The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform
Sabrina A. Assoumou - One of the best experts on this subject based on the ideXlab platform.
-
HIV Pre-exposure Prophylaxis and Buprenorphine at a Drug Detoxification Center During the Opioid Epidemic: Opportunities and Challenges
AIDS and Behavior, 2021Co-Authors: Sabrina A. Assoumou, Samantha M Paniagua, Jianing Wang, Jeffrey H. Samet, Laura F. White, Curt G. Beckwith, Priscilla Gonzalez, Jessica L. Taylor, Kristen Coogan, Benjamin P. LinasAbstract:Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) and buprenorphine decrease HIV acquisition. Between November, 2016 and July, 2017, we surveyed persons (N = 200) at a Drug Detoxification center to assess their interest in PrEP and in buprenorphine, and to examine factors associated with such interests. Over the previous 6 months, 58% (117/200) injected Drugs, 87% (173/200) used opioids, 50% (85/171) had condomless sex. Only 22% (26/117) of persons who injected Drugs were aware of PrEP, yet 74% (86/116) and 72% (84/116) were interested in oral or injectable PrEP, respectively. Thirty-eight percent (47/125) of persons not receiving buprenorphine or methadone expressed interest in buprenorphine. After multivariable adjustment, Latinx ethnicity was associated with interest in PrEP (aOR 3.80; 95% CI 1.37–10.53), while male gender (aOR 2.76; 95% CI 1.21–6.34) was associated with interest in buprenorphine. Opportunities exist to implement PrEP and buprenorphine within Drug Detoxification centers. Clinical trial registration NCT02869776. Clinicaltrials.gov https://clinicaltrials.gov/ct2/show/NCT02869776?term=Sabrina+Assoumou&cond=HIV+HCV&rank=1 .
-
Patients at a Drug Detoxification center share perspectives on how to increase hepatitis C treatment uptake: A qualitative study.
Drug and alcohol dependence, 2021Co-Authors: Sabrina A. Assoumou, Benjamin P. Linas, Jeffrey H. Samet, Carlos R. Sian, Christina Gebel, Judith BernsteinAbstract:Abstract Background The US opioid crisis is associated with a surge in hepatitis C virus (HCV) infections among persons who inject Drugs (PWID), and yet the uptake of HCV curative therapy among PWID is low. Purpose To explore potential solutions to overcome barriers to HCV treatment uptake among individuals at a Drug Detoxification center. Methods Qualitative study with in-depth interviews and thematic analysis of coded data. Results Patients (N = 24) had the following characteristics: mean age 37 years; 67 % White, 13 % Black, 8 % Latinx, 4 % Native Hawaiian/Pacific Islander, 8 % other; 71 % with a history of injecting Drugs. Most patients with a positive HCV test had not pursued treatment due to few perceived immediate consequences from a positive test and possible complications arising in a distant poorly imagined future. Active substance use was a major barrier to HCV treatment uptake because of disruptions to routine activities. In addition, re-infection after treatment was perceived as inevitable. Patients had suggestions to improve HCV treatment uptake: high-intensity wraparound care characterized by frequent interactions with supportive services; same-day/walk-in options; low-barrier access to substance use treatment; assistance with navigating the health care system; attention to immediate needs, such as housing; and the opportunity to select an approach that best fits individual circumstances. Conclusions Active substance use was a major barrier to treatment initiation. To improve uptake, affected individuals recommended that HCV treatment be integrated within substance use treatment programs. Such a model should incorporate patient education within low-barrier, high-intensity wraparound care, tailored to patients’ needs and priorities.
-
Rapid Versus Laboratory-Based Testing for HIV and Hepatitis C at a Drug Detoxification Treatment Center: A Randomized Trial.
