The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
Paul Matejtschuk - One of the best experts on this subject based on the ideXlab platform.
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process understanding in freeze Drying Cycle development applications for through vial impedance spectroscopy tvis in mini pilot studies
Journal of Pharmaceutical Innovation, 2017Co-Authors: Geoff Smith, Muhammad Arshad, E Polygalov, I Ermolina, Timothy R Mccoy, Paul MatejtschukAbstract:Purpose The freeze-Drying Cycle comprises three stages: (1) freezing, to form ice and to crystallise out any solutes with a propensity to crystallise, (2) primary Drying to remove the ice phase by sublimation and (3) secondary Drying to remove the remaining unfrozen water which is bound to the remaining matrix of crystalline and amorphous solids. Given the impact of scale on the process outcomes, any freeze-Drying Cycle developed based on mini-pilot studies will inevitably require measurement technologies for characterising each stage of the Cycle at each scale of the process. However, there are inherent challenges in the development of reliable mini-piloting studies, with the first being the fact that no single PAT technology for freeze Drying may be implemented across all levels of scale, and the second being the inherent changes in process characteristics (process parameters that result from scale-up).
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Process Understanding in Freeze-Drying Cycle Development: Applications for Through-Vial Impedance Spectroscopy (TVIS) in Mini-pilot Studies
Journal of Pharmaceutical Innovation, 2017Co-Authors: Geoff Smith, E Polygalov, I Ermolina, Timothy R Mccoy, Muhammad Sohail Arshad, Paul MatejtschukAbstract:Purpose The freeze-Drying Cycle comprises three stages: (1) freezing, to form ice and to crystallise out any solutes with a propensity to crystallise, (2) primary Drying to remove the ice phase by sublimation and (3) secondary Drying to remove the remaining unfrozen water which is bound to the remaining matrix of crystalline and amorphous solids. Given the impact of scale on the process outcomes, any freeze-Drying Cycle developed based on mini-pilot studies will inevitably require measurement technologies for characterising each stage of the Cycle at each scale of the process. However, there are inherent challenges in the development of reliable mini-piloting studies, with the first being the fact that no single PAT technology for freeze Drying may be implemented across all levels of scale, and the second being the inherent changes in process characteristics (process parameters that result from scale-up). Methods Here, we present a new approach for process understanding in freeze-Drying Cycle development, which uses a through-vial impedance measurement. Results The technique has been used to characterise a broad range of features of the process, including, ice onset times, the completion of ice solidification, the glass transition and the structural relaxation of the amorphous solid, a surrogate for primary Drying rate and the primary Drying end point. Conclusions The on-going development of this technology may see the application with microtitre plate technologies for formulation screening (microscale down) and for scale-up into production by using a non-contact probes for monitoring problematic regions within the dryer.
Geoff Smith - One of the best experts on this subject based on the ideXlab platform.
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process understanding in freeze Drying Cycle development applications for through vial impedance spectroscopy tvis in mini pilot studies
Journal of Pharmaceutical Innovation, 2017Co-Authors: Geoff Smith, Muhammad Arshad, E Polygalov, I Ermolina, Timothy R Mccoy, Paul MatejtschukAbstract:Purpose The freeze-Drying Cycle comprises three stages: (1) freezing, to form ice and to crystallise out any solutes with a propensity to crystallise, (2) primary Drying to remove the ice phase by sublimation and (3) secondary Drying to remove the remaining unfrozen water which is bound to the remaining matrix of crystalline and amorphous solids. Given the impact of scale on the process outcomes, any freeze-Drying Cycle developed based on mini-pilot studies will inevitably require measurement technologies for characterising each stage of the Cycle at each scale of the process. However, there are inherent challenges in the development of reliable mini-piloting studies, with the first being the fact that no single PAT technology for freeze Drying may be implemented across all levels of scale, and the second being the inherent changes in process characteristics (process parameters that result from scale-up).
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Process Understanding in Freeze-Drying Cycle Development: Applications for Through-Vial Impedance Spectroscopy (TVIS) in Mini-pilot Studies
Journal of Pharmaceutical Innovation, 2017Co-Authors: Geoff Smith, E Polygalov, I Ermolina, Timothy R Mccoy, Muhammad Sohail Arshad, Paul MatejtschukAbstract:Purpose The freeze-Drying Cycle comprises three stages: (1) freezing, to form ice and to crystallise out any solutes with a propensity to crystallise, (2) primary Drying to remove the ice phase by sublimation and (3) secondary Drying to remove the remaining unfrozen water which is bound to the remaining matrix of crystalline and amorphous solids. Given the impact of scale on the process outcomes, any freeze-Drying Cycle developed based on mini-pilot studies will inevitably require measurement technologies for characterising each stage of the Cycle at each scale of the process. However, there are inherent challenges in the development of reliable mini-piloting studies, with the first being the fact that no single PAT technology for freeze Drying may be implemented across all levels of scale, and the second being the inherent changes in process characteristics (process parameters that result from scale-up). Methods Here, we present a new approach for process understanding in freeze-Drying Cycle development, which uses a through-vial impedance measurement. Results The technique has been used to characterise a broad range of features of the process, including, ice onset times, the completion of ice solidification, the glass transition and the structural relaxation of the amorphous solid, a surrogate for primary Drying rate and the primary Drying end point. Conclusions The on-going development of this technology may see the application with microtitre plate technologies for formulation screening (microscale down) and for scale-up into production by using a non-contact probes for monitoring problematic regions within the dryer.
