The Experts below are selected from a list of 90783 Experts worldwide ranked by ideXlab platform
Xinsong Li - One of the best experts on this subject based on the ideXlab platform.
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in vitro and in vivo evaluation of ketotifen fumarate loaded silicone hydrogel contact lenses for ocular Drug delivery
Drug Delivery, 2011Co-Authors: Jinku Xu, Xinsong LiAbstract:The purpose of this work was to evaluate the usefulness of silicone hydrogel contact lenses loaded with ketotifen fumarate for ocular Drug delivery. First, silicone contact lenses were prepared by photopolymerization of bitelechelic methacrylated polydimethylsiloxanes macromonomer, 3-methacryloxypropyltris(trimethylsiloxy)silane, and N,N-dimethylacrylamide using ethylene glycol dimethacrylate as a cross-linker and Darocur 1173 as an initiator followed by surface plasma treatment. Then, the silicone hydrogel matrices of the contact lenses were characterized by equilibrium swelling ratio (ESR), tensile tests, ion permeability, and surface contact angle. Finally, the contact lenses were loaded with ketotifen fumarate by pre-soaking in Drug Solution to evaluate Drug loading capacity, in vitro and in vivo release behavior of the silicone contact lenses. The results showed that ESR and ion permeability increase, and the surface contact angle and tensile strength decreased with the increase of DMA component in t...
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in vitro and in vivo evaluation of ketotifen fumarate loaded silicone hydrogel contact lenses for ocular Drug delivery
Drug Delivery, 2011Co-Authors: Jinku Xu, Xinsong LiAbstract:The purpose of this work was to evaluate the usefulness of silicone hydrogel contact lenses loaded with ketotifen fumarate for ocular Drug delivery. First, silicone contact lenses were prepared by photopolymerization of bitelechelic methacrylated polydimethylsiloxanes macromonomer, 3-methacryloxypropyltris(trimethylsiloxy)silane, and N,N-dimethylacrylamide using ethylene glycol dimethacrylate as a cross-linker and Darocur 1173 as an initiator followed by surface plasma treatment. Then, the silicone hydrogel matrices of the contact lenses were characterized by equilibrium swelling ratio (ESR), tensile tests, ion permeability, and surface contact angle. Finally, the contact lenses were loaded with ketotifen fumarate by pre-soaking in Drug Solution to evaluate Drug loading capacity, in vitro and in vivo release behavior of the silicone contact lenses. The results showed that ESR and ion permeability increase, and the surface contact angle and tensile strength decreased with the increase of DMA component in t...
Jinku Xu - One of the best experts on this subject based on the ideXlab platform.
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in vitro and in vivo evaluation of ketotifen fumarate loaded silicone hydrogel contact lenses for ocular Drug delivery
Drug Delivery, 2011Co-Authors: Jinku Xu, Xinsong LiAbstract:The purpose of this work was to evaluate the usefulness of silicone hydrogel contact lenses loaded with ketotifen fumarate for ocular Drug delivery. First, silicone contact lenses were prepared by photopolymerization of bitelechelic methacrylated polydimethylsiloxanes macromonomer, 3-methacryloxypropyltris(trimethylsiloxy)silane, and N,N-dimethylacrylamide using ethylene glycol dimethacrylate as a cross-linker and Darocur 1173 as an initiator followed by surface plasma treatment. Then, the silicone hydrogel matrices of the contact lenses were characterized by equilibrium swelling ratio (ESR), tensile tests, ion permeability, and surface contact angle. Finally, the contact lenses were loaded with ketotifen fumarate by pre-soaking in Drug Solution to evaluate Drug loading capacity, in vitro and in vivo release behavior of the silicone contact lenses. The results showed that ESR and ion permeability increase, and the surface contact angle and tensile strength decreased with the increase of DMA component in t...
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in vitro and in vivo evaluation of ketotifen fumarate loaded silicone hydrogel contact lenses for ocular Drug delivery
Drug Delivery, 2011Co-Authors: Jinku Xu, Xinsong LiAbstract:The purpose of this work was to evaluate the usefulness of silicone hydrogel contact lenses loaded with ketotifen fumarate for ocular Drug delivery. First, silicone contact lenses were prepared by photopolymerization of bitelechelic methacrylated polydimethylsiloxanes macromonomer, 3-methacryloxypropyltris(trimethylsiloxy)silane, and N,N-dimethylacrylamide using ethylene glycol dimethacrylate as a cross-linker and Darocur 1173 as an initiator followed by surface plasma treatment. Then, the silicone hydrogel matrices of the contact lenses were characterized by equilibrium swelling ratio (ESR), tensile tests, ion permeability, and surface contact angle. Finally, the contact lenses were loaded with ketotifen fumarate by pre-soaking in Drug Solution to evaluate Drug loading capacity, in vitro and in vivo release behavior of the silicone contact lenses. The results showed that ESR and ion permeability increase, and the surface contact angle and tensile strength decreased with the increase of DMA component in t...
