The Experts below are selected from a list of 297 Experts worldwide ranked by ideXlab platform
Manuel Mameli - One of the best experts on this subject based on the ideXlab platform.
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neural circuit adaptations during Drug Withdrawal spotlight on the lateral habenula
Pharmacology Biochemistry and Behavior, 2017Co-Authors: Frank Julius Meye, Massimo Trusel, Mariano Soizareilly, Manuel MameliAbstract:Withdrawal after Drug intake triggers a wealth of affective states including negative feelings reminiscent of depressive symptoms. This negative state can ultimately be crucial for relapse, a hallmark of addiction. Adaptations in a wide number of neuronal circuits underlie aspects of Drug Withdrawal, however causality between cellular modifications within these systems and precise behavioral phenotypes remains poorly described. Recent advances point to an instrumental role of the lateral habenula in driving depressive-like states during Drug Withdrawal. In this review we will discuss the general behavioral features of Drug Withdrawal, the importance of plasticity mechanisms in the mesolimbic systems, and the latest discoveries highlighting the implications of lateral habenula in Drug addiction. We will further stress how specific interventions in the lateral habenula efficiently ameliorate depressive symptoms. Altogether, this work aims to provide a general knowledge on the cellular and circuit basis underlying Drug Withdrawal, ultimately speculating on potential treatment for precise aspects of addiction.
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Neural circuit adaptations during Drug Withdrawal — Spotlight on the lateral habenula
Pharmacology Biochemistry and Behavior, 2017Co-Authors: Frank Julius Meye, Massimo Trusel, Mariano Soiza-reilly, Manuel MameliAbstract:Withdrawal after Drug intake triggers a wealth of affective states including negative feelings reminiscent of depressive symptoms. This negative state can ultimately be crucial for relapse, a hallmark of addiction. Adaptations in a wide number of neuronal circuits underlie aspects of Drug Withdrawal, however causality between cellular modifications within these systems and precise behavioral phenotypes remains poorly described. Recent advances point to an instrumental role of the lateral habenula in driving depressive-like states during Drug Withdrawal. In this review we will discuss the general behavioral features of Drug Withdrawal, the importance of plasticity mechanisms in the mesolimbic systems, and the latest discoveries highlighting the implications of lateral habenula in Drug addiction. We will further stress how specific interventions in the lateral habenula efficiently ameliorate depressive symptoms. Altogether, this work aims to provide a general knowledge on the cellular and circuit basis underlying Drug Withdrawal, ultimately speculating on potential treatment for precise aspects of addiction.
Massimo Trusel - One of the best experts on this subject based on the ideXlab platform.
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neural circuit adaptations during Drug Withdrawal spotlight on the lateral habenula
Pharmacology Biochemistry and Behavior, 2017Co-Authors: Frank Julius Meye, Massimo Trusel, Mariano Soizareilly, Manuel MameliAbstract:Withdrawal after Drug intake triggers a wealth of affective states including negative feelings reminiscent of depressive symptoms. This negative state can ultimately be crucial for relapse, a hallmark of addiction. Adaptations in a wide number of neuronal circuits underlie aspects of Drug Withdrawal, however causality between cellular modifications within these systems and precise behavioral phenotypes remains poorly described. Recent advances point to an instrumental role of the lateral habenula in driving depressive-like states during Drug Withdrawal. In this review we will discuss the general behavioral features of Drug Withdrawal, the importance of plasticity mechanisms in the mesolimbic systems, and the latest discoveries highlighting the implications of lateral habenula in Drug addiction. We will further stress how specific interventions in the lateral habenula efficiently ameliorate depressive symptoms. Altogether, this work aims to provide a general knowledge on the cellular and circuit basis underlying Drug Withdrawal, ultimately speculating on potential treatment for precise aspects of addiction.
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Neural circuit adaptations during Drug Withdrawal — Spotlight on the lateral habenula
Pharmacology Biochemistry and Behavior, 2017Co-Authors: Frank Julius Meye, Massimo Trusel, Mariano Soiza-reilly, Manuel MameliAbstract:Withdrawal after Drug intake triggers a wealth of affective states including negative feelings reminiscent of depressive symptoms. This negative state can ultimately be crucial for relapse, a hallmark of addiction. Adaptations in a wide number of neuronal circuits underlie aspects of Drug Withdrawal, however causality between cellular modifications within these systems and precise behavioral phenotypes remains poorly described. Recent advances point to an instrumental role of the lateral habenula in driving depressive-like states during Drug Withdrawal. In this review we will discuss the general behavioral features of Drug Withdrawal, the importance of plasticity mechanisms in the mesolimbic systems, and the latest discoveries highlighting the implications of lateral habenula in Drug addiction. We will further stress how specific interventions in the lateral habenula efficiently ameliorate depressive symptoms. Altogether, this work aims to provide a general knowledge on the cellular and circuit basis underlying Drug Withdrawal, ultimately speculating on potential treatment for precise aspects of addiction.
Antony G Marson - One of the best experts on this subject based on the ideXlab platform.