The Journal of infectious diseases, 2020Co-Authors: Sabrina A. Assoumou, Samantha M Paniagua, Benjamin P. Linas, Jianing Wang, Jeffrey H. Samet, Jonathan Hall, Laura F. White, Curt G. BeckwithAbstract:Background A health department survey revealed nearly half employ laboratory-based HIV and HCV testing (LBT) over rapid testing (RT) in nonhospital settings such as Drug Detoxification centers. LBT has higher sensitivity for acute HIV infection compared to RT but LBT is not point of care and may result in fewer diagnoses due to loss to follow-up before result delivery. Methods We conducted a randomized trial comparing real-world case notification of RT (Orasure) vs LBT (HIV Combo Ag/Ab EIA, HCV EIA) for HIV and HCV at a Drug Detoxification center. Primary outcome was receipt of test results within 2 weeks. Results Among 341 individuals screened (11/2016-7/2017), 200 met inclusion criteria; 58% injected Drugs and 31% shared needles in the previous 6 months. Of the 200 randomized, 98 received RT and 102 LBT. Among all participants, 0.5% were positive for HIV and 48% for HCV; 96% received test results in the RT arm and 42% in the LBT arm (odds ratio, 28.72; 95% confidence interval, 10.27-80.31). Real-world case notification was 95% and 93% for HIV and HCV RT, respectively, compared to 42% for HIV and HCV LBT. Conclusions RT has higher real-world case notification than LBT at Drug Detoxification centers.Clinical trials registration: NCT02869776.
Bruce E Mackey - One of the best experts on this subject based on the ideXlab platform.
-
dietary trans 10 cis 12 conjugated linoleic acid reduces the expression of fatty acid oxidation and Drug Detoxification enzymes in mouse liver
British Journal of Nutrition, 2007Co-Authors: Reuven Rasooly, Darshan S Kelley, Jeff Greg, Bruce E MackeyAbstract:Mice fed diets containing trans 10, cis 12 (tlO, cl2)-conjugated linoleic acid (CLA) develop fatty livers and the role of hepatic fatty acid oxidation enzymes in this development is not well defined. We examined the effects of dietary cis 9, trans 11-CLA (c9, tl 1-CLA) and t10, cl2-CLA on the expression of hepatic genes for fatty acid metabolism. Female mice, 8 weeks old, (six animals per group) were fed either a control diet or diets supplemented with 0·5 % c9, t11- or t10, c12-CLA for 8 weeks. DNA microarray analysis showed that t10, cl2-CLA increased the expression of 278 hepatic genes and decreased those of 121 genes (>2-fold); c9, tl 1-CLA increased expression of twenty-two genes and decreased those of nine. Real-time PCR confirmed that t10, c12-CLA reduced by the expression of fatty acid oxidation genes including flavin monooxygenase (FMO)-3 95 %, cytochrome P450 (cyt P450) 69%, carnitine palmitoyl transferase la 77%, acetyl CoA oxidase (ACOX) 50% and PPARa 65 %; it increased the expression of fatty acid synthase by 3·5-fold (P<0·05 for all genes, except ACOX P=0·08). It also reduced the enzymatic activity of hepatic microsomal FMO by 40 % and the FM03 specific protein by 67 %. c9, tl 1-CLA reduced FM03 and cyt P450 expression by 61 % (P= 0·001) and 38 % (P=0·06) and increased steoryl CoA desaturase transcription by 5·9-fold (P=0·07). Both decreased fatty acid oxidation and increased fatty acid synthesis seem to contribute to the CLA-induced fatty liver. Since FMO and cyt P450 are also involved in Drug Detoxification, suppression of the transcription of these genes by CLA may have other health consequences besides development of fatty liver.