Sung-joo Hwang - One of the best experts on this subject based on the ideXlab platform.
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Preparation, characterization and in vivo evaluation of amorphous atorvastatin calcium nanoparticles using supercritical antisolvent (SAS) process.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2008Co-Authors: Min-soo Kim, Hee Jun Park, Shun-ji Jin, Jeong-soo Kim, Ha-seung Song, Reinhard H.h. Neubert, Sung-joo HwangAbstract:Abstract In this work, amorphous atorvastatin calcium nanoparticles were successfully prepared using the supercritical antisolvent (SAS) process. The effect of process variables on particle size and distribution of atorvastatin calcium during particle formation was investigated. Solid state characterization, solubility, intrinsic disSolution, powder disSolution studies and pharmacokinetic study in rats were performed. Spherical particles with mean particle size ranging between 152 and 863 nm were obtained by varying process parameters such as precipitation vessel pressure and temperature, Drug Solution concentration and feed rate ratio of CO2/Drug Solution. XRD, TGA, FT-IR, FT-Raman, NMR and HPLC analysis indicated that atorvastatin calcium existed as anhydrous amorphous form and no degradation occurred after SAS process. When compared with crystalline form (unprocessed Drug), amorphous atorvastatin calcium nanoparticles were of better performance in solubility and intrinsic disSolution rate, resulting in higher solubility and faster disSolution rate. In addition, intrinsic disSolution rate showed a good correlation with the solubility. The disSolution rates of amorphous atorvastatin calcium nanoparticles were highly increased in comparison with unprocessed Drug by the enhancement of intrinsic disSolution rate and the reduction of particle size resulting in an increased specific surface area. The absorption of atorvastatin calcium after oral administration of amorphous atorvastatin calcium nanoparticles to rats was markedly increased.
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micronization of cilostazol using supercritical antisolvent sas process effect of process parameters
Powder Technology, 2007Co-Authors: Min-soo Kim, Sibeum Lee, Jeongsook Park, Jong Soo Woo, Sung-joo HwangAbstract:Abstract The aim of this study was to improve disSolution rate of poorly water-soluble Drug, cilostazol, using supercritical antisolvent (SAS) process. The effect of process variables, such as pressure, temperature, Drug concentration, type of solvents, feed rate ratio of CO2/Drug Solution, on Drug particle formation during SAS process was investigated. Particles with mean particle size ranging between 0.90 and 4.52 μm were obtained by varying process parameters such as precipitation vessel pressure and temperature, Drug Solution concentration, solvent type, feed rate ratio of CO2/Drug Solution. In particular, mean particle size and distribution were markedly influenced by Drug Solution concentration during SAS process. Moreover, the Drug did not change its crystal form and the operating parameters might control the ‘crystal texture’ due to the change in crystallinity and preferred orientation during SAS process, as confirmed by differential scanning calorimetry and powder X-ray diffraction study. In addition, the disSolution rate of Drug precipitated using SAS process was highly increased in comparison with unprocessed Drug. Therefore, it is concluded that the disSolution rate of Drug is significantly increased by micronization of cilostazol, leading to the reduction in particle size and increased specific surface area after SAS process.
Jaydeep Patel - One of the best experts on this subject based on the ideXlab platform.
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formulation and development of a self nanoemulsifying Drug delivery system of irbesartan
Journal of advanced pharmaceutical technology & research, 2011Co-Authors: Jaydeep Patel, Anjali Patel, Mihir Raval, Navin ShethAbstract:Irbesartan (IRB) is an angiotensin II receptor blocker antihypertensive agent. The aim of the present investigation was to develop a self-nanoemulsifying Drug delivery system (SNEDDS) to enhance the oral bioavailability of poorly water-soluble IRB. The solubility of IRB in various oils was determined to identify the oil phase of SNEDDS. Various surfactants and co-surfactants were screened for their ability to emulsify the selected oil. Pseudoternary phase diagrams were constructed to identify the efficient self-emulsifying region. The optimized SNEDDS formulation contained IRB (75 mg), Cremophor® EL (43.33%), Carbitol® (21.67%) and Capryol® 90 (32%). SNEDDS was further evaluated for its percentage transmittance, emulsification time, Drug content, phase separation, dilution, droplet size and zeta potential. The optimized formulation of IRB-loaded SNEDDS exhibited complete in vitro Drug release in 15 min as compared with the plain Drug, which had a limited disSolution rate. It was also compared with the pure Drug Solution by oral administration in male Wister rats. The in vivo study exhibited a 7.5-fold increase in the oral bioavailability of IRB from SNEDDS compared with the pure Drug Solution. These results suggest the potential use of SNEDDS to improve disSolution and oral bioavailability of poorly water-soluble IRB.
