The Experts below are selected from a list of 15 Experts worldwide ranked by ideXlab platform
Zoe Rizos - One of the best experts on this subject based on the ideXlab platform.
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reconditioning of Drug related cues a potential contributor to relapse after Drug Reexposure
Pharmacology Biochemistry and Behavior, 2005Co-Authors: Francesco Leri, Zoe RizosAbstract:To investigate the process of relapse to Drug seeking caused by Reexposure to Drugs, we studied the consequences of recurring instances of stimuli-Drug associations using heroin conditioned place preference (CPP) in rats. After original conditioning and extinction, rats received either a single compartment-heroin pairing (reconditioning) or were primed with heroin and tested for reinstatement of CPP. It was found that the session of reconditioning, but not the session of reinstatement, caused the reappearance of a preference for the heroin-paired compartment on a test given 24 h later, in Drug-free conditions. The effect of reconditioning was found to be dependent on heroin doses, and was not seen when heroin injections were given outside the conditioning environment. Furthermore, a single session of reconditioning elevated heroin seeking even on a test given 96 h later. Finally, heroin seeking was found to be significantly elevated on a test given 28 days after the last extinction session whether animals received 1 or 3 reconditioning sessions. These results suggest that the motivational value of cues associated with heroin is not eliminated by extinction and, importantly, that these cues can rapidly regain their ability to promote Drug seeking behavior if they are re-associated with the effect of heroin.
Francesco Leri - One of the best experts on this subject based on the ideXlab platform.
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reconditioning of Drug related cues a potential contributor to relapse after Drug Reexposure
Pharmacology Biochemistry and Behavior, 2005Co-Authors: Francesco Leri, Zoe RizosAbstract:To investigate the process of relapse to Drug seeking caused by Reexposure to Drugs, we studied the consequences of recurring instances of stimuli-Drug associations using heroin conditioned place preference (CPP) in rats. After original conditioning and extinction, rats received either a single compartment-heroin pairing (reconditioning) or were primed with heroin and tested for reinstatement of CPP. It was found that the session of reconditioning, but not the session of reinstatement, caused the reappearance of a preference for the heroin-paired compartment on a test given 24 h later, in Drug-free conditions. The effect of reconditioning was found to be dependent on heroin doses, and was not seen when heroin injections were given outside the conditioning environment. Furthermore, a single session of reconditioning elevated heroin seeking even on a test given 96 h later. Finally, heroin seeking was found to be significantly elevated on a test given 28 days after the last extinction session whether animals received 1 or 3 reconditioning sessions. These results suggest that the motivational value of cues associated with heroin is not eliminated by extinction and, importantly, that these cues can rapidly regain their ability to promote Drug seeking behavior if they are re-associated with the effect of heroin.
Firas Muwalla - One of the best experts on this subject based on the ideXlab platform.
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severe neutropenia following a prolonged course of vancomycin that progressed to agranulocytosis with Drug Reexposure
Annals of Pharmacotherapy, 2012Co-Authors: Jennifer M Duff, Jan S Moreb, Firas MuwallaAbstract:OBJECTIVE:To report a case of severe neutropenia after discontinuing prolonged treatment with vancomycin that progressed to agranulocytosis with vancomycin Reexposure.CASE SUMMARY:A 78-year-old woman presented with severe neutropenia (absolute neutrophil count [ANC] 37 cells/μL) and hypocellular bone marrow with absence of myeloid elements 8 weeks after discontinuing a 3-week treatment course of vancomycin 750 mg every 12 hours. Filgrastim 300 μg daily was started for neutropenia and vancomycin 750 mg every 12 hours and aztreonam 1 g every 8 hours were initiated for catheter-related acute thrombophlebitis of the upper extremity. The patient's ANC decreased to 10 cells/μL within 3 days of starting vancomycin. We suspected an autoimmune process, potentially related to vancomycin exposure, and began treatment with methylprednisolone 1 mg/kg daily. The ANC precipitously dropped to 0 cells/μL despite treatment with steroids and an increased filgrastim dose of 480 μg/day. All antibiotics were discontinued on th...
Jennifer M Duff - One of the best experts on this subject based on the ideXlab platform.
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severe neutropenia following a prolonged course of vancomycin that progressed to agranulocytosis with Drug Reexposure
Annals of Pharmacotherapy, 2012Co-Authors: Jennifer M Duff, Jan S Moreb, Firas MuwallaAbstract:OBJECTIVE:To report a case of severe neutropenia after discontinuing prolonged treatment with vancomycin that progressed to agranulocytosis with vancomycin Reexposure.CASE SUMMARY:A 78-year-old woman presented with severe neutropenia (absolute neutrophil count [ANC] 37 cells/μL) and hypocellular bone marrow with absence of myeloid elements 8 weeks after discontinuing a 3-week treatment course of vancomycin 750 mg every 12 hours. Filgrastim 300 μg daily was started for neutropenia and vancomycin 750 mg every 12 hours and aztreonam 1 g every 8 hours were initiated for catheter-related acute thrombophlebitis of the upper extremity. The patient's ANC decreased to 10 cells/μL within 3 days of starting vancomycin. We suspected an autoimmune process, potentially related to vancomycin exposure, and began treatment with methylprednisolone 1 mg/kg daily. The ANC precipitously dropped to 0 cells/μL despite treatment with steroids and an increased filgrastim dose of 480 μg/day. All antibiotics were discontinued on th...
Jan S Moreb - One of the best experts on this subject based on the ideXlab platform.
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severe neutropenia following a prolonged course of vancomycin that progressed to agranulocytosis with Drug Reexposure
Annals of Pharmacotherapy, 2012Co-Authors: Jennifer M Duff, Jan S Moreb, Firas MuwallaAbstract:OBJECTIVE:To report a case of severe neutropenia after discontinuing prolonged treatment with vancomycin that progressed to agranulocytosis with vancomycin Reexposure.CASE SUMMARY:A 78-year-old woman presented with severe neutropenia (absolute neutrophil count [ANC] 37 cells/μL) and hypocellular bone marrow with absence of myeloid elements 8 weeks after discontinuing a 3-week treatment course of vancomycin 750 mg every 12 hours. Filgrastim 300 μg daily was started for neutropenia and vancomycin 750 mg every 12 hours and aztreonam 1 g every 8 hours were initiated for catheter-related acute thrombophlebitis of the upper extremity. The patient's ANC decreased to 10 cells/μL within 3 days of starting vancomycin. We suspected an autoimmune process, potentially related to vancomycin exposure, and began treatment with methylprednisolone 1 mg/kg daily. The ANC precipitously dropped to 0 cells/μL despite treatment with steroids and an increased filgrastim dose of 480 μg/day. All antibiotics were discontinued on th...