-
dietary trans 10 cis 12 conjugated linoleic acid reduces the expression of fatty acid oxidation and Drug Detoxification enzymes in mouse liver
British Journal of Nutrition, 2007Co-Authors: Reuven Rasooly, Darshan S Kelley, Jeff Greg, Bruce E MackeyAbstract:Mice fed diets containing trans 10, cis 12 (t10, c12)-conjugated linoleic acid (CLA) develop fatty livers and the role of the hepatic fatty acid oxidation enzymes in this development is not well defined. We examined the effects of dietary cis 9, trans 11-CLA (c9, t11-CLA) and t10, c12-CLA on the expression of hepatic genes for fatty acid metabolism. Female mice, 8 weeks old, (six animals per group) were fed either a control diet or diets supplemented with 0.5% c9, t11- or c12-CLA for 8 weeks. DNA microarray analysis showed that t10, c12-CLA increased the expression of 278 hepatic genes and decreased those of 121 genes (>2 fold); c9, t11-CLA increased expression of twenty-two genes and decreased those of nine. Real-time PCR confirmed that t10, c12-CLA reduced by the expression of fatty acid oxidation genes including flavin monooxygenase (FMO)-3 95%, cytochrome P450 (cyt p450) 69%, carnitine palmitoyl transferase 1a 77%, acetyl CoA oxidase (ACOX) 50% and PPARalpha 65%: it increased the expression of fatty acid synthase by 3.5-fold (P<0.05 for all genes, except ACOX P=0.08). It also reduced the enzymatic activity of hepatic microsomal FMO by 40% and the FMO3 specific protein by 67%. c9, t11-CLA reduced FMO3 and cyt P450 expression by 61% (P=0.001) and 38% (P=0.06) and increased steoryl CoA desaturase transcription by 5.9-fold (P=0.07). Both decreased fatty acid oxidation and increased fatty acid synthesis seem to contribute to the CLA-induced fatty liver. Since FMO and cyt P450 are also involved in Drug Detoxification, suppression of the transcription of these genes by CLA may have other health consequences besides development of fatty liver.
Joseph I. Okogun - One of the best experts on this subject based on the ideXlab platform.
-
antioxidant and Drug Detoxification potentials of hibiscus sabdariffa anthocyanin extract
Drug and Chemical Toxicology, 2011Co-Authors: Taofeek O Ajiboye, Nasir A Salawu, M T Yakubu, A T Oladiji, M A Akanji, Joseph I. OkogunAbstract:The antioxidant and Drug metabolizing potentials of Hibiscus anthocyanin extract in CCl4- induced oxidative damage of rat liver was investigated. Hibiscus anthocyanin extract effectively scavenge α-diphenyl-β-picrylhydrazyl (DPPH) radical, superoxide ion, and hydrogen peroxide. It produced a 92% scavenging effect of DPPH radical at a concentration of 2.0 mg/mL. Hibiscus anthocyanin extract produced a 69 and 90% scavenging effect on superoxide ion and hydrogen peroxide, respectively, at 1.0 mg/mL, which compared favorably with the synthetic antioxidant (butylated hydroanisole and α-tocopherol). A reducing power of this anthocyanin was examined using K3Fe(CN)6. Hibiscus anthocyanin extract has reducing power that is approximately 2-fold that of the synthetic antioxidant, butylated hydroanisole. Hibiscus anthocyanin extract produced a significantly increase and completely attenuated the CCl4-mediated decrease in antioxidant enzymes (e.g., catalase, superoxide dismutase, glutathione peroxidase, and glutathion...
-
antioxidant and Drug Detoxification potential of aqueous extract of annona senegalensis leaves in carbon tetrachloride induced hepatocellular damage
Pharmaceutical Biology, 2010Co-Authors: Taofeek O Ajboye, Musa Toyin Yakubu, Amadu Kayode Salau, Adenike Temidayo Oladiji, Musbau A. Akanji, Joseph I. OkogunAbstract:Context: Despite the myriad uses of Annona senegalensis Pers. (Annonaceae) leaves in folklore medicine of Nigeria, the basis is yet to be substantiated by scientific investigations.Objectives: To investigate the antioxidant (in vitro and in vivo) and Drug Detoxification potential of aqueous extract of A. senegalensis leaves in CCl4-induced hepatocellular damage.Materials and methods: In vitro antioxidant activity of the aqueous extract of A. senegalensis leaves was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH), H2O2, superoxide ion, 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate) (ABTS) and ferric ion models while in vivo antioxidant and Drug Detoxification activities of the extract at 100, 200, and 400 mg/kg body weight were done by assaying the levels of enzymic and non-enzymic indices in CCl4-induced hepatocellular damage.Results: The extract at 1 mg/mL scavenged DPPH, H2O2, superoxide ion, and ABTS radicals, whereas ferric ion was significantly (P <0.05) reduced. The levels of alkaline and ...
