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Mary Osborn - One of the best experts on this subject based on the ideXlab platform.
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Increased PCNA/cyclin index correlates with severity of Duodenitis defined by histological criteria
Virchows Archiv A, 1993Co-Authors: Wenancjusz Domagala, Krzysztof Marlicz, Dariusz Bielicki, Mary OsbornAbstract:The proliferative activity of crypt epithelial cells was studied in 64 duodenal biopsies using immunohistochemistry and proliferating cell nuclear antigen (PCNA)/cyclin monoclonal antibodies in alcohol-fixed paraffin-embedded sections. A positive correlation between Duodenitis as defined by histological criteria and increased mean percentage of PCNA positive crypt cell nuclei (PCNA index) was found. The mean PCNA index in normal mucosa was 11.8±2.7% (mean ± SD), in mild (grade 1) Duodenitis 17.3±3.9%, in moderate (grade 2) 30.6±6.9%, and in severe (grade 3) Duodenitis 41.1±8.5%. The inclusion of PCNA index, which is easily measured in paraffin-embedded sections, in the existing histopathological grading systems of Duodenitis may improve their clinical relevance.
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increased pcna cyclin index correlates with severity of Duodenitis defined by histological criteria
Virchows Archiv, 1993Co-Authors: Wenancjusz Domagala, Krzysztof Marlicz, Dariusz Bielicki, Mary OsbornAbstract:The proliferative activity of crypt epithelial cells was studied in 64 duodenal biopsies using immunohistochemistry and proliferating cell nuclear antigen (PCNA)/cyclin monoclonal antibodies in alcohol-fixed paraffin-embedded sections. A positive correlation between Duodenitis as defined by histological criteria and increased mean percentage of PCNA positive crypt cell nuclei (PCNA index) was found. The mean PCNA index in normal mucosa was 11.8±2.7% (mean ± SD), in mild (grade 1) Duodenitis 17.3±3.9%, in moderate (grade 2) 30.6±6.9%, and in severe (grade 3) Duodenitis 41.1±8.5%. The inclusion of PCNA index, which is easily measured in paraffin-embedded sections, in the existing histopathological grading systems of Duodenitis may improve their clinical relevance.
Wenancjusz Domagala - One of the best experts on this subject based on the ideXlab platform.
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Increased PCNA/cyclin index correlates with severity of Duodenitis defined by histological criteria
Virchows Archiv A, 1993Co-Authors: Wenancjusz Domagala, Krzysztof Marlicz, Dariusz Bielicki, Mary OsbornAbstract:The proliferative activity of crypt epithelial cells was studied in 64 duodenal biopsies using immunohistochemistry and proliferating cell nuclear antigen (PCNA)/cyclin monoclonal antibodies in alcohol-fixed paraffin-embedded sections. A positive correlation between Duodenitis as defined by histological criteria and increased mean percentage of PCNA positive crypt cell nuclei (PCNA index) was found. The mean PCNA index in normal mucosa was 11.8±2.7% (mean ± SD), in mild (grade 1) Duodenitis 17.3±3.9%, in moderate (grade 2) 30.6±6.9%, and in severe (grade 3) Duodenitis 41.1±8.5%. The inclusion of PCNA index, which is easily measured in paraffin-embedded sections, in the existing histopathological grading systems of Duodenitis may improve their clinical relevance.
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increased pcna cyclin index correlates with severity of Duodenitis defined by histological criteria
Virchows Archiv, 1993Co-Authors: Wenancjusz Domagala, Krzysztof Marlicz, Dariusz Bielicki, Mary OsbornAbstract:The proliferative activity of crypt epithelial cells was studied in 64 duodenal biopsies using immunohistochemistry and proliferating cell nuclear antigen (PCNA)/cyclin monoclonal antibodies in alcohol-fixed paraffin-embedded sections. A positive correlation between Duodenitis as defined by histological criteria and increased mean percentage of PCNA positive crypt cell nuclei (PCNA index) was found. The mean PCNA index in normal mucosa was 11.8±2.7% (mean ± SD), in mild (grade 1) Duodenitis 17.3±3.9%, in moderate (grade 2) 30.6±6.9%, and in severe (grade 3) Duodenitis 41.1±8.5%. The inclusion of PCNA index, which is easily measured in paraffin-embedded sections, in the existing histopathological grading systems of Duodenitis may improve their clinical relevance.
