Dumping Syndrome

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Yehong Yang - One of the best experts on this subject based on the ideXlab platform.

  • prevalence and risk factors for symptoms suggestive of hypoglycemia and early Dumping Syndrome after sleeve gastrectomy
    Surgery for Obesity and Related Diseases, 2019
    Co-Authors: Wanwan Sun, Yawen Zhang, Qiwei Shen, Wen Zhang, Qiyuan Yao, Yehong Yang
    Abstract:

    Abstract Background Postprandial hypoglycemia and early Dumping Syndrome are common complications after bariatric surgery. Although sleeve gastrectomy (SG) has become a primary option for many bariatric surgeons, limited information was available for the prevalence and risk factors of the complications. Objective To assess the prevalence and possible risk factors for postprandial hypoglycemia and early Dumping Syndrome based on self-reported symptoms of SG patients. Setting The study was conducted at a bariatric surgery center in a university hospital. Methods In this study, all patients who underwent an SG (n = 222) between December 2011 and May 2018 in our center were invited to participate in a questionnaire survey. The Edinburgh Hypoglycemia Scoring System and the Dumping Symptom Rating Scale were used to evaluate symptoms, and clinical data of the patients were collected. The median follow-up time was 1.1 years. Results The questionnaire was completed and returned by 54.95% (122/222) of the patients and 62.30% (76/122) of the responders were women. The prevalence rates of mild and moderate symptoms suggestive of hypoglycemia were 65.57% (80/122) and .82%, respectively. An associated risk factor was younger age (adjusted for sex, body mass index, and waist circumference at baseline: odds ratio 3.69; 95% confidence interval [1.22–11.21]), but this association disappeared after further adjustment of low-density protein cholesterol (LDL-C) (odds ratio 6.42; 95% confidence interval [.38–108],;P > .05). The prevalence rate of mild symptoms suggestive of early Dumping was 40.98% (50/122), associated risk factor was lower LDL-C. Conclusion Mild-to-moderate symptoms suggestive of hypoglycemia and early Dumping Syndrome were common in patients after SG, with the prevalence rates of 66.39% (81/122) and 40.98% (50/122), respectively. Patients with both symptoms suggestive of early Dumping Syndrome and hypoglycemia accounted for 33.61% (41/122) of all patients. Younger age indicated higher risk of hypoglycemia after SG and lower LDL-C may play an important role in this relationship. Lower LDL-C was associated with higher risk of early Dumping Syndrome after SG.

Pochih Chang - One of the best experts on this subject based on the ideXlab platform.

C. B. H. W. Lamers - One of the best experts on this subject based on the ideXlab platform.

  • The Dumping Syndrome. Current insights into pathophysiology, diagnosis and treatment.
    Scandinavian journal of gastroenterology. Supplement, 1997
    Co-Authors: J. Vecht, A.a.m. Masclee, C. B. H. W. Lamers
    Abstract:

    The Dumping Syndrome is encountered in approximately 10% of patients after gastric surgery. A postprandial peripheral and splanchnic vasodilatation and ensuing relative hypovolaemia are pivotal in the pathophysiology of early systemic symptoms. Late Dumping symptoms are a consequence of a reactive hypoglycaemia, which results from an exaggerated insulin and glucagon-like peptide-1 release. The diagnosis of Dumping Syndrome can reliably be made with the aid of a provocation test using 50 g glucose orally. Most patients with Dumping can be treated with advice on diet and lifestyle. Octreotide effectively controls the signs and symptoms of Dumping in patients refractory to standard therapy. It acts through its inhibitory effects on insulin and gut hormone release, a delay of intestinal transit time and inhibition of food-induced circulatory changes. Its long-term use is somewhat limited by side effects, particularly diarrhoea and steatorrhoea.

Thomas F. Mangan - One of the best experts on this subject based on the ideXlab platform.

Barbara Broggelwirth - One of the best experts on this subject based on the ideXlab platform.

  • Prevalence of Dumping Syndrome After Laparoscopic Sleeve Gastrectomy and Comparison with Laparoscopic Roux-en-Y Gastric Bypass.
    Obesity surgery, 2019
    Co-Authors: Arif Ahmad, Daphne Baldwin Kornrich, Helaine Krasner, Sarah Eckardt, Zoha F. Ahmad, Annamarie Braslow, Barbara Broggelwirth
    Abstract:

    Dumping Syndrome is a well-known side effect of laparoscopic gastric bypass (LRYGB), and it is commonly believed that Dumping Syndrome is less likely to occur after laparoscopic sleeve gastrectomy (LSG), due to the preservation of the pyloric sphincter. However, it is not uncommon for patients undergoing LSG at our center to report symptoms suggestive of Dumping Syndrome. To assess the prevalence of symptoms of Dumping Syndrome after LSG compared with LRYGB. A single surgical group at a high-volume (700 cases per year) Bariatric and Metabolic Surgery Center of Excellence. One thousand four hundred seventy-one LRYGB (366) and LSG (1105) patients received a questionnaire to assess symptoms of Dumping Syndrome, utilizing a modified version of the Sigstad scoring system. Dumping Syndrome was considered to be present when the questionnaire score exceeded a threshold value. A total of 360 responses were received (249 LSG, 111 LRYGB). 26.5% (66) LSG and 41.4% (46) LRYGB exceeded the threshold for Dumping Syndrome (p   0.05). Thirty-six percent (24) LSG and 28% (13) LRYGB reported late Dumping Syndrome (p > 0.05). Twenty-seven percent (62) LSG and 44.4% (44) LRYGB reported at least one symptom of Dumping Syndrome with sweets (p   0.05). 14.5% (36) LSG and 17.3% (19) LRYGB reported symptoms after alcohol consumption (p > 0.05). Dumping Syndrome after LSG is prevalent but has not been widely reported. This finding may impact clinicians and patients in their choice of procedure and has relevance in post-operative education and care.