-
Antioxidant and Drug Detoxification potential of aqueous extract of Annona senegalensis leaves in carbon tetrachloride-induced hepatocellular damage.
Pharmaceutical biology, 2010Co-Authors: Taofeek O Ajboye, Musa Toyin Yakubu, Amadu Kayode Salau, Adenike Temidayo Oladiji, Musbau A. Akanji, Joseph I. OkogunAbstract:Context: Despite the myriad uses of Annona senegalensis Pers. (Annonaceae) leaves in folklore medicine of Nigeria, the basis is yet to be substantiated by scientific investigations.Objectives: To investigate the antioxidant (in vitro and in vivo) and Drug Detoxification potential of aqueous extract of A. senegalensis leaves in CCl4-induced hepatocellular damage.Materials and methods: In vitro antioxidant activity of the aqueous extract of A. senegalensis leaves was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH), H2O2, superoxide ion, 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate) (ABTS) and ferric ion models while in vivo antioxidant and Drug Detoxification activities of the extract at 100, 200, and 400 mg/kg body weight were done by assaying the levels of enzymic and non-enzymic indices in CCl4-induced hepatocellular damage.Results: The extract at 1 mg/mL scavenged DPPH, H2O2, superoxide ion, and ABTS radicals, whereas ferric ion was significantly (P
Ronald H. Baney - One of the best experts on this subject based on the ideXlab platform.
-
aromatic aromatic interaction of amitriptyline implication of overdosed Drug Detoxification
Journal of Pharmaceutical Sciences, 2005Co-Authors: Dongwon Lee, Jason A. Flint, Timothy E. Morey, Donn M. Dennis, Richard E. Partch, Ronald H. BaneyAbstract:The objectives of this work are to explore the pi-pi complexation of amitriptyline with pi electron-deficient aromatic rings and demonstrate the feasibility of pi-pi complexation for overdosed Drug Detoxification. Water-soluble oligochitosan was chemically modified with dinitrobenzenesulfonyl groups to induce selective binding toward amitriptyline through pi-pi complexation. NMR studies showed that benzenesulfonyl and dinitrobenzenesulfonyl protons were upfield shifted by the addition of amitriptyline, indicating the formation of pi-pi complexes. The pi-pi complexation of amitriptyline is driven primarily by a desolvation driving force, whereas the magnitude of interaction is dictated by the complementrary electrostatic interaction. Isolated rat heart tests revealed that dinitrobenzenesulfonyl oligochitosan prevented the amitriptyline-induced cardiotoxicity and was itself not cardiotoxic.
-
Aromatic–Aromatic Interaction of Amitriptyline: Implication of Overdosed Drug Detoxification
Journal of pharmaceutical sciences, 2005Co-Authors: Dongwon Lee, Jason A. Flint, Timothy E. Morey, Donn M. Dennis, Richard E. Partch, Ronald H. BaneyAbstract:The objectives of this work are to explore the pi-pi complexation of amitriptyline with pi electron-deficient aromatic rings and demonstrate the feasibility of pi-pi complexation for overdosed Drug Detoxification. Water-soluble oligochitosan was chemically modified with dinitrobenzenesulfonyl groups to induce selective binding toward amitriptyline through pi-pi complexation. NMR studies showed that benzenesulfonyl and dinitrobenzenesulfonyl protons were upfield shifted by the addition of amitriptyline, indicating the formation of pi-pi complexes. The pi-pi complexation of amitriptyline is driven primarily by a desolvation driving force, whereas the magnitude of interaction is dictated by the complementrary electrostatic interaction. Isolated rat heart tests revealed that dinitrobenzenesulfonyl oligochitosan prevented the amitriptyline-induced cardiotoxicity and was itself not cardiotoxic.
