photosensitizing Drug entrapped in nanoparticles with light of suitable wavelength results in efficient generation of singlet oxygen, which is made possible by the inherent porosity of the nanoparticles. In vitro studies have demonstrated the active uptake of Drug-doped nanoparticles into the cytosol of tumor cells. Significant damage to such impregnated tumor cells was observed upon irradiation with light of wavelength 650 nm. Thus, the potential of using ceramic-based nanoparticles as Drug Carriers for photodynamic therapy has been demonstrated.