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seizure recurrence after antiepileptic Drug Withdrawal and the implications for driving further results from the mrc antiepileptic Drug Withdrawal study and a systematic review
Journal of Neurology Neurosurgery and Psychiatry, 2011Co-Authors: Laura J Bonnett, Arif Shukralla, Catrin Tudursmith, Paula R Williamson, Antony G MarsonAbstract:Background In the UK, patients with epilepsy in remission, who withdraw antiepileptic Drug (AED) treatment, are advised not to drive during Withdrawal and for 6 months thereafter, assuming the risk of recurrence in the next 12 months is below 20%. Those with a seizure recurrence currently have to be seizure-free for 12 months before returning to drive, whether treatment is restarted or not. New EU regulations recommend returning to driving 3 months after restarting treatment. Methods Regression modelling of data from the Medical Research Council AED Withdrawal study was undertaken to estimate the risk of seizure recurrence in the next 12 months at various time points following: completion of Drug Withdrawal; AED reinstatement for those with a recurrence. A systematic review of prospective studies was also undertaken. Results Immediately following treatment Withdrawal, the recurrence risk in the next 12 months was 30% (95% CI 25% to 35%) and at 3 months after Withdrawal was 15% (95% CI 10% to 19%). At 3 months following the recommencement of treatment following a seizure recurrence, the risk of a seizure in the next 12 months was 26% (95% CI 17% to 35%), at 6 months 18% (95% CI 10% to 27%) and at 12 months 17% (95% CI 3% to 27%). Systematic review results were similar. Conclusion Current UK legislation concerning time off driving after withdrawing AED treatment may be too conservative. For those restarting treatment after a recurrence, current UK guidance may be too conservative but the new EU guidance too liberal.
Frank Julius Meye - One of the best experts on this subject based on the ideXlab platform.
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neural circuit adaptations during Drug Withdrawal spotlight on the lateral habenula
Pharmacology Biochemistry and Behavior, 2017Co-Authors: Frank Julius Meye, Massimo Trusel, Mariano Soizareilly, Manuel MameliAbstract:Withdrawal after Drug intake triggers a wealth of affective states including negative feelings reminiscent of depressive symptoms. This negative state can ultimately be crucial for relapse, a hallmark of addiction. Adaptations in a wide number of neuronal circuits underlie aspects of Drug Withdrawal, however causality between cellular modifications within these systems and precise behavioral phenotypes remains poorly described. Recent advances point to an instrumental role of the lateral habenula in driving depressive-like states during Drug Withdrawal. In this review we will discuss the general behavioral features of Drug Withdrawal, the importance of plasticity mechanisms in the mesolimbic systems, and the latest discoveries highlighting the implications of lateral habenula in Drug addiction. We will further stress how specific interventions in the lateral habenula efficiently ameliorate depressive symptoms. Altogether, this work aims to provide a general knowledge on the cellular and circuit basis underlying Drug Withdrawal, ultimately speculating on potential treatment for precise aspects of addiction.
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Neural circuit adaptations during Drug Withdrawal — Spotlight on the lateral habenula
Pharmacology Biochemistry and Behavior, 2017Co-Authors: Frank Julius Meye, Massimo Trusel, Mariano Soiza-reilly, Manuel MameliAbstract:Withdrawal after Drug intake triggers a wealth of affective states including negative feelings reminiscent of depressive symptoms. This negative state can ultimately be crucial for relapse, a hallmark of addiction. Adaptations in a wide number of neuronal circuits underlie aspects of Drug Withdrawal, however causality between cellular modifications within these systems and precise behavioral phenotypes remains poorly described. Recent advances point to an instrumental role of the lateral habenula in driving depressive-like states during Drug Withdrawal. In this review we will discuss the general behavioral features of Drug Withdrawal, the importance of plasticity mechanisms in the mesolimbic systems, and the latest discoveries highlighting the implications of lateral habenula in Drug addiction. We will further stress how specific interventions in the lateral habenula efficiently ameliorate depressive symptoms. Altogether, this work aims to provide a general knowledge on the cellular and circuit basis underlying Drug Withdrawal, ultimately speculating on potential treatment for precise aspects of addiction.
Thibault Renoir - One of the best experts on this subject based on the ideXlab platform.
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Drug Withdrawal induced depression serotonergic and plasticity changes in animal models
Neuroscience & Biobehavioral Reviews, 2012Co-Authors: Thibault Renoir, Terence Y Pang, Laurence LanfumeyAbstract:Abstract This review discusses recent research of mood disorders associated with the cessation of psychoactive substances, with an emphasis on preclinical studies that have been published in the last decade. Animal models exhibiting anhedonic and depressive-like behaviours associated with Drug Withdrawal have been used to study the neurobiology of mood disorders and have culminated in the identification of novel targets for the treatment of depressive-like symptoms. This review will introduce the behavioural as well as the neurochemical and plasticity changes in depressed patients and several animal models of depression. Following, we provide a more in-depth discussion of the role of serotonergic neurotransmission and Hypothalamic-Pituitary-Adrenal (HPA) axis regulation as well as the neurogenic changes occurring after chronic Drug intake focusing on the Withdrawal associated depression. Although we mainly focus on animal data, some relevant human studies are also discussed. Establishing the commonalities of depression and Drug-seeking behaviour will allow us to elucidate the factors driving the high co-morbidity between mood disorders and Drug dependence.