-
oligochitosan derivatives bearing electron deficient aromatic rings for adsorption of amitriptyline implications for Drug Detoxification
Biomacromolecules, 2004Co-Authors: Dongwon Lee, Ronald H. BaneyAbstract:The objective of this work is the synthesis of water-soluble oligochitosan derivatives with electron deficient aromatic rings for selective and rapid adsorption of amitriptyline through pi-pi complexation. Oligochitosan was chemically modified under homogeneous conditions in dimethyl sulfoxide (DMSO). (1)H NMR, FT-IR, and MALDI-TOF were employed in characterization, confirming that the electron deficient aromatic rings were chemically attached to the backbone of oligochitosan. Thromboelastography (TEG) revealed functionalized oligochitosan derivatives did not affect blood clotting. (1)H NMR was also utilized to observe the aromatic-aromatic interaction between electron deficient aromatic rings on oligochitosan and electron rich aromatic rings in amitriptyline. The chemical shift variation of aromatic protons in oligochitosan derivatives was followed to monitor the aromatic-aromatic interaction. Upfield shift of aromatic protons on benzenesulfonyl and dinitrobenzenesulfonyl groups was observed upon the addition of amitriptyline, supporting the formation of pi-pi complexes through aromatic-aromatic interactions. Dinitrobenzenesulfonyl rings show a larger variation in chemical shift due to the presence of the electron deficient nitro groups.
-
Oligochitosan derivatives bearing electron-deficient aromatic rings for adsorption of amitriptyline: implications for Drug Detoxification.
Biomacromolecules, 2004Co-Authors: Dongwon Lee, Ronald H. BaneyAbstract:The objective of this work is the synthesis of water-soluble oligochitosan derivatives with electron deficient aromatic rings for selective and rapid adsorption of amitriptyline through π−π complexation. Oligochitosan was chemically modified under homogeneous conditions in dimethyl sulfoxide (DMSO). 1H NMR, FT-IR, and MALDI-TOF were employed in characterization, confirming that the electron deficient aromatic rings were chemically attached to the backbone of oligochitosan. Thromboelastography (TEG) revealed functionalized oligochitosan derivatives did not affect blood clotting. 1H NMR was also utilized to observe the aromatic−aromatic interaction between electron deficient aromatic rings on oligochitosan and electron rich aromatic rings in amitriptyline. The chemical shift variation of aromatic protons in oligochitosan derivatives was followed to monitor the aromatic−aromatic interaction. Upfield shift of aromatic protons on benzenesulfonyl and dinitrobenzenesulfonyl groups was observed upon the addition ...
Benjamin P. Linas - One of the best experts on this subject based on the ideXlab platform.
-
HIV Pre-exposure Prophylaxis and Buprenorphine at a Drug Detoxification Center During the Opioid Epidemic: Opportunities and Challenges
AIDS and Behavior, 2021Co-Authors: Sabrina A. Assoumou, Samantha M Paniagua, Jianing Wang, Jeffrey H. Samet, Laura F. White, Curt G. Beckwith, Priscilla Gonzalez, Jessica L. Taylor, Kristen Coogan, Benjamin P. LinasAbstract:Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) and buprenorphine decrease HIV acquisition. Between November, 2016 and July, 2017, we surveyed persons (N = 200) at a Drug Detoxification center to assess their interest in PrEP and in buprenorphine, and to examine factors associated with such interests. Over the previous 6 months, 58% (117/200) injected Drugs, 87% (173/200) used opioids, 50% (85/171) had condomless sex. Only 22% (26/117) of persons who injected Drugs were aware of PrEP, yet 74% (86/116) and 72% (84/116) were interested in oral or injectable PrEP, respectively. Thirty-eight percent (47/125) of persons not receiving buprenorphine or methadone expressed interest in buprenorphine. After multivariable adjustment, Latinx ethnicity was associated with interest in PrEP (aOR 3.80; 95% CI 1.37–10.53), while male gender (aOR 2.76; 95% CI 1.21–6.34) was associated with interest in buprenorphine. Opportunities exist to implement PrEP and buprenorphine within Drug Detoxification centers. Clinical trial registration NCT02869776. Clinicaltrials.gov https://clinicaltrials.gov/ct2/show/NCT02869776?term=Sabrina+Assoumou&cond=HIV+HCV&rank=1 .
