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Geoffrey Lee - One of the best experts on this subject based on the ideXlab platform.
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Non Steady-state Descriptions of Drug Permeation Through Stratum Corneum. I. The Biphasic Brick-and-Mortar Model
Pharmaceutical research, 1996Co-Authors: Michael Heisig, Gabriel Wittum, Renate Lieckfeldt, George Mazurkevich, Geoffrey LeeAbstract:Purpose. The Diffusion equation should be solved for the non-steady-state problem of Drug Diffusion within a two-dimensional, biphasic stratum corneum membrane having homogeneous lipid and corneocyte phases.
Stefaan C De Smedt - One of the best experts on this subject based on the ideXlab platform.
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Laser-induced vapour nanobubbles improve Drug Diffusion and efficiency in bacterial biofilms
Nature Communications, 2018Co-Authors: Eline Teirlinck, Ranhua Xiong, Toon Brans, Katrien Forier, Juan Fraire, Heleen Van Acker, Nele Matthijs, Riet De Rycke, Stefaan C De Smedt, Tom CoenyeAbstract:Eradication of bacterial infections can be hindered by poor penetration of antibiotics through biofilms. Here, Teirlinck et al . show that laser-induced vapour nanobubbles formed around plasmonic nanoparticles can be used to locally disturb biofilm integrity and improve antibiotic Diffusion.AbstractHindered penetration of antibiotics through biofilms is one of the reasons for the alarming increase in bacterial tolerance to antibiotics. Here, we investigate the potential of laser-induced vapour nanobubbles (VNBs) formed around plasmonic nanoparticles to locally disturb biofilm integrity and improve antibiotics Diffusion. Our results show that biofilms of both Gram-negative ( Burkholderia multivorans , Pseudomonas aeruginosa ) and Gram-positive ( Staphylococcus aureus ) bacteria can be loaded with cationic 70-nm gold nanoparticles and that subsequent laser illumination results in VNB formation inside the biofilms. In all types of biofilms tested, VNB formation leads to substantial local biofilm disruption, increasing tobramycin efficacy up to 1-3 orders of magnitude depending on the organism and treatment conditions. Altogether, our results support the potential of laser-induced VNBs as a new approach to disrupt biofilms of a broad range of organisms, resulting in improved antibiotic Diffusion and more effective biofilm eradication.
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laser induced vapour nanobubbles improve Drug Diffusion and efficiency in bacterial biofilms
Nature Communications, 2018Co-Authors: Eline Teirlinck, Ranhua Xiong, Toon Brans, Katrien Forier, Juan Fraire, Heleen Van Acker, Nele Matthijs, Riet De Rycke, Stefaan C De SmedtAbstract:Hindered penetration of antibiotics through biofilms is one of the reasons for the alarming increase in bacterial tolerance to antibiotics. Here, we investigate the potential of laser-induced vapour nanobubbles (VNBs) formed around plasmonic nanoparticles to locally disturb biofilm integrity and improve antibiotics Diffusion. Our results show that biofilms of both Gram-negative (Burkholderia multivorans, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria can be loaded with cationic 70-nm gold nanoparticles and that subsequent laser illumination results in VNB formation inside the biofilms. In all types of biofilms tested, VNB formation leads to substantial local biofilm disruption, increasing tobramycin efficacy up to 1-3 orders of magnitude depending on the organism and treatment conditions. Altogether, our results support the potential of laser-induced VNBs as a new approach to disrupt biofilms of a broad range of organisms, resulting in improved antibiotic Diffusion and more effective biofilm eradication.
Katrien Forier - One of the best experts on this subject based on the ideXlab platform.