Andreas G. Boudouvis - One of the best experts on this subject based on the ideXlab platform.
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hierarchical plasma nanotextured robust superamphiphobic polymeric surfaces structurally stabilized through a wetting Drying Cycle
Plasma Processes and Polymers, 2012Co-Authors: Arun Kumar Gnanappa, Dimitrios P. Papageorgiou, Evangelos Gogolides, Angeliki Tserepi, Athanasios G. Papathanasiou, Andreas G. BoudouvisAbstract:Plasma etched and simultaneously randomly roughened (nanotextured) polymethylmethacrylate (PMMA) substrates show hierarchical roughness and complex high-aspect-ratio morphology. Here, they are investigated as superamphiphobic surfaces, after plasma deposition of a thin fluorocarbon film. Inspired by the need to allow their “real world” use, we explore two major stability issues of such superamphiphobic surfaces: (i) the structural stability of the nanotexture against capillary and adhesion forces during successive wetting–Drying Cycles, and (ii) the thermodynamic stability (robustness) of these surfaces related to the maximum sustainable pressure of the Cassie–Baxter inhomogeneous wetting state. We show that surfaces etched in oxygen plasma up to 4 min (with texture height ≈600 nm) are stable against successive wetting–Drying Cycles, while surfaces treated for longer time show highly porous nanofibrous morphology which is coalesced and stabilized upon wetting, allowing their potential long-term use. Robust superhydrophobic and superoleophobic behavior is observed in drop compression tests with water (on 2, 4, 10 min plasma etched surfaces) and diiodomethane (on 4 and 10 min plasma etched surfaces), respectively, and no wetting transition is observed for these two liquids even at maximum drop compression possible (1.5 kPa). Robust oleophobic behavior with sticky surfaces is observed for 1 and 2 min etching and with diiodomethane without transition to wetted states even upon maximum compression. On the contrary, wetting transition is observed for soya oil upon repeated compression.
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Hierarchical, Plasma Nanotextured, Robust Superamphiphobic Polymeric Surfaces Structurally Stabilized Through a Wetting–Drying Cycle
Plasma Processes and Polymers, 2011Co-Authors: Arun Kumar Gnanappa, Dimitrios P. Papageorgiou, Evangelos Gogolides, Angeliki Tserepi, Athanasios G. Papathanasiou, Andreas G. BoudouvisAbstract:Plasma etched and simultaneously randomly roughened (nanotextured) polymethylmethacrylate (PMMA) substrates show hierarchical roughness and complex high-aspect-ratio morphology. Here, they are investigated as superamphiphobic surfaces, after plasma deposition of a thin fluorocarbon film. Inspired by the need to allow their “real world” use, we explore two major stability issues of such superamphiphobic surfaces: (i) the structural stability of the nanotexture against capillary and adhesion forces during successive wetting–Drying Cycles, and (ii) the thermodynamic stability (robustness) of these surfaces related to the maximum sustainable pressure of the Cassie–Baxter inhomogeneous wetting state. We show that surfaces etched in oxygen plasma up to 4 min (with texture height ≈600 nm) are stable against successive wetting–Drying Cycles, while surfaces treated for longer time show highly porous nanofibrous morphology which is coalesced and stabilized upon wetting, allowing their potential long-term use. Robust superhydrophobic and superoleophobic behavior is observed in drop compression tests with water (on 2, 4, 10 min plasma etched surfaces) and diiodomethane (on 4 and 10 min plasma etched surfaces), respectively, and no wetting transition is observed for these two liquids even at maximum drop compression possible (1.5 kPa). Robust oleophobic behavior with sticky surfaces is observed for 1 and 2 min etching and with diiodomethane without transition to wetted states even upon maximum compression. On the contrary, wetting transition is observed for soya oil upon repeated compression.
Timothy R Mccoy - One of the best experts on this subject based on the ideXlab platform.