Dinesh S. Pashankar - One of the best experts on this subject based on the ideXlab platform.
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prevalence and clinical endoscopic and pathological features of Duodenitis in children
Journal of Pediatric Gastroenterology and Nutrition, 2016Co-Authors: Arik Alper, Steven Hardee, Sandra Escalera, Raffaella A. Morotti, Danilo Rojasvelasquez, Dinesh S. PashankarAbstract:OBJECTIVES Although gastritis and esophagitis are well studied in children, there is very limited literature on Duodenitis in children. We aimed to assess the prevalence, etiology, clinical, endoscopic, and pathological features in a large cohort of unselected children with Duodenitis. METHODS We reviewed the pathology reports of all the upper endoscopies performed at our institution during 5 years to identify children with Duodenitis. Biopsy sections were reviewed to confirm the diagnosis of Duodenitis. Demographic, clinical, endoscopic data, and the presence of associated gastritis and esophagitis were noted in all of the children with Duodenitis. The etiology of Duodenitis was correlated with the patients' clinical diagnosis. RESULTS Out of 2772 children who had endoscopy, 352 had Duodenitis with the prevalence rate of 12.7%. Gastritis was seen in 64% of children with Duodenitis compared with 46% of children without Duodenitis (P < 0.001). Common indications for endoscopy in children with Duodenitis were abdominal pain, positive celiac serology, and diarrhea. The most common etiology was celiac disease (32%), followed by Crohn disease (13%), ulcerative colitis (3%), and Helicobacter pylori infection (6%). In 63% of cases, the endoscopic appearance of duodenum was normal. Cryptitis, villous changes, and cellular infiltration were noted on histology. CONCLUSIONS Prevalence of Duodenitis is 12.7% in children undergoing endoscopy. Celiac disease and inflammatory bowel disease are common causes of Duodenitis. Associated gastritis is common in children with Duodenitis, and the correlation of endoscopic appearance with histology is poor.
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Prevalence and Clinical, Endoscopic, and Pathological Features of Duodenitis in Children.
Journal of pediatric gastroenterology and nutrition, 2016Co-Authors: Arik Alper, Steven Hardee, Danilo Rojas-velasquez, Sandra Escalera, Raffaella A. Morotti, Dinesh S. PashankarAbstract:OBJECTIVES Although gastritis and esophagitis are well studied in children, there is very limited literature on Duodenitis in children. We aimed to assess the prevalence, etiology, clinical, endoscopic, and pathological features in a large cohort of unselected children with Duodenitis. METHODS We reviewed the pathology reports of all the upper endoscopies performed at our institution during 5 years to identify children with Duodenitis. Biopsy sections were reviewed to confirm the diagnosis of Duodenitis. Demographic, clinical, endoscopic data, and the presence of associated gastritis and esophagitis were noted in all of the children with Duodenitis. The etiology of Duodenitis was correlated with the patients' clinical diagnosis. RESULTS Out of 2772 children who had endoscopy, 352 had Duodenitis with the prevalence rate of 12.7%. Gastritis was seen in 64% of children with Duodenitis compared with 46% of children without Duodenitis (P
Dariusz Bielicki - One of the best experts on this subject based on the ideXlab platform.