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Laser-induced vapour nanobubbles improve Drug Diffusion and efficiency in bacterial biofilms
Nature Communications, 2018Co-Authors: Eline Teirlinck, Ranhua Xiong, Toon Brans, Katrien Forier, Juan Fraire, Heleen Van Acker, Nele Matthijs, Riet De Rycke, Stefaan C De Smedt, Tom CoenyeAbstract:Eradication of bacterial infections can be hindered by poor penetration of antibiotics through biofilms. Here, Teirlinck et al . show that laser-induced vapour nanobubbles formed around plasmonic nanoparticles can be used to locally disturb biofilm integrity and improve antibiotic Diffusion.AbstractHindered penetration of antibiotics through biofilms is one of the reasons for the alarming increase in bacterial tolerance to antibiotics. Here, we investigate the potential of laser-induced vapour nanobubbles (VNBs) formed around plasmonic nanoparticles to locally disturb biofilm integrity and improve antibiotics Diffusion. Our results show that biofilms of both Gram-negative ( Burkholderia multivorans , Pseudomonas aeruginosa ) and Gram-positive ( Staphylococcus aureus ) bacteria can be loaded with cationic 70-nm gold nanoparticles and that subsequent laser illumination results in VNB formation inside the biofilms. In all types of biofilms tested, VNB formation leads to substantial local biofilm disruption, increasing tobramycin efficacy up to 1-3 orders of magnitude depending on the organism and treatment conditions. Altogether, our results support the potential of laser-induced VNBs as a new approach to disrupt biofilms of a broad range of organisms, resulting in improved antibiotic Diffusion and more effective biofilm eradication.
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laser induced vapour nanobubbles improve Drug Diffusion and efficiency in bacterial biofilms
Nature Communications, 2018Co-Authors: Eline Teirlinck, Ranhua Xiong, Toon Brans, Katrien Forier, Juan Fraire, Heleen Van Acker, Nele Matthijs, Riet De Rycke, Stefaan C De SmedtAbstract:Hindered penetration of antibiotics through biofilms is one of the reasons for the alarming increase in bacterial tolerance to antibiotics. Here, we investigate the potential of laser-induced vapour nanobubbles (VNBs) formed around plasmonic nanoparticles to locally disturb biofilm integrity and improve antibiotics Diffusion. Our results show that biofilms of both Gram-negative (Burkholderia multivorans, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria can be loaded with cationic 70-nm gold nanoparticles and that subsequent laser illumination results in VNB formation inside the biofilms. In all types of biofilms tested, VNB formation leads to substantial local biofilm disruption, increasing tobramycin efficacy up to 1-3 orders of magnitude depending on the organism and treatment conditions. Altogether, our results support the potential of laser-induced VNBs as a new approach to disrupt biofilms of a broad range of organisms, resulting in improved antibiotic Diffusion and more effective biofilm eradication.
Eline Teirlinck - One of the best experts on this subject based on the ideXlab platform.
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Laser-induced vapour nanobubbles improve Drug Diffusion and efficiency in bacterial biofilms
Nature Communications, 2018Co-Authors: Eline Teirlinck, Ranhua Xiong, Toon Brans, Katrien Forier, Juan Fraire, Heleen Van Acker, Nele Matthijs, Riet De Rycke, Stefaan C De Smedt, Tom CoenyeAbstract:Eradication of bacterial infections can be hindered by poor penetration of antibiotics through biofilms. Here, Teirlinck et al . show that laser-induced vapour nanobubbles formed around plasmonic nanoparticles can be used to locally disturb biofilm integrity and improve antibiotic Diffusion.AbstractHindered penetration of antibiotics through biofilms is one of the reasons for the alarming increase in bacterial tolerance to antibiotics. Here, we investigate the potential of laser-induced vapour nanobubbles (VNBs) formed around plasmonic nanoparticles to locally disturb biofilm integrity and improve antibiotics Diffusion. Our results show that biofilms of both Gram-negative ( Burkholderia multivorans , Pseudomonas aeruginosa ) and Gram-positive ( Staphylococcus aureus ) bacteria can be loaded with cationic 70-nm gold nanoparticles and that subsequent laser illumination results in VNB formation inside the biofilms. In all types of biofilms tested, VNB formation leads to substantial local biofilm disruption, increasing tobramycin efficacy up to 1-3 orders of magnitude depending on the organism and treatment conditions. Altogether, our results support the potential of laser-induced VNBs as a new approach to disrupt biofilms of a broad range of organisms, resulting in improved antibiotic Diffusion and more effective biofilm eradication.
