The Experts below are selected from a list of 36312 Experts worldwide ranked by ideXlab platform
Charles C Han - One of the best experts on this subject based on the ideXlab platform.
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lamellar orientation inversion under Dynamic Interplay between crystallization and phase separation
Macromolecules, 2012Co-Authors: Weichao Shi, Jian Yang, Yan Zhang, Jun Luo, Yongri Liang, Charles C HanAbstract:Crystallization Dynamics and lamellar orientation are affected under the Dynamic Interplay between crystallization and phase separation. We carried out the experiment in a Dynamically asymmetric bl...
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lamellar orientation inversion under Dynamic Interplay between crystallization and phase separation
Macromolecules, 2012Co-Authors: Weichao Shi, Jian Yang, Yan Zhang, Jun Luo, Yongri Liang, Charles C HanAbstract:Crystallization Dynamics and lamellar orientation are affected under the Dynamic Interplay between crystallization and phase separation. We carried out the experiment in a Dynamically asymmetric blend of amorphous poly(methyl methacrylate) (PMMA) and crystalline poly(ethylene oxide) (PEO). If phase separation is really weak, lamellae are normally grown in the radial direction within spherulites. Growth rate shows a bell-like curve with respect to temperature. However, when strong phase separation intervenes, the growth rate curve is characterized by double peaks, one of which is dominated by crystallization and the other by phase separation. Meanwhile, lamellae tend to orient in the tangential direction in concentric alternating structures, whose formation mechanism has been explained in previous studies. This lamellar orientation inversion is reflected by a negative to positive birefringence inversion under optical microscopy. Within lamellar stacks, more amorphous molecules tend to be pushed out under t...
Malcolm F. White - One of the best experts on this subject based on the ideXlab platform.
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The Dynamic Interplay of host and viral enzymes in type III CRISPR-mediated cyclic nucleotide signalling
eLife, 2020Co-Authors: Januka S Athukoralage, Shirley Graham, Christophe Rouillon, Sabine Grüschow, Clarissa M. Czekster, Malcolm F. WhiteAbstract:Cyclic nucleotide second messengers are increasingly implicated in prokaryotic anti-viral defence systems. Type III CRISPR systems synthesise cyclic oligoadenylate (cOA) upon detecting foreign RNA, activating ancillary nucleases that can be toxic to cells, necessitating mechanisms to remove cOA in systems that operate via immunity rather than abortive infection. Previously, we demonstrated that the Sulfolobus solfataricus type III-D CRISPR complex generates cyclic tetra-adenylate (cA4), activating the ribonuclease Csx1, and showed that subsequent RNA cleavage and dissociation acts as an 'off-switch' for the cyclase activity. Subsequently, we identified the cellular ring nuclease Crn1, which slowly degrades cA4 to reset the system (Rouillon et al., 2018), and demonstrated that viruses can subvert type III CRISPR immunity by means of a potent anti-CRISPR ring nuclease variant AcrIII-1. Here, we present a comprehensive analysis of the Dynamic Interplay between these enzymes, governing cyclic nucleotide levels and infection outcomes in virus-host conflict.
A F Mannion - One of the best experts on this subject based on the ideXlab platform.
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negative beliefs and psychological disturbance in spine surgery patients a cause or consequence of a poor treatment outcome
European Spine Journal, 2013Co-Authors: S Havakeshian, A F MannionAbstract:Purpose Chronic musculoskeletal pain is often associated with psychological distress and maladaptive beliefs and these are sometimes reported to have a negative impact on surgical outcome. The influence of a surgical intervention, and in particular its outcome, on the course of change in psychological status is poorly documented. In this prospective study, we sought to examine the Dynamic Interplay between psychological factors and outcome in patients undergoing decompression surgery for spinal stenosis/herniated disc.
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erratum to negative beliefs and psychological disturbance in spine surgery patients a cause or consequence of a poor treatment outcome
European Spine Journal, 2013Co-Authors: S Havakeshian, A F MannionAbstract:Purpose Chronic musculoskeletal pain is often associated with psychological distress and maladaptive beliefs and these are sometimes reported to have a negative impact on surgical outcome. The influence of a surgical intervention, and in particular its outcome, on the course of change in psychological status is poorly documented. In this prospective study, we sought to examine the Dynamic Interplay between psychological factors and outcome in patients undergoing decompression surgery for spinal stenosis/herniated disc.
Weichao Shi - One of the best experts on this subject based on the ideXlab platform.
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lamellar orientation inversion under Dynamic Interplay between crystallization and phase separation
Macromolecules, 2012Co-Authors: Weichao Shi, Jian Yang, Yan Zhang, Jun Luo, Yongri Liang, Charles C HanAbstract:Crystallization Dynamics and lamellar orientation are affected under the Dynamic Interplay between crystallization and phase separation. We carried out the experiment in a Dynamically asymmetric bl...
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lamellar orientation inversion under Dynamic Interplay between crystallization and phase separation
Macromolecules, 2012Co-Authors: Weichao Shi, Jian Yang, Yan Zhang, Jun Luo, Yongri Liang, Charles C HanAbstract:Crystallization Dynamics and lamellar orientation are affected under the Dynamic Interplay between crystallization and phase separation. We carried out the experiment in a Dynamically asymmetric blend of amorphous poly(methyl methacrylate) (PMMA) and crystalline poly(ethylene oxide) (PEO). If phase separation is really weak, lamellae are normally grown in the radial direction within spherulites. Growth rate shows a bell-like curve with respect to temperature. However, when strong phase separation intervenes, the growth rate curve is characterized by double peaks, one of which is dominated by crystallization and the other by phase separation. Meanwhile, lamellae tend to orient in the tangential direction in concentric alternating structures, whose formation mechanism has been explained in previous studies. This lamellar orientation inversion is reflected by a negative to positive birefringence inversion under optical microscopy. Within lamellar stacks, more amorphous molecules tend to be pushed out under t...
Januka S Athukoralage - One of the best experts on this subject based on the ideXlab platform.
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The Dynamic Interplay of host and viral enzymes in type III CRISPR-mediated cyclic nucleotide signalling
eLife, 2020Co-Authors: Januka S Athukoralage, Shirley Graham, Christophe Rouillon, Sabine Grüschow, Clarissa M. Czekster, Malcolm F. WhiteAbstract:Cyclic nucleotide second messengers are increasingly implicated in prokaryotic anti-viral defence systems. Type III CRISPR systems synthesise cyclic oligoadenylate (cOA) upon detecting foreign RNA, activating ancillary nucleases that can be toxic to cells, necessitating mechanisms to remove cOA in systems that operate via immunity rather than abortive infection. Previously, we demonstrated that the Sulfolobus solfataricus type III-D CRISPR complex generates cyclic tetra-adenylate (cA4), activating the ribonuclease Csx1, and showed that subsequent RNA cleavage and dissociation acts as an 'off-switch' for the cyclase activity. Subsequently, we identified the cellular ring nuclease Crn1, which slowly degrades cA4 to reset the system (Rouillon et al., 2018), and demonstrated that viruses can subvert type III CRISPR immunity by means of a potent anti-CRISPR ring nuclease variant AcrIII-1. Here, we present a comprehensive analysis of the Dynamic Interplay between these enzymes, governing cyclic nucleotide levels and infection outcomes in virus-host conflict.
