The Experts below are selected from a list of 173736 Experts worldwide ranked by ideXlab platform
Pranesh B. Aswath - One of the best experts on this subject based on the ideXlab platform.
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Fabrication of porous, Drug-releasing, biodegradable, polymer scaffolds for sustained Drug Release.
Journal of biomedical materials research. Part B Applied biomaterials, 2008Co-Authors: Mayur Uttarwar, Pranesh B. AswathAbstract:Two different approaches were used to fabricate porous scaffolds, and their in vitro Drug releasing characteristics were examined. In the first method, a poly(L-lactic acid) (PLLA) solution and poly(vinyl alcohol) (PVA) + acetaminophen solution was homogenized. The emulsion was then blended with a PLLA solution in chloroform. The resultant emulsion was freeze-dried to form porous scaffolds. Various combinations were obtained by varying homogenizer speed and blender speed, and by varying the concentration of PVA and acetaminophen solutions. The in vitro Drug-Release study was performed for 6 days in a phosphate buffer. The influence of structure, porosity, and Drug concentration of the scaffolds on Drug-Release rate was examined using design of experiments. In the second approach, scaffolds were prepared in layered constructs, with either a three-layered or five-layered structure. The PVA + acetaminophen solution was blended with PLLA solution using a blender. The Drug-Release study was performed for 19 days. The effect of Drug concentration, blender speed, and the thickness of the layers on Drug-Release rate was examined.
S. Kalachandra - One of the best experts on this subject based on the ideXlab platform.
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In vitro Drug Release study of methacrylate polymer blend system: effect of polymer blend composition, Drug loading and solubilizing surfactants on Drug Release.
Journal of Materials Science: Materials in Medicine, 2009Co-Authors: Jun Li, Holly Howell, David A Barrow, S. KalachandraAbstract:The application of polymers as the Drug delivery systems for treating oral infections is a relatively new area of research. The present study was to test the Release of the antibacterial Drug chlorhexidine diacetate (CHDA), the antifungal Drug Nystatin (NYS) and the antiviral Drug acyclovir (ACY) from polymer blends of poly(ethyl methacrylate) and poly(n-hexyl methacrylate) of different compositions. The effects of polymer blend composition, Drug loading and solubilizing surfactants on the Release of the Drugs have been studied. Measurements of the in vitro rate of Drug Release showed a sustained Release of Drug over extended periods of time. Drug Release rates decreased with increasing PEMA content in polymer blends. CHDA Release rates increased steadily with increasing Drug load. The Drug Release rates increased with the addition of surfactants. This study demonstrates that the three therapeutic agents show a sustained rate of Drug Release from polymer blends of PEMA and PHMA over extended periods of time. By varying polymer blend compositions as well as the Drug concentration (loading), it is possible to control the Drug Release rates to a desired value. The Drug Release rate is enhanced by addition of surfactants that solubilize Drugs in the polymer blends.
Laura Mora - One of the best experts on this subject based on the ideXlab platform.
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real time electrochemical monitoring of Drug Release from therapeutic nanoparticles
Journal of Controlled Release, 2009Co-Authors: Laura Mora, Corbin Clawson, Karin Y Chumbimunitorres, L Hernandez, Liangfang Zhang, Joseph WangAbstract:An electrochemical protocol for real-time monitoring of Drug Release kinetics from therapeutic nanoparticles (NPs) is described. The method is illustrated for repetitive square-wave voltammetric measurements of the reduction of doxorubicin Released from liposomes at a glassy-carbon electrode. Such operation couples high sensitivity down to 20 nM doxorubicin with high speed and stability. It can thus monitor in real time the Drug Release from NP carriers, including continuous measurements in diluted serum. Such direct and continuous monitoring of the Drug Release kinetics from therapeutic NPs holds great promise for designing new Drug delivery NPs with optimal Drug Release properties. These NPs can potentially be used to deliver many novel compounds such as marine-life derived Drugs and hydrophobic Drugs with limited water solubility that are usually difficult to be characterized by traditional analytical tools.
Mahdi B Fawzi - One of the best experts on this subject based on the ideXlab platform.
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mechanism of Drug Release from an acrylic polymer wax matrix tablet
Journal of Pharmaceutical Sciences, 1994Co-Authors: Huapin Huang, Surendra C Mehta, Galen Wesley Radebaugh, Mahdi B FawziAbstract:Abstract An acrylic polymer‐wax matrix system was evaluated for oral sustained‐Release tablets of diphenhydramine HCl. A desirable Release profile of diphenhydramine was achieved by incorporating Eudragit L in a carnauba wax matrix. In this polymer‐wax system, carnauba wax maintained the integrity of the matrix, whereas Eudragit L slowly eroded in the matrix as the Drug was Released. Thus, the area‐to‐volume ratio of the tablet remained constant over the duration of the Drug Release. In vitro Drug Release studies were conducted at physiological pHs that exist in the gastrointestinal tract. Drug Release rates decreased as the polymer:Drug ratio increased from 1:2 to 2:1. The Drug Release rate was faster in pH 7.5 phosphate buffer than in 0.1 N HCl solution. The Drug Release from these polymer‐wax matrices is described by a combination diffusion/erosion mechanism. Based on the typical pH encountered in intestinal fluids, complete dissolution of the Drug and polymer at pH 7.5 in 8–10 h would ensure good bioavailability of the Drug following oral administration.
Takehisa Matsuda - One of the best experts on this subject based on the ideXlab platform.
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In situ hydrogelation of photocurable gelatin and Drug Release.
Journal of biomedical materials research, 2001Co-Authors: Hidenobu Okino, Y. Nakayama, Masao Tanaka, Takehisa MatsudaAbstract:We devised an in situ tissue-adhesive, Drug-Release technology based on a photoreactive gelatin, which allows in situ Drug-incorporated gel formation on living tissues and sustained Drug Release directly on diseased tissues. Styrene-derivatized gelatins, synthesized by condensation reaction of gelatin with 4-vinylbenzoic acid, were photopolymerized in the presence of a water-soluble camphorquinone derivative as a photoinitiator upon visible-light irradiation to form swollen gels. Using albumin as a Drug model, gelation characteristics and Drug-Release characteristics easily were manipulated by material variables, formulation variables, and operation variables. Tissue adhesivity of the gel was superior to that of fibrin glue. The biologic response, which was evaluated by intraperitoneal implantation in rats, showed that the gel was biodegraded and biosorbed, without cytotoxicity, within a few months after implantation. An in situ processable tissue-adhesive local Drug Release system effectively may be used to help inhibit tumor recurrence.