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laser induced vapour nanobubbles improve Drug Diffusion and efficiency in bacterial biofilms
Nature Communications, 2018Co-Authors: Eline Teirlinck, Ranhua Xiong, Toon Brans, Katrien Forier, Juan Fraire, Heleen Van Acker, Nele Matthijs, Riet De Rycke, Stefaan C De SmedtAbstract:Hindered penetration of antibiotics through biofilms is one of the reasons for the alarming increase in bacterial tolerance to antibiotics. Here, we investigate the potential of laser-induced vapour nanobubbles (VNBs) formed around plasmonic nanoparticles to locally disturb biofilm integrity and improve antibiotics Diffusion. Our results show that biofilms of both Gram-negative (Burkholderia multivorans, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria can be loaded with cationic 70-nm gold nanoparticles and that subsequent laser illumination results in VNB formation inside the biofilms. In all types of biofilms tested, VNB formation leads to substantial local biofilm disruption, increasing tobramycin efficacy up to 1-3 orders of magnitude depending on the organism and treatment conditions. Altogether, our results support the potential of laser-induced VNBs as a new approach to disrupt biofilms of a broad range of organisms, resulting in improved antibiotic Diffusion and more effective biofilm eradication.
Michael Heisig - One of the best experts on this subject based on the ideXlab platform.
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A Geometry Model for the Simulation of Drug Diffusion through the Stratum Corneum
Computing and Visualization in Science, 2006Co-Authors: D. Feuchter, Michael Heisig, Gabriel WittumAbstract:We present a three-dimensional geometry model with tetrakaidecahedra for the biphasic model stratum corneum (SC) membrane Ω_SC consisting of corneocytes embedded in a lipid matrix. Two practical domains for Ω_SC are realized: the simple model SC-membrane Ω_sSC and a realistic model SC-membrane Ω_rSC with dimensions for abdominal human SC. The new geometry model uses tetrakaidecahedra as basic units. It is possible to assemble the tetrakaidecahedra one upon the other and side by side without gaps in a densest packing and with minimal area for all required interfaces. Geometric characteristics such as length, depth, height and angles of the corneocytes as well as the thickness of the lipid channels can be chosen arbitrarily. Furthermore, we are able to control the shift of the corneocytes and our concept allows to assemble many corneocytes in rows, columns and layers all embedded in a lipid matrix. With the aid of this concept the non-steady-state problem of Drug Diffusion within a three-dimensional, biphasic model SC-membrane, such as Ω_sSC or Ω_rSC, having homogeneous lipid and corneocyte phases is solved numerically with a multigrid method. The numerical computations are done with our simulation system UG. Our method for solving the Diffusion problem is validated with homogeneous model SC-membranes with varying size of corneocytes and lipid channels, different numbers of corneocytes, and corneocyte alignment. Several time-dependent Drug concentration profiles within the heterogeneous model SC-membranes are calculated and graphically shown for different values of relative corneocyte permeability ɛ = D _cor/ D _lip.
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Non Steady-state Descriptions of Drug Permeation Through Stratum Corneum. I. The Biphasic Brick-and-Mortar Model
Pharmaceutical research, 1996Co-Authors: Michael Heisig, Gabriel Wittum, Renate Lieckfeldt, George Mazurkevich, Geoffrey LeeAbstract:Purpose. The Diffusion equation should be solved for the non-steady-state problem of Drug Diffusion within a two-dimensional, biphasic stratum corneum membrane having homogeneous lipid and corneocyte phases.