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Increased PCNA/cyclin index correlates with severity of Duodenitis defined by histological criteria
Virchows Archiv A, 1993Co-Authors: Wenancjusz Domagala, Krzysztof Marlicz, Dariusz Bielicki, Mary OsbornAbstract:The proliferative activity of crypt epithelial cells was studied in 64 duodenal biopsies using immunohistochemistry and proliferating cell nuclear antigen (PCNA)/cyclin monoclonal antibodies in alcohol-fixed paraffin-embedded sections. A positive correlation between Duodenitis as defined by histological criteria and increased mean percentage of PCNA positive crypt cell nuclei (PCNA index) was found. The mean PCNA index in normal mucosa was 11.8±2.7% (mean ± SD), in mild (grade 1) Duodenitis 17.3±3.9%, in moderate (grade 2) 30.6±6.9%, and in severe (grade 3) Duodenitis 41.1±8.5%. The inclusion of PCNA index, which is easily measured in paraffin-embedded sections, in the existing histopathological grading systems of Duodenitis may improve their clinical relevance.
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increased pcna cyclin index correlates with severity of Duodenitis defined by histological criteria
Virchows Archiv, 1993Co-Authors: Wenancjusz Domagala, Krzysztof Marlicz, Dariusz Bielicki, Mary OsbornAbstract:The proliferative activity of crypt epithelial cells was studied in 64 duodenal biopsies using immunohistochemistry and proliferating cell nuclear antigen (PCNA)/cyclin monoclonal antibodies in alcohol-fixed paraffin-embedded sections. A positive correlation between Duodenitis as defined by histological criteria and increased mean percentage of PCNA positive crypt cell nuclei (PCNA index) was found. The mean PCNA index in normal mucosa was 11.8±2.7% (mean ± SD), in mild (grade 1) Duodenitis 17.3±3.9%, in moderate (grade 2) 30.6±6.9%, and in severe (grade 3) Duodenitis 41.1±8.5%. The inclusion of PCNA index, which is easily measured in paraffin-embedded sections, in the existing histopathological grading systems of Duodenitis may improve their clinical relevance.
Krzysztof Marlicz - One of the best experts on this subject based on the ideXlab platform.
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Increased PCNA/cyclin index correlates with severity of Duodenitis defined by histological criteria
Virchows Archiv A, 1993Co-Authors: Wenancjusz Domagala, Krzysztof Marlicz, Dariusz Bielicki, Mary OsbornAbstract:The proliferative activity of crypt epithelial cells was studied in 64 duodenal biopsies using immunohistochemistry and proliferating cell nuclear antigen (PCNA)/cyclin monoclonal antibodies in alcohol-fixed paraffin-embedded sections. A positive correlation between Duodenitis as defined by histological criteria and increased mean percentage of PCNA positive crypt cell nuclei (PCNA index) was found. The mean PCNA index in normal mucosa was 11.8±2.7% (mean ± SD), in mild (grade 1) Duodenitis 17.3±3.9%, in moderate (grade 2) 30.6±6.9%, and in severe (grade 3) Duodenitis 41.1±8.5%. The inclusion of PCNA index, which is easily measured in paraffin-embedded sections, in the existing histopathological grading systems of Duodenitis may improve their clinical relevance.
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increased pcna cyclin index correlates with severity of Duodenitis defined by histological criteria
Virchows Archiv, 1993Co-Authors: Wenancjusz Domagala, Krzysztof Marlicz, Dariusz Bielicki, Mary OsbornAbstract:The proliferative activity of crypt epithelial cells was studied in 64 duodenal biopsies using immunohistochemistry and proliferating cell nuclear antigen (PCNA)/cyclin monoclonal antibodies in alcohol-fixed paraffin-embedded sections. A positive correlation between Duodenitis as defined by histological criteria and increased mean percentage of PCNA positive crypt cell nuclei (PCNA index) was found. The mean PCNA index in normal mucosa was 11.8±2.7% (mean ± SD), in mild (grade 1) Duodenitis 17.3±3.9%, in moderate (grade 2) 30.6±6.9%, and in severe (grade 3) Duodenitis 41.1±8.5%. The inclusion of PCNA index, which is easily measured in paraffin-embedded sections, in the existing histopathological grading systems of Duodenitis may improve their clinical relevance.