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formulation and development of a self nanoemulsifying Drug delivery system of irbesartan
Journal of advanced pharmaceutical technology & research, 2011Co-Authors: Jaydeep Patel, Anjali Patel, Mihir Raval, Navin R ShethAbstract:Irbesartan (IRB) is an angiotensin II receptor blocker antihypertensive agent. The aim of the present investigation was to develop a self-nanoemulsifying Drug delivery system (SNEDDS) to enhance the oral bioavailability of poorly water-soluble IRB. The solubility of IRB in various oils was determined to identify the oil phase of SNEDDS. Various surfactants and co-surfactants were screened for their ability to emulsify the selected oil. Pseudoternary phase diagrams were constructed to identify the efficient self-emulsifying region. The optimized SNEDDS formulation contained IRB (75 mg), Cremophor® EL (43.33%), Carbitol® (21.67%) and Capryol® 90 (32%). SNEDDS was further evaluated for its percentage transmittance, emulsification time, Drug content, phase separation, dilution, droplet size and zeta potential. The optimized formulation of IRB-loaded SNEDDS exhibited complete in vitro Drug release in 15 min as compared with the plain Drug, which had a limited disSolution rate. It was also compared with the pure Drug Solution by oral administration in male Wister rats. The in vivo study exhibited a 7.5-fold increase in the oral bioavailability of IRB from SNEDDS compared with the pure Drug Solution. These results suggest the potential use of SNEDDS to improve disSolution and oral bioavailability of poorly water-soluble IRB.
Min-soo Kim - One of the best experts on this subject based on the ideXlab platform.
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Preparation, characterization and in vivo evaluation of amorphous atorvastatin calcium nanoparticles using supercritical antisolvent (SAS) process.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2008Co-Authors: Min-soo Kim, Hee Jun Park, Shun-ji Jin, Jeong-soo Kim, Ha-seung Song, Reinhard H.h. Neubert, Sung-joo HwangAbstract:Abstract In this work, amorphous atorvastatin calcium nanoparticles were successfully prepared using the supercritical antisolvent (SAS) process. The effect of process variables on particle size and distribution of atorvastatin calcium during particle formation was investigated. Solid state characterization, solubility, intrinsic disSolution, powder disSolution studies and pharmacokinetic study in rats were performed. Spherical particles with mean particle size ranging between 152 and 863 nm were obtained by varying process parameters such as precipitation vessel pressure and temperature, Drug Solution concentration and feed rate ratio of CO2/Drug Solution. XRD, TGA, FT-IR, FT-Raman, NMR and HPLC analysis indicated that atorvastatin calcium existed as anhydrous amorphous form and no degradation occurred after SAS process. When compared with crystalline form (unprocessed Drug), amorphous atorvastatin calcium nanoparticles were of better performance in solubility and intrinsic disSolution rate, resulting in higher solubility and faster disSolution rate. In addition, intrinsic disSolution rate showed a good correlation with the solubility. The disSolution rates of amorphous atorvastatin calcium nanoparticles were highly increased in comparison with unprocessed Drug by the enhancement of intrinsic disSolution rate and the reduction of particle size resulting in an increased specific surface area. The absorption of atorvastatin calcium after oral administration of amorphous atorvastatin calcium nanoparticles to rats was markedly increased.
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micronization of cilostazol using supercritical antisolvent sas process effect of process parameters
Powder Technology, 2007Co-Authors: Min-soo Kim, Sibeum Lee, Jeongsook Park, Jong Soo Woo, Sung-joo HwangAbstract:Abstract The aim of this study was to improve disSolution rate of poorly water-soluble Drug, cilostazol, using supercritical antisolvent (SAS) process. The effect of process variables, such as pressure, temperature, Drug concentration, type of solvents, feed rate ratio of CO2/Drug Solution, on Drug particle formation during SAS process was investigated. Particles with mean particle size ranging between 0.90 and 4.52 μm were obtained by varying process parameters such as precipitation vessel pressure and temperature, Drug Solution concentration, solvent type, feed rate ratio of CO2/Drug Solution. In particular, mean particle size and distribution were markedly influenced by Drug Solution concentration during SAS process. Moreover, the Drug did not change its crystal form and the operating parameters might control the ‘crystal texture’ due to the change in crystallinity and preferred orientation during SAS process, as confirmed by differential scanning calorimetry and powder X-ray diffraction study. In addition, the disSolution rate of Drug precipitated using SAS process was highly increased in comparison with unprocessed Drug. Therefore, it is concluded that the disSolution rate of Drug is significantly increased by micronization of cilostazol, leading to the reduction in particle size and increased specific surface area after SAS process.
