The Experts below are selected from a list of 333 Experts worldwide ranked by ideXlab platform
John F Steffensen - One of the best experts on this subject based on the ideXlab platform.
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the blood volumes of the primary and secondary circulatory system in the atlantic cod gadus morhua l using plasma bound evans blue and compartmental analysis
The Journal of Experimental Biology, 2003Co-Authors: Peter Vilhelm Skov, John F SteffensenAbstract:The volume of the primary (PCS) and secondary (SCS) circulatory system in the Atlantic cod Gadus morhua was determined using a modified Dye Dilution technique. Cod (N=10) were chronically cannulated in the second afferent branchial artery with PE-50 tubing. Evans Blue Dye was bound to harvested fish plasma at a concentration of 1 mg Dye ml(-1) plasma, and injected at a concentration of 1 mg kg(-1) body mass. Serial sampling from the cannula produced a Dye Dilution Curve, which could be described by a double exponential decay equation. Curve analysis enabled the calculation of the primary circulatory and total distribution volume. The difference between these volumes is assumed to be the volume of the SCS. From the Dilution Curve, it was also possible to calculate flow rates between and within the systems. The results of these experiments suggest a plasma volume in the PCS of 3.42+/-0.89 ml 100 g(-1) body mass, and in the SCS of 1.68+/-0.35 ml 100 g(-1) body mass (mean +/- S.D.) or approximately 50% that of the PCS. Flow rates to the SCS were calculated as 2.7% of the resting cardiac output. There was an allometric relationship between body mass and blood volumes. Increasing condition factor showed a tendency towards smaller blood volumes of the PCS, expressed as percentage body mass, but this was not evident for the volume of the SCS.
Peter Vilhelm Skov - One of the best experts on this subject based on the ideXlab platform.
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the blood volumes of the primary and secondary circulatory system in the atlantic cod gadus morhua l using plasma bound evans blue and compartmental analysis
The Journal of Experimental Biology, 2003Co-Authors: Peter Vilhelm Skov, John F SteffensenAbstract:The volume of the primary (PCS) and secondary (SCS) circulatory system in the Atlantic cod Gadus morhua was determined using a modified Dye Dilution technique. Cod (N=10) were chronically cannulated in the second afferent branchial artery with PE-50 tubing. Evans Blue Dye was bound to harvested fish plasma at a concentration of 1 mg Dye ml(-1) plasma, and injected at a concentration of 1 mg kg(-1) body mass. Serial sampling from the cannula produced a Dye Dilution Curve, which could be described by a double exponential decay equation. Curve analysis enabled the calculation of the primary circulatory and total distribution volume. The difference between these volumes is assumed to be the volume of the SCS. From the Dilution Curve, it was also possible to calculate flow rates between and within the systems. The results of these experiments suggest a plasma volume in the PCS of 3.42+/-0.89 ml 100 g(-1) body mass, and in the SCS of 1.68+/-0.35 ml 100 g(-1) body mass (mean +/- S.D.) or approximately 50% that of the PCS. Flow rates to the SCS were calculated as 2.7% of the resting cardiac output. There was an allometric relationship between body mass and blood volumes. Increasing condition factor showed a tendency towards smaller blood volumes of the PCS, expressed as percentage body mass, but this was not evident for the volume of the SCS.
Gnielinski Roman - One of the best experts on this subject based on the ideXlab platform.
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Bestimmung von arteriovenöser Passagezeit, Farbstoffbolusgeschwindigkeit und Steigung des Farbstoffeinstroms sowie Berechnung des okulären Blutflusses in den retinalen Blutgefäßen bei Normaldruckglaukompatienten mittels Scanning-Laser-Fluoreszein-Angiographie
Publikationsserver der RWTH Aachen University, 2002Co-Authors: Gnielinski RomanAbstract:Circulatory deficits around the optic nerve head are a primary factor in the pathogenesis of the Normal-Tension-Glaucoma. In this study AVP and FBG were measured and as in previous studies a slower velocity in NDG-Patients. However, the ocular blood flow is of primary importance for the nutrition of the optic nerve head. It was calculated by a formula using different parameters measured as diameter, velocity and so forth, which proved to be rather time consuming. In this study another parameter is introduced, the Increase of the Dye Dilution Curve, which correlates well with the calculated ocular blood flow
Messerli, Franz H. - One of the best experts on this subject based on the ideXlab platform.