-
Patients at a Drug Detoxification center share perspectives on how to increase hepatitis C treatment uptake: A qualitative study.
Drug and alcohol dependence, 2021Co-Authors: Sabrina A. Assoumou, Benjamin P. Linas, Jeffrey H. Samet, Carlos R. Sian, Christina Gebel, Judith BernsteinAbstract:Abstract Background The US opioid crisis is associated with a surge in hepatitis C virus (HCV) infections among persons who inject Drugs (PWID), and yet the uptake of HCV curative therapy among PWID is low. Purpose To explore potential solutions to overcome barriers to HCV treatment uptake among individuals at a Drug Detoxification center. Methods Qualitative study with in-depth interviews and thematic analysis of coded data. Results Patients (N = 24) had the following characteristics: mean age 37 years; 67 % White, 13 % Black, 8 % Latinx, 4 % Native Hawaiian/Pacific Islander, 8 % other; 71 % with a history of injecting Drugs. Most patients with a positive HCV test had not pursued treatment due to few perceived immediate consequences from a positive test and possible complications arising in a distant poorly imagined future. Active substance use was a major barrier to HCV treatment uptake because of disruptions to routine activities. In addition, re-infection after treatment was perceived as inevitable. Patients had suggestions to improve HCV treatment uptake: high-intensity wraparound care characterized by frequent interactions with supportive services; same-day/walk-in options; low-barrier access to substance use treatment; assistance with navigating the health care system; attention to immediate needs, such as housing; and the opportunity to select an approach that best fits individual circumstances. Conclusions Active substance use was a major barrier to treatment initiation. To improve uptake, affected individuals recommended that HCV treatment be integrated within substance use treatment programs. Such a model should incorporate patient education within low-barrier, high-intensity wraparound care, tailored to patients’ needs and priorities.
-
Rapid Versus Laboratory-Based Testing for HIV and Hepatitis C at a Drug Detoxification Treatment Center: A Randomized Trial.
The Journal of infectious diseases, 2020Co-Authors: Sabrina A. Assoumou, Samantha M Paniagua, Benjamin P. Linas, Jianing Wang, Jeffrey H. Samet, Jonathan Hall, Laura F. White, Curt G. BeckwithAbstract:Background A health department survey revealed nearly half employ laboratory-based HIV and HCV testing (LBT) over rapid testing (RT) in nonhospital settings such as Drug Detoxification centers. LBT has higher sensitivity for acute HIV infection compared to RT but LBT is not point of care and may result in fewer diagnoses due to loss to follow-up before result delivery. Methods We conducted a randomized trial comparing real-world case notification of RT (Orasure) vs LBT (HIV Combo Ag/Ab EIA, HCV EIA) for HIV and HCV at a Drug Detoxification center. Primary outcome was receipt of test results within 2 weeks. Results Among 341 individuals screened (11/2016-7/2017), 200 met inclusion criteria; 58% injected Drugs and 31% shared needles in the previous 6 months. Of the 200 randomized, 98 received RT and 102 LBT. Among all participants, 0.5% were positive for HIV and 48% for HCV; 96% received test results in the RT arm and 42% in the LBT arm (odds ratio, 28.72; 95% confidence interval, 10.27-80.31). Real-world case notification was 95% and 93% for HIV and HCV RT, respectively, compared to 42% for HIV and HCV LBT. Conclusions RT has higher real-world case notification than LBT at Drug Detoxification centers.Clinical trials registration: NCT02869776.
