The Experts below are selected from a list of 146955 Experts worldwide ranked by ideXlab platform
Alex Cable - One of the best experts on this subject based on the ideXlab platform.
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optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast
Proceedings of SPIE, 2012Co-Authors: Vivek J Srinivasan, Harsha Radhakrishnan, James Jiang, Scott Barry, Alex CableAbstract:We demonstrate Optical Coherence Microscopy (OCM) for in vivo imaging of the rat cerebral cortex. Imaging does not require addition of Dyes or contrast agents, and is achieved through intrinsic scattering contrast and image processing alone. Furthermore, we demonstrate in vivo, quantitative measurements of optical properties and angiography in the rat cerebral cortex. Imaging depths greater than those achieved by conventional two-photon microscopy are demonstrated.
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optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast
Optics Express, 2012Co-Authors: Vivek J Srinivasan, Harsha Radhakrishnan, James Jiang, Scott Barry, Alex CableAbstract:In vivo optical microscopic imaging techniques have recently emerged as important tools for the study of neurobiological development and pathophysiology. In particular, two-photon microscopy has proved to be a robust and highly flexible method for in vivo imaging in highly scattering tissue. However, two-photon imaging typically requires extrinsic Dyes or contrast agents, and imaging depths are limited to a few hundred microns. Here we demonstrate Optical Coherence Microscopy (OCM) for in vivo imaging of neuronal cell bodies and cortical myelination up to depths of ~1.3 mm in the rat neocortex. Imaging does not require the administration of exogenous Dyes or contrast agents, and is achieved through intrinsic scattering contrast and image processing alone. Furthermore, using OCM we demonstrate in vivo, quantitative measurements of optical properties (index of refraction and attenuation coefficient) in the cortex, and correlate these properties with laminar cellular architecture determined from the images. Lastly, we show that OCM enables direct visualization of cellular changes during cell depolarization and may therefore provide novel optical markers of cell viability.
Nararak Leesakul - One of the best experts on this subject based on the ideXlab platform.
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photoactive azoimine Dyes 4 2 pyridylazo n n diethylaniline and 4 2 pyridylazo n n dimethylaniline computational and experimental investigation
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2012Co-Authors: Suthirat Yoopensuk, Pornthip Tongying, Kanidtha Hansongnern, Chaveng Pakawatchai, Saowanit Saithong, Yuthana Tantirungrotechai, Nararak LeesakulAbstract:Abstract 4-(2-Pyridylazo)-N,N-dimethylaniline and 4-(2-pyridylazo)-N,N-diethylaniline, two photoactive azoimine Dyes, were prepared from the reaction of 2-aminopyridine with N,N-dialkyl-1,4-nitrosoaniline at room temperature. Structural characterizations of these Dyes using single crystal X-ray diffraction, 1H NMR, elemental analysis, mass spectroscopy and IR spectroscopy have been carried out. The X-ray structure indicates a trans configuration around the azo group. The photochemical behavior of these compounds differs from that of 2-phenylazopyridine, the non-dialkylamino substituent compound. The synthesized compounds show emission spectra at room temperature while 2-phenylazopyridine does not. The excitation spectra of these compounds differ from their absorption spectra which can be explained on the basis of the trans to cis photoisomerization which is supported by the TD-PBE0/6-31G(d,p) calculations. Both oxidation of the dialkylamino substituents (–NR2; R = –CH3 and –C2H5) and reduction of –N N–/–N N–− and –N N–−/–N N–2− were observed in the cyclic voltammogram indicating a π-acidity of both Dyes.
Lee A King - One of the best experts on this subject based on the ideXlab platform.