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Central blood volume: A determinant of early cardiac adaptation in arterial hypertension?
American College of Cardiology. Published by Elsevier Inc., 1995Co-Authors: Schmieder, Roland E., Schobel, Hans P., Messerli, Franz H.Abstract:Objectives.This study was undertaken to assess the influence of the fluid volume state on cardiac adaptation to hypertension.Background.Left ventricular hypertrophy is an important predictor of hypertensive complications. We analyzed volume status and its impact on cardiac structural changes in early hypertension.Methods.In 33 normotensive subjects, 40 patients with borderline hypertension and 63 patients with established essential hypertension, mean arterial pressure was measured invasively; total blood volume was measured by iodine-125—labeled plasma albumin and hematocrit; central blood volume by indocyanine green Dye Dilution Curve; and diastolic diameter and left ventricular mass by two-dimensional—guided M-mode echocardiography.Results.Central blood volume was ∼20% higher in patients with stage I borderline hypertension than in normotensive subjects ([mean ±SD] 3,001 ± 663 vs. 2,493 ± 542 ml, p < 0.05), whereas total blood volume was similar in all three groups. This shift in intravascular volume toward the cardiopulmonary circulation was accompanied by a significant increase in diastolic diameter (5.29 ± 0.80 vs. 4.86 ± 0.77 cm, p < 0.05) and in left ventricular mass (239.4 ± 90.6 vs 183.5 ± 68.8 g, p < 0.05) in patients with borderline hypertension compared with subjects with normotension. In patients with established essential hypertension, volume status of stroke volume and diastolic dimension returned to normal values, whereas left ventricular mass increased further.Conclusions.We conclude that the early phase of hypertension is characterized by centripetal distribution of intravascular volume, leading to an increased preload to the left ventricle. This change in volume status appears to be related to cardiac structural adaptation to an increase in arterial pressure
Schmieder, Roland E. - One of the best experts on this subject based on the ideXlab platform.
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Central blood volume: A determinant of early cardiac adaptation in arterial hypertension?
American College of Cardiology. Published by Elsevier Inc., 1995Co-Authors: Schmieder, Roland E., Schobel, Hans P., Messerli, Franz H.Abstract:Objectives.This study was undertaken to assess the influence of the fluid volume state on cardiac adaptation to hypertension.Background.Left ventricular hypertrophy is an important predictor of hypertensive complications. We analyzed volume status and its impact on cardiac structural changes in early hypertension.Methods.In 33 normotensive subjects, 40 patients with borderline hypertension and 63 patients with established essential hypertension, mean arterial pressure was measured invasively; total blood volume was measured by iodine-125—labeled plasma albumin and hematocrit; central blood volume by indocyanine green Dye Dilution Curve; and diastolic diameter and left ventricular mass by two-dimensional—guided M-mode echocardiography.Results.Central blood volume was ∼20% higher in patients with stage I borderline hypertension than in normotensive subjects ([mean ±SD] 3,001 ± 663 vs. 2,493 ± 542 ml, p < 0.05), whereas total blood volume was similar in all three groups. This shift in intravascular volume toward the cardiopulmonary circulation was accompanied by a significant increase in diastolic diameter (5.29 ± 0.80 vs. 4.86 ± 0.77 cm, p < 0.05) and in left ventricular mass (239.4 ± 90.6 vs 183.5 ± 68.8 g, p < 0.05) in patients with borderline hypertension compared with subjects with normotension. In patients with established essential hypertension, volume status of stroke volume and diastolic dimension returned to normal values, whereas left ventricular mass increased further.Conclusions.We conclude that the early phase of hypertension is characterized by centripetal distribution of intravascular volume, leading to an increased preload to the left ventricle. This change in volume status appears to be related to cardiac structural adaptation to an increase in arterial pressure