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process understanding in freeze Drying Cycle development applications for through vial impedance spectroscopy tvis in mini pilot studies
Journal of Pharmaceutical Innovation, 2017Co-Authors: Geoff Smith, Muhammad Arshad, E Polygalov, I Ermolina, Timothy R Mccoy, Paul MatejtschukAbstract:Purpose The freeze-Drying Cycle comprises three stages: (1) freezing, to form ice and to crystallise out any solutes with a propensity to crystallise, (2) primary Drying to remove the ice phase by sublimation and (3) secondary Drying to remove the remaining unfrozen water which is bound to the remaining matrix of crystalline and amorphous solids. Given the impact of scale on the process outcomes, any freeze-Drying Cycle developed based on mini-pilot studies will inevitably require measurement technologies for characterising each stage of the Cycle at each scale of the process. However, there are inherent challenges in the development of reliable mini-piloting studies, with the first being the fact that no single PAT technology for freeze Drying may be implemented across all levels of scale, and the second being the inherent changes in process characteristics (process parameters that result from scale-up).
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Process Understanding in Freeze-Drying Cycle Development: Applications for Through-Vial Impedance Spectroscopy (TVIS) in Mini-pilot Studies
Journal of Pharmaceutical Innovation, 2017Co-Authors: Geoff Smith, E Polygalov, I Ermolina, Timothy R Mccoy, Muhammad Sohail Arshad, Paul MatejtschukAbstract:Purpose The freeze-Drying Cycle comprises three stages: (1) freezing, to form ice and to crystallise out any solutes with a propensity to crystallise, (2) primary Drying to remove the ice phase by sublimation and (3) secondary Drying to remove the remaining unfrozen water which is bound to the remaining matrix of crystalline and amorphous solids. Given the impact of scale on the process outcomes, any freeze-Drying Cycle developed based on mini-pilot studies will inevitably require measurement technologies for characterising each stage of the Cycle at each scale of the process. However, there are inherent challenges in the development of reliable mini-piloting studies, with the first being the fact that no single PAT technology for freeze Drying may be implemented across all levels of scale, and the second being the inherent changes in process characteristics (process parameters that result from scale-up). Methods Here, we present a new approach for process understanding in freeze-Drying Cycle development, which uses a through-vial impedance measurement. Results The technique has been used to characterise a broad range of features of the process, including, ice onset times, the completion of ice solidification, the glass transition and the structural relaxation of the amorphous solid, a surrogate for primary Drying rate and the primary Drying end point. Conclusions The on-going development of this technology may see the application with microtitre plate technologies for formulation screening (microscale down) and for scale-up into production by using a non-contact probes for monitoring problematic regions within the dryer.
I Ermolina - One of the best experts on this subject based on the ideXlab platform.
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process understanding in freeze Drying Cycle development applications for through vial impedance spectroscopy tvis in mini pilot studies
Journal of Pharmaceutical Innovation, 2017Co-Authors: Geoff Smith, Muhammad Arshad, E Polygalov, I Ermolina, Timothy R Mccoy, Paul MatejtschukAbstract:Purpose The freeze-Drying Cycle comprises three stages: (1) freezing, to form ice and to crystallise out any solutes with a propensity to crystallise, (2) primary Drying to remove the ice phase by sublimation and (3) secondary Drying to remove the remaining unfrozen water which is bound to the remaining matrix of crystalline and amorphous solids. Given the impact of scale on the process outcomes, any freeze-Drying Cycle developed based on mini-pilot studies will inevitably require measurement technologies for characterising each stage of the Cycle at each scale of the process. However, there are inherent challenges in the development of reliable mini-piloting studies, with the first being the fact that no single PAT technology for freeze Drying may be implemented across all levels of scale, and the second being the inherent changes in process characteristics (process parameters that result from scale-up).
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Process Understanding in Freeze-Drying Cycle Development: Applications for Through-Vial Impedance Spectroscopy (TVIS) in Mini-pilot Studies
Journal of Pharmaceutical Innovation, 2017Co-Authors: Geoff Smith, E Polygalov, I Ermolina, Timothy R Mccoy, Muhammad Sohail Arshad, Paul MatejtschukAbstract:Purpose The freeze-Drying Cycle comprises three stages: (1) freezing, to form ice and to crystallise out any solutes with a propensity to crystallise, (2) primary Drying to remove the ice phase by sublimation and (3) secondary Drying to remove the remaining unfrozen water which is bound to the remaining matrix of crystalline and amorphous solids. Given the impact of scale on the process outcomes, any freeze-Drying Cycle developed based on mini-pilot studies will inevitably require measurement technologies for characterising each stage of the Cycle at each scale of the process. However, there are inherent challenges in the development of reliable mini-piloting studies, with the first being the fact that no single PAT technology for freeze Drying may be implemented across all levels of scale, and the second being the inherent changes in process characteristics (process parameters that result from scale-up). Methods Here, we present a new approach for process understanding in freeze-Drying Cycle development, which uses a through-vial impedance measurement. Results The technique has been used to characterise a broad range of features of the process, including, ice onset times, the completion of ice solidification, the glass transition and the structural relaxation of the amorphous solid, a surrogate for primary Drying rate and the primary Drying end point. Conclusions The on-going development of this technology may see the application with microtitre plate technologies for formulation screening (microscale down) and for scale-up into production by using a non-contact probes for monitoring problematic regions within the dryer.