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mordant Dyes as sensitisers in dye sensitised solar cells
Solar Energy Materials and Solar Cells, 2007Co-Authors: Keith R. Millington, Keith William Fincher, Lee A KingAbstract:Abstract Many mordant Dyes commonly used in the textile industry form coordination complexes at the surface of nanocrystalline TiO 2 . Dyes having a salicylate chelating group are particularly effective. Forty-nine commercial mordant Dyes were studied as sensitisers in a non-optimised dye-sensitised solar cell (DSSC) and their performance compared to the N3 ruthenium complex. Although N3 produced the highest output, six mordant Dyes produced photocurrents >0.2 mA. UV–visible spectra of the dye-complexed photoanodes suggest that some mordant Dyes are more strongly bound to the TiO 2 surface than N3. Photocatalytic oxidation of these Dyes does not appear to occur in a DSSC environment.
Yuthana Tantirungrotechai - One of the best experts on this subject based on the ideXlab platform.
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photoactive azoimine Dyes 4 2 pyridylazo n n diethylaniline and 4 2 pyridylazo n n dimethylaniline computational and experimental investigation
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2012Co-Authors: Suthirat Yoopensuk, Pornthip Tongying, Kanidtha Hansongnern, Chaveng Pakawatchai, Saowanit Saithong, Yuthana Tantirungrotechai, Nararak LeesakulAbstract:Abstract 4-(2-Pyridylazo)-N,N-dimethylaniline and 4-(2-pyridylazo)-N,N-diethylaniline, two photoactive azoimine Dyes, were prepared from the reaction of 2-aminopyridine with N,N-dialkyl-1,4-nitrosoaniline at room temperature. Structural characterizations of these Dyes using single crystal X-ray diffraction, 1H NMR, elemental analysis, mass spectroscopy and IR spectroscopy have been carried out. The X-ray structure indicates a trans configuration around the azo group. The photochemical behavior of these compounds differs from that of 2-phenylazopyridine, the non-dialkylamino substituent compound. The synthesized compounds show emission spectra at room temperature while 2-phenylazopyridine does not. The excitation spectra of these compounds differ from their absorption spectra which can be explained on the basis of the trans to cis photoisomerization which is supported by the TD-PBE0/6-31G(d,p) calculations. Both oxidation of the dialkylamino substituents (–NR2; R = –CH3 and –C2H5) and reduction of –N N–/–N N–− and –N N–−/–N N–2− were observed in the cyclic voltammogram indicating a π-acidity of both Dyes.
Vivek J Srinivasan - One of the best experts on this subject based on the ideXlab platform.
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optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast
Proceedings of SPIE, 2012Co-Authors: Vivek J Srinivasan, Harsha Radhakrishnan, James Jiang, Scott Barry, Alex CableAbstract:We demonstrate Optical Coherence Microscopy (OCM) for in vivo imaging of the rat cerebral cortex. Imaging does not require addition of Dyes or contrast agents, and is achieved through intrinsic scattering contrast and image processing alone. Furthermore, we demonstrate in vivo, quantitative measurements of optical properties and angiography in the rat cerebral cortex. Imaging depths greater than those achieved by conventional two-photon microscopy are demonstrated.
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optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast
Optics Express, 2012Co-Authors: Vivek J Srinivasan, Harsha Radhakrishnan, James Jiang, Scott Barry, Alex CableAbstract:In vivo optical microscopic imaging techniques have recently emerged as important tools for the study of neurobiological development and pathophysiology. In particular, two-photon microscopy has proved to be a robust and highly flexible method for in vivo imaging in highly scattering tissue. However, two-photon imaging typically requires extrinsic Dyes or contrast agents, and imaging depths are limited to a few hundred microns. Here we demonstrate Optical Coherence Microscopy (OCM) for in vivo imaging of neuronal cell bodies and cortical myelination up to depths of ~1.3 mm in the rat neocortex. Imaging does not require the administration of exogenous Dyes or contrast agents, and is achieved through intrinsic scattering contrast and image processing alone. Furthermore, using OCM we demonstrate in vivo, quantitative measurements of optical properties (index of refraction and attenuation coefficient) in the cortex, and correlate these properties with laminar cellular architecture determined from the images. Lastly, we show that OCM enables direct visualization of cellular changes during cell depolarization and may therefore provide novel optical markers of cell viability.